Publications by authors named "Travis Vandergriff"

76 Publications

Apocrine Mixed Tumor with Pilomatrical Differentiation.

J Cutan Pathol 2021 Jul 21. Epub 2021 Jul 21.

Department of Pathology, UT Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1111/cup.14103DOI Listing
July 2021

A severe presentation of acute generalized exanthematous pustulosis with non-infectious circulatory shock in an adolescent.

Pediatr Dermatol 2021 Jul 16. Epub 2021 Jul 16.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

We present a severe case of acute generalized exanthematous pustulosis (AGEP) secondary to trimethoprim-sulfamethoxazole complicated by non-infectious circulatory shock in a 16-year-old boy. Hemodynamic instability has been reported as a complication of AGEP in adults, but is rarely observed in pediatric patients. The patient we present demonstrated characteristic cutaneous findings of AGEP including isolated non-follicular, sterile pustules on a background of erythema with involvement at intertriginous areas and subsequently developed non-infectious circulatory shock. This case expands the spectrum of possible clinical presentations for AGEP in pediatric patients.
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http://dx.doi.org/10.1111/pde.14704DOI Listing
July 2021

Opportunities for education during the COVID-19 pandemic.

JAAD Int 2020 Jul 4;1(1):21-22. Epub 2020 May 4.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdin.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252190PMC
July 2020

A lobulated mass on the upper back with prominent vasculature: A giant basal cell carcinoma.

Dermatol Reports 2021 Mar 7;13(1):9046. Epub 2021 Apr 7.

Department of Dermatology, UT Southwestern Medical Center, Dallas, TX.

Basal cell carcinoma (BCC) is characterized by slow but locally invasive growth. Although there is low metastatic potential, if not treated early, these skin cancers can lead to significant morbidity and mortality. In this case report, we present a man with a neglected BCC that developed into what is termed a giant BCC or one that is greater than 5 cm. This tumor was discovered only upon workup of orthostatic lightheadedness and iron deficiency anemia. Although rare, basal cell carcinoma must be included on the differential of a large cutaneous lesion and may be a source of significant blood loss.
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http://dx.doi.org/10.4081/dr.2021.9046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056320PMC
March 2021

Ichthyosiform sarcoidosis: Report of a case and comprehensive review of the literature.

Int J Dermatol 2021 Apr 30. Epub 2021 Apr 30.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Sarcoidosis is a disease that can affect a multitude of organs and manifest as cutaneous disease. Cutaneous manifestations of sarcoidosis vary widely in morphology, earning the nickname of "great imitator," and the diagnosis often requires clinicopathologic correlation and additional laboratory and radiographic workup. We present the case of a 42-year-old African American woman with ichthyosiform sarcoidosis on the bilateral lower extremities. As one of the rarest specific variants of cutaneous sarcoidosis, ichthyosiform is understudied and has been primarily documented in case reports and series. We undertake a comprehensive review of the literature to identify key clinicopathologic features including the characterization of sites of cutaneous and systemic involvement, as well as typical histopathological findings. Lower extremities were the most involved body site (85.7%). Extracutaneous organ involvement centered around pulmonary (65.7%), lymph node (57.1%), and ocular (31.4%) involvement. Of the histopathological features reported, hyperkeratosis (51.4%) and diminished stratum granulosum (62.9%) were most frequently reported in conjunction with dermal granulomas (100%). We hope that these findings will serve to aid clinicopathological correlation and accurate diagnosis of ichthyosiform sarcoidosis.
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http://dx.doi.org/10.1111/ijd.15604DOI Listing
April 2021

Assessing comfort level with pediatric skin specimens among dermatopathologists and pediatric pathologists: A national cross-sectional survey.

J Cutan Pathol 2021 Feb 26. Epub 2021 Feb 26.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Background: Cutaneous histopathologic diagnoses in children often differ from those in adults. Depending on practice setting, these specimens may be evaluated by dermatopathologists or pediatric pathologists. We sought to determine whether comfort level with pediatric dermatopathology is associated with prior training, pediatric dermatopathology exposure during fellowship, career duration, or specimen subtype.

Methods: We surveyed dermatopathologists and pediatric pathologists practicing in the United States. Training and practice variables were evaluated by multivariable regression for association with comfort level.

Results: Of the 156 respondents, 72% were dermatopathologists (response rate 11.6%) and 28% were pediatric pathologists (response rate 9.3%). Dermatopathologists reported higher comfort overall (P < .001); this was also true for inflammatory dermatoses and melanocytic neoplasms (P < .001). Thirty-four percent and 75% of dermatopathologists and pediatric pathologists, respectively, reported lower comfort with pediatric skin specimens than their usual cases. Pediatric pathologists were 28% more likely to refer these cases to colleagues. Among dermatopathologists, dermatology-trained were more comfortable than pathology-trained colleagues interpreting inflammatory dermatoses (P < .001).

Conclusions: Pathologists' comfort with pediatric dermatopathology varied significantly based upon prior training, career duration, and specimen subtype. These results suggest opportunities for improving education in this domain.
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http://dx.doi.org/10.1111/cup.13997DOI Listing
February 2021

Blastic plasmacytoid dendritic cell neoplasm in a young patient.

Dermatol Online J 2021 Jan 15;27(1). Epub 2021 Jan 15.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.

Blastic plasmacytoid dendritic cell neoplasm is a rare hematologic neoplasm originating from plasmacytoid dendritic cell precursors that has an aggressive disease course with typically poor prognosis. Herein, we report a man in his early twenties who presented with rapid onset of violaceous nodules and purpuric papules and macules that began on his chest before spreading to his arms, back, face, scalp, and legs. He also exhibited systemic symptoms including weight loss and night sweats. He was diagnosed with blastic plasmacytoid dendritic cell neoplasm and began treatment with aggressive multidrug therapy. Thus far his treatment has resulted in complete resolution of his cutaneous manifestations.
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January 2021

Kikuchi disease with cutaneous involvement complicated by features of hemophagocytic lymphohistiocytosis.

J Cutan Pathol 2021 03 20;48(3):343-346. Epub 2021 Jan 20.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1111/cup.13720DOI Listing
March 2021

Cutaneous polyarteritis nodosa with clinical features of pyoderma gangrenosum.

JAAD Case Rep 2020 Dec 15;6(12):1291-1293. Epub 2020 Sep 15.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2020.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701038PMC
December 2020

Treatment of extensive elastosis perforans serpiginosa with acitretin in a man with Down syndrome.

Int J Dermatol 2021 May 23;60(5):611-612. Epub 2020 Nov 23.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1111/ijd.15321DOI Listing
May 2021

Cutaneous infection in an immunocompromised patient in the setting of postthrombotic syndrome successfully treated with posaconazole.

JAAD Case Rep 2020 Nov 11;6(11):1144-1146. Epub 2020 Jul 11.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2020.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591334PMC
November 2020

Ashy dermatosis-like hyperpigmentation in a patient taking hydroxyurea.

JAAD Case Rep 2020 Sep 25;6(9):797-800. Epub 2020 Jun 25.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2020.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452229PMC
September 2020

Chondrodermatitis nodularis nasi.

J Cutan Pathol 2020 Nov 13;47(11):1046-1049. Epub 2020 Sep 13.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Chondrodermatitis nodularis helicis is a relatively common ulcerative, inflammatory condition affecting the skin, and cartilage of the ear. We present a case of chondrodermatitis affecting the skin and cartilage of the nose, designated chondrodermatitis nodularis nasi. Clinically, chondrodermatitis presents as a singular, painful, ulcerated papule or nodule that results from prolonged pressure, trauma, sun exposure, or vascular compromise. The clinical features resemble those seen in skin cancer, and a biopsy is often required to secure the diagnosis. Histopathologic analysis of chondrodermatitis demonstrates a central ulcer, beneath which there is fibrinoid necrosis of the dermis and inflammatory infiltrates. The ulcer is bordered by pseudoepitheliomatous hyperplasia with underlying granulation tissue. In addition to a clinical and morphologic description of chondrodermatitis nodularis nasi, a discussion of etiological factors and differential diagnoses is included. Increased recognition and reporting of the condition will allow for the exploration of optimal treatment strategies.
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http://dx.doi.org/10.1111/cup.13786DOI Listing
November 2020

Acute generalized exanthematous pustulosis induced by empiric hydroxychloroquine for presumed COVID-19.

Dermatol Ther 2020 Nov 8;33(6):e13834. Epub 2020 Jul 8.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1111/dth.13834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323399PMC
November 2020

A retrospective analysis of atypical fibroxanthoma treated with Mohs micrographic surgery at a single academic institution.

J Am Acad Dermatol 2021 Mar 1;84(3):794-796. Epub 2020 Jun 1.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.05.123DOI Listing
March 2021

Collision tumor of microcystic adnexal carcinoma and squamous cell carcinoma discovered on Mohs sections.

JAAD Case Rep 2020 Jun 18;6(6):479-481. Epub 2020 Apr 18.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256221PMC
June 2020

Vulvar phyllodes tumor presenting as an epidermoid cyst.

J Cutan Pathol 2020 Oct;47(10):879-881

Department of Dermatology, University of Texas Southwestern Medical Center.

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http://dx.doi.org/10.1111/cup.13699DOI Listing
October 2020

Metabolic heterogeneity confers differences in melanoma metastatic potential.

Nature 2020 01 18;577(7788):115-120. Epub 2019 Dec 18.

Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Metastasis requires cancer cells to undergo metabolic changes that are poorly understood. Here we show that metabolic differences among melanoma cells confer differences in metastatic potential as a result of differences in the function of the MCT1 transporter. In vivo isotope tracing analysis in patient-derived xenografts revealed differences in nutrient handling between efficiently and inefficiently metastasizing melanomas, with circulating lactate being a more prominent source of tumour lactate in efficient metastasizers. Efficient metastasizers had higher levels of MCT1, and inhibition of MCT1 reduced lactate uptake. MCT1 inhibition had little effect on the growth of primary subcutaneous tumours, but resulted in depletion of circulating melanoma cells and reduced the metastatic disease burden in patient-derived xenografts and in mouse melanomas. In addition, inhibition of MCT1 suppressed the oxidative pentose phosphate pathway and increased levels of reactive oxygen species. Antioxidants blocked the effects of MCT1 inhibition on metastasis. MCT1 and MCT1 cells from the same melanomas had similar capacities to form subcutaneous tumours, but MCT1 cells formed more metastases after intravenous injection. Metabolic differences among cancer cells thus confer differences in metastatic potential as metastasizing cells depend on MCT1 to manage oxidative stress.
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http://dx.doi.org/10.1038/s41586-019-1847-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930341PMC
January 2020

Pigmented fungiform papillae of the tongue: a clinical and histologic description.

Dermatol Online J 2019 Sep 15;25(9). Epub 2019 Sep 15.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX.

A 28-year-old man with a history of mycosis fungoides presented for evaluation of multiple dark-brown macules and hyperpigmented dome-shaped papules on the distal tongue. A shave biopsy of the tongue revealed melanin pigment in the basal keratinocytes and melanophages in the lamina propria, consistent with pigmented fungiform papillae of the tongue. Relevant clinical and histologic features of this diagnosis are reviewed.
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September 2019

Mammary Paget's Disease of the Male Breast: A Rare Case With an Unusual Immunohistochemical Profile.

Int J Surg Pathol 2020 Apr 12;28(2):210-215. Epub 2019 Sep 12.

University of Texas Southwestern Medical Center, Dallas, TX, USA.

Mammary Paget's disease is rare and comprises about 0.62% of all breast cancer cases, only 1.65% of which occur in male patients. This case report involves a 76-year-old man who presented to his primary care physician with an itching, scaly, unilateral lesion involving the nipple skin. He underwent wide local excision of the lesion for a diagnosis of Bowen's disease (squamous cell carcinoma ). Histologic examination of the specimen revealed mammary Paget's disease with ductal carcinoma in the underlying breast tissue. A panel of immunohistochemical stains revealed the Paget cells to be positive for cytokeratin 7, MUC1, GATA3, and androgen receptor and negative for cytokeratins 5/6, p63, SOX10, and MART-1/Melan-A. Paget cells were also negative for estrogen receptor and progesterone receptor, and positive for HER2/neu. However, the underlying ductal carcinoma was positive for both estrogen receptor and progesterone receptor and negative for HER2/neu. This discordance, supported by the current literature, suggests an alternative etiology for Paget's disease in certain cases that cannot be explained by the well-established epidermotropic and transformative theories of Paget's disease evolution.
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http://dx.doi.org/10.1177/1066896919874878DOI Listing
April 2020

Intradermal nevus with osteoclast-like giant cell melanocytes.

J Cutan Pathol 2019 Nov 9;46(11):888-891. Epub 2019 Jul 9.

Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1111/cup.13519DOI Listing
November 2019

Widespread Eruption of Comedones: Answer.

Am J Dermatopathol 2019 Jun;41(6):459

Department of Dermatology, University of Texas Southwestern, Dallas, TX.

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http://dx.doi.org/10.1097/DAD.0000000000001074DOI Listing
June 2019

Refractory macrophage activation syndrome in the setting of adult-onset Still disease with hemophagocytic lymphohistiocytosis detected on skin biopsy treated with canakinumab and tacrolimus.

J Cutan Pathol 2019 Jul 23;46(7):528-531. Epub 2019 Apr 23.

Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas.

A 19-year-old Caucasian female with adult-onset Still disease (AOSD) presented for evaluation of an acute clinical decompensation and atypical annular papules and plaques with purpura on the lower extremities. A punch biopsy demonstrated histiocytes with engulfed degenerated erythrocytes and lymphocytes, consistent with hemophagocytic lymphohistiocytosis (HLH). HLH, clinically referred to as macrophage activation syndrome, is a rare complication of AOSD and is life-threatening. Relevant clinical, laboratory, and histologic features of this diagnosis are reviewed.
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http://dx.doi.org/10.1111/cup.13466DOI Listing
July 2019

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation.

Nat Commun 2018 11 27;9(1):5014. Epub 2018 Nov 27.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Neurofibromatosis type 1 (NF1) is an autosomal genetic disorder. Patients with NF1 are associated with mono-allelic loss of the tumor suppressor gene NF1 in their germline, which predisposes them to develop a wide array of benign lesions. Intriguingly, recent sequencing efforts revealed that the NF1 gene is frequently mutated in multiple malignant tumors not typically associated with NF1 patients, suggesting that NF1 heterozygosity is refractory to at least some cancer types. In two orthogonal mouse models representing NF1- and non-NF1-related tumors, we discover that an Nf1 microenvironment accelerates the formation of benign tumors but impairs further progression to malignancy. Analysis of benign and malignant tumors commonly associated with NF1 patients, as well as those with high NF1 gene mutation frequency, reveals an antagonistic role for NF1 heterozygosity in tumor initiation and malignant transformation and helps to reconciliate the role of the NF1 gene in both NF1 and non-NF1 patient contexts.
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http://dx.doi.org/10.1038/s41467-018-07452-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258697PMC
November 2018

Multiple reactive keratoacanthomas treated with zinc oxide wraps and intralesional corticosteroids.

JAAD Case Rep 2018 Aug 15;4(7):701-704. Epub 2018 Aug 15.

Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098212PMC
August 2018

Multiple Tumors on the Extremities: Answer.

Am J Dermatopathol 2018 08;40(8):624-625

Departments of Dermatology, and.

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http://dx.doi.org/10.1097/DAD.0000000000000851DOI Listing
August 2018