Tuulia Tynkkynen

Tuulia Tynkkynen

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Tuulia Tynkkynen

Tuulia Tynkkynen

Publications by authors named "Tuulia Tynkkynen"

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Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase.

J Am Coll Cardiol 2016 Mar;67(10):1200-1210

Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Oulu University Hospital, Oulu, Finland; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom; Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.12.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783625PMC
March 2016

Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates.

Int J Epidemiol 2015 Apr 6;44(2):623-37. Epub 2015 Jun 6.

Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, NordLab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland, Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland, Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland, Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland, National Institute for Health and Welfare, Helsinki, Finland, Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Estonian Genome Center, University of Tartu, Tartu, Estonia, Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland, Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK, Institute of Health Sciences & Biocenter Oulu, University of Oulu, Oulu, Finland, Unit of Primary Care, Oulu University Hospital, Oulu, Finland, Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, UK and Computational Medicine, Oulu University Hospital, Oulu, Finland. Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, F

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http://dx.doi.org/10.1093/ije/dyv093DOI Listing
April 2015

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts.

Circulation 2015 Mar 8;131(9):774-85. Epub 2015 Jan 8.

From Computational Medicine, Institute of Health Sciences, University of Oulu, Finland (P.W., P.S., T. Tynkkynen, Q.W., M.T., A.J.K., J. Kettunen, M.A.-K.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Finland (P.W., A.S.H., J. Kettunen, A.J., M.P., V.S.); Institute for Molecular Medicine Finland, University of Helsinki (P.W., A.S.H., M.P., S.P.); NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio (P.S., T. Tynkkynen, Q.W., M.T., M.A.-K.); Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, United Kingdom (D.P.-M., J.-P.C.); Institute of Cardiovascular Science, University College London, United Kingdom (T. Tillin, A.D.H., J.-P.C., N.C.); Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, MA (A.G., R.S.V.); Genome Analysis Center, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany (A.A., J.A.); Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (J. Kaikkonen, V.M., O.T.R.); Department of Food and Environmental Sciences, University of Helsinki, Finland (V.M.,); Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Finland (M.K.); Department of Clinical Chemistry, Fimlab Laboratories, and School of Medicine, University of Tampere, Finland (T.L.); Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom (D.A.L., T.R.G., M.A.-K.); School of Social and Community Medicine, University of Bristol, United Kingdom (D.A.L., T.R.G., M.A.-K.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (N.S.); Hannover Medical School, Hannover Unified Biobank, Germany (T.I.); Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351161PMC
March 2015

Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.

PLoS Med 2014 Dec 9;11(12):e1001765. Epub 2014 Dec 9.

Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260795PMC
December 2014

(1) H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments.

Magn Reson Chem 2012 Sep 25;50(9):598-607. Epub 2012 Jul 25.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland.

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http://dx.doi.org/10.1002/mrc.3847DOI Listing
September 2012

Metabolic diversity of progressive kidney disease in 325 patients with type 1 diabetes (the FinnDiane Study).

J Proteome Res 2012 Mar 26;11(3):1782-90. Epub 2012 Jan 26.

Computational Medicine Research Group, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu , Finland.

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http://dx.doi.org/10.1021/pr201036jDOI Listing
March 2012

High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism.

Analyst 2009 Sep 30;134(9):1781-5. Epub 2009 Jul 30.

NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland.

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http://dx.doi.org/10.1039/b910205aDOI Listing
September 2009

From proton nuclear magnetic resonance spectra to pH. Assessment of 1H NMR pH indicator compound set for deuterium oxide solutions.

Anal Chim Acta 2009 Aug 24;648(1):105-12. Epub 2009 Jun 24.

Laboratory of Chemistry, Department of Biosciences, University of Kuopio, 70211 Kuopio, Finland.

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http://dx.doi.org/10.1016/j.aca.2009.06.047DOI Listing
August 2009

A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.

Biochem Biophys Res Commun 2008 Oct 26;375(3):356-61. Epub 2008 Aug 26.

Computational Medicine Research Group, Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, P.O. Box 9203, FI-02015 HUT, Finland.

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http://dx.doi.org/10.1016/j.bbrc.2008.08.007DOI Listing
October 2008