Publications



Molecular mechanism underlying promiscuous polyamine recognition by spermidine acetyltransferase.
Int J Biochem Cell Biol 2016 Jul 6;76:87-97. Epub 2016 May 6.
SOSHO Inc., Suita, Osaka 565-0871, Japan; Department of Biotechnology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan. Electronic address:





Structure-based design of a streptavidin mutant specific for an artificial biotin analogue.
J Biochem 2015 Jun 2;157(6):467-75. Epub 2015 Feb 2.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan; and Radioisotope Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.
Dev Biol 2015 Jun 16;402(2):162-74. Epub 2015 Apr 16.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan; Institute for Biology and Mathematics of Dynamical Cell Processes (iBMath), The University of Tokyo, 3-8-1 Komaba, Tokyo 153-8914, Japan. Electronic address:


The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein.
FEBS Lett 2015 Apr 31;589(10):1136-42. Epub 2015 Mar 31.
Health Research Institute, National Institute of Advanced Industrial Science and Technology, 3-11-46 Nakoji, Amagasaki, Hyogo 661-0974, Japan. Electronic address:


Preliminary X-ray analysis of the binding domain of the soybean vacuolar sorting receptor complexed with a sorting determinant of a seed storage protein.
Acta Crystallogr F Struct Biol Commun 2015 Feb 28;71(Pt 2):132-5. Epub 2015 Jan 28.
Laboratory of Applied Structural Biology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.


Water-mediated recognition of simple alkyl chains by heart-type fatty-acid-binding protein.
Angew Chem Int Ed Engl 2015 Jan 9;54(5):1508-11. Epub 2014 Dec 9.
JST-ERATO and Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Project Research Centre for Fundamental Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560-0043 (Japan).

Molecular cloning and characterization of a geranyl diphosphate-specific aromatic prenyltransferase from lemon.
Plant Physiol 2014 Sep 30;166(1):80-90. Epub 2014 Jul 30.
Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere (R.M., A.S., K.T., K.Y.), and Institute for Chemical Research (T.K.), Kyoto University, Gokasho, Uji 611-0011, Japan;Division of Environmental Science and Technology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan (T.I., J.-I.A.);Institut National de la Recherche Agronomique (F.K., A.O., A.D., A.H., F.B.), and Université de Lorraine (F.K., A.O., A.D., A.H., F.B.), Unité Mixte de Recherche 1121 Laboratoire Agronomie et Environnement Nancy-Colmar, TSA 40602, 54518 Vandœuvre-lès-Nancy cedex, France;Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Unité Mixte de Recherche Amélioration Génétique et Adaptation des Plantes Méditerranéennes et Tropicales, F-34398 Montpellier, France (Y.F.); andDepartment of Life System, Institute of Technology and Science, Graduate School, University of Tokushima, Tokushima 770-8506, Japan (R.T., Y.U., H.H.)





Structural and functional characterization of the Geobacillus copper nitrite reductase: involvement of the unique N-terminal region in the interprotein electron transfer with its redox partner.
Biochim Biophys Acta 2014 Mar 14;1837(3):396-405. Epub 2014 Jan 14.
Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan. Electronic address:


Structural insights into the function of a thermostable copper-containing nitrite reductase.
J Biochem 2014 Feb 30;155(2):123-35. Epub 2013 Nov 30.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Department of Applied Chemistry, School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Faculty of Life and Environmental Sciences, Department of Environmental Information, Kyoto Prefectural University, Shimogamo-Hanki-cho, Sakyou, Kyoto 606-8522, Japan; Molecular-Recognition Structure Analysis Team, Molecular Profiling Research Center for Drug Discovery (molprof) National Institute of Advanced Industrial Science and Technology (AIST) 2-3-26 Aomi, Koto-ku, Tokyo 135-0064, Japan; Microbial Genome Research Group, Japan Agency of Marine-Earth Science and Technology, 2-15 Natsushima, Yokosuka, Kanagawa 237-0061, Japan; and RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan.



Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies.
Biochem Biophys Res Commun 2013 Nov 12;441(4):1011-7. Epub 2013 Nov 12.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.



Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistant Staphylococcus aureus.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Aug 27;69(Pt 8):895-8. Epub 2013 Jul 27.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Crystallization and preliminary X-ray crystallographic analysis of UDP-glucuronic acid:flavonol-3-O-glucuronosyltransferase (VvGT5) from the grapevine Vitis vinifera.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Jan 25;69(Pt 1):65-8. Epub 2012 Dec 25.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease.
Mol Neurodegener 2012 Oct 3;7:50. Epub 2012 Oct 3.
Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12-Nishi6, Kita-ku, Sapporo, 060-0812, Japan.

Crystal structure of rice Rubisco and implications for activation induced by positive effectors NADPH and 6-phosphogluconate.
J Mol Biol 2012 Sep 17;422(1):75-86. Epub 2012 May 17.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, Osaka 565-0871, Japan.



Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Feb 27;68(Pt 2):244-6. Epub 2012 Jan 27.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.


Crystallization and preliminary X-ray crystallographic analysis of a helicase-like domain from a tomato mosaic virus replication protein.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Dec 30;67(Pt 12):1649-52. Epub 2011 Nov 30.
Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan.

Structure basis for the regulation of glyceraldehyde-3-phosphate dehydrogenase activity via the intrinsically disordered protein CP12.
Structure 2011 Dec;19(12):1846-54
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Implications of oligomeric forms of POD-1 and POD-2 proteins isolated from cell walls of the biocontrol agent Pythium oligandrum in relation to their ability to induce defense reactions in tomato.
J Plant Physiol 2011 Nov 15;168(16):1972-9. Epub 2011 Jun 15.
Memuro Research Station, National Agricultural Research Center for Hokkaido Region, National Agriculture and Food Research Organization, Hokkaido 082-0081, Japan.

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of GK0767, the copper-containing nitrite reductase from Geobacillus kaustophilus.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Jun 26;67(Pt 6):692-5. Epub 2011 May 26.
Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, Japan.

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