Publications by authors named "Tuomas Tammela"

54Publications

Expression of R-spondin1 in Apc Mice Reduces Growth of Intestinal Adenomas by Altering Wnt and TGFB Signaling.

Gastroenterology 2020 Sep 14. Epub 2020 Sep 14.

Translational Cancer Medicine Program (CAN-PRO), Research Programs Unit, Faculty of Medicine, University of Helsinki, and iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, 00014, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.09.011DOI Listing
September 2020

Exercise and immunometabolic regulation in cancer.

Nat Metab 2020 Sep 14;2(9):849-857. Epub 2020 Sep 14.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s42255-020-00277-4DOI Listing
September 2020

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.

Sci Transl Med 2020 Apr;12(537)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaw0262DOI Listing
April 2020

Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.

Nat Protoc 2018 02 4;13(2):217-234. Epub 2018 Jan 4.

The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2017.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145089PMC
February 2018

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.

Cell 2017 Sep;170(6):1149-1163.e12

Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary & Respiratory Diseases, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607351PMC
September 2017

VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.

Circ Res 2017 Apr 15;120(9):1414-1425. Epub 2017 Mar 15.

From the Wihuri Research Institute and Translational Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland (K.H., S.K., G.D'A., T.T., K.A., G.Z.); Biocenter Oulu and Department of Pathology, University of Oulu and Oulu University Hospital, Finland (R.S.); and Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland (L.E.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959003PMC
April 2017

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers.

Nat Commun 2016 09 2;7:12685. Epub 2016 Sep 2.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue 75-453, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncomms12685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025814PMC
September 2016

A Modular Assembly Platform for Rapid Generation of DNA Constructs.

Sci Rep 2016 Feb 18;6:16836. Epub 2016 Feb 18.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep16836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757859PMC
February 2016

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

Immunity 2015 Sep 1;43(3):579-90. Epub 2015 Sep 1.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826619PMC
September 2015

Growth factor therapy and lymph node graft for lymphedema.

J Surg Res 2015 Jun 19;196(1):200-7. Epub 2015 Feb 19.

Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jss.2015.02.031DOI Listing
June 2015

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Nature 2014 Dec 22;516(7531):428-31. Epub 2014 Oct 22.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature13906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292871PMC
December 2014

CRISPR-mediated direct mutation of cancer genes in the mouse liver.

Nature 2014 Oct 6;514(7522):380-4. Epub 2014 Aug 6.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature13589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199937PMC
October 2014

Small RNA combination therapy for lung cancer.

Proc Natl Acad Sci U S A 2014 Aug 11;111(34):E3553-61. Epub 2014 Aug 11.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Departments of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1412686111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151750PMC
August 2014

Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization.

Blood 2013 Aug 26;122(5):658-65. Epub 2013 Jun 26.

Wihuri Research Institute and Translational Cancer Biology Program, Faculty of Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2012-07-441527DOI Listing
August 2013

In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):6223-8. Epub 2012 Apr 2.

Biotechnology Programme, Spanish National Cancer Research Centre, CNIO, 28029 Madrid, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1115542109
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http://dx.doi.org/10.1073/pnas.1115542109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341065PMC
April 2012

Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses.

J Cell Sci 2012 May 22;125(Pt 9):2212-23. Epub 2012 Feb 22.

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.098020
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http://dx.doi.org/10.1242/jcs.098020DOI Listing
May 2012

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

Nat Cell Biol 2011 Sep 11;13(10):1202-13. Epub 2011 Sep 11.

Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Research Programs Unit and Department of Pathology, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261765PMC
http://dx.doi.org/10.1038/ncb2331DOI Listing
September 2011

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.

Blood 2011 Jul 12;118(4):1154-62. Epub 2011 May 12.

Molecular/Cancer Biology Laboratory, Research Programs Unit, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2010-11-317800DOI Listing
July 2011

Biological basis of therapeutic lymphangiogenesis.

Circulation 2011 Mar;123(12):1335-51

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, P.O.B. 63 (Haartmaninkatu 8), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.704098DOI Listing
March 2011

Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis.

Sci Transl Med 2011 Feb;3(69):69ra11

Molecular/Cancer Biology Laboratory, Faculty of Medicine Research Programs, Haartman Institute, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, POB 63 (Haartmaninkatu 8), University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1126/scitranslmed.3001699DOI Listing
February 2011

Growth factor therapy and autologous lymph node transfer in lymphedema.

Circulation 2011 Feb 31;123(6):613-20. Epub 2011 Jan 31.

Plastic Surgery, Turku University Central Hospital, Finland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.965384DOI Listing
February 2011

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Cancer Cell 2010 Dec 2;18(6):630-40. Epub 2010 Dec 2.

Institute for Molecular Medicine Finland, Department of Pathology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ccr.2010.11.001DOI Listing
December 2010

Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.

Circulation 2010 Oct 11;122(17):1725-33. Epub 2010 Oct 11.

Molecular/Cancer Biology Laboratory and Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.957332DOI Listing
October 2010

Lymphangiogenesis: Molecular mechanisms and future promise.

Cell 2010 Feb;140(4):460-76

Molecular/Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674100011
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http://dx.doi.org/10.1016/j.cell.2010.01.045DOI Listing
February 2010

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.

Curr Opin Cell Biol 2009 Apr 21;21(2):154-65. Epub 2009 Feb 21.

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ceb.2008.12.012DOI Listing
April 2009

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.

Nature 2008 Jul 25;454(7204):656-60. Epub 2008 Jun 25.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nature07083DOI Listing
July 2008

Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.

Nat Med 2007 Dec 2;13(12):1458-66. Epub 2007 Dec 2.

Molecular/Cancer Biology Laboratory, Haartman Institute and Ludwig Institute for Cancer Research, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.

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http://www.nature.com/articles/nm1689
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http://dx.doi.org/10.1038/nm1689DOI Listing
December 2007

Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.

J Exp Med 2007 Jun 29;204(6):1431-40. Epub 2007 May 29.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1084/jem.20062642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118625PMC
June 2007

Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein.

Circ Res 2007 May 3;100(10):1460-7. Epub 2007 May 3.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1161/01.RES.0000269042.58594.f6DOI Listing
May 2007

Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.

Circ Res 2007 May 3;100(10):1468-75. Epub 2007 May 3.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, the Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1161/01.RES.0000269043.51272.6dDOI Listing
May 2007

Vascular endothelial growth factor-C accelerates diabetic wound healing.

Am J Pathol 2006 Sep;169(3):1080-7

Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Hospital, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698814PMC
http://dx.doi.org/10.2353/ajpath.2006.051251DOI Listing
September 2006

Lymphangiogenesis in development and human disease.

Nature 2005 Dec;438(7070):946-53

Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer, Research, P.O.B. 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1038/nature04480DOI Listing
December 2005

Molecular lymphangiogenesis: new players.

Trends Cell Biol 2005 Aug;15(8):434-41

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Helsinki University Central Hospital, POB 63 (Haartmaninkatu 8), 00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.tcb.2005.06.004DOI Listing
August 2005

Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.

Blood 2005 Jun 3;105(12):4642-8. Epub 2005 Mar 3.

Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2004-08-3327DOI Listing
June 2005

The biology of vascular endothelial growth factors.

Cardiovasc Res 2005 Feb;65(3):550-63

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, 00014 Helsinki, Finland.

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://cardiovascres.oxfordjournals.org/cgi/doi/10.1016/j.ca
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http://dx.doi.org/10.1016/j.cardiores.2004.12.002DOI Listing
February 2005

Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds.

FASEB J 2004 Nov 10;18(14):1707-9. Epub 2004 Sep 10.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1096/fj.04-1592fjeDOI Listing
November 2004

Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.

Trends Immunol 2004 Jul;25(7):387-95

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, P.O.B. 63 (Haartmaninkatu 8), 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.it.2004.05.003DOI Listing
July 2004

Genesis and pathogenesis of lymphatic vessels.

Cell Tissue Res 2003 Oct 27;314(1):69-84. Epub 2003 Aug 27.

Molecular and Cancer Biology Laboratory, Ludwig Institute for Cancer Research, and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, Postbox 63, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00441-003-0777-2DOI Listing
October 2003

Lymphangiogenic gene therapy with minimal blood vascular side effects.

J Exp Med 2002 Sep;196(6):719-30

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Helsinki University Central Hospital, University of Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194057PMC
http://dx.doi.org/10.1084/jem.20020587DOI Listing
September 2002