Publications by authors named "Tsunehiro Mizushima"

54Publications

Crystallographic snapshots of the EF-hand protein MCFD2 complexed with the intracellular lectin ERGIC-53 involved in glycoprotein transport.

Acta Crystallogr F Struct Biol Commun 2020 May 29;76(Pt 5):216-221. Epub 2020 Apr 29.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1107/S2053230X20005452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193514PMC
May 2020

Structural and biochemical characterization of mitochondrial citrate synthase 4 from Arabidopsis thaliana.

Acta Crystallogr F Struct Biol Commun 2020 Mar 1;76(Pt 3):109-115. Epub 2020 Mar 1.

Picobiology Institute, Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan.

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http://dx.doi.org/10.1107/S2053230X20001521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057349PMC
March 2020

Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology.

Front Physiol 2019 19;10:104. Epub 2019 Feb 19.

Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.3389/fphys.2019.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389600PMC
February 2019

Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae.

Acta Crystallogr F Struct Biol Commun 2018 Oct 19;74(Pt 10):617-624. Epub 2018 Sep 19.

Picobiology Institute, Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan.

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http://dx.doi.org/10.1107/S2053230X18011895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168765PMC
October 2018

Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.

EMBO Rep 2018 01 30;19(1):89-101. Epub 2017 Nov 30.

Division of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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http://dx.doi.org/10.15252/embr.201643841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757219PMC
January 2018

Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.

Sci Rep 2017 10 9;7(1):12816. Epub 2017 Oct 9.

Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan.

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http://dx.doi.org/10.1038/s41598-017-13146-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634459PMC
October 2017

Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase.

Acta Crystallogr F Struct Biol Commun 2016 08 27;72(Pt 8):619-26. Epub 2016 Jul 27.

Picobiology Institute, Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan.

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http://scripts.iucr.org/cgi-bin/paper?S2053230X16011018
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http://dx.doi.org/10.1107/S2053230X16011018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973303PMC
August 2016

Crystal structure of the substrate-recognition domain of the Shigella E3 ligase IpaH9.8.

Acta Crystallogr F Struct Biol Commun 2016 Apr 16;72(Pt 4):269-75. Epub 2016 Mar 16.

Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan.

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http://dx.doi.org/10.1107/S2053230X16002715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822982PMC
April 2016

FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy.

J Biol Chem 2015 Dec 14;290(49):29361-74. Epub 2015 Oct 14.

From the Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø - The Arctic University of Norway, 9037 Tromsø, Norway and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.686915
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http://dx.doi.org/10.1074/jbc.M115.686915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705940PMC
December 2015

N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function.

Mol Cell Biol 2015 Jan 20;35(1):141-52. Epub 2014 Oct 20.

Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00582-14
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http://dx.doi.org/10.1128/MCB.00582-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295373PMC
January 2015

Bacterial effectors and their functions in the ubiquitin-proteasome system: insight from the modes of substrate recognition.

Cells 2014 Aug 18;3(3):848-64. Epub 2014 Aug 18.

Picobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1, Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan.

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http://www.mdpi.com/2073-4409/3/3/848
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http://dx.doi.org/10.3390/cells3030848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197628PMC
August 2014

Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation.

Biochem Biophys Res Commun 2014 Jul 1;450(2):1110-4. Epub 2014 Jul 1.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaiji, Okazaki 444-8787, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.06.119DOI Listing
July 2014

Structural basis for proteasome formation controlled by an assembly chaperone nas2.

Structure 2014 May 27;22(5):731-43. Epub 2014 Mar 27.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Okazaki Institute for Integrative Bioscience and Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.02.014DOI Listing
May 2014

[Structure and functional mechanisms of proteasome dedicated chaperones].

Seikagaku 2013 Sep;85(9):789-94

Department of Life Science, University of Hyogo, 3-2-1 Koto, Kamigori, Akoh, Hyogo 678-1297, Japan.

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September 2013

Backbone ¹H, ¹³C and ¹⁵N assignments of yeast Ump1, an intrinsically disordered protein that functions as a proteasome assembly chaperone.

Biomol NMR Assign 2014 Oct 25;8(2):383-6. Epub 2013 Sep 25.

Graduate School and Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan.

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http://dx.doi.org/10.1007/s12104-013-9523-1DOI Listing
October 2014

The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection.

Cell Host Microbe 2013 May;13(5):570-583

Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan; Division of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan; Nippon Institute for Biological Science, 9-2221-1 Shinmachi, Ome, Tokyo 198-0024, Japan; Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2013.04.012DOI Listing
May 2013

Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI.

J Mol Biol 2013 Aug 27;425(15):2623-31. Epub 2013 Mar 27.

Picobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan.

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http://dx.doi.org/10.1016/j.jmb.2013.02.037DOI Listing
August 2013

A bacterial effector targets the TRAF6-NFκB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells.

Virulence 2012 Oct 1;3(6):518-21. Epub 2012 Oct 1.

Department of Infectious Disease Control, International Research Center for Infectious Diseases, University of Tokyo, Tokyo, Japan.

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http://www.tandfonline.com/doi/abs/10.4161/viru.21451
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http://dx.doi.org/10.4161/viru.21451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524152PMC
October 2012

The proteasome: molecular machinery and pathophysiological roles.

Biol Chem 2012 Apr;393(4):217-34

Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa 2-1-6, Setagayaku, Tokyo 156-8506 , Japan.

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https://www.degruyter.com/view/j/bchm.2012.393.issue-4/hsz-2
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http://dx.doi.org/10.1515/hsz-2011-0285DOI Listing
April 2012

New crystal structure of the proteasome-dedicated chaperone Rpn14 at 1.6 Å resolution.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 May 20;68(Pt 5):517-21. Epub 2012 Apr 20.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

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http://dx.doi.org/10.1107/S1744309112011359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374504PMC
May 2012

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.

Nature 2012 Mar 11;483(7391):623-6. Epub 2012 Mar 11.

Department of Infectious Disease Control, International Research Center for Infectious Diseases, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/nature10894DOI Listing
March 2012

Structural basis for specific recognition of Rpt1p, an ATPase subunit of 26 S proteasome, by proteasome-dedicated chaperone Hsm3p.

J Biol Chem 2012 Apr 8;287(15):12172-82. Epub 2012 Feb 8.

Picobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1, Kouto, Kamigori-cho, Ako-gun, Hyogo, 678-1297, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.345876
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http://dx.doi.org/10.1074/jbc.M112.345876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320968PMC
April 2012

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans.

Genes Cells 2011 Nov;16(11):1071-80

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2011.01552.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258418PMC
November 2011

Conformational dynamics of wild-type Lys-48-linked diubiquitin in solution.

J Biol Chem 2011 Oct 7;286(43):37496-502. Epub 2011 Sep 7.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori Mizuho-ku, Nagoya 467-8603, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.256354
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http://dx.doi.org/10.1074/jbc.M111.256354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199495PMC
October 2011

Structure of ST0929, a putative glycosyl transferase from Sulfolobus tokodaii.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Apr 26;66(Pt 4):397-400. Epub 2010 Mar 26.

Department of Biotechnology, School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.

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http://dx.doi.org/10.1107/S1744309110006354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852329PMC
April 2010

Crystal structure of yeast rpn14, a chaperone of the 19 S regulatory particle of the proteasome.

J Biol Chem 2010 May 16;285(20):15159-66. Epub 2010 Mar 16.

Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan.

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http://dx.doi.org/10.1074/jbc.M110.104042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865284PMC
May 2010

Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency.

Proc Natl Acad Sci U S A 2010 Mar 8;107(9):4034-9. Epub 2010 Feb 8.

Department of Structural Biology and Biomolecular Engineering, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

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http://dx.doi.org/10.1073/pnas.0908526107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840101PMC
March 2010

Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Jan 25;66(Pt 1):95-8. Epub 2009 Dec 25.

Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.

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http://dx.doi.org/10.1107/S1744309109050581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805547PMC
January 2010

Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain.

Biochem Biophys Res Commun 2009 Dec 20;390(3):855-60. Epub 2009 Oct 20.

Kyoto University, Research Reactor Institute, Kumatori, Osaka Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.10.062DOI Listing
December 2009

[Structural basis for dynamic formation and mechanistic actions of huge and complicated proteolytic machinery].

Tanpakushitsu Kakusan Koso 2009 Sep;54(12 Suppl):1670-5

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September 2009

The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae.

Biochemistry 2009 Feb;48(5):941-50

Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan.

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http://dx.doi.org/10.1021/bi801574pDOI Listing
February 2009

Structural basis for sorting mechanism of p62 in selective autophagy.

J Biol Chem 2008 Aug 4;283(33):22847-57. Epub 2008 Jun 4.

Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421.

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http://dx.doi.org/10.1074/jbc.M802182200DOI Listing
August 2008

Structures of D-amino-acid amidase complexed with L-phenylalanine and with L-phenylalanine amide: insight into the D-stereospecificity of D-amino-acid amidase from Ochrobactrum anthropi SV3.

Acta Crystallogr D Biol Crystallogr 2008 Mar 20;64(Pt 3):331-4. Epub 2008 Feb 20.

Department of Biotechnology, School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan.

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http://scripts.iucr.org/cgi-bin/paper?S0907444907067479
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http://dx.doi.org/10.1107/S0907444907067479DOI Listing
March 2008

Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes.

Nat Struct Mol Biol 2008 Mar 17;15(3):228-36. Epub 2008 Feb 17.

Laboratory of Frontier Science, Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Tokyo 113-8613, Japan.

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http://dx.doi.org/10.1038/nsmb.1386DOI Listing
March 2008

Crystal structure of Ufc1, the Ufm1-conjugating enzyme.

Biochem Biophys Res Commun 2007 Nov 30;362(4):1079-84. Epub 2007 Aug 30.

Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.08.129DOI Listing
November 2007

Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase.

Proc Natl Acad Sci U S A 2007 Apr 26;104(14):5777-81. Epub 2007 Mar 26.

Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.

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http://dx.doi.org/10.1073/pnas.0610312104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851568PMC
April 2007

The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers.

J Mol Biol 2006 Jan 28;355(4):612-8. Epub 2005 Nov 28.

Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.

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http://dx.doi.org/10.1016/j.jmb.2005.11.018DOI Listing
January 2006

Structural basis of sugar-recognizing ubiquitin ligase.

Nat Struct Mol Biol 2004 Apr 29;11(4):365-70. Epub 2004 Feb 29.

Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.

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http://dx.doi.org/10.1038/nsmb732DOI Listing
April 2004

The structure of the mammalian 20S proteasome at 2.75 A resolution.

Structure 2002 May;10(5):609-18

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1016/s0969-2126(02)00748-7DOI Listing
May 2002

Structure determination of the constitutive 20S proteasome from bovine liver at 2.75 A resolution.

J Biochem 2002 Feb;131(2):171-3

Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003084DOI Listing
February 2002