Publications by authors named "Tsuguo Honma"

7 Publications

  • Page 1 of 1

Clarithromycin As an Alternative and Prophylactic Agent in a Hematopoietic Stem Cell Transplantation Patient.

Am J Case Rep 2021 Jun 15;22:e931731. Epub 2021 Jun 15.

Medical Mycology Research Center, Chiba University, Chiba, Japan.

BACKGROUND Nocardia infections have rarely been reported in hematopoietic stem cell transplantation (HSCT) patients, who usually receive the prophylactic use of sulfamethoxazole/trimethoprim (ST) against Pneumocystis jiroveci. However, the ST prophylaxis, sensitive to Nocardia species, sometimes induces renal toxicities. Therefore, alternative prophylactic or therapeutic drugs are required for nocardiosis in HSCT patients. CASE REPORT A 34-year-old Japanese man with acute mixed phenotypic leukemia with t(9; 22) received allogenic peripheral blood HSCT from a haplo-identical sibling donor. He developed graft versus host disease (GVHD) with grade II, and was treated with prednisolone and cyclosporine A with concurrent ciprofloxacin, fluconazole, valacyclovir, and ST. However, the prophylactic ST was ceased because of its renal toxicity. He developed a pulmonary nodular lesion with elevated ß-D-glucan and Aspergillus galactomannan antigen. Repeated blood and sputum culture isolated no pathogens. Voriconazole treatment administered once improved these lesions and laboratory findings. One month later, he presented with right pleuritic chest pain and multiple ring-enhancing cavitation lesions along the ribs. A needle biopsy demonstrated Nocardia elegans, which is an extremely rare infection induced by Nocardia species, in the cavitation lesions, shown by 16S rRNA gene sequencing. He was started on doripenem and liposomal amphotericin B, and a subsequent treatment kept him free from Nocardia elegans infection, without any adverse effects, while continuing the cyclosporine A and prednisolone treatment for chronic GVHD. CONCLUSIONS Clarithromycin has fewer adverse effects than ST. This case suggests that clarithromycin is an appropriate alternative and prophylactic therapy for patients with nocardiosis and ST toxicities.
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http://dx.doi.org/10.12659/AJCR.931731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216568PMC
June 2021

Computed Tomographic Findings of Enterohemorrhagic Escherichia coli O157 Infection: An Analysis of a 7-Case Regional Outbreak.

J Comput Assist Tomogr 2015 May-Jun;39(3):406-8

From the *Department of Diagnostic Radiology, Yamagata University Faculty of Medicine; †Department of Diagnostic Radiology, Yamagata Prefectural Central Hospital; and ‡Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.

Purpose: We experienced an outbreak of enterohemorrhagic Escherichia coli (EHEC) colitis. The purpose of this study was to reveal the computed tomographic (CT) findings on EHEC colitis.

Methods: The subjects were 7 patients with EHEC colitis, which was caused by eating a contaminated Japanese rice cake. Contrast CT was performed on all patients. Two radiologists evaluated the CT findings (the thickness of colon wall, the range of thickened colon, and the existence of dirty fat signs around the colon, ascites, and swelling of lymph nodes), in accordance with our PACS system.

Results: Wall swelling of the proximal colon from cecum to ascending colon was noted in all patients. Small intestine lesions were not noted in any cases.

Conclusions: We should consider EHEC infection as part of a differential diagnosis when the findings of severe right colitis are seen without enteritis.
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http://dx.doi.org/10.1097/RCT.0000000000000209DOI Listing
July 2015

Focal deformity of the cranial nerves observed on multislice motion-sensitized driven equilibrium (MSDE) in patients with neurovascular compression.

J Comput Assist Tomogr 2012 Jan-Feb;36(1):121-4

Department of Diagnostic Radiology, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Objective: Our purpose is to demonstrate the deformity of the cranial nerves by arterial compression using a novel technique, multislice motion-sensitized driven equilibrium (MSDE).

Methods: Subjects were 10 patients with neurovascular compression (5 patients with trigeminal neuralgia and 5 patients with hemifacial spasm). We observed the existence and extent of deformity of nerves by MSDE. Afterward, we compared operative findings with preoperative imaging findings and evaluated the validity of the latter.

Results: All compressing, blood vessels could be correctly identified through preoperative evaluation. Of all patients, 7 showed deformity of the cranial nerves, which was consistent with operative findings except in one case. In postoperative evaluation, patients' neurological symptoms improved and the deformity disappeared. Three patients did not show deformity on preoperative MSDE images. In these patients, neural compression was also not observed during the operation.

Conclusions: The deformity of cranial nerves in patients with neurovascular compression was clearly shown using MSDE.
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http://dx.doi.org/10.1097/RCT.0b013e3182416f3bDOI Listing
April 2012

Inverse-direction scanning improves the image quality of whole carotid CT angiography with 64-MDCT.

Eur J Radiol 2011 Dec 22;80(3):749-54. Epub 2010 Oct 22.

Department of Radiation Oncology, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Purpose: The purpose of this prospective study was to clarify whether reducing the incidence of perivenous artifacts through craniocaudal scanning improves the quality of 64-multidetecter computed tomography (MDCT) angiography images of the whole carotid artery.

Methods: Forty patients underwent MDCT angiography in the caudocranial (n=20) or craniocaudal (n=20) direction in 2007. All patients were injected with 75 ml of contrast media followed by a 35-ml saline chaser bolus at 4.0 ml/s in the right antecubital vein. Maximum intensity projection (MIP) images were scored according to image quality on a scale of 1-5. Bilateral arterial and venous attenuation was measured on 10 separated slices. We compared the mean image quality score of the two groups (i.e. those scanned caudocranially and those scanned craniocaudally). We analyzed the correlation between vascular attenuation and mean image quality.

Results: Compared with the caudocranial group, the craniocaudal group had higher image quality scores (median, 3.70 vs. 3.40; 95% CI, 3.50-3.96 vs. 3.06-3.60; p<0.05), higher arterial attenuation (median, 550 HU vs. 489 HU; range, 270-686 vs. 302-574; p<0.05), and lower maximum venous attenuation (median, 436 vs. 1452 HU; range, 250-617 vs. 377-2044; p<0.01). Multiple regression analysis revealed that the most significant correlation factor with image quality was minimum arterial attenuation (R2=0.42, p<0.001) measured near the brachiocephalic artery. In the caudocranial group only, there was a negative correlation between right brachiocephalic venous attenuation and minimum arterial attenuation.

Conclusions: Compared with conventional caudocranial scanning, craniocaudal scanning improves the image quality of 64-MDCT angiography images of the whole carotid artery.
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http://dx.doi.org/10.1016/j.ejrad.2010.09.037DOI Listing
December 2011

Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer.

Eur J Cardiothorac Surg 2009 Apr 11;35(4):706-10; discussion 710-1. Epub 2009 Feb 11.

Department of Thoracic and Cardiovascular Surgery, Yamagata University School of Medicine, Japan.

Objectives: Recently, diffusion-weighted MR imaging (DWI) for the whole body has become available for clinical use, as has been previously used for the central nervous system. Favorable results have been reported using this imaging system to differentiate between benign and malignant lesions in some organs, and to correlate with the degree of cell differentiation in lung cancer. The purpose of this study was to assess the role of DWI for predicting tumor invasiveness of non-small cell lung cancers (NSCLC), especially for clinical stage IA patients.

Methods: From January 2006 to September 2007, preoperative DWI and 18F-FDG-PET/CT were performed on 41 patients with clinical stage IA NSCLC who had undergone curative operations. Lung cancers that exhibited nodal, lymphovascular or pleural invasion were defined as invasive lung cancers. Nodules with strong dark signal, as observed by DWI in spinal cords, were defined as DWI-positive. We analyzed the associations between the pathological findings and the following preoperative clinical factors: age, gender, smoking history, preoperative CEA levels (<5.0 or >/=5.0ng/ml), preoperative tumor size, SUV max on PET/CT (<5.0 or >/=5.0) and DWI (positive or negative).

Results: A total of 15 lesions (37%) were assessed as DWI-positive and 26 lesions (63%) were DWI-negative. Univariate analyses showed positive correlations for development of invasive cancer with the preoperative CEA level (p=0.049), SUV max (p=0.001) and DWI (p<0.001). Multivariate analysis showed that DWI (p=0.005) was an independent predictive factor for tumor invasiveness.

Conclusion: Our results suggest that DWI might be a useful method for predicting tumor invasiveness for clinical stage IA NSCLC.
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http://dx.doi.org/10.1016/j.ejcts.2008.12.039DOI Listing
April 2009

In vivo evidence of endothelial injury in chronic obstructive pulmonary disease by lung scintigraphic assessment of (123)I-metaiodobenzylguanidine.

J Nucl Med 2003 Nov;44(11):1747-54

First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.

Unlabelled: Scintigraphic evaluation of (123)I-metaiodobenzylguanidine ((123)I-MIBG) in the lungs is considered to recognize endothelial cell lesions. The aim of this study was to clarify the involvement of the pulmonary microvascular injury in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Methods: We investigated lung (123)I-MIBG kinetics and clinical indices in 25 COPD patients and 12 control subjects. Mean uptake ratios of lung to mediastinum (L/M) were calculated in anterior planer images at 30 min (early image) and 270 min (delayed image) after intravenous injection of (123)I-MIBG. Pulmonary mean washout rate (WR) of the (123)I-MIBG was also calculated.

Results: The L/M ratios in both early and delayed images of COPD patients, as well as its WR, were significantly lower than those of the control subjects (L/M early: 1.26 +/- 0.18 vs. 1.54 +/- 0.11, P < 0.0001; L/M delayed: 1.20 +/- 0.12 vs. 1.33 +/- 0.09, P < 0.001; WR: 27.4% +/- 5.3% vs. 34.2% +/- 5.7%, P < 0.01). There were significant relationships between lung WR of the (123)I-MIBG and other diagnostic tests for the severity of COPD, such as forced expiratory volume in 1 s (% FEV(1.0): r = 0.386, P < 0.05), carbon monoxide diffusing capacity/alveolar volume (DL(CO)/V(A): r = 0.449, P < 0.01), arterial blood oxygen pressure (PaO(2): r = 0.474, P < 0.01), alveolar-arterial oxygen tension gradient [A-a]DO(2) (r = -0.446, P < 0.01), and percentage of low-attenuation area (r = -0.458, P < 0.01) in the study population.

Conclusion: Because lung WR of the (123)I-MIBG is considered to be independent of an alteration of the pulmonary vascular surface area, these results suggest that the microvascular endothelial cell injury plays a significant role in the pathogenesis of COPD.
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November 2003

Morphology of the inner structure of the hippocampal formation in Alzheimer disease.

AJNR Am J Neuroradiol 2003 Sep;24(8):1575-81

Department of Radiology, Yamagata University School of Medicine, Japan.

Background And Purpose: To our knowledge, inner structural alterations of the hippocampus have never been demonstrated because of the lack of contrast between the hippocampus proper and the superficial medullary lamina. We sought to demonstrate the anatomic details of the inner hippocampus and to elucidate its alterations in Alzheimer disease (AD) in vivo.

Methods: We obtained multishot diffusion- and T2-weighted MR images in 14 healthy control subjects and 26 patients with mild or moderate AD (diagnosis based on Mini-Mental Status Examination scores). We measured the width of the subiculum, CA1 and CA3-4, and the height of CA3-4 on coronal images.

Results: The subiculum and hippocampus proper were demonstrated as whirlpool-shaped hyperintense areas, and the superficial medullary lamina was visible as a hypointense structure along the inner margin of the hippocampus proper. Regarding the width of the subiculum and CA1, intergroup analysis revealed significant differences between the control and mild or moderate AD groups. In the width of CA3-4, we found no significant difference between the control and mild AD groups; however, differences between the control and moderate AD groups and between the mild and moderate AD groups were significant. In the height of CA3-4, we observed no significant differences between groups.

Conclusion: We clearly visualized the inner structure of the hippocampal formation by using multishot diffusion-weighted imaging. The subiculum and CA1 are the most vulnerable regions in AD, and atrophy of these structures was evident in both mild and moderate AD.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973980PMC
September 2003
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