Tse Wen Chang

Tse Wen Chang

UNVERIFIED PROFILE

Are you Tse Wen Chang?   Register this Author

Register author
Tse Wen Chang

Tse Wen Chang

Publications by authors named "Tse Wen Chang"

Are you Tse Wen Chang?   Register this Author

28Publications

338Reads

45Profile Views

Bispecific Antibody Binding To RANKL and Osteonectin with Enhanced Localization to the Bone.

Mol Pharm 2017 11 9;14(11):4113-4120. Epub 2017 Oct 9.

Immunwork, Inc. , Taipei 115, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.7b00501DOI Listing
November 2017

Skewed Exposure to Environmental Antigens Complements Hygiene Hypothesis in Explaining the Rise of Allergy.

Acta Biotheor 2017 Jun 24;65(2):117-134. Epub 2017 Mar 24.

Genomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10441-017-9306-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418306PMC
June 2017

Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps.

J Allergy Clin Immunol 2017 Apr 19;139(4):1195-1204.e11. Epub 2016 Sep 19.

Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom; MRC & Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Campus, London, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.06.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380656PMC
April 2017

Treating IgE-mediated diseases via targeting IgE-expressing B cells using an anti-CεmX antibody.

Pediatr Allergy Immunol 2016 08 18;27(5):446-51. Epub 2016 May 18.

Genomics Research Center, Taipei, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.12584DOI Listing
August 2016

Two potential therapeutic antibodies bind to a peptide segment of membrane-bound IgE in different conformations.

Nat Commun 2014 ;5:3139

1] Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan [2] Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4139DOI Listing
March 2016

Structural and Physical Basis for Anti-IgE Therapy.

Sci Rep 2015 Jun 26;5:11581. Epub 2015 Jun 26.

1] Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan [2] Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep11581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481376PMC
June 2015

The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria.

J Allergy Clin Immunol 2015 Feb 17;135(2):337-42. Epub 2014 Jun 17.

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749140065
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2014.04.036DOI Listing
February 2015

Changing patterns of antigen exposure and their impact on the prevalence of allergy.

Authors:
Tse Wen Chang

Pediatr Allergy Immunol 2014 Dec 5;25(8):733-9. Epub 2015 Jan 5.

Genomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.12297DOI Listing
December 2014

Manipulating mIgD-expressing B cells with anti-migis-δ monoclonal antibodies.

Mol Immunol 2013 Mar 1;53(3):187-97. Epub 2012 Sep 1.

Genomics Research Center, Academia Sinica, Taipei, Taiwan; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S016158901200369
Publisher Site
http://dx.doi.org/10.1016/j.molimm.2012.08.010DOI Listing
March 2013

CɛmX peptide-carrying HBcAg virus-like particles induced antibodies that down-regulate mIgE-B lymphocytes.

Mol Immunol 2012 Oct 15;52(3-4):190-9. Epub 2012 Jun 15.

Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2012.05.015DOI Listing
October 2012

An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors.

Immunobiology 2012 Jul 25;217(7):676-83. Epub 2011 Nov 25.

Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imbio.2011.11.006DOI Listing
July 2012

The IgE gene in primates exhibits extraordinary evolutionary diversity.

Immunogenetics 2012 Apr 10;64(4):279-87. Epub 2011 Nov 10.

Genomics Research Center, Academia Sinica, Nankang, Taipei, 115, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00251-011-0586-9DOI Listing
April 2012

Lipid rafts hinder binding of antibodies to the extracellular segment of the membrane-anchor peptide of mIgA.

Mol Immunol 2011 Sep 1;48(15-16):1975-82. Epub 2011 Jul 1.

Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2011.06.219DOI Listing
September 2011

Genetic variations in the C epsilon mX domain of human membrane-bound IgE.

Immunogenetics 2010 May 24;62(5):273-80. Epub 2010 Mar 24.

Genetic Center, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 40447, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00251-010-0437-0DOI Listing
May 2010

Accumulated immune complexes of IgE and omalizumab trap allergens in an in vitro model.

Int Immunopharmacol 2010 Apr 6;10(4):533-9. Epub 2010 Feb 6.

Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769100004
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2010.02.001DOI Listing
April 2010

Unique epitopes on C epsilon mX in IgE-B cell receptors are potentially applicable for targeting IgE-committed B cells.

J Immunol 2010 Feb 18;184(4):1748-56. Epub 2010 Jan 18.

Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0902437DOI Listing
February 2010

Cumulative environmental changes, skewed antigen exposure, and the increase of allergy.

Adv Immunol 2008 ;98:39-83

Genomics Research Center, Academia Sinica, Nankang, Taipei 11529, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0065-2776(08)00402-1DOI Listing
December 2008

Alleles and isoforms of human membrane-bound IgA1.

Mol Immunol 2008 Aug 6;45(13):3624-30. Epub 2008 Jun 6.

Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S016158900800174
Publisher Site
http://dx.doi.org/10.1016/j.molimm.2008.04.023DOI Listing
August 2008

Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases.

Adv Immunol 2007 ;93:63-119

Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0065-2776(06)93002-8DOI Listing
June 2007

Developing antibodies for targeting immunoglobulin and membrane-bound immunoglobulin E.

Authors:
Tse Wen Chang

Allergy Asthma Proc 2006 Mar-Apr;27(2 Suppl 1):S7-14

Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC.

View Article

Download full-text PDF

Source
July 2006

Anti-IgE as a mast cell-stabilizing therapeutic agent.

J Allergy Clin Immunol 2006 Jun 11;117(6):1203-12; quiz 1213. Epub 2006 May 11.

Institute of Biotechnology, National Tsing Hua University, Genomics Research Center, Academia Sinica, Taipei, Taiwan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S009167490600856
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2006.04.005DOI Listing
June 2006

Improving pharmacokinetic properties of adrenocorticotropin by site-specific lipid modification.

J Pharm Sci 2003 Sep;92(9):1882-92

Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 300.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S002235491631309
Publisher Site
http://dx.doi.org/10.1002/jps.10442DOI Listing
September 2003

Realizing potential: the state of Asian bioentrepreneurship.

Nat Biotechnol 2003 Jul;21 Suppl:BE15-22

National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand.

View Article

Download full-text PDF

Source
July 2003

Comparative effects of human Ig alpha and Ig beta in inducing autoreactive antibodies against B cells in mice.

J Immunol 2003 Feb;170(3):1158-66

Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.170.3.1158DOI Listing
February 2003

Monoclonal antibodies against the C(epsilon)mX domain of human membrane-bound IgE and their potential use for targeting IgE-expressing B cells.

Int Arch Allergy Immunol 2002 Aug;128(4):315-24

Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, ROC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000063860DOI Listing
August 2002

Site-specific lipophilic modification of interferon-alpha.

J Protein Chem 2002 Aug;21(6):371-81

Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 300.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1023/a:1021134131250DOI Listing
August 2002

Down regulation of B cells by immunization with a fusion protein of a self CD20 peptide and a foreign IgG.Fc fragment.

Immunol Lett 2002 Apr;81(1):49-58

College of Life Science, National Tsing Hua University, Hsinchu, Taiwan, ROC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0165-2478(01)00332-7DOI Listing
April 2002