Publications by authors named "Troy R Torgerson"

100Publications

Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares.

Pediatr Rheumatol Online J 2020 Oct 16;18(1):80. Epub 2020 Oct 16.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Jack MacDonald Building - 6th floor, 1900 9th Avenue, Seattle, Washington, 98101, USA.

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http://dx.doi.org/10.1186/s12969-020-00474-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565350PMC
October 2020

Primary immune regulatory disorders: a growing universe of immune dysregulation.

Curr Opin Allergy Clin Immunol 2020 Dec;20(6):582-590

Allen Institute for Immunology and Department of Pediatrics, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1097/ACI.0000000000000689DOI Listing
December 2020

Behçet disease (BD) and BD-like clinical phenotypes: NF-κB pathway in mucosal ulcerating diseases.

Scand J Immunol 2020 Nov 10;92(5):e12973. Epub 2020 Oct 10.

Rare Disease and Pediatric Research Centers, Hospital for Children and Adolescents and Adult Immunodeficiency Unit, Inflammation Center, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/sji.12973DOI Listing
November 2020

HLA-Haploidentical Hematopoietic Cell Transplantation for Treatment of Nonmalignant Diseases Using Nonmyeloablative Conditioning and Post-Transplant Cyclophosphamide.

Biol Blood Marrow Transplant 2020 Jul 28;26(7):1332-1341. Epub 2020 Mar 28.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington; Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2020.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306430PMC
July 2020

Eczematous dermatitis in primary immunodeficiencies: A review of cutaneous clues to diagnosis.

Clin Immunol 2020 02 30;211:108330. Epub 2019 Dec 30.

Division of Dermatology, Department of Pediatrics, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.108330DOI Listing
February 2020

Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology.

J Allergy Clin Immunol 2020 01 27;145(1):46-69. Epub 2019 Sep 27.

Departments of Pediatrics and Medicine, University of South Florida, St Petersburg, Fla; Division of Pediatric Allergy/Immunology, Johns Hopkins-All Children's Hospital, St Petersburg, Fla; Division of Pediatric Allergy Immunology, Massachusetts General Hospital, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2019.09.009DOI Listing
January 2020

CAR-T - and a side order of IgG, to go? - Immunoglobulin replacement in patients receiving CAR-T cell therapy.

Blood Rev 2019 11 7;38:100596. Epub 2019 Aug 7.

Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.blre.2019.100596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810871PMC
November 2019

Primary immune regulatory disorders for the pediatric hematologist and oncologist: A case-based review.

Pediatr Blood Cancer 2019 05 29;66(5):e27619. Epub 2019 Jan 29.

Department of Hematology, Children's Hospital of Orange County, Orange, California.

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http://dx.doi.org/10.1002/pbc.27619DOI Listing
May 2019

Corrigendum: A Novel Homozygous Mutation Leading to T-B+NK- SCID in Two Brazilian Patients.

Front Pediatr 2018 23;6:358. Epub 2018 Nov 23.

Laboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.3389/fped.2018.00358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265411PMC
November 2018

A Novel Homozygous Mutation Leading to T-B+NK- SCID in Two Brazilian Patients.

Front Pediatr 2018 20;6:230. Epub 2018 Aug 20.

Laboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.3389/fped.2018.00230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109756PMC
August 2018

Neutralizing Anti-Cytokine Autoantibodies Against Interferon-α in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked.

Front Immunol 2018 29;9:544. Epub 2018 Mar 29.

Department of Pediatric Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885158PMC
May 2019

Paternal gonadal mosaicism as cause of a puzzling inheritance pattern of activated PI3-kinase delta syndrome.

Ann Allergy Asthma Immunol 2017 12 6;119(6):564-566. Epub 2017 Nov 6.

Department of Pediatrics, University of Washington, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

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http://dx.doi.org/10.1016/j.anai.2017.09.054DOI Listing
December 2017

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 10;8:1244. Epub 2017 Oct 10.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
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http://dx.doi.org/10.3389/fimmu.2017.01244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641412PMC
October 2017

Suppression by human FOXP3 regulatory T cells requires FOXP3-TIP60 interactions.

Sci Immunol 2017 Jun;2(12)

Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.

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http://dx.doi.org/10.1126/sciimmunol.aai9297DOI Listing
June 2017

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 17;8:798. Epub 2017 Jul 17.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
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http://dx.doi.org/10.3389/fimmu.2017.00798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511964PMC
July 2017

Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.

J Allergy Clin Immunol 2017 08 16;140(2):616-619.e7. Epub 2017 Mar 16.

Department of Pediatrics, University of Washington School of Medicine, Seattle, Wash; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Wash. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.02.017DOI Listing
August 2017

Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary Immunodeficiencies.

J Allergy Clin Immunol Pract 2016 Nov - Dec;4(6):1089-1100

Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St Louis, Mo.

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http://dx.doi.org/10.1016/j.jaip.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289744PMC
October 2017

Extremely Early Onset IPEX Syndrome Caused by a Novel Small Exonic Deletion in FOXP3.

J Pediatr Gastroenterol Nutr 2016 11;63(5):e119-e120

*University of Alabama, Birmingham †Kovler Diabetes Center, University of Chicago, Chicago, IL ‡University of Washington and Seattle Children's Hospital, Seattle, WA.

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http://dx.doi.org/10.1097/MPG.0000000000000554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346554PMC
November 2016

X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis.

J Clin Immunol 2016 08 20;36(6):564-70. Epub 2016 Jun 20.

Division of Asthma, Department of Pediatrics, Allergy and Clinical Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1007/s10875-016-0307-0DOI Listing
August 2016

Primary Immune Deficiency Treatment Consortium (PIDTC) update.

J Allergy Clin Immunol 2016 08 22;138(2):375-85. Epub 2016 Apr 22.

Pediatric Immunology and Pediatrics, Mother and Child Ste-Justine Hospital, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jaci.2016.01.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986691PMC
August 2016

Autoimmunity and Primary Immunodeficiency Disorders.

J Clin Immunol 2016 05 23;36 Suppl 1:57-67. Epub 2016 May 23.

Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.1007/s10875-016-0294-1DOI Listing
May 2016

Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome.

Blood 2016 05 22;127(21):2513-22. Epub 2016 Feb 22.

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA; and Department of Pediatrics and.

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http://dx.doi.org/10.1182/blood-2015-11-683235DOI Listing
May 2016

Hematopoietic Stem Cell Transplant for Immune Deficiency and Immune Dysregulation Disorders.

Immunol Allergy Clin North Am 2015 Nov 4;35(4):695-711. Epub 2015 Sep 4.

Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA; University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA; Seattle Children's Research Institute, 1900 9th Avenue, JMB-7, Seattle, WA 98101-1304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.iac.2015.07.010DOI Listing
November 2015

Health-related quality of life in patients with primary immunodeficiency disease.

Allergy Asthma Clin Immunol 2015 29;11:27. Epub 2015 Sep 29.

University of Washington, Seattle, WA USA ; Seattle Children's Hospital, Seattle, WA USA.

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http://dx.doi.org/10.1186/s13223-015-0092-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587876PMC
September 2015

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.

J Exp Med 2015 Sep 14;212(10):1663-77. Epub 2015 Sep 14.

Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101

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http://dx.doi.org/10.1084/jem.20150585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577851PMC
September 2015

Severe combined immunodeficiency (SCID) presenting with neonatal aplastic anemia.

Pediatr Blood Cancer 2015 Nov 22;62(11):2047-9. Epub 2015 May 22.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1002/pbc.25587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583355PMC
November 2015

Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia.

Pediatr Blood Cancer 2015 Sep 20;62(9):1674-6. Epub 2015 Apr 20.

Pediatric Blood and Marrow Transplant, Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pbc.25554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876715PMC
September 2015

Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial.

Biol Blood Marrow Transplant 2014 Dec 6;20(12):1996-2003. Epub 2014 Sep 6.

Fred Hutchinson Cancer Research Center, Seattle, Washington; University of Washington School of Medicine, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

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http://dx.doi.org/10.1016/j.bbmt.2014.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324724PMC
December 2014

Intravenous injection of a foamy virus vector to correct canine SCID-X1.

Blood 2014 Jun 18;123(23):3578-84. Epub 2014 Mar 18.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA;

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http://dx.doi.org/10.1182/blood-2013-11-538926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047497PMC
June 2014

First report of the Hyper-IgM syndrome Registry of the Latin American Society for Immunodeficiencies: novel mutations, unique infections, and outcomes.

J Clin Immunol 2014 Feb 9;34(2):146-56. Epub 2014 Jan 9.

Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 1730 Lineu Prestes Avenue, São Paulo, SP, ZIP 05508-000, Brazil.

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http://link.springer.com/10.1007/s10875-013-9980-4
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http://dx.doi.org/10.1007/s10875-013-9980-4DOI Listing
February 2014

Diagnosis and evaluation of primary panhypogammaglobulinemia: a molecular and genetic challenge.

J Allergy Clin Immunol 2013 Jun;131(6):1717-8

Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.jaci.2013.03.045DOI Listing
June 2013

Clinical ambiguities--ongoing questions.

J Clin Immunol 2013 Jan 16;33 Suppl 2:S99-103. Epub 2012 Dec 16.

University of Washington School of Medicine, 1900 9th Ave., C9S-7, Seattle, WA 98101-1304, USA.

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http://dx.doi.org/10.1007/s10875-012-9851-4DOI Listing
January 2013

Overview of routes of IgG administration.

Authors:
Troy R Torgerson

J Clin Immunol 2013 Jan 11;33 Suppl 2:S87-9. Epub 2012 Dec 11.

University of Washington School of Medicine, 1900 9th Ave., C9S-7, Seattle, WA 98101-1304, USA.

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http://dx.doi.org/10.1007/s10875-012-9845-2DOI Listing
January 2013

Comparing routes of IgG administration for primary immunodeficiency disorders.

Authors:
Troy R Torgerson

J Clin Immunol 2013 Jan 14;33 Suppl 2:S85-6. Epub 2012 Sep 14.

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http://dx.doi.org/10.1007/s10875-012-9784-yDOI Listing
January 2013

Tryptic peptide screening for primary immunodeficiency disease by LC/MS-MS.

Proteomics Clin Appl 2012 Aug;6(7-8):394-402

Seattle Children's Hospital Research Institute, Seattle, WA, USA.

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http://dx.doi.org/10.1002/prca.201100096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489469PMC
August 2012

Immunodeficiency diseases with rheumatic manifestations.

Authors:
Troy R Torgerson

Pediatr Clin North Am 2012 Apr;59(2):493-507

Division of Immunology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.pcl.2012.03.010DOI Listing
April 2012

Genetic disorders with immune dysregulation.

Cell Mol Life Sci 2012 Jan 9;69(1):49-58. Epub 2011 Oct 9.

Department of Sciences for Woman and Child's Health, Anna Meyer Children's Hospital, University of Florence, Florence, Italy.

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http://link.springer.com/content/pdf/10.1007/s00018-011-0838
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http://link.springer.com/10.1007/s00018-011-0838-8
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http://dx.doi.org/10.1007/s00018-011-0838-8DOI Listing
January 2012

Autoimmune hepatitis type 2 in a child with IPEX syndrome.

J Pediatr Gastroenterol Nutr 2011 Dec;53(6):690-3

Division of Hepatology and Gastroenterology, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.

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http://dx.doi.org/10.1097/MPG.0b013e3182250651DOI Listing
December 2011

The spectrum of autoantibodies in IPEX syndrome is broad and includes anti-mitochondrial autoantibodies.

J Autoimmun 2010 Nov 22;35(3):265-8. Epub 2010 Jul 22.

Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089684111000072
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http://dx.doi.org/10.1016/j.jaut.2010.06.017DOI Listing
November 2010

Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.

Ther Clin Risk Manag 2010 Feb 2;6:1-10. Epub 2010 Feb 2.

Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, Washington.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817783PMC
http://dx.doi.org/10.1057/rm.2009.17DOI Listing
February 2010

Autoantibodies in scurfy mice and IPEX patients recognize keratin 14.

J Invest Dermatol 2010 May 11;130(5):1391-9. Epub 2010 Feb 11.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/jid.2010.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767981PMC
May 2010

TH17 cells and regulatory T cells in primary immunodeficiency diseases.

J Allergy Clin Immunol 2009 May;123(5):977-83; quiz 984-5

Department of Pediatrics, University of Washington School of Medicine and Seattle Children's Hospital, Seattle, Wash 98101, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708116PMC
May 2009

Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.

Clin Immunol 2009 Feb 25;130(2):162-74. Epub 2008 Oct 25.

Department of Pediatrics, University of Washington and Seattle Children's Hospital Research Institute, Seattle, WA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152166160800810
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http://dx.doi.org/10.1016/j.clim.2008.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727638PMC
February 2009

Immune dysregulation in primary immunodeficiency disorders.

Authors:
Troy R Torgerson

Immunol Allergy Clin North Am 2008 May;28(2):315-27, viii-ix

Divisions of Pediatric Immunology and Rheumatology, University of Washington School of Medicine and Children's Hospital Regional Medical Center, Seattle, WA 98109, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088985610800028
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http://dx.doi.org/10.1016/j.iac.2008.02.002DOI Listing
May 2008

Familial hemophagocytic lymphohistiocytosis in two brothers with X-linked agammaglobulinemia.

Pediatr Blood Cancer 2008 Aug;51(2):293-5

Division of Hematology/Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1002/pbc.21573DOI Listing
August 2008