Troy Ketela

Troy Ketela

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Troy Ketela

Troy Ketela

Publications by authors named "Troy Ketela"

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38Publications

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Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Am J Physiol Renal Physiol 2019 Dec 30;317(6):F1593-F1604. Epub 2019 Sep 30.

Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1152/ajprenal.00195.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962514PMC
December 2019

Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.

Mol Pharmacol 2019 06 12;95(6):638-651. Epub 2019 Apr 12.

Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medical and Health Sciences (F.W.H., C.R.H., A.K., I.S., W.R.W.), Maurice Wilkins Centre for Molecular Biodiscovery (F.W.H., A.J.R.H., C.G.P., W.R.W.), School of Biological Sciences, Faculty of Science (J.B.L.D., A.J.R.H.), and Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences (P.T., P.M.K., C.G.P., S.K.B.), University of Auckland, Auckland, New Zealand; Threshold Pharmaceuticals, South San Francisco, California (F.M., C.P.H.); Princess Margaret Genomics Centre (T.W.K.) and Princess Margaret Cancer Centre (S.M., Z.S., B.G.W.), University Health Network, and Departments of Radiation Oncology (B.G.W.) and Medical Biophysics (B.G.W.), University of Toronto, Toronto, Ontario, Canada.

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
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http://dx.doi.org/10.1124/mol.118.115196DOI Listing
June 2019

Evaluation of methods to assign cell type labels to cell clusters from single-cell RNA-sequencing data.

F1000Res 2019 15;8. Epub 2019 Mar 15.

Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94143, USA.

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http://dx.doi.org/10.12688/f1000research.18490.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720041.3PMC
March 2019

Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling.

Cell Rep 2017 12;21(13):3970-3986

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Institute of Medical Science , University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics , University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173181
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http://dx.doi.org/10.1016/j.celrep.2017.12.017DOI Listing
December 2017

Cytokinetic effects of Wee1 disruption in pancreatic cancer.

Cell Cycle 2016 ;15(4):593-604

a Ontario Cancer Institute/Princess Margaret Cancer Center , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1080/15384101.2016.1138188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056606PMC
December 2016

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

Cancer Res 2015 Oct 21;75(19):4211-23. Epub 2015 Aug 21.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/content/early/2015/08/21/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-1107DOI Listing
October 2015

Global analysis of fungal morphology exposes mechanisms of host cell escape.

Nat Commun 2015 Mar 31;6:6741. Epub 2015 Mar 31.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://www.nature.com/articles/ncomms7741
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http://dx.doi.org/10.1038/ncomms7741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382923PMC
March 2015

Differential regulation of FGFR3 by PTPN1 and PTPN2.

Proteomics 2015 Jan 17;15(2-3):419-33. Epub 2014 Dec 17.

Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Canada.

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http://dx.doi.org/10.1002/pmic.201400259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032629PMC
January 2015

shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.

Cancer Res 2014 Apr 31;74(7):2119-30. Epub 2014 Jan 31.

Authors' Affiliations: Division of Advanced Diagnostics, Toronto General Research Institute-University Health Network; Medicinal Chemistry Platform, Ontario Institute for Cancer Research; The Donnelly Centre, University of Toronto; Program in Developmental and Stem Cell Biology, Department of Molecular Genetics, The Hospital for Sick Children; Ontario Cancer Institute, University of Toronto, and Drug Discovery Program, Department of Pharmacology and Toxicology; Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/content/74/7/2119.full.pdf
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2138DOI Listing
April 2014

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.

Cancer Cell 2014 Feb;25(2):181-95

Princess Margaret Cancer Center, University Health Network, 101 College Street, Room 8-703, Toronto Medical Discovery Tower, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Rheumatology, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108140003
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http://dx.doi.org/10.1016/j.ccr.2014.01.025DOI Listing
February 2014

Pooled lentiviral shRNA screening for functional genomics in mammalian cells.

Methods Mol Biol 2011 ;781:161-82

Donnelly Centre and Banting & Best Department of Medical Research, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-276-2_9DOI Listing
January 2012

COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines.

Nucleic Acids Res 2012 Jan 18;40(Database issue):D957-63. Epub 2011 Nov 18.

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada M5G 0A3.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkr959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245009PMC
January 2012

SATB2 augments ΔNp63α in head and neck squamous cell carcinoma.

EMBO Rep 2010 Oct 10;11(10):777-83. Epub 2010 Sep 10.

Department of Molecular Genetics, University of Toronto, Cell Biology Program, Hospital for Sick Children Research Institute, Department of Paediatrics, 555 University Avenue, Toronto, Ontario, M5G 1L7, Canada.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2010.125
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http://dx.doi.org/10.1038/embor.2010.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948183PMC
October 2010

Systematic validation and atomic force microscopy of non-covalent short oligonucleotide barcode microarrays.

PLoS One 2008 Feb 6;3(2):e1546. Epub 2008 Feb 6.

Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001546PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212718PMC
February 2008