Publications by authors named "Tuan Zea Tan"

89Publications

Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C-Mutant Non-Small Cell Lung Cancer.

Clin Cancer Res 2020 Sep 8. Epub 2020 Sep 8.

Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-2077DOI Listing
September 2020

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

Authors:
Aline Talhouk Joshy George Chen Wang Timothy Budden Tuan Zea Tan Derek S Chiu Stefan Kommoss Huei San Leong Stephanie Chen Maria P Intermaggio Blake Gilks Tayyebeh M Nazeran Mila Volchek Wafaa Elatre Rex C Bentley Janine Senz Amy Lum Veronica Chow Hanwei Sudderuddin Robertson Mackenzie Samuel C Y Leong Geyi Liu Dustin Johnson Billy Chen Aocs Group Jennifer Alsop Susana N Banerjee Sabine Behrens Clara Bodelon Alison H Brand Louise Brinton Michael E Carney Yoke-Eng Chiew Kara L Cushing-Haugen Cezary Cybulski Darren Ennis Sian Fereday Renée T Fortner Jesús García-Donas Aleksandra Gentry-Maharaj Rosalind Glasspool Teodora Goranova Casey S Greene Paul Haluska Holly R Harris Joy Hendley Brenda Y Hernandez Esther Herpel Mercedes Jimenez-Linan Chloe Karpinskyj Scott H Kaufmann Gary L Keeney Catherine J Kennedy Martin Köbel Jennifer M Koziak Melissa C Larson Jenny Lester Liz-Anne Lewsley Jolanta Lissowska Jan Lubiński Hugh Luk Geoff Macintyre Sven Mahner Iain A McNeish Janusz Menkiszak Nikilyn Nevins Ana Osorio Oleg Oszurek José Palacios Samantha Hinsley Celeste L Pearce Malcolm C Pike Anna M Piskorz Isabelle Ray-Coquard Valerie Rhenius Cristina Rodriguez-Antona Raghwa Sharma Mark E Sherman Dilrini De Silva Naveena Singh Peter Sinn Dennis Slamon Honglin Song Helen Steed Euan A Stronach Pamela J Thompson Aleksandra Tołoczko Britton Trabert Nadia Traficante Chiu-Chen Tseng Martin Widschwendter Lynne R Wilkens Stacey J Winham Boris Winterhoff Alicia Beeghly-Fadiel Javier Benitez Andrew Berchuck James D Brenton Robert Brown Jenny Chang-Claude Georgia Chenevix-Trench Anna deFazio Peter A Fasching María J García Simon A Gayther Marc T Goodman Jacek Gronwald Michelle J Henderson Beth Y Karlan Linda E Kelemen Usha Menon Sandra Orsulic Paul D P Pharoah Nicolas Wentzensen Anna H Wu Joellen M Schildkraut Mary Anne Rossing Gottfried E Konecny David G Huntsman Ruby Yun-Ju Huang Ellen L Goode Susan J Ramus Jennifer A Doherty David D Bowtell Michael S Anglesio

Clin Cancer Res 2020 Oct 17;26(20):5411-5423. Epub 2020 Jun 17.

British Columbia's Gynecological Cancer Research Program (OVCARE), BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0103DOI Listing
October 2020

SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2.

Cancers (Basel) 2020 May 2;12(5). Epub 2020 May 2.

Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.

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http://dx.doi.org/10.3390/cancers12051140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281482PMC
May 2020

Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit.

Antioxid Redox Signal 2020 May 19. Epub 2020 May 19.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1089/ars.2019.7850DOI Listing
May 2020

Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective.

Cancers (Basel) 2020 Jan 18;12(1). Epub 2020 Jan 18.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593 Singapore, Singapore.

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http://dx.doi.org/10.3390/cancers12010238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017214PMC
January 2020

Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers.

Life Sci 2020 Jan 9;241:117147. Epub 2019 Dec 9.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Departments of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.117147DOI Listing
January 2020

Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes.

EBioMedicine 2019 Dec 21;50:203-210. Epub 2019 Nov 21.

Center for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599, Singapore; School of Medicine, College of Medicine, National Taiwan University, No. 1 Ren Ai Road Sec. 1, Taipei 100, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921362PMC
December 2019

The role of GRHL2 and epigenetic remodeling in epithelial-mesenchymal plasticity in ovarian cancer cells.

Commun Biol 2019 24;2:272. Epub 2019 Jul 24.

1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599 Singapore.

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http://dx.doi.org/10.1038/s42003-019-0506-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656769PMC
May 2020

SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition.

Sci Rep 2019 06 5;9(1):8295. Epub 2019 Jun 5.

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, 14 Medical Drive, MD6 #12-01, 117599, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41598-019-44826-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549180PMC
June 2019

Reply to Pontus Eriksson and Gottfrid Sjödahl's Letter to the Editor re: Tuan Zea Tan, Mathieu Rouanne, Kien Thiam Tan, Ruby Yun-Ju Huang, Jean-Paul Thiery. Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors. Eur Urol 2019;75:423-32.

Eur Urol 2019 04 5;75(4):e108-e109. Epub 2018 Dec 5.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, People's Republic of China; CNRS Emeritus CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.11.048DOI Listing
April 2019

Decoding transcriptomic intra-tumour heterogeneity to guide personalised medicine in ovarian cancer.

J Pathol 2019 03 18;247(3):305-319. Epub 2018 Dec 18.

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore.

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http://doi.wiley.com/10.1002/path.5191
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http://dx.doi.org/10.1002/path.5191DOI Listing
March 2019

Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.

Oncogene 2019 02 10;38(9):1508-1519. Epub 2018 Oct 10.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://www.nature.com/articles/s41388-018-0526-3
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http://dx.doi.org/10.1038/s41388-018-0526-3DOI Listing
February 2019

Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors.

Eur Urol 2019 03 10;75(3):423-432. Epub 2018 Sep 10.

Biochemistry Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, People's Republic of China; CNRS Emeritus CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, PSL, Fac. de Médecine - University Paris-Sud, Université Paris-Saclay, Villejuif, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183061
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http://dx.doi.org/10.1016/j.eururo.2018.08.027DOI Listing
March 2019

RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair.

Cell Rep 2018 08;24(7):1747-1755

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183112
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http://dx.doi.org/10.1016/j.celrep.2018.07.038DOI Listing
August 2018

BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia.

BMC Cancer 2018 Jul 11;18(1):731. Epub 2018 Jul 11.

Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Centre for Translational Medicine, Singapore, 117599, Republic of Singapore.

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http://dx.doi.org/10.1186/s12885-018-4661-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042241PMC
July 2018

Integrated use of bioinformatic resources reveals that co-targeting of histone deacetylases, IKBK and SRC inhibits epithelial-mesenchymal transition in cancer.

Brief Bioinform 2019 03;20(2):717-731

Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

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http://dx.doi.org/10.1093/bib/bby030DOI Listing
March 2019

NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B.

World J Stem Cells 2018 Apr;10(4):34-42

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

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http://dx.doi.org/10.4252/wjsc.v10.i4.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919888PMC
April 2018

Dual role of autophagy in hallmarks of cancer.

Oncogene 2018 03 19;37(9):1142-1158. Epub 2017 Dec 19.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41388-017-0046-6DOI Listing
March 2018

X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.

Mol Oncol 2018 01 1;12(1):33-47. Epub 2017 Dec 1.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore.

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http://dx.doi.org/10.1002/1878-0261.12146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748481PMC
January 2018

Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer.

Gene 2017 Nov 5;635:9-15. Epub 2017 Sep 5.

Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, 117599, Singapore; Department of Obstetrics & Gynaecology, National University Hospital of Singapore, 5 Lower Kent Ridge Road, 119074, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, 117594, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2017.09.001DOI Listing
November 2017

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia.

J Hematol Oncol 2017 07 11;10(1):138. Epub 2017 Jul 11.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Republic of Singapore.

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http://dx.doi.org/10.1186/s13045-017-0507-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504806PMC
July 2017

Targeting the AXL signaling pathway in ovarian cancer.

Mol Cell Oncol 2017 28;4(2):e1263716. Epub 2016 Nov 28.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1080/23723556.2016.1263716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383361PMC
November 2016

USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7.

EMBO Rep 2017 05 5;18(5):797-808. Epub 2017 Apr 5.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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http://dx.doi.org/10.15252/embr.201643270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412796PMC
May 2017

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity.

Oncoimmunology 2017 17;6(2):e1271858. Epub 2017 Jan 17.

INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, Fac. de médecine - Univ. Paris-Sud, University Paris-Saclay , Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2016.1271858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353930PMC
January 2017

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200.

Oncoimmunology 2017 23;6(1):e1263412. Epub 2017 Jan 23.

INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, Fac. de médecine - Univ. Paris-Sud, Université Paris-Saclay , Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2016.1263412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283623PMC
January 2017

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.

J Natl Cancer Inst 2017 01 25;109(6). Epub 2017 Jan 25.

Affiliations of authors: Cancer Science Institute of Singapore, National University of Singapore, Singapore (WC, GR, SSS, CW, YY, TZT, HY, BCG, TB, APK); Departments of Pharmacology (WC, GR, SSS, CW, BCG, GS, APK), Physiology (ZXC, ZC, CTY), and Biochemistry (VT), Yong Loo Lin School of Medicine, National University of Singapore, Singapore; KK Women's and Children's Hospital, Singapore (ZXC); Stem Cell and Cancer Biology Laboratory (FA), School of Biomedical Sciences (GS, APK), Curtin Health Innovation Research Institute, Curtin Medical School (APK), Curtin University, Perth, WA, Australia; National University Cancer Institute, National University Health System, Singapore (CTY, BCG, APK); 2 Department of Pediatrics, Semmelweis University, Budapest, Hungary (LSP); MTA TTK Lendület Cancer Biomarker Research Group, Research Centre for Natural Sciences, Budapest, Hungary (LSP); Department of Renal Medicine (MBL) and Department of Haematology-Oncology (BCG), National University Health System, Singapore; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore (VT); Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia (VT); Department of Biological Sciences, University of North Texas, Denton, TX (APK).

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http://dx.doi.org/10.1093/jnci/djw278DOI Listing
January 2017

LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML.

Mol Cancer Res 2017 03 23;15(3):294-303. Epub 2016 Dec 23.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore, Republic of Singapore.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0275-TDOI Listing
March 2017

A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets.

Cancer Lett 2016 11 5;382(2):203-214. Epub 2016 Sep 5.

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077659PMC
http://dx.doi.org/10.1016/j.canlet.2016.09.001DOI Listing
November 2016

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.

Sci Signal 2016 10 4;9(448):ra97. Epub 2016 Oct 4.

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Department of Obstetrics and Gynecology, National University Health System, Singapore 119228, Singapore. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1126/scisignal.aaf8175DOI Listing
October 2016

Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse.

Int J Mol Sci 2016 Apr 28;17(5). Epub 2016 Apr 28.

Molecular Pathology Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait 13110, Kuwait.

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http://dx.doi.org/10.3390/ijms17050598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881437PMC
April 2016

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Sci Rep 2016 Feb 18;6:19943. Epub 2016 Feb 18.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore 117599.

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http://dx.doi.org/10.1038/srep19943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757891PMC
February 2016

Identification of AIM2 as a downstream target of JAK2V617F.

Exp Hematol Oncol 2015 28;5. Epub 2016 Jan 28.

Department of Hematology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.

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http://dx.doi.org/10.1186/s40164-016-0032-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730608PMC
January 2016

CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype.

Oncotarget 2015 Dec;6(41):43843-52

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.

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https://www.csi.nus.edu.sg/ws/wp-content/uploads/12-In-the-s
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http://www.oncotarget.com/abstract/5983
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http://dx.doi.org/10.18632/oncotarget.5983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791271PMC
December 2015

The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.

Hum Pathol 2015 Jan 16;46(1):1-8. Epub 2014 Oct 16.

Cancer Science Institute (CSI), Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 117599 Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 117599 Singapore; Institute of Molecular and Cell Biology (IMCB) A*STAR, Proteos 138673, Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177140041
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http://dx.doi.org/10.1016/j.humpath.2014.10.004DOI Listing
January 2015

Non-invasive prenatal diagnostic testing for β-thalassaemia using cell-free fetal DNA and next generation sequencing.

Prenat Diagn 2015 Mar 29;35(3):258-65. Epub 2014 Dec 29.

Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Gynecology & Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1002/pd.4536DOI Listing
March 2015

Utilization of the Eμ-Myc mouse to model heterogeneity of therapeutic response.

Mol Cancer Ther 2014 Dec 27;13(12):3219-29. Epub 2014 Oct 27.

Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina. Department of Medicine, Duke University Medical Center, Durham, North Carolina. Durham Veterans Affairs Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258467PMC
December 2014

A central role for TRPS1 in the control of cell cycle and cancer development.

Oncotarget 2014 Sep;5(17):7677-90

The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202153PMC
http://dx.doi.org/10.18632/oncotarget.2291DOI Listing
September 2014

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.

EMBO Mol Med 2014 Oct;6(10):1279-93

Cancer Science Institute of Singapore, National University of Singapore, Singapore Institute of Molecular and Cell Biology, A*STAR, Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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http://dx.doi.org/10.15252/emmm.201404208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287932PMC
October 2014

Detection of aneuploidy from single fetal nucleated red blood cells using whole genome sequencing.

Prenat Diagn 2015 Jul 16;35(7):637-44. Epub 2014 Oct 16.

Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S119228.

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http://dx.doi.org/10.1002/pd.4491DOI Listing
July 2015

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.

Oncotarget 2014 Aug;5(15):5920-33

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore; National University Cancer Institute, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171602PMC
http://dx.doi.org/10.18632/oncotarget.1874DOI Listing
August 2014

Phosphatase of regenerating liver-3 is regulated by signal transducer and activator of transcription 3 in acute myeloid leukemia.

Exp Hematol 2014 Dec 17;42(12):1041-52.e1-2. Epub 2014 Aug 17.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore; Department of Hematology-Oncology, National University Hospital, Singapore, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.08.001DOI Listing
December 2014

Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

Cell Rep 2014 Aug 24;8(3):767-82. Epub 2014 Jul 24.

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Institute of Molecular and Cell Biology, A(∗)STAR, Singapore 138673, Singapore; Institute of Bioengineering and Nanotechnology, A(∗)STAR, Singapore 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.046DOI Listing
August 2014

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia.

Nat Cell Biol 2014 Aug 6;16(8):745-57. Epub 2014 Jul 6.

1] A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore [2] Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, EH16 4TJ, UK [3] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.

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http://dx.doi.org/10.1038/ncb3000DOI Listing
August 2014

Raf kinase inhibitory protein role in the molecular subtyping of breast cancer.

J Cell Biochem 2014 Mar;115(3):488-97

Department of Pathology, Faculty of Medicine, Kuwait University Health Sciences Centre, Safat, 13110, Kuwait.

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http://dx.doi.org/10.1002/jcb.24682DOI Listing
March 2014

Protein arginine methyltransferase 6 regulates embryonic stem cell identity.

Stem Cells Dev 2012 Sep 8;21(14):2613-22. Epub 2012 May 8.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1089/scd.2011.0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729635PMC
September 2012

Ovarian cancer diagnosis with complementary learning fuzzy neural network.

Artif Intell Med 2008 Jul 9;43(3):207-22. Epub 2008 Jun 9.

School of Computer Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.

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http://dx.doi.org/10.1016/j.artmed.2008.04.003DOI Listing
July 2008

A novel biologically and psychologically inspired fuzzy decision support system: hierarchical complementary learning.

IEEE/ACM Trans Comput Biol Bioinform 2008 Jan-Mar;5(1):67-79

Nanyang Technological University, Singapore.

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http://ieeexplore.ieee.org/document/4359859/
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http://dx.doi.org/10.1109/TCBB.2007.1064DOI Listing
May 2008