Tuomas P Knowles

Tuomas P J Knowles

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Tuomas P J Knowles

Publications by authors named "Tuomas P J Knowles"

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1PubMed Central Citations

Kinetic Analysis of Amyloid Formation.

Methods Mol Biol 2018 ;1779:181-196

Department of Chemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-4939-7816-8_12DOI Listing
July 2019

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis.

Analyst 2019 Jul 19;144(14):4413-4424. Epub 2019 Jun 19.

Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK. and Department of Physics, University of Cambridge, JJ Thomson Ave, Cambridge CB3 0HE, UK.

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http://dx.doi.org/10.1039/c9an00382gDOI Listing
July 2019

Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein.

Small 2019 Jun 17:e1901780. Epub 2019 Jun 17.

School of Molecular Cell Biology & Biotechnology, Faculty of Life Science, Tel Aviv University, Tel Aviv, 69978, Israel.

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http://dx.doi.org/10.1002/smll.201901780DOI Listing
June 2019

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.

Macromol Rapid Commun 2019 Apr 6;40(8):e1800898. Epub 2019 Mar 6.

X. Liu, Z. Toprakcioglu, A. J. Dear, Dr. A. Levin, Dr. F. S. Ruggeri, C. G. Taylor, M. Hu, Dr. J. R. Kumita, Dr. M. Andreasen, Prof. C. M. Dobson, Prof. T. P. J. Knowles, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1002/marc.201800898DOI Listing
April 2019

The Amyloid Phenomenon and Its Significance in Biology and Medicine.

Cold Spring Harb Perspect Biol 2019 Apr 1. Epub 2019 Apr 1.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a033878DOI Listing
April 2019

Atomic force microscopy for single molecule characterisation of protein aggregation.

Arch Biochem Biophys 2019 Mar 8;664:134-148. Epub 2019 Feb 8.

Centre for Misfolding Disease, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom; Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420408PMC
March 2019

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

ACS Chem Neurosci 2018 12 17;9(12):3060-3071. Epub 2018 Jul 17.

Department of Chemistry , Cambridge University , Lensfield Rd , Cambridge CB2 1EW , United Kingdom.

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http://dx.doi.org/10.1021/acschemneuro.8b00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302314PMC
December 2018

Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

ACS Chem Neurosci 2018 12 10;9(12):2959-2971. Epub 2018 Aug 10.

Centre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , UK.

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http://dx.doi.org/10.1021/acschemneuro.8b00141DOI Listing
December 2018

Statistical Mechanics of Globular Oligomer Formation by Protein Molecules.

J Phys Chem B 2018 Dec 31;122(49):11721-11730. Epub 2018 Oct 31.

Centre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.

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http://dx.doi.org/10.1021/acs.jpcb.8b07805DOI Listing
December 2018

Direct Observation of Murine Prion Protein Replication in Vitro.

J Am Chem Soc 2018 Nov 23;140(44):14789-14798. Epub 2018 Oct 23.

Department of Chemistry , University of Cambridge , Cambridge , CB2 1EW , U.K.

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http://pubs.acs.org/doi/10.1021/jacs.8b08311
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http://dx.doi.org/10.1021/jacs.8b08311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225343PMC
November 2018

Quantifying Co-Oligomer Formation by α-Synuclein.

ACS Nano 2018 Nov 29;12(11):10855-10866. Epub 2018 Oct 29.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.

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http://pubs.acs.org/doi/10.1021/acsnano.8b03575
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http://dx.doi.org/10.1021/acsnano.8b03575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262461PMC
November 2018

Mechanobiology of Protein Droplets: Force Arises from Disorder.

Cell 2018 Nov;175(6):1457-1459

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK; Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.11.020DOI Listing
November 2018

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform.

J Vis Exp 2018 11 28(141). Epub 2018 Nov 28.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge;

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http://dx.doi.org/10.3791/58643DOI Listing
November 2018

SAR by kinetics for drug discovery in protein misfolding diseases.

Proc Natl Acad Sci U S A 2018 10 26;115(41):10245-10250. Epub 2018 Sep 26.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1807884115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187117PMC
October 2018

Observation of molecular self-assembly events in massively parallel microdroplet arrays.

Lab Chip 2018 10;18(21):3303-3309

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

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http://xlink.rsc.org/?DOI=C8LC00862K
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http://dx.doi.org/10.1039/c8lc00862kDOI Listing
October 2018

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

Anal Chem 2018 09 13;90(17):10385-10393. Epub 2018 Aug 13.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.8b02226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127805PMC
September 2018

Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.

Anal Chem 2018 09 15;90(17):10302-10310. Epub 2018 Aug 15.

Cavendish Laboratory , University of Cambridge , JJ Thomson Avenue , Cambridge CB3 0HE , U.K.

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http://dx.doi.org/10.1021/acs.analchem.8b02051DOI Listing
September 2018

Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.

Anal Chem 2018 08 9;90(15):8998-9005. Epub 2018 Jul 9.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.8b01205DOI Listing
August 2018

Secondary nucleation in amyloid formation.

Chem Commun (Camb) 2018 Aug;54(63):8667-8684

Lund University, Department of Biochemistry and Structural Biology, Chemical Centre, PO Box 124, SE221 00 Lund, Sweden.

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http://xlink.rsc.org/?DOI=C8CC02204F
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http://dx.doi.org/10.1039/c8cc02204fDOI Listing
August 2018

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces.

ACS Appl Mater Interfaces 2018 Aug 9;10(33):27578-27583. Epub 2018 Aug 9.

Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.

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http://dx.doi.org/10.1021/acsami.8b09511DOI Listing
August 2018

DNA-Coated Functional Oil Droplets.

Langmuir 2018 08 17;34(34):10073-10080. Epub 2018 Aug 17.

Optoelectronics Group, Cavendish Laboratory , University of Cambridge , J. J. Thomson Avenue , Cambridge CB3 0HE , U.K.

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http://pubs.acs.org/doi/10.1021/acs.langmuir.8b01828
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http://dx.doi.org/10.1021/acs.langmuir.8b01828DOI Listing
August 2018

Cooperative Assembly of Hsp70 Subdomain Clusters.

Biochemistry 2018 07 29;57(26):3641-3649. Epub 2018 May 29.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.

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http://dx.doi.org/10.1021/acs.biochem.8b00151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202011PMC
July 2018

Determination of Polypeptide Conformation with Nanoscale Resolution in Water.

ACS Nano 2018 Jul 28;12(7):6612-6619. Epub 2018 Jun 28.

Center for Nanoscale Science and Technology , National Institute of Standards and Technology , Gaithersburg , Maryland 20899 , United States.

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http://dx.doi.org/10.1021/acsnano.8b01425DOI Listing
July 2018

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

Proc Natl Acad Sci U S A 2018 07 25;115(28):7230-7235. Epub 2018 Jun 25.

Laboratory of Physics of Living Matter, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland;

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http://dx.doi.org/10.1073/pnas.1721220115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048494PMC
July 2018

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.

Chem Commun (Camb) 2018 Jul;54(56):7854-7857

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. and German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany.

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http://xlink.rsc.org/?DOI=C8CC03002B
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http://dx.doi.org/10.1039/c8cc03002bDOI Listing
July 2018

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH.

Chem Sci 2018 Jul 24;9(25):5506-5516. Epub 2018 May 24.

Centre for Misfolding Diseases , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: ; Email:

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http://dx.doi.org/10.1039/c8sc01109eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048717PMC
July 2018

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.

Adv Healthc Mater 2018 Jun 10;7(11):e1701485. Epub 2018 Apr 10.

Institute of Physiological Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

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http://dx.doi.org/10.1002/adhm.201701485DOI Listing
June 2018

Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals.

ACS Nano 2018 Jun 22;12(6):5408-5416. Epub 2018 May 22.

Interdisciplinary Nanoscience Center , Aarhus University , Aarhus 8000 , Denmark.

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http://dx.doi.org/10.1021/acsnano.8b00448DOI Listing
June 2018

On the role of sidechain size and charge in the aggregation of A42 with familial mutations.

Proc Natl Acad Sci U S A 2018 06 12;115(26):E5849-E5858. Epub 2018 Jun 12.

Division of Biochemistry & Structural Biology, Centre for Molecular Protein Science, Department of Chemistry, Lund University, SE221 00 Lund, Sweden;

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http://dx.doi.org/10.1073/pnas.1803539115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042101PMC
June 2018

Biophotonics of Native Silk Fibrils.

Macromol Biosci 2018 04 29;18(4):e1700295. Epub 2018 Jan 29.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1002/mabi.201700295DOI Listing
April 2018

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Annu Rev Phys Chem 2018 04 28;69:273-298. Epub 2018 Feb 28.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-physchem-050317-021322DOI Listing
April 2018

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Chem Sci 2018 Apr 9;9(14):3503-3507. Epub 2018 Feb 9.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK . Email: ; Email: ; Tel: +44 (0)1223 336344.

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http://dx.doi.org/10.1039/c7sc04331gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934698PMC
April 2018

Microfluidics for Protein Biophysics.

J Mol Biol 2018 03 29;430(5):565-580. Epub 2017 Dec 29.

Chemistry Department, University of Cambridge, Lensfield Road, Cambridge, CB3 0FF, UK; Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue, Cambridge, CB3 1HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.12.015DOI Listing
March 2018

Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.

Anal Chem 2018 03 13;90(5):3284-3290. Epub 2018 Feb 13.

Centre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.analchem.7b04820
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http://dx.doi.org/10.1021/acs.analchem.7b04820DOI Listing
March 2018

Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.

Anal Chem 2018 03 28;90(6):3849-3855. Epub 2018 Feb 28.

Department of Chemistry , University of Cambridge , Lensfield Road , CB2 1EW Cambridge , U.K.

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http://dx.doi.org/10.1021/acs.analchem.7b04523DOI Listing
March 2018

Microfluidic approaches for probing amyloid assembly and behaviour.

Lab Chip 2018 03;18(7):999-1016

The Centre for Misfolding Disease, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1039/c7lc01241aDOI Listing
March 2018

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.

J Am Chem Soc 2018 02 7;140(7):2493-2503. Epub 2018 Feb 7.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , 15 Datun Road, Chaoyang District, Beijing 100101, China.

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http://dx.doi.org/10.1021/jacs.7b10439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880511PMC
February 2018

Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements.

Interface Focus 2017 Dec 20;7(6):20170013. Epub 2017 Oct 20.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

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http://dx.doi.org/10.1098/rsfs.2017.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665796PMC
December 2017

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.

Lab Chip 2017 12;18(1):162-170

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

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http://dx.doi.org/10.1039/c7lc00797cDOI Listing
December 2017

Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry.

Biomacromolecules 2017 Nov 19;18(11):3642-3651. Epub 2017 Oct 19.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, United Kingdom.

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http://dx.doi.org/10.1021/acs.biomac.7b01159DOI Listing
November 2017

Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems.

Anal Chem 2017 11 3;89(22):11929-11936. Epub 2017 Nov 3.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.7b01174DOI Listing
November 2017

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.

J Am Chem Soc 2017 11 23;139(45):16134-16142. Epub 2017 Oct 23.

Institute of Physical Biology, University of Düsseldorf , Düsseldorf 40225, Germany.

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http://dx.doi.org/10.1021/jacs.7b00229DOI Listing
November 2017

Sequential Release of Proteins from Structured Multishell Microcapsules.

Biomacromolecules 2017 Oct 7;18(10):3052-3059. Epub 2017 Sep 7.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1021/acs.biomac.7b00351DOI Listing
October 2017

Nanoscale click-reactive scaffolds from peptide self-assembly.

J Nanobiotechnology 2017 Oct 6;15(1):70. Epub 2017 Oct 6.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.

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http://dx.doi.org/10.1186/s12951-017-0300-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389178PMC
October 2017

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Chem Sci 2017 Oct 31;8(10):7087-7097. Epub 2017 Aug 31.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: ; Email:

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http://dx.doi.org/10.1039/c7sc01965cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637470PMC
October 2017

Kinetic constraints on self-assembly into closed supramolecular structures.

Sci Rep 2017 09 25;7(1):12295. Epub 2017 Sep 25.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1038/s41598-017-12528-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613031PMC
September 2017

Gradient-free determination of isoelectric points of proteins on chip.

Phys Chem Chem Phys 2017 Aug;19(34):23060-23067

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. and Department of Physics, Cavendish Laboratory, 19 J J Thomson Avenue, Cambridge CB3 0HE, UK.

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http://dx.doi.org/10.1039/c7cp01503hDOI Listing
August 2017

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Proc Natl Acad Sci U S A 2017 07 11;114(30):8005-8010. Epub 2017 Jul 11.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1700239114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544282PMC
July 2017

Ultrasensitive Measurement of Ca Influx into Lipid Vesicles Induced by Protein Aggregates.

Angew Chem Int Ed Engl 2017 06 5;56(27):7750-7754. Epub 2017 May 5.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1002/anie.201700966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615231PMC
June 2017

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

Proc Natl Acad Sci U S A 2017 06 5;114(25):6444-6449. Epub 2017 Jun 5.

Department of Biochemistry and Structural Biology, Chemical Centre, Lund University, SE221 00 Lund, Sweden;

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http://dx.doi.org/10.1073/pnas.1700407114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488933PMC
June 2017

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.

Chem Sci 2017 Jun 26;8(6):4352-4362. Epub 2017 Apr 26.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: ; Email:

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http://dx.doi.org/10.1039/c7sc00215gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580342PMC
June 2017

Physical principles of filamentous protein self-assembly kinetics.

J Phys Condens Matter 2017 Apr 7;29(15):153002. Epub 2017 Feb 7.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, United States of America.

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http://stacks.iop.org/0953-8984/29/i=15/a=153002?key=crossre
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http://dx.doi.org/10.1088/1361-648X/aa5f10DOI Listing
April 2017

Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.

J Chem Phys 2017 Apr;146(13):135102

Department of Chemistry, University of California, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1063/1.4977932DOI Listing
April 2017

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Biochemistry 2017 03 23;56(9):1177-1180. Epub 2017 Feb 23.

Biocomputation and Complex Systems Physics Institute (BIFI)-Joint Unit BIFI-IQFR (CSIC), University of Zaragoza , 50018 Zaragoza, Spain.

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http://dx.doi.org/10.1021/acs.biochem.6b01178DOI Listing
March 2017

Acceleration of α-synuclein aggregation.

Amyloid 2017 03;24(sup1):20-21

b Department of Biochemistry and Structural Biology , Lund University , Sweden.

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http://dx.doi.org/10.1080/13506129.2017.1292904DOI Listing
March 2017

Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning.

Biomicrofluidics 2017 Jan 17;11(1):014113. Epub 2017 Feb 17.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1063/1.4976690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315664PMC
January 2017

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.

J Chem Phys 2016 Dec;145(21):211926

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1063/1.4965040DOI Listing
December 2016

Dynamics of heteromolecular filament formation.

J Chem Phys 2016 Nov;145(17):175101

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://aip.scitation.org/doi/10.1063/1.4966571
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http://dx.doi.org/10.1063/1.4966571DOI Listing
November 2016

Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.

Nat Commun 2016 10 11;7:12934. Epub 2016 Oct 11.

Department of Mechanical Engineering, the University of Hong Kong, Pokfulam Road, Hong Kong.

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http://dx.doi.org/10.1038/ncomms12934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062572PMC
October 2016

Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.

Chembiochem 2016 10 24;17(20):1920-1924. Epub 2016 Aug 24.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1002/cbic.201600384DOI Listing
October 2016

Dynamic microfluidic control of supramolecular peptide self-assembly.

Nat Commun 2016 10 25;7:13190. Epub 2016 Oct 25.

Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1038/ncomms13190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093325PMC
October 2016

Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials.

Adv Mater 2016 Aug 11;28(31):6546-61. Epub 2016 May 11.

Department of Health Sciences and Technology, ETH Zurich, Switzerland.

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http://dx.doi.org/10.1002/adma.201505961DOI Listing
August 2016

Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform.

J Am Chem Soc 2016 08 26;138(30):9589-96. Epub 2016 Jul 26.

Department of Chemistry, University of Cambridge , Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1021/jacs.6b04136DOI Listing
August 2016

Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.

Anal Biochem 2016 07 28;504:7-13. Epub 2016 Mar 28.

Department of Biochemistry and Structural Biology, Lund University, SE-221 00 Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.03.015DOI Listing
July 2016

Fluctuations in the Kinetics of Linear Protein Self-Assembly.

Phys Rev Lett 2016 Jun 21;116(25):258103. Epub 2016 Jun 21.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1103/PhysRevLett.116.258103DOI Listing
June 2016

A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.

Biophys J 2016 05;110(9):1957-66

Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939750PMC
May 2016

Quantitative thermophoretic study of disease-related protein aggregates.

Sci Rep 2016 Mar 17;6:22829. Epub 2016 Mar 17.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

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http://dx.doi.org/10.1038/srep22829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794802PMC
March 2016