Publications

Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine.
FEBS J 2017 Nov 22;284(21):3684-3701. Epub 2017 Sep 22.
Department of Bioscience, Graduate School of Science and Technology, Kwansei-Gakuin University, Sanda, Japan.


Loop of Streptomyces feruloyl esterase plays an important role in its activity of releasing ferulic acid from biomass.
Appl Environ Microbiol 2017 Nov 17. Epub 2017 Nov 17.
Research Institute for Biological Sciences (RIBS), Okayama Prefectural Technology Center for Agriculture, Forestry, and Fisheries, 7549-1 Kibichuo-cho, Kaga-gun, Okayama 716-1241, Japan







Structure-based design of a streptavidin mutant specific for an artificial biotin analogue.
J Biochem 2015 Jun 2;157(6):467-75. Epub 2015 Feb 2.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan; and Radioisotope Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.
Dev Biol 2015 Jun 16;402(2):162-74. Epub 2015 Apr 16.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan; Institute for Biology and Mathematics of Dynamical Cell Processes (iBMath), The University of Tokyo, 3-8-1 Komaba, Tokyo 153-8914, Japan. Electronic address:


The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein.
FEBS Lett 2015 Apr 31;589(10):1136-42. Epub 2015 Mar 31.
Health Research Institute, National Institute of Advanced Industrial Science and Technology, 3-11-46 Nakoji, Amagasaki, Hyogo 661-0974, Japan. Electronic address:


Preliminary X-ray analysis of the binding domain of the soybean vacuolar sorting receptor complexed with a sorting determinant of a seed storage protein.
Acta Crystallogr F Struct Biol Commun 2015 Feb 28;71(Pt 2):132-5. Epub 2015 Jan 28.
Laboratory of Applied Structural Biology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.


Water-mediated recognition of simple alkyl chains by heart-type fatty-acid-binding protein.
Angew Chem Int Ed Engl 2015 Jan 9;54(5):1508-11. Epub 2014 Dec 9.
JST-ERATO and Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Project Research Centre for Fundamental Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560-0043 (Japan).

Molecular cloning and characterization of a geranyl diphosphate-specific aromatic prenyltransferase from lemon.
Plant Physiol 2014 Sep 30;166(1):80-90. Epub 2014 Jul 30.
Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere (R.M., A.S., K.T., K.Y.), and Institute for Chemical Research (T.K.), Kyoto University, Gokasho, Uji 611-0011, Japan;Division of Environmental Science and Technology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan (T.I., J.-I.A.);Institut National de la Recherche Agronomique (F.K., A.O., A.D., A.H., F.B.), and Université de Lorraine (F.K., A.O., A.D., A.H., F.B.), Unité Mixte de Recherche 1121 Laboratoire Agronomie et Environnement Nancy-Colmar, TSA 40602, 54518 Vandœuvre-lès-Nancy cedex, France;Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Unité Mixte de Recherche Amélioration Génétique et Adaptation des Plantes Méditerranéennes et Tropicales, F-34398 Montpellier, France (Y.F.); andDepartment of Life System, Institute of Technology and Science, Graduate School, University of Tokushima, Tokushima 770-8506, Japan (R.T., Y.U., H.H.)





Structural and functional characterization of the Geobacillus copper nitrite reductase: involvement of the unique N-terminal region in the interprotein electron transfer with its redox partner.
Biochim Biophys Acta 2014 Mar 14;1837(3):396-405. Epub 2014 Jan 14.
Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan. Electronic address:


Structural insights into the function of a thermostable copper-containing nitrite reductase.
J Biochem 2014 Feb 30;155(2):123-35. Epub 2013 Nov 30.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Department of Applied Chemistry, School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Faculty of Life and Environmental Sciences, Department of Environmental Information, Kyoto Prefectural University, Shimogamo-Hanki-cho, Sakyou, Kyoto 606-8522, Japan; Molecular-Recognition Structure Analysis Team, Molecular Profiling Research Center for Drug Discovery (molprof) National Institute of Advanced Industrial Science and Technology (AIST) 2-3-26 Aomi, Koto-ku, Tokyo 135-0064, Japan; Microbial Genome Research Group, Japan Agency of Marine-Earth Science and Technology, 2-15 Natsushima, Yokosuka, Kanagawa 237-0061, Japan; and RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan.



Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies.
Biochem Biophys Res Commun 2013 Nov 12;441(4):1011-7. Epub 2013 Nov 12.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.



Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistant Staphylococcus aureus.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Aug 27;69(Pt 8):895-8. Epub 2013 Jul 27.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Crystallization and preliminary X-ray crystallographic analysis of UDP-glucuronic acid:flavonol-3-O-glucuronosyltransferase (VvGT5) from the grapevine Vitis vinifera.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Jan 25;69(Pt 1):65-8. Epub 2012 Dec 25.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease.
Mol Neurodegener 2012 Oct 3;7:50. Epub 2012 Oct 3.
Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12-Nishi6, Kita-ku, Sapporo, 060-0812, Japan.

Crystal structure of rice Rubisco and implications for activation induced by positive effectors NADPH and 6-phosphogluconate.
J Mol Biol 2012 Sep 17;422(1):75-86. Epub 2012 May 17.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, Osaka 565-0871, Japan.



Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Feb 27;68(Pt 2):244-6. Epub 2012 Jan 27.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.


Crystallization and preliminary X-ray crystallographic analysis of a helicase-like domain from a tomato mosaic virus replication protein.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Dec 30;67(Pt 12):1649-52. Epub 2011 Nov 30.
Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan.

Structure basis for the regulation of glyceraldehyde-3-phosphate dehydrogenase activity via the intrinsically disordered protein CP12.
Structure 2011 Dec;19(12):1846-54
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Implications of oligomeric forms of POD-1 and POD-2 proteins isolated from cell walls of the biocontrol agent Pythium oligandrum in relation to their ability to induce defense reactions in tomato.
J Plant Physiol 2011 Nov 15;168(16):1972-9. Epub 2011 Jun 15.
Memuro Research Station, National Agricultural Research Center for Hokkaido Region, National Agriculture and Food Research Organization, Hokkaido 082-0081, Japan.

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of GK0767, the copper-containing nitrite reductase from Geobacillus kaustophilus.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Jun 26;67(Pt 6):692-5. Epub 2011 May 26.
Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, Japan.

Molecular mechanism underlying promiscuous polyamine recognition by spermidine acetyltransferase.
Int J Biochem Cell Biol 2016 07 6;76:87-97. Epub 2016 May 6.
SOSHO Inc., Suita, Osaka 565-0871, Japan; Department of Biotechnology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan. Electronic address:

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