Trygve O Tollefsbol

Trygve O Tollefsbol

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Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.

Cancers (Basel) 2018 Dec 27;11(1). Epub 2018 Dec 27.

Department of Biology, University of Alabama at Birmingham, 1300 University Blvd, Birmingham, AL 35294, USA.

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http://www.mdpi.com/2072-6694/11/1/23
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http://dx.doi.org/10.3390/cancers11010023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356328PMC
December 2018

The Role of Non-Coding RNAs and Isothiocyanates in Cancer.

Mol Nutr Food Res 2018 09 28;62(18):e1700913. Epub 2018 May 28.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA.

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http://doi.wiley.com/10.1002/mnfr.201700913
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http://dx.doi.org/10.1002/mnfr.201700913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248329PMC
September 2018

Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms.

Exp Cell Res 2018 Jul 22;368(1):67-74. Epub 2018 Apr 22.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, 175 Campbell Hall, Birmingham, AL 35294, USA; Comprehensive Cancer Center, University of Alabama Birmingham, 1802 6th Avenue South, Birmingham, AL 35294, USA; Comprehensive Center for Healthy Aging, University of Alabama Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA; Nutrition Obesity Research Center, University of Alabama Birmingham, 1675 University Boulevard, Birmingham, AL 35294, USA; Comprehensive Diabetes Center, University of Alabama Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2018.04.015DOI Listing
July 2018

Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic⁻Mediating Machinery.

Int J Mol Sci 2018 Jul 27;19(8). Epub 2018 Jul 27.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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http://www.mdpi.com/1422-0067/19/8/2204
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http://dx.doi.org/10.3390/ijms19082204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121898PMC
July 2018

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation.

Int J Mol Sci 2018 Jun 13;19(6). Epub 2018 Jun 13.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.3390/ijms19061754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032337PMC
June 2018

Pterostilbene down-regulates hTERT at physiological concentrations in breast cancer cells: Potentially through the inhibition of cMyc.

J Cell Biochem 2018 04 26;119(4):3326-3337. Epub 2017 Dec 26.

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1002/jcb.26495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985967PMC
April 2018

Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory.

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):529-550. Epub 2017 Dec 11.

a Center for Biomedical Network Research on Rare Diseases (CIBERER) , Institute of Health Carlos III , Valencia , Spain.

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http://dx.doi.org/10.1080/10408363.2017.1410520DOI Listing
April 2018

Transforming Cancer Epigenetics Using Nutritive Approaches and Noncoding RNAs.

Curr Cancer Drug Targets 2018 ;18(1):32-38

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.

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http://dx.doi.org/10.2174/1568009617666170203165326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577388PMC
January 2018

The influence of an epigenetics diet on the cancer epigenome.

Epigenomics 2017 09 11;9(9):1153-1155. Epub 2017 Aug 11.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.2217/epi-2017-0077DOI Listing
September 2017

Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERα expression.

Sci Rep 2017 Aug 24;7(1):9345. Epub 2017 Aug 24.

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.

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http://dx.doi.org/10.1038/s41598-017-09764-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570897PMC
August 2017

A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells.

PLoS One 2016 9;11(5):e0155057. Epub 2016 May 9.

Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, Alabama, 35294, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861292PMC
July 2017

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells.

Int J Mol Sci 2017 May 19;18(5). Epub 2017 May 19.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.3390/ijms18051092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455001PMC
May 2017

Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases.

Epigenomics 2016 12 24;8(12):1637-1651. Epub 2016 Nov 24.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.2217/epi-2016-0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618938PMC
December 2016

Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals.

Epigenomics 2016 08 1;8(8):1019-37. Epub 2016 Aug 1.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.2217/epi-2016-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066124PMC
August 2016

Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 Transcription, and Proliferation of MCF-7 Breast Cancer Cells.

J Cell Biochem 2016 07 28;117(7):1688-96. Epub 2015 Dec 28.

Department of Biology, University of Alabama, Birmingham, Alabama.

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http://doi.wiley.com/10.1002/jcb.25462
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http://dx.doi.org/10.1002/jcb.25462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135016PMC
July 2016

Erratum to "Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 cancer cells with PX-866 and Raloxifene" [Exp. Cell Res. 344 (2016) 95-102].

Exp Cell Res 2016 Jul 2;345(2):255. Epub 2016 Jun 2.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL, USA; Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.05.021DOI Listing
July 2016

Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 Cancer cells with PX-866 and Raloxifene.

Exp Cell Res 2016 05 23;344(1):95-102. Epub 2016 Mar 23.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL, USA; Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879042PMC
May 2016

Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms.

Front Genet 2016 9;7:83. Epub 2016 May 9.

Department of Biology, University of Alabama at Birmingham, BirminghamAL, USA; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, BirminghamAL, USA; Comprehensive Cancer Center, University of Alabama at Birmingham, BirminghamAL, USA; Nutrition Obesity Research Center, University of Alabama at Birmingham, BirminghamAL, USA; Comprehensive Diabetes Center, University of Alabama at Birmingham, BirminghamAL, USA.

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http://dx.doi.org/10.3389/fgene.2016.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860561PMC
May 2016

Impact of Epigenetic Dietary Components on Cancer through Histone Modifications.

Curr Med Chem 2015 ;22(17):2051-64

CH175, 1300 University Boulevard, Birmingham, AL 35294-1170.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012963PMC
February 2016

Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing.

Int J Mol Sci 2015 Dec 24;17(1). Epub 2015 Dec 24.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA.

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http://dx.doi.org/10.3390/ijms17010016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730263PMC
December 2015

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases.

Clin Epigenetics 2015 16;7:112. Epub 2015 Oct 16.

Department of Biology, University of Alabama at Birmingham, 175 Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294-1170 USA ; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL USA ; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, AL USA ; Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL USA ; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL USA.

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http://dx.doi.org/10.1186/s13148-015-0144-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609101PMC
October 2015

Impact of Nutrition on Non-Coding RNA Epigenetics in Breast and Gynecological Cancer.

Front Nutr 2015 27;2:16. Epub 2015 May 27.

Department of Biology, University of Alabama at Birmingham , Birmingham, AL , USA ; Comprehensive Center for Healthy Ageing, University of Alabama at Birmingham , Birmingham, AL , USA ; Comprehensive Cancer Center, University of Alabama at Birmingham , Birmingham, AL , USA ; Nutrition Obesity Research Center, University of Alabama at Birmingham , Birmingham, AL , USA ; Comprehensive Diabetes Center, University of Alabama at Birmingham , Birmingham, AL , USA.

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http://dx.doi.org/10.3389/fnut.2015.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445322PMC
June 2015

Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells.

Mol Cell Endocrinol 2015 May 25;406:102-14. Epub 2015 Feb 25.

Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow 226 031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132185PMC
May 2015

The Epigenetic Impact of Cruciferous Vegetables on Cancer Prevention.

Curr Pharmacol Rep 2015 Feb;1(1):46-51

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA. ; Comprehensive Center for Healthy Aging, University of Alabama Birmingham, 1530 3 Avenue South, Birmingham, AL 35294, USA. ; Comprehensive Cancer Center, University of Alabama Birmingham, 1802 6 Avenue South, Birmingham, AL 35294, USA. ; Nutrition Obesity Research Center, University of Alabama Birmingham, 1675 University Boulevard, Birmingham, AL 35294, USA. ; Comprehensive Diabetes Center, University of Alabama Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1007/s40495-014-0003-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354933PMC
February 2015

Epigenetic linkage of aging, cancer and nutrition.

J Exp Biol 2015 Jan;218(Pt 1):59-70

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA Comprehensive Cancer Center, University of Alabama at Birmingham, 1802 6th Avenue South, Birmingham, AL 35294, USA Nutrition Obesity Research Center, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294, USA Comprehensive Diabetes Center, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA

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http://dx.doi.org/10.1242/jeb.107110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286704PMC
January 2015

Aging and energetics' 'Top 40' future research opportunities 2010-2013.

F1000Res 2014 12;3:219. Epub 2014 Sep 12.

Nutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biology, University of Alabama at Birmingham, Birmingham, USA ; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.

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http://dx.doi.org/10.12688/f1000research.5212.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197746PMC
October 2014

Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate.

Exp Cell Res 2014 May 8;324(1):40-53. Epub 2014 Feb 8.

Department of Biology, University of Alabama at Birmingham, 175 Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294, USA; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Comprehensive Diabetes Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043227PMC
May 2014

Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis.

J Cell Physiol 2014 Apr;229(4):393-406

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Biological Sciences, Alabama State University, Montgomery, Alabama.

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http://dx.doi.org/10.1002/jcp.24466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875779PMC
April 2014

Dietary epigenetics in cancer and aging.

Cancer Treat Res 2014 ;159:257-67

Department of Biology, Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, Comprehensive Diabetes Center, University of Alabama, Birmingham, AL, USA,

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http://dx.doi.org/10.1007/978-3-642-38007-5_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875399PMC
April 2014

Cell senescence culturing methods.

Methods Mol Biol 2013 ;1048:1-10

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1007/978-1-62703-556-9_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873382PMC
March 2014

Analysis of biomarkers of caloric restriction in aging cells.

Methods Mol Biol 2013 ;1048:19-29

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1007/978-1-62703-556-9_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875466PMC
March 2014

Impact of epigenetic dietary compounds on transgenerational prevention of human diseases.

AAPS J 2014 Jan 11;16(1):27-36. Epub 2013 Oct 11.

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA,

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http://dx.doi.org/10.1208/s12248-013-9538-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877417PMC
January 2014

Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein.

PLoS One 2013 14;8(1):e54369. Epub 2013 Jan 14.

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054369PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544723PMC
August 2013

Real-time methylomic aberrations during initiation and progression of induced human mammary epithelial cell tumorigenesis.

Epigenomics 2013 Apr;5(2):155-65

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.2217/epi.13.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893889PMC
April 2013

Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and Sulforaphane.

J Oncol 2013 17;2013:872957. Epub 2013 Feb 17.

Department of Biology, University of Alabama at Birmingham, CH175, 1300 University Boulevard, Birmingham, AL 35294-1170, USA.

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http://dx.doi.org/10.1155/2013/872957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588178PMC
March 2013

MicroRNAs: an emerging science in cancer epigenetics.

J Clin Bioinforma 2013 Mar 16;3(1). Epub 2013 Mar 16.

Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1186/2043-9113-3-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608239PMC
March 2013

Epigenomics of ovarian cancer and its chemoprevention.

Front Genet 2011 4;2:67. Epub 2011 Oct 4.

Department of Biology, University of Alabama at Birmingham Birmingham, AL, USA.

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http://dx.doi.org/10.3389/fgene.2011.00067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268620PMC
October 2012

The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.

J Oncol 2012 7;2012:192464. Epub 2011 Dec 7.

Department of Biology, University of Alabama at Birmingham, 175A Campbell Hall, 1300 University Blvd, Birmingham, AL 35294-1170, USA.

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http://www.hindawi.com/journals/jo/2012/192464/
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http://dx.doi.org/10.1155/2012/192464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236518PMC
August 2012

Regulation of the human catalytic subunit of telomerase (hTERT).

Gene 2012 May 13;498(2):135-46. Epub 2012 Feb 13.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03781119120016
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http://dx.doi.org/10.1016/j.gene.2012.01.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312932PMC
May 2012

Mitochondrial regulation of epigenetics and its role in human diseases.

Epigenetics 2012 Apr 1;7(4):326-34. Epub 2012 Apr 1.

Wilhelm Johannsen Centre for Functional Genome Research, Institute for Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.4161/epi.19547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368816PMC
April 2012

Advances in epigenetic technology.

Methods Mol Biol 2011 ;791:1-10

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1007/978-1-61779-316-5_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227536PMC
December 2011

DNA methylation detection: bisulfite genomic sequencing analysis.

Methods Mol Biol 2011 ;791:11-21

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://link.springer.com/10.1007/978-1-61779-316-5_2
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http://dx.doi.org/10.1007/978-1-61779-316-5_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233226PMC
December 2011

Methylated-CpG Island Recovery Assay.

Methods Mol Biol 2011 ;791:125-33

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://link.springer.com/10.1007/978-1-61779-316-5_10
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http://dx.doi.org/10.1007/978-1-61779-316-5_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225287PMC
December 2011

Combined chromatin immunoprecipitation and bisulfite methylation sequencing analysis.

Methods Mol Biol 2011 ;791:239-51

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1007/978-1-61779-316-5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233221PMC
December 2011

A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells.

Cancer Prev Res (Phila) 2011 Aug 16;4(8):1243-54. Epub 2011 Mar 16.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall 175, Birmingham, AL 35294-1170, USA.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128170PMC
August 2011

Epigenetic regulation of caloric restriction in aging.

BMC Med 2011 Aug 25;9:98. Epub 2011 Aug 25.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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http://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7
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http://dx.doi.org/10.1186/1741-7015-9-98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175174PMC
August 2011

Epigenetic diet: impact on the epigenome and cancer.

Epigenomics 2011 Aug;3(4):503-18

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.2217/epi.11.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197720PMC
August 2011

Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.

Am J Respir Cell Mol Biol 2011 Jul 19;45(1):16-23. Epub 2010 Aug 19.

Department of Pediatrics, University of California-San Diego, 9500 Gilman Dr., MC 0731, San Diego, CA 92093-0731, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0154OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145068PMC
July 2011

Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice.

Carcinogenesis 2011 Apr 24;32(4):597-604. Epub 2010 Dec 24.

Department of Dermatology, University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, Birmingham, AL 35294, USA.

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https://academic.oup.com/carcin/article/32/4/597/2463619
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http://dx.doi.org/10.1093/carcin/bgq282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066413PMC
April 2011

2D difference gel electrophoresis analysis of different time points during the course of neoplastic transformation of human mammary epithelial cells.

J Proteome Res 2011 Feb 20;10(2):447-58. Epub 2010 Dec 20.

Department of Biology, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-1170, USA.

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http://dx.doi.org/10.1021/pr100533kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390236PMC
February 2011

p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms.

PLoS One 2011 Feb 24;6(2):e17421. Epub 2011 Feb 24.

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017421PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044759PMC
February 2011

Epigenetic targets of bioactive dietary components for cancer prevention and therapy.

Clin Epigenetics 2010 Dec;1(3-4):101-116

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall 175, Birmingham, AL 35294-1170, USA.

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http://dx.doi.org/10.1007/s13148-010-0011-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024548PMC
December 2010

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.

PLoS One 2010 Jul 6;5(7):e11457. Epub 2010 Jul 6.

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897894PMC
July 2010

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression.

FASEB J 2010 May 17;24(5):1442-53. Epub 2009 Dec 17.

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1096/fj.09-149328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996891PMC
May 2010

Polyphenols and aging.

Curr Aging Sci 2010 Feb;3(1):34-42

Department of Biology, University of Alabama at Birmingham, AL 35294, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896035PMC
February 2010

Retinoid-induced histone deacetylation inhibits telomerase activity in estrogen receptor-negative breast cancer cells.

Anticancer Res 2009 Dec;29(12):4959-64

Department of Biology, 175 Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294-1170, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888005PMC
December 2009

Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms.

Int J Cancer 2009 Jul;125(2):286-96

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1002/ijc.24398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995334PMC
July 2009

DNA methylation impacts on learning and memory in aging.

Neurobiol Aging 2009 Apr 11;30(4):549-60. Epub 2007 Sep 11.

Department of Biology, University of Alabama at Birmingham, 175 Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294-1170, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656583PMC
April 2009

Differential expression of epigenetic modulators during human embryonic stem cell differentiation.

Mol Biotechnol 2009 Mar 25;41(3):201-7. Epub 2008 Oct 25.

Department of Biology, University of Alabama at Birmingham, 175 Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294-1170, USA.

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http://link.springer.com/10.1007/s12033-008-9118-8
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http://dx.doi.org/10.1007/s12033-008-9118-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629501PMC
March 2009

Strategies targeting telomerase inhibition.

Mol Biotechnol 2009 Feb 28;41(2):194-9. Epub 2008 Oct 28.

Department of Biology, University of Alabama at Birmingham, 175 Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294-1170, USA.

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http://dx.doi.org/10.1007/s12033-008-9117-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628964PMC
February 2009

Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells.

Anticancer Res 2009 Jan;29(1):139-44

Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, GA 30310, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737468PMC
January 2009

Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis.

Am J Respir Cell Mol Biol 2008 Nov 12;39(5):610-8. Epub 2008 Jun 12.

Department of Pediatrics, Division of Pulmonary Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1165/rcmb.2007-0322OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574530PMC
November 2008

EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase.

Biochem Biophys Res Commun 2008 Oct 8;375(1):162-7. Epub 2008 Aug 8.

Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, Birmingham, AL, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.07.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568882PMC
October 2008

Gene-environment interactions and epigenetic basis of human diseases.

Curr Issues Mol Biol 2008 ;10(1-2):25-36

Department of Medicine, University of Alabama at Birmingham, AL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2434999PMC
September 2008

The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells.

Transl Oncol 2008 Sep;1(3):148-52

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533143PMC
September 2008

Methods of telomerase inhibition.

Methods Mol Biol 2007 ;405:1-7

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1007/978-1-60327-070-0_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423206PMC
August 2008

hTERT knockdown in human embryonic kidney cells using double-stranded RNA.

Methods Mol Biol 2007 ;405:23-9

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1007/978-1-60327-070-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423205PMC
August 2008

RNA interference using a plasmid construct expressing short-hairpin RNA.

Methods Mol Biol 2007 ;405:31-7

Department of Biology, University of Alabama Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1007/978-1-60327-070-0_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423213PMC
August 2008

Epigenetic regulation of telomerase in retinoid-induced differentiation of human leukemia cells.

Int J Oncol 2008 Mar;32(3):625-31

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435486PMC
March 2008

Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG.

J Cell Biochem 2008 Feb;103(2):509-19

Department of Biology, University of Alabama Birmingham, Birmingham, Alabama 35294, USA.

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http://doi.wiley.com/10.1002/jcb.21417
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435482PMC
February 2008

An overview of epigenetic assays.

Mol Biotechnol 2008 Feb 18;38(2):179-83. Epub 2007 Oct 18.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA.

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http://dx.doi.org/10.1007/s12033-007-9010-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423347PMC
February 2008

Techniques for analysis of biological aging.

Methods Mol Biol 2007 ;371:1-7

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423215PMC
http://dx.doi.org/10.1007/978-1-59745-361-5_1DOI Listing
September 2007

Aging cell culture: methods and observations.

Methods Mol Biol 2007 ;371:9-19

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423218PMC
http://dx.doi.org/10.1007/978-1-59745-361-5_2DOI Listing
September 2007

A method to detect DNA methyltransferase I gene transcription in vitro in aging systems.

Methods Mol Biol 2007 ;371:73-80

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423211PMC
http://dx.doi.org/10.1007/978-1-59745-361-5_6DOI Listing
September 2007

A method to study the expression of DNA methyltransferases in aging systems in vitro.

Methods Mol Biol 2007 ;371:81-7

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435000PMC
http://dx.doi.org/10.1007/978-1-59745-361-5_7DOI Listing
September 2007

The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells.

Int J Oncol 2007 Mar;30(3):641-50

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435481PMC
March 2007

Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop.

Exp Cell Res 2007 Jan 25;313(2):322-30. Epub 2006 Oct 25.

Department of Biology, University of Alabama at Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.yexcr.2006.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829489PMC
January 2007

Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems.

Front Biosci 2005 May 1;10:1779-96. Epub 2005 May 1.

Department of Biology, University of Alabama at Birmingham, AL 35294-1170, USA.

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May 2005

The impact of metabolism on DNA methylation.

Hum Mol Genet 2005 Apr;14 Spec No 1:R139-47

Department of Biology, University of Alabama at Birmingham, 35294, USA.

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http://dx.doi.org/10.1093/hmg/ddi100DOI Listing
April 2005

Methods of epigenetic analysis.

Methods Mol Biol 2004 ;287:1-8

Department of Biology, University of Alabama at Birmingham, USA.

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http://link.springer.com/10.1385/1-59259-828-5:001
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http://dx.doi.org/10.1385/1-59259-828-5:001DOI Listing
October 2004

Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation.

Genes Chromosomes Cancer 2004 Sep;41(1):26-37

Department of Biology, University of Alabama at Birmingham, Alabama, USA.

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http://dx.doi.org/10.1002/gcc.20058DOI Listing
September 2004

Genetic and epigenetic modulation of telomerase activity in development and disease.

Gene 2004 Sep;340(1):1-10

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA.

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http://dx.doi.org/10.1016/j.gene.2004.06.011DOI Listing
September 2004

Telomerase inhibition by retinoids precedes cytodifferentiation of leukemia cells and may contribute to terminal differentiation.

Mol Cancer Ther 2004 Aug;3(8):1003-9

Department of Biology, University of Alabama-Birmingham, 175 Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294-1170, USA.

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August 2004

Telomerase, telomerase inhibition, and cancer.

J Anti Aging Med 2003 ;6(4):315-25

University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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https://www.liebertpub.com/doi/10.1089/109454503323028911
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http://dx.doi.org/10.1089/109454503323028911DOI Listing
June 2004

EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis.

Int J Oncol 2004 Mar;24(3):703-10

Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://img.pathfinder.gr/clubs/files/4093/6832.pdf
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March 2004

Aging, cancer and nutrition: the DNA methylation connection.

Mech Ageing Dev 2003 Dec;124(10-12):989-98

Department of Biology, University of Alabama at Birmingham,Birmingham, AL 35294-1170, USA.

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December 2003

Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements.

Gene 2003 Oct;316:57-65

Department of Biology, University of Alabama at Birmingham, 175A Campbell Hall, 1300 University Boulevard, Birmingham, AL 35294-1170, USA.

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October 2003

Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts.

Mol Cell Biochem 2003 Oct;252(1-2):33-43

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA.

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http://www.springerlink.com/index/P1340731W3846187.pdf
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October 2003

Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells.

Biochem Biophys Res Commun 2003 Jul;306(3):650-9

Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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July 2003