Trixie Wagner

Optimization of the Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

J Med Chem 2020 12 20;63(23):14594-14608. Epub 2020 Nov 20.

Novartis Pharma AG, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

December 2020

Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.

Authors:

Juraj Velcicky Rainer Wilcken Simona Cotesta Philipp Janser Achim Schlapbach Trixie Wagner Philippe Piechon Frederic Villard Rochdi Bouhelal Fabian Piller Stephanie Harlfinger Rowan Stringer Dominique Fehlmann Klemens Kaupmann Amanda Littlewood-Evans Matthias Haffke Nina Gommermann

J Med Chem 2020 09 28;63(17):9856-9875. Epub 2020 Aug 28.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF

September 2020

Determination of Absolute Stereochemistry of Flexible Molecules Using a Vibrational Circular Dichroism Spectra Alignment Algorithm.

Authors:

Lennard Böselt Dominik Sidler Tobias Kittelmann Jürgen Stohner Daniel Zindel Trixie Wagner Sereina Riniker

J Chem Inf Model 2019 05 27;59(5):1826-1838. Epub 2019 Mar 27.

Laboratory of Physical Chemistry , ETH Zürich , Vladimir-Prelog-Weg 2 , 8093 Zürich , Switzerland.

View Article and Find Full Text PDF

May 2019

Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its Predominant Metabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy.

Authors:

Paul W Manley Giorgio Caravatti Pascal Furet Johannes Roesel Phi Tran Trixie Wagner Markus Wartmann

Biochemistry 2018 09 13;57(38):5576-5590. Epub 2018 Sep 13.

Oncology Disease Area, Novartis Institutes for Biomedical Research , Novartis International AG , CH-4002 Basel , Switzerland.

View Article and Find Full Text PDF

September 2018

The importance of configurational disorder in crystal structure prediction: the case of loratadine.

Authors:

Grahame R Woollam Marcus A Neumann Trixie Wagner Roger J Davey

Faraday Discuss 2018 10;211(0):209-234

Novartis Pharma AG, Basel 4002, Switzerland.

View Article and Find Full Text PDF

October 2018

Interconversion Rates between Conformational States as Rationale for the Membrane Permeability of Cyclosporines.

Authors:

Jagna Witek Max Mühlbauer Bettina G Keller Markus Blatter Axel Meissner Trixie Wagner Sereina Riniker

Chemphyschem 2017 Dec 2;18(23):3309-3314. Epub 2017 Nov 2.

Laboratory of Physical Chemistry, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland.

View Article and Find Full Text PDF

December 2017

Correction to Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States.

Authors:

Jagna Witek Bettina G Keller Markus Blatter Axel Meissner Trixie Wagner Sereina Riniker

J Chem Inf Model 2017 09 12;57(9):2393. Epub 2017 Sep 12.

Laboratory of Physical Chemistry, ETH Zürich , Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland.

View Article and Find Full Text PDF

September 2017

Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit.

Authors:

Cyrille S Kounde Hui-Quan Yeo Qing-Yin Wang Kah Fei Wan Hongping Dong Ratna Karuna Ina Dix Trixie Wagner Bin Zou Oliver Simon Ghislain M C Bonamy Bryan K S Yeung Fumiaki Yokokawa

Bioorg Med Chem Lett 2017 03 4;27(6):1385-1389. Epub 2017 Feb 4.

Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, 138670, Singapore. Electronic address:

View Article and Find Full Text PDF

March 2017

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.

ACS Med Chem Lett 2017 Feb 16;8(2):151-156. Epub 2016 Dec 16.

Novartis Institutes for Biomedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

View Article and Find Full Text PDF

February 2017

Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States.

Authors:

Jagna Witek Bettina G Keller Markus Blatter Axel Meissner Trixie Wagner Sereina Riniker

J Chem Inf Model 2016 08 19;56(8):1547-62. Epub 2016 Jul 19.

Laboratory of Physical Chemistry, ETH Zürich , Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland.

View Article and Find Full Text PDF

August 2016

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).

Authors:

Dirk Behnke Simona Cotesta Samuel Hintermann Markus Fendt Christine E Gee Laura H Jacobson Grit Laue Arndt Meyer Trixie Wagner Sangamesh Badiger Vinod Chaudhari Murali Chebrolu Chetan Pandit Daniel Hoyer Claudia Betschart

Bioorg Med Chem Lett 2015 Dec 19;25(23):5555-60. Epub 2015 Oct 19.

Global Discovery Chemistry, Novartis Institutes for BioMedical Research, WKL-136.3.26, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF

December 2015

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Nat Commun 2015 Oct 12;6:8613. Epub 2015 Oct 12.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland.

View Article and Find Full Text PDF

October 2015

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.

Angew Chem Int Ed Engl 2015 Aug 15;54(35):10149-54. Epub 2015 Jul 15.

Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel (Switzerland).

View Article and Find Full Text PDF

August 2015

Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.

ACS Med Chem Lett 2015 Mar 2;6(3):344-8. Epub 2015 Feb 2.

Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, Singapore 138670, Singapore.

View Article and Find Full Text PDF

March 2015

trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.

Authors:

Edwige Lorthiois Frederic Cumin Claus Ehrhardt Takatoshi Kosaka Holger Sellner Nils Ostermann Eric Francotte Trixie Wagner Jürgen Maibaum

Bioorg Med Chem Lett 2015 Apr 21;25(8):1782-1786. Epub 2015 Feb 21.

Novartis Pharma AG, Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland. Electronic address:

View Article and Find Full Text PDF

April 2015

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.

Authors:

Holger Sellner Sylvain Cottens Frédéric Cumin Claus Ehrhardt Takatoshi Kosaka Edwige Lorthiois Nils Ostermann Randy L Webb Dean F Rigel Trixie Wagner Jürgen Maibaum

Bioorg Med Chem Lett 2015 Apr 23;25(8):1787-1791. Epub 2015 Feb 23.

Novartis Pharma AG, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland. Electronic address:

View Article and Find Full Text PDF

April 2015

A cyclic carbo-isosteric penta-depsipeptide: cyclo(Phe(1)-d-Ala(2)-Gly(3)-Phe(4)-APO(5)).

Authors:

Stéphanie M Guéret Trixie Wagner

Acta Crystallogr E Crystallogr Commun 2015 Jan 1;71(Pt 1):113-6. Epub 2015 Jan 1.

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis International AG, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF

January 2015

Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.

ACS Med Chem Lett 2014 Jul 21;5(7):787-92. Epub 2014 Apr 21.

Novartis Institutes for BioMedical Research , Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.

View Article and Find Full Text PDF

July 2014

Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.

ACS Med Chem Lett 2013 May 1;4(5):451-5. Epub 2013 Apr 1.

Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore.

View Article and Find Full Text PDF

May 2013

Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics.

Authors:

Anke Bill Michelle Lynn Hall Jason Borawski Catherine Hodgson Jeremy Jenkins Philippe Piechon Oana Popa Christopher Rothwell Pamela Tranter Scott Tria Trixie Wagner Lewis Whitehead L Alex Gaither

J Biol Chem 2014 Apr 5;289(16):11029-41. Epub 2014 Mar 5.

From the Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139.

View Article and Find Full Text PDF

April 2014

Use of intensity quotients and differences in absolute structure refinement.

Authors:

Simon Parsons Howard D Flack Trixie Wagner

Acta Crystallogr B Struct Sci Cryst Eng Mater 2013 Jun 17;69(Pt 3):249-59. Epub 2013 May 17.

EaStCHEM School of Chemistry and Centre for Science at Extreme Conditions, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, Scotland.

View Article and Find Full Text PDF

June 2013

The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.

Authors:

Edwige Lorthiois Werner Breitenstein Frederic Cumin Claus Ehrhardt Eric Francotte Edgar Jacoby Nils Ostermann Holger Sellner Takatoshi Kosaka Randy L Webb Dean F Rigel Ulrich Hassiepen Paul Richert Trixie Wagner Jürgen Maibaum

J Med Chem 2013 Mar 15;56(6):2207-17. Epub 2013 Mar 15.

Novartis Pharma AG, Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

View Article and Find Full Text PDF

March 2013

A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.

J Med Chem 2013 Mar 15;56(6):2196-206. Epub 2013 Mar 15.

Novartis Pharma AG, Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

View Article and Find Full Text PDF

March 2013

Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.

J Med Chem 2012 Sep 30;55(17):7472-9. Epub 2012 Aug 30.

Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.

View Article and Find Full Text PDF

September 2012

C-26 vs. C-27 hydroxylation of insect steroid hormones: regioselectivity of a microsomal cytochrome P450 from a hormone-resistant cell line.

Authors:

Hartmut Kayser Philipp Eilinger Philippe Piechon Trixie Wagner

Arch Biochem Biophys 2011 Sep 6;513(1):27-35. Epub 2011 Jul 6.

Institute of General Zoology and Endocrinology, University of Ulm, Germany.

View Article and Find Full Text PDF

September 2011

Phyteumosides A and B: new saponins with unique triterpenoid aglycons from Phyteuma orbiculare L.

Authors:

Christian Abbet Markus Neuburger Trixie Wagner Melanie Quitschau Matthias Hamburger Olivier Potterat

Org Lett 2011 Mar 15;13(6):1354-7. Epub 2011 Feb 15.

Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

View Article and Find Full Text PDF

March 2011

DAST-mediated cyclization of α,α-disubstituted-α-acylaminoketones: efficient and divergent synthesis of unprecedented heterocycles.

Authors:

Aurélien Bigot Judith Blythe Chirag Pandya Trixie Wagner Olivier Loiseleur

Org Lett 2011 Jan 8;13(2):192-5. Epub 2010 Dec 8.

Syngenta Crop Protection Münchwilen AG, Schaffhauserestrasse, CH-4332 Stein, Switzerland.

View Article and Find Full Text PDF

January 2011

Novel thione-thiol rearrangement of dithiocarbonic acid O-(2,2,6,6-tetramethylpiperidin-1-yl) ester in the context of controlled radical polymerization.

Authors:

Peter Nesvadba Lucienne Bugnon Trixie Wagner

Chimia (Aarau) 2010 ;64(1-2):56-8

Ciba Inc., Performance Chemicals Research, R-1059.6.05, Klybeckstr. 141, CH-4002 Basel.

View Article and Find Full Text PDF

February 2011

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

J Med Chem 2010 Jul;53(14):5155-64

Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01 Chromos, Singapore 138670.

View Article and Find Full Text PDF

July 2010

Metal ion roles and the movement of hydrogen during reaction catalyzed by D-xylose isomerase: a joint x-ray and neutron diffraction study.

Authors:

Andrey Y Kovalevsky Leif Hanson S Zoe Fisher Marat Mustyakimov Sax A Mason V Trevor Forsyth Matthew P Blakeley David A Keen Trixie Wagner H L Carrell Amy K Katz Jenny P Glusker Paul Langan

Structure 2010 Jun;18(6):688-99

Bioscience Division, Los Alamos National Laboratory, MS M888, Los Alamos, NM 87545, USA.

View Article and Find Full Text PDF

June 2010

Publications by authors named "Trixie Wagner"

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors: