Tsan Sam Xiao

Tsan Sam Xiao

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Tsan Sam Xiao

Tsan Sam Xiao

Publications by authors named "Tsan Sam Xiao"

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Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.

Immunity 2019 07 13;51(1):43-49.e4. Epub 2019 May 13.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 USA; Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106 USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640092PMC
July 2019

Functional and structural characterization of zebrafish ASC.

FEBS J 2018 07 14;285(14):2691-2707. Epub 2018 Jun 14.

Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1111/febs.14514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105367PMC
July 2018

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.

Proc Natl Acad Sci U S A 2018 06 11;115(26):6792-6797. Epub 2018 Jun 11.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106;

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http://dx.doi.org/10.1073/pnas.1800562115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042100PMC
June 2018

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

Structure 2018 05 22;26(5):778-784.e3. Epub 2018 Mar 22.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932255PMC
May 2018

The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism.

J Biol Chem 2018 02 21;293(6):1924-1932. Epub 2017 Dec 21.

From the Department of Molecular Biosciences and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 and

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http://dx.doi.org/10.1074/jbc.M117.815076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808756PMC
February 2018

Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction.

PLoS One 2018 2;13(1):e0190547. Epub 2018 Jan 2.

Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190547PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749810PMC
February 2018

Post-translational regulation of inflammasomes.

Cell Mol Immunol 2017 01 27;14(1):65-79. Epub 2016 Jun 27.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-7288, USA.

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http://www.nature.com/articles/cmi201629
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http://dx.doi.org/10.1038/cmi.2016.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214939PMC
January 2017

Innate immunity and inflammation.

Authors:
Tsan Sam Xiao

Cell Mol Immunol 2017 01 22;14(1):1-3. Epub 2016 Aug 22.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1038/cmi.2016.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214945PMC
January 2017

Design of an expression system to enhance MBP-mediated crystallization.

Sci Rep 2017 01 23;7:40991. Epub 2017 Jan 23.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 USA.

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http://www.nature.com/articles/srep40991
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http://dx.doi.org/10.1038/srep40991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256280PMC
January 2017

RAGE Enhances TLR Responses through Binding and Internalization of RNA.

J Immunol 2016 11 19;197(10):4118-4126. Epub 2016 Oct 19.

Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany;

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http://dx.doi.org/10.4049/jimmunol.1502169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062438PMC
November 2016

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.

PLoS One 2016;11(9):e0163359. Epub 2016 Sep 22.

Cell Biology Program, Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033456PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163359PLOS
September 2016

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Pathogens 2016 Feb 29;5(1). Epub 2016 Feb 29.

Institute of Medical Microbiology and Hygiene, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.

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http://dx.doi.org/10.3390/pathogens5010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810146PMC
February 2016

STRUCTURAL BIOLOGY. Assembling the wheel of death.

Science 2015 Oct;350(6259):376-7

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1126/science.aad3981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668828PMC
October 2015

The nucleic acid-sensing inflammasomes.

Authors:
Tsan Sam Xiao

Immunol Rev 2015 May;265(1):103-11

Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/imr.12281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545668PMC
May 2015

Activation and assembly of the inflammasomes through conserved protein domain families.

Apoptosis 2015 Feb;20(2):151-6

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA,

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http://dx.doi.org/10.1007/s10495-014-1053-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364414PMC
February 2015

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.

Proc Natl Acad Sci U S A 2013 Apr 8;110(17):6985-90. Epub 2013 Apr 8.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1215770110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637702PMC
April 2013

Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B.

Structure 2012 May 5;20(5):887-98. Epub 2012 Apr 5.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.str.2012.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350598PMC
May 2012

NLRX1 has a tail to tell.

Immunity 2012 Mar;36(3):311-2

Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613120009
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http://dx.doi.org/10.1016/j.immuni.2012.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658283PMC
March 2012

The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.

Structure 2011 Oct 1;19(10):1485-95. Epub 2011 Sep 1.

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.str.2011.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195861PMC
October 2011

Subversion of innate immune signaling through molecular mimicry.

Authors:
Tsan Sam Xiao

J Clin Immunol 2010 Sep 30;30(5):638-42. Epub 2010 Jun 30.

Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Memorial Drive, Building 4, Room 138, Bethesda, MD 20892-0430, USA.

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http://dx.doi.org/10.1007/s10875-010-9435-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946320PMC
September 2010