Trevor J Pugh

Trevor J Pugh

UNVERIFIED PROFILE

Are you Trevor J Pugh?   Register this Author

Register author
Trevor J Pugh

Trevor J Pugh

Publications by authors named "Trevor J Pugh"

Are you Trevor J Pugh?   Register this Author

65Publications

3865Reads

25Profile Views

High efficiency error suppression for accurate detection of low-frequency variants.

Nucleic Acids Res 2019 09;47(15):e87

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735726PMC
September 2019

Translational genomics of nasopharyngeal cancer.

Semin Cancer Biol 2019 Sep 12. Epub 2019 Sep 12.

Department of Anatomical and cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcancer.2019.09.006DOI Listing
September 2019

Evaluation of methods to assign cell type labels to cell clusters from single-cell RNA-sequencing data.

F1000Res 2019 15;8. Epub 2019 Mar 15.

Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.18490.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720041.3PMC
March 2019

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma.

Clin Cancer Res 2018 11 31;24(22):5685-5696. Epub 2018 Jul 31.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-0554DOI Listing
November 2018

Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma.

Cell Rep 2018 10;25(5):1318-1331.e4

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.10.004DOI Listing
October 2018

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Bamgineer: Introduction of simulated allele-specific copy number variants into exome and targeted sequence data sets.

PLoS Comput Biol 2018 03 28;14(3):e1006080. Epub 2018 Mar 28.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891060PMC
March 2018

Circulating Tumour DNA for Detecting Minimal Residual Disease in Multiple Myeloma.

Authors:
Trevor J Pugh

Semin Hematol 2018 01 7;55(1):38-40. Epub 2018 Mar 7.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminhematol.2018.03.002DOI Listing
January 2018

Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition.

J Clin Oncol 2017 Apr 21;35(11):1240-1249. Epub 2017 Feb 21.

Stephanie Lheureux, Jeff P. Bruce, Julia V. Burnier, Katherine Karakasis, S.Y. Cindy Yang, Rene Quevedo, Tiantian Li, Mark Dowar, Valerie Bowering, Trevor J. Pugh, and Amit M. Oza, Princess Margaret Cancer Centre; Stephanie Lheureux, Patricia A. Shaw, Blaise A. Clarke, S.Y. Cindy Yang, Rene Quevedo, Trevor J. Pugh, and Amit M. Oza, University of Toronto; Patricia A. Shaw and Blaise A. Clarke, University Health Network, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.71.3677DOI Listing
April 2017

VisCap: inference and visualization of germ-line copy-number variants from targeted clinical sequencing data.

Genet Med 2016 07 17;18(7):712-9. Epub 2015 Dec 17.

Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/gim.2015.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940431PMC
July 2016

Human Papillomavirus Genotype Association With Survival in Head and Neck Squamous Cell Carcinoma.

JAMA Oncol 2016 Jun;2(6):823-6

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada2Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2015.6587DOI Listing
June 2016

Next generation sequencing-based copy number analysis reveals low prevalence of deletions and duplications in 46 genes associated with genetic cardiomyopathies.

Mol Genet Genomic Med 2016 Mar 16;4(2):143-51. Epub 2015 Dec 16.

Laboratory for Molecular MedicinePartners HealthCare Personalized MedicineCambridgeMassachusetts; Department of PathologyMassachusetts General Hospital and Harvard Medical SchoolBostonMassachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799872PMC
March 2016

Oncotator: cancer variant annotation tool.

Hum Mutat 2015 Apr 16;36(4):E2423-9. Epub 2015 Mar 16.

Cancer Program, Broad Institute, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/humu.22771
Publisher Site
http://dx.doi.org/10.1002/humu.22771DOI Listing
April 2015

Pugh et al. reply.

Nature 2015 Apr;520(7547):E12-4

1] Department of Medical Oncology and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Cancer Program, Broad Institute, Cambridge, Massachusetts, 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14266DOI Listing
April 2015

The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing.

Genet Med 2014 Aug 6;16(8):601-8. Epub 2014 Feb 6.

1] Laboratory for Molecular Medicine, Partners HealthCare Center for Personalized Molecular Medicine, Cambridge, Massachusetts, USA [2] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/gim.2013.204DOI Listing
August 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

Landscape of genomic alterations in cervical carcinomas.

Nature 2014 Feb 25;506(7488):371-5. Epub 2013 Dec 25.

1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [4].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161954PMC
February 2014

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.

Cancer Discov 2013 Dec 27;3(12):1355-63. Epub 2013 Sep 27.

Departments of 1Medicine and 2Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute; 3Harvard Medical School; 4Ludwig Institute for Cancer Research; 5Department of Neurosurgery, Massachusetts General Hospital; 6Belfer Institute for Applied Cancer Science; 7Department of Pathology, Brigham and Women's Hospital, Boston; 8Broad Institute, Cambridge, Massachusetts; 9UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and 10Department of Molecular Pharmacology and Therapeutics, Oncology Institute, Loyola University, Chicago, Illinois; 11Department of Physiology, University of Valencia, Valencia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-13-0310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864135PMC
December 2013

A comprehensive assay for CFTR mutational analysis using next-generation sequencing.

Clin Chem 2013 Oct 17;59(10):1481-8. Epub 2013 Jun 17.

Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, NH, and Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2013.206466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570467PMC
October 2013

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.

Clin Cancer Res 2009 Aug 28;15(15):5008-16. Epub 2009 Jul 28.

Genome Sciences Centre, Provincial Prostate Brachytherapy Program, and Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-08-3357DOI Listing
August 2009