Tryfon Zarganes-Tzitzikas

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

View Article and Find Full Text PDF

January 2021

TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics.

Angew Chem Int Ed Engl 2020 11 15;59(46):20338-20342. Epub 2020 Jul 15.

TU Dortmund University, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.

View Article and Find Full Text PDF

November 2020

[F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action.

Authors:

Gonçalo S Clemente Jens Rickmeier Inês F Antunes Tryfon Zarganes-Tzitzikas Alexander Dömling Tobias Ritter Philip H Elsinga

EJNMMI Res 2020 Apr 15;10(1):34. Epub 2020 Apr 15.

Department of Nuclear Medicine and Molecular Imaging - University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713, GZ, Groningen, The Netherlands.

View Article and Find Full Text PDF

April 2020

Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin.

Authors:

Gonçalo S Clemente Tryfon Zarganes-Tzitzikas Alexander Dömling Philip H Elsinga

Molecules 2019 Nov 20;24(23). Epub 2019 Nov 20.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

View Article and Find Full Text PDF

November 2019

Rapid approach to complex boronic acids.

Authors:

Constantinos G Neochoritis Shabnam Shaabani Maryam Ahmadianmoghaddam Tryfon Zarganes-Tzitzikas Li Gao Michaela Novotná Tatiana Mitríková Atilio Reyes Romero Marina Ika Irianti Ruixue Xu Joe Olechno Richard Ellson Victoria Helan Michael Kossenjans Matthew R Groves Alexander Dömling

Sci Adv 2019 07 5;5(7):eaaw4607. Epub 2019 Jul 5.

Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands.

View Article and Find Full Text PDF

July 2019

MCR Scaffolds Get Hotter with F-Labeling.

Authors:

Tryfon Zarganes-Tzitzikas Gonçalo S Clemente Philip H Elsinga Alexander Dömling

Molecules 2019 Apr 4;24(7). Epub 2019 Apr 4.

Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.

View Article and Find Full Text PDF

April 2019

Atorvastatin (Lipitor) by MCR.

Authors:

Tryfon Zarganes-Tzitzikas Constantinos G Neochoritis Alexander Dömling

ACS Med Chem Lett 2019 Mar 7;10(3):389-392. Epub 2019 Feb 7.

Department of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, Groningen 9700 AV, The Netherlands.

View Article and Find Full Text PDF

March 2019

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists.

Authors:

Constantinos G Neochoritis Maryam Kazemi Miraki Eman M M Abdelraheem Ewa Surmiak Tryfon Zarganes-Tzitzikas Beata Łabuzek Tad A Holak Alexander Dömling

Beilstein J Org Chem 2019 20;15:513-520. Epub 2019 Feb 20.

Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, 9700 AD Groningen, The Netherlands.

View Article and Find Full Text PDF

February 2019

Application of Silver Nanoparticles in the Multicomponent Reaction Domain: A Combined Catalytic Reduction Methodology to Efficiently Access Potential Hypertension or Inflammation Inhibitors.

Authors:

Domna Iordanidou Tryfon Zarganes-Tzitzikas Constantinos G Neochoritis Alexander Dömling Ioannis N Lykakis

ACS Omega 2018 Nov 27;3(11):16005-16013. Epub 2018 Nov 27.

Department of Chemistry, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54124, Greece.

View Article and Find Full Text PDF

November 2018

Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR.

Authors:

Rudrakshula Madhavachary Tryfon Zarganes-Tzitzikas Pravin Patil Katarzyna Kurpiewska Justyna Kalinowska-Tłuścik Alexander Dömling

ACS Comb Sci 2018 04 26;20(4):192-196. Epub 2018 Feb 26.

University of Groningen , Department of Drug Design , A. Deusinglaan 1 , 9713 AV Groningen , The Netherlands.

View Article and Find Full Text PDF

April 2018

Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.

Authors:

Tjie Kok Hannah Wapenaar Kan Wang Constantinos G Neochoritis Tryfon Zarganes-Tzitzikas Giordano Proietti Nikolaos Eleftheriadis Katarzyna Kurpiewska Justyna Kalinowska-Tłuścik Robbert H Cool Gerrit J Poelarends Alexander Dömling Frank J Dekker

Bioorg Med Chem 2018 03 24;26(5):999-1005. Epub 2017 Dec 24.

Department of Chemical and Pharmaceutical Biology, University of Groningen, Groningen, The Netherlands. Electronic address:

View Article and Find Full Text PDF

March 2018

Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?

Authors:

Markella Konstantinidou Tryfon Zarganes-Tzitzikas Katarzyna Magiera-Mularz Tad A Holak Alexander Dömling

Angew Chem Int Ed Engl 2018 04 23;57(18):4840-4848. Epub 2018 Feb 23.

Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.

View Article and Find Full Text PDF

April 2018

Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.

Authors:

Katarzyna Magiera-Mularz Lukasz Skalniak Krzysztof M Zak Bogdan Musielak Ewa Rudzinska-Szostak Łukasz Berlicki Justyna Kocik Przemyslaw Grudnik Dominik Sala Tryfon Zarganes-Tzitzikas Shabnam Shaabani Alexander Dömling Grzegorz Dubin Tad A Holak

Angew Chem Int Ed Engl 2017 10 26;56(44):13732-13735. Epub 2017 Sep 26.

Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060, Krakow, Poland.

View Article and Find Full Text PDF

October 2017

Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015).

Authors:

Tryfon Zarganes-Tzitzikas Markella Konstantinidou Yongzhi Gao Dobroslawa Krzemien Krzysztof Zak Grzegorz Dubin Tad A Holak Alexander Dömling

Expert Opin Ther Pat 2016 Sep 6;26(9):973-7. Epub 2016 Jul 6.

a Department of Drug Design , University of Groningen , Groningen , The Netherlands.

View Article and Find Full Text PDF

September 2016

Multicomponent Reactions, Union of MCRs and Beyond.

Authors:

Tryfon Zarganes-Tzitzikas Ajay L Chandgude Alexander Dömling

Chem Rec 2015 Oct 11;15(5):981-96. Epub 2015 Sep 11.

Department of Drug Design, University of Groningen, The Netherlands.

View Article and Find Full Text PDF

October 2015

Leuckart-Wallach Route Toward Isocyanides and Some Applications.

Authors:

Constantinos G Neochoritis Tryfon Zarganes-Tzitzikas Silvia Stotani Adrian Dömling Eberhardt Herdtweck Kareem Khoury Alexander Dömling

ACS Comb Sci 2015 Sep 10;17(9):493-9. Epub 2015 Aug 10.

Department of Drug Design, University of Gröningen , A. Deusinglaan 1, Gröningen 9700AV, The Netherlands.

View Article and Find Full Text PDF

September 2015

Concise Synthesis of Tetrazole-keto-piperazines by Two Consecutive Ugi Reactions.

Authors:

Tryfon Zarganes-Tzitzikas Pravin Patil Kareem Khoury Eberhardt Herdtweck Alexander Dömling

European J Org Chem 2015 Jan 17;2015(1):51-55. Epub 2014 Nov 17.

Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, Postbus 196, 9700 AD Groningen, Netherlands, Homepage: www.drugdesign.nl.

View Article and Find Full Text PDF

January 2015

Modern Multicomponent Reactions for better Drug Syntheses**

Authors:

Tryfon Zarganes-Tzitzikas Alexander Dömling

Org Chem Front 2014 Sep;1(7):834-837

View Article and Find Full Text PDF

September 2014

One-pot five-component synthesis of spirocyclopenta[b]chromene derivatives and their acid-catalyzed rearrangement.

Authors:

Michael A Terzidis Tryfon Zarganes-Tzitzikas Constantinos Tsimenidis Julia Stephanidou-Stephanatou Constantinos A Tsoleridis George E Kostakis

J Org Chem 2012 Oct 28;77(20):9018-28. Epub 2012 Sep 28.

Department of Chemistry, Laboratory of Organic Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.

View Article and Find Full Text PDF

October 2012

One-pot synthesis of functionalized spirobenzofuranones via MCR involving 3-cyanochromones.

Authors:

Tryfon Zarganes-Tzitzikas Michael A Terzidis Julia Stephanidou-Stephanatou Constantinos A Tsoleridis George E Kostakis

J Org Chem 2011 Nov 12;76(21):9008-14. Epub 2011 Oct 12.

Department of Chemistry, Laboratory of Organic Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.

View Article and Find Full Text PDF

November 2011

Synthesis of 2-keto-imidazoles utilizing N-arylamino-substituted N-heterocyclic carbenes.

Authors:

Tryfon Zarganes-Tzitzikas Constantinos G Neochoritis Julia Stephanidou-Stephanatou Constantinos A Tsoleridis

J Org Chem 2011 Mar 20;76(5):1468-71. Epub 2011 Jan 20.

Department of Chemistry, Laboratory of Organic Chemistry, University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.

View Article and Find Full Text PDF

March 2011

One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones.

Authors:

Constantinos G Neochoritis Tryfon Zarganes-Tzitzikas Constantinos A Tsoleridis Julia Stephanidou-Stephanatou Christos A Kontogiorgis Dimitra J Hadjipavlou-Litina Theodora Choli-Papadopoulou

Eur J Med Chem 2011 Jan 19;46(1):297-306. Epub 2010 Nov 19.

Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54124, Macedonia, Greece.

View Article and Find Full Text PDF

January 2011

Publications by authors named "Tryfon Zarganes-Tzitzikas"

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors: