Publications by authors named "Tudor Pinteala"

13 Publications

  • Page 1 of 1

New insights into human hair: SAXS, SEM, TEM and EDX for Alopecia Areata investigations.

PeerJ 2020 14;8:e8376. Epub 2020 Jan 14.

Centre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry, Iasi, Iasi, Romania.

Background: Alopecia areata (AA) is a T-cell-mediated autoimmune disease and affects up to 2% of the population. There is a need for a more profound and rigorous understanding of the structure and composition of human hair affected by AA in order to manage this disease. The aim of this article is to understand the effects of AA on the structure and composition of human hair.

Methods: Several physico-chemical investigation methods, such as Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-ray Spectroscopy (EDX), and microbeam Small Angle X-ray Scattering (SAXS), were used to analyze human hair samples obtained from healthy donors and patients with AA.

Results: SEM revealed more severe hair surface defects for the white regrown hair (W-AA) samples. TEM showed the presence of air-like vesicles located in the endocuticle of regrown hair. Analysis of ultrathin sections of W-AA showed the existence of empty vesicles and smaller melanin granules compared to control samples. SAXS demonstrated that unaffected hair of patients with AA (B-AA) and W-AA melanin aggregates are different in their sizes and shapes compared to the control samples. EDX data showed that W-AA elemental composition was significantly different from the other sample groups. Our study showcases promising non-invasive techniques for a better and more accurate understanding of changes in the internal structure and composition of hair affected by AA.
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http://dx.doi.org/10.7717/peerj.8376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968496PMC
January 2020

"Chemical" surgery in treating basal cell carcinoma in elderly.

Dermatol Ther 2019 01 16;32(1):e12753. Epub 2018 Oct 16.

"Nicolae Testemitanu" State University of Medicine and Pharmacy, Department of Dermatovenereology, Kishinev, Republic of Moldova.

The incidence of basal cell carcinoma (BCC) has been increasing in the last decades due to population aging and precise diagnosis. The difficulty that physicians face frequently is related to the treatment decision for BCC; when treating BCC, correct and personalized choices must be taken into consideration by selecting from a large variety of therapeutic options such as: surgical excision ("the golden standard therapy"), electrodessication, cryosurgery, radiation therapy, laser, photodynamic therapy, curettage, topical treatment (imiquimod, 5-fluorouracil, vismodegib), or combining different treatments. The present authors present series of cases of patients diagnosed with BCC, highlighting that "chemical surgery" using 70% trichloroacetic acid could be a valuable option in the treatment of nonaggressive BCC of the face.
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http://dx.doi.org/10.1111/dth.12753DOI Listing
January 2019

Nail Damage (Severe Onychodystrophy) Induced by Acrylate Glue: Scanning Electron Microscopy and Energy Dispersive X-Ray Investigations.

Skin Appendage Disord 2017 Jan 11;2(3-4):137-142. Epub 2016 Oct 11.

Centre of Advanced Research in Bionanoconjugates and Biopolymers, Institute of Macromolecular Chemistry Petru Poni, Iasi, Romania.

Background: Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) techniques have been used in various fields of medical research, including different pathologies of the nails; however, no studies have focused on obtaining high-resolution microscopic images and elemental analysis of disorders caused by synthetic nails and acrylic adhesives.

Methods: Damaged/injured fingernails caused by the use of acrylate glue and synthetic nails were investigated using SEM and EDX methods.

Results: SEM and EDX proved that synthetic nails, acrylic glue, and nails damaged by contact with acrylate glue have a different morphology and different composition compared to healthy human nails.

Conclusions: SEM and EDX analysis can give useful information about the aspects of topography (surface sample), morphology (shape and size), hardness or reflectivity, and the elemental composition of nails.
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http://dx.doi.org/10.1159/000450791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264361PMC
January 2017

Allergic Contact Dermatitis from Topical Acyclovir: Case Series.

J Emerg Med 2017 Feb 19;52(2):e37-e39. Epub 2016 Sep 19.

Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

Background: Despite the widespread use of oral or topical acyclovir, allergic contact dermatitis caused by it has been rarely reported, with fewer than 20 case studies published in the English literature to date.

Case Reports: A diagnosis of allergic contact dermatitis from acyclovir cream was established in a 62-year-old female patient who had been continuously using acyclovir cream for 3 weeks after systemic therapy for herpes zoster with acyclovir, and in a 35-year-old female patient, who had undergone liver transplantation in 2008 and subsequently developed a severe form of herpes zoster treated orally with 4 g/day acyclovir and prolonged topical administration of acyclovir cream. In both cases, patch tests were performed with extended European Baseline Series, with the excipients of acyclovir cream (propylene glycol, sodium lauryl sulfate, cetostearyl alcohol, dimethyl sulfoxide) and commercial cream containing acyclovir 2%. Positive reactions were obtained only with the commercial cream with acyclovir 2%. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Allergic contact dermatitis caused by acyclovir is rarely reported and frequently misdiagnosed, despite the wide use of oral or topical acyclovir. Allergic contact dermatitis due to acyclovir applied topically is a clinical problem with which health care providers should be familiar, and which prompts patch testing in suspected patients. Knowledge and education focused on allergens are important to clinicians in daily practice.
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http://dx.doi.org/10.1016/j.jemermed.2016.07.083DOI Listing
February 2017

Cutaneous larva migrans in a temperate area.

Arch Dis Child 2016 Sep 2;101(9):813. Epub 2016 Jun 2.

Department of Pathology, University of Medicine and Pharmacy of Targu-Mures, Targu-Mures, Romania.

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http://dx.doi.org/10.1136/archdischild-2016-310845DOI Listing
September 2016

Degradation Mechanism Induced by Psoriasis in Human Fingernails: A Different Approach.

J Invest Dermatol 2016 Jan;136(1):311-3

Centre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1038/JID.2015.387DOI Listing
January 2016

Diabetic dermopathy ("shin spots") and diabetic bullae ("bullosis diabeticorum") at the same patient.

Pak J Med Sci 2015 Sep-Oct;31(5):1275-6

Prof. Anca Chiriac, MD, PhD. Department of Dermatology, University Apollonia, Nicolina Medical Center, "P.Poni" Research Institute, Iasi, Romania.

We present a diabetic patient with associated two diabetic dermatoses: diabetic dermopathy ("shin spots") and diabetic bullae. A 34-year-old man, with long history of diabetes mellitus, hypertension, and moderate obesity presented to Dermatology Unit for diagnosis of his skin lesions. On clinical examination multiple, light brown, irregular patches, with atrophic scars and crusts over large bullae were observed on the anterior aspect of both legs.
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http://dx.doi.org/10.12669/pjms.315.7521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641298PMC
December 2015

Ulcerated Hemangioma - Surveillance Only.

Folia Med (Plovdiv) 2015 Jan-Mar;57(1):75-7

Department of Dermatology, 6th Military Support Unit, Ustka, Poland

Infantile hemangiomas are reported in 10-12% of children less than 1 year of age, with ulceration in about 5-13% of cases. Little is known about the mechanism of this disease and explanations are still being looked for. We present a 4-month-old female infant with haemangioma on the left buttock; the hemangioma was noticed at 2 weeks of age, progressively enlarging and ulcerated.
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http://dx.doi.org/10.1515/folmed-2015-0023DOI Listing
December 2015

Why Is Tinea an Annular Lesion With Centrifugal Growth?

Int J Surg Pathol 2015 Dec 17;23(8):652-3. Epub 2015 Sep 17.

University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

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http://dx.doi.org/10.1177/1066896915606972DOI Listing
December 2015

Common psychocutaneous disorders in children.

Neuropsychiatr Dis Treat 2015 9;11:333-7. Epub 2015 Feb 9.

Gr T Popa University of Medicine and Pharmacy, Iași, Romania.

The prevalence of psychosomatic disorders among dermatological patients is high but frequently unreported because of difficulties in diagnosing and treating this patient group. Psychiatric and psychological factors may play different roles in the pathogenic mechanism of some skin diseases. The mainstay of diagnosis and treatment is the differentiation between skin disorders associated with psychiatric illness and those of a purely psychiatric nature. Dermatologists and psychiatrists should be aware of this pathology and work together as a team to resolve difficult cases, especially in children. The present paper highlights the psychocutaneous diseases most frequently seen by dermatologists in pediatric population.
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http://dx.doi.org/10.2147/NDT.S78522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332316PMC
February 2015

Aplasia cutis congenita of the scalp--what are the steps to be followed? Case report and review of the literature.

An Bras Dermatol 2015 Jan-Feb;90(1):100-3

Nicolina Medical Center, Iasi, Romania.

Aplasia cutis congenita is a rare malformation characterized by localized congenital absence of the skin. It rarely occurs on the trunk and limbs, and can occur in isolation or as part of a heterogeneous group of syndromes. We report a case of a 4-day-old boy with a 5.6-cm- diameter tumor, with a central crust, non-indurate and no inflammatory rim; localized on the scalp and a small, atrophic hairless scar appeared 6 months later (approximately 5 cm in length) at the site of the previous tumor.
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http://dx.doi.org/10.1590/abd1806-4841.20153078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323704PMC
July 2015

Psoriasis and tuberculosis binomial distribution?

J Res Med Sci 2014 May;19(5):477

Department of Dermatology, 6 Military Support Unit, Ustka, Poland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116583PMC
May 2014

Autosensitisation (Autoeczematisation) reactions in a case of diaper dermatitis candidiasis.

Niger Med J 2014 May;55(3):274-5

Student, University of Medicine and Pharmacy "Grigore T. Popa", Str. Universitatii nr. 16, Iasi, Romania.

Diaper dermatitis is the most common cutaneous diagnosis in infants. Most cases are associated with the yeast colonisation of Candida or diaper dermatitis candidiasis (DDC). It is an irritating and inflammatory acute dermatitis in the perineal and perianal areas resulting from the occlusion and irritation caused by diapers. Autoeczematization to a distant focus of dermatophyte infection very rarely presents as DDC. We present a 1-month-old boy with lesion on diaper area (gluteal area, perineum, groin and genitalia) and with clusters of pustules and vesicles on a large erythematous base over the dorsal area of both hands.
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http://dx.doi.org/10.4103/0300-1652.132070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089061PMC
May 2014