Publications by authors named "Tracy T Batchelor"

100Publications

An integrated RF-receive/B-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T.

Sci Rep 2020 09 14;10(1):15029. Epub 2020 Sep 14.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-020-71623-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490394PMC
September 2020

Mechanisms and therapeutic implications of hypermutation in gliomas.

Nature 2020 04 15;580(7804):517-523. Epub 2020 Apr 15.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2209-9DOI Listing
April 2020

Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas.

Radiology 2020 03 7;294(3):589-597. Epub 2020 Jan 7.

From the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, Suite 2301, Charlestown, MA 02129 (X.L., B.S., B.T., O.C.A.); iCAD, Nashua, NH (K.J.); Departments of Neurosurgery (J.S., D.P.C.) and Neurology (J.D.), Massachusetts General Hospital, Boston, Mass; Department of Neurology, Brigham and Women's Hospital, Boston, Mass (T.T.B.); and Dana-Farber Cancer Institute, Boston, Mass (T.T.B.).

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http://dx.doi.org/10.1148/radiol.2020191529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053225PMC
March 2020

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Cell 2019 08 18;178(4):835-849.e21. Epub 2019 Jul 18.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703186PMC
August 2019

Is it time to revisit R-CHOP for primary CNS lymphoma?

Blood 2019 07;134(3):221-222

Brigham and Women's Hospital.

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http://dx.doi.org/10.1182/blood.2019001383DOI Listing
July 2019

Primary central nervous system lymphoma: A curable disease.

Hematol Oncol 2019 Jun;37 Suppl 1:15-18

Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/hon.2598DOI Listing
June 2019

Treatment-induced brain tissue necrosis: a clinical challenge in neuro-oncology.

Neuro Oncol 2019 09;21(9):1118-1130

MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1093/neuonc/noz048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594558PMC
September 2019

Introduction of novel agents in the treatment of primary CNS lymphoma.

Neuro Oncol 2019 02;21(3):306-313

Departments of Neurology and Radiation Oncology, Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts.

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noy193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380407PMC
February 2019

Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.

Neuro Oncol 2019 02;21(3):296-305

Departments of Neurology and Radiation Oncology, Division of Hematology and Oncology, Boston, Massachusetts.

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noy192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380418PMC
February 2019

Primary central nervous system lymphoma.

Ther Adv Neurol Disord 2018 5;11:1756286418793562. Epub 2018 Oct 5.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Yawkey 9E, 55 Fruit Street, Boston, MA 02114, USA.

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http://journals.sagepub.com/doi/10.1177/1756286418793562
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http://dx.doi.org/10.1177/1756286418793562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174646PMC
October 2018

Wide Range of Clinical Outcomes in Patients with Gliomatosis Cerebri Growth Pattern: A Clinical, Radiographic, and Histopathologic Study.

Oncologist 2019 03 10;24(3):402-413. Epub 2018 Aug 10.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2018-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519760PMC
March 2019

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

Cancer Cell 2018 05 19;33(5):874-889.e7. Epub 2018 Apr 19.

Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of Cambridge and Wellcome Trust-MRC Stem Cell Institute, Hills Road, Cambridge CB2 0AN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211172PMC
May 2018

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate.

Nat Commun 2018 04 16;9(1):1474. Epub 2018 Apr 16.

Department of Neurology, Massachusetts General Hospital, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41467-018-03905-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902553PMC
April 2018

Primary Central Nervous System Lymphoma.

Semin Neurol 2018 02 16;38(1):86-94. Epub 2018 Mar 16.

Division of Hematology/Oncology, Department of Neurology and Radiation Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0038-1627470DOI Listing
February 2018

cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC).

Acta Neuropathol 2018 03 25;135(3):481-484. Epub 2018 Jan 25.

The Brain Tumor Center at Erasmus MC Cancer Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-018-1808-0DOI Listing
March 2018

Bone marrow drives central nervous system regeneration after radiation injury.

J Clin Invest 2018 01 4;128(1):281-293. Epub 2017 Dec 4.

Center for Regenerative Medicine, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI90647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749546PMC
January 2018

Primary Central Nervous System Lymphoma.

Continuum (Minneap Minn) 2017 12;23(6, Neuro-oncology):1601-1618

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http://dx.doi.org/10.1212/CON.0000000000000539DOI Listing
December 2017

A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma.

Oncotarget 2017 Oct 12;8(45):79298-79304. Epub 2017 May 12.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.17837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668041PMC
October 2017

Glioblastoma in elderly patients: solid conclusions built on shifting sand?

Neuro Oncol 2018 01;20(2):174-183

Neurology Clinic & German Consortium for Translational Cancer Research (DKTK), Heidelberg University Medical Center & DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777484PMC
January 2018

Diagnosis and management of primary central nervous system lymphoma.

Cancer 2017 Nov 26;123(22):4314-4324. Epub 2017 Sep 26.

Department of Neurology, Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.30965DOI Listing
November 2017

Isocitrate dehydrogenase mutation as a therapeutic target in gliomas.

Chin Clin Oncol 2017 Jun;6(3):33

Departments of Neurology and Radiation Oncology, Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.21037/cco.2017.06.11DOI Listing
June 2017

New Directions in Anti-Angiogenic Therapy for Glioblastoma.

Neurotherapeutics 2017 04;14(2):321-332

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s13311-016-0510-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398985PMC
April 2017

Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models.

Neuro Oncol 2017 06;19(6):820-832

Experimental Therapeutics and Molecular Imaging Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1093/neuonc/now253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464448PMC
June 2017

Diagnosis and treatment of epidural metastases.

Cancer 2017 04 27;123(7):1106-1114. Epub 2016 Dec 27.

Department of Neurology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.30521DOI Listing
April 2017

Management of primary central nervous system lymphoma in children.

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):386-389

Department of Neurology and.

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http://dx.doi.org/10.1182/asheducation-2016.1.386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142451PMC
December 2016

Primary central nervous system lymphoma.

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):379-385

Departments of Neurology and Radiation Oncology, Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1182/asheducation-2016.1.379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142465PMC
December 2016

Reliable estimation of microvascular flow patterns in patients with disrupted blood-brain barrier using dynamic susceptibility contrast MRI.

J Magn Reson Imaging 2017 08 30;46(2):537-549. Epub 2016 Nov 30.

Center of Functionally Integrative Neuroscience and MINDLab, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1002/jmri.25549DOI Listing
August 2017

Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline.

J Clin Oncol 2017 Jan 28;35(3):361-369. Epub 2016 Nov 28.

Erik P. Sulman and Terri S. Armstrong, MD Anderson Cancer Center; Terri S. Armstrong, University of Texas Health Science Center, Houston, TX; Nofisat Ismaila, American Society of Clinical Oncology, Alexandria, VA; Christina Tsien, Washington University Physicians, St Louis, MO; Tracy T. Batchelor, Massachusetts General Hospital, Boston, MA; Tim Cloughesy, University of California, Los Angeles, Los Angeles; Mary Lovely and Susan M. Chang, University of California, San Francisco, San Francisco, CA; Evanthia Galanis, Mayo Clinic, Rochester, MN; Mark Gilbert, National Cancer Institute, Bethesda; Minesh Mehta, University of Maryland School of Medicine, Baltimore, MD; Vinai Gondi, Northwestern Medicine Cancer Center, Warrenville, IL; Matthew P. Mumber, Harbin Clinic Radiation Oncology, Rome, GA; and Andrew Sloan, University Hospitals Cleveland Medical Center, Cleveland, OH.

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http://dx.doi.org/10.1200/JCO.2016.70.7562DOI Listing
January 2017

Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma.

J Neurooncol 2017 02 16;131(3):603-610. Epub 2016 Nov 16.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, Yawkey 9E, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11060-016-2332-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672995PMC
February 2017

Deformable image registration between pathological images and MR image via an optical macro image.

Pathol Res Pract 2016 Oct 2;212(10):927-936. Epub 2016 Aug 2.

Harvard Medical School, Boston, MA 02215, USA; Massachusetts General Hospital Pathology Imaging and Communication Technology (PICT) Center, Boston, MA 02214, USA.

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http://dx.doi.org/10.1016/j.prp.2016.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097673PMC
October 2016

Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients.

Neuro Oncol 2016 11 5;18(11):1569-1578. Epub 2016 Jul 5.

Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (K.J.-K., W.B., B.R.R., O.C.A.); Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (F.L., D.P.C.); Department of Neurosurgery, Charité Medical University, Berlin, Germany (F.L.); High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria (W.B.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (O.R., G.R.G.); Pappas Center of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (E.G., A.S.C., T.T.B.); Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (J.U., H.A.S.).

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http://dx.doi.org/10.1093/neuonc/now100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063518PMC
November 2016

Impact of histopathological transformation and overall survival in patients with progressive anaplastic glioma.

J Clin Neurosci 2016 Sep 6;31:99-105. Epub 2016 Jun 6.

Stephen E. and Catherine Pappas Center for Neuro-Oncology and Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, 55 Fruit Street/Y9E, Boston, MA 02114, USA; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S096758681600123
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http://dx.doi.org/10.1016/j.jocn.2016.02.019DOI Listing
September 2016

Current Management Concepts: Primary Central Nervous System Lymphoma, Natural Killer T-Cell Lymphoma Nasal Type, and Post-transplant Lymphoproliferative Disorder.

Am Soc Clin Oncol Educ Book 2016 ;35:e354-66

From the Division of Hematology/Oncology, Departments of Neurology and Radiation Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA; Department of Medical Oncology, National Cancer Centre, Duke-National University of Singapore Medical School, Singapore; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1200/EDBK_159030DOI Listing
January 2017

The role of whole brain radiation in primary CNS lymphoma.

Blood 2016 07 13;128(1):32-6. Epub 2016 May 13.

Partners Neurology Residency Program, Harvard Medical School, Boston, MA; and Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-01-650101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968379PMC
July 2016

Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma.

Clin Cancer Res 2016 Sep 13;22(17):4452-65. Epub 2016 Apr 13.

Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010492PMC
September 2016

Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma.

Clin Cancer Res 2016 06 12;22(12):2885-96. Epub 2016 Feb 12.

Harvard Medical School, Boston, Massachusetts. Department of Medicine, Dana Farber Cancer Institute, Boston, Massachusetts. Cancer Vaccine Center, Dana Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911283PMC
June 2016

Glioblastoma care in the elderly.

Cancer 2016 Jan 30;122(2):189-97. Epub 2015 Nov 30.

Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.29742DOI Listing
January 2016

Neurocognitive effects of proton radiation therapy in adults with low-grade glioma.

J Neurooncol 2016 Jan;126(1):157-164

Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11060-015-1952-5DOI Listing
January 2016

Standard chemoradiation for glioblastoma results in progressive brain volume loss.

Neurology 2015 Aug 24;85(8):683-91. Epub 2015 Jul 24.

From Harvard Medical School (M.J.P., J.D.), Boston; and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (M.J.P., K.J.-K., J.K.-C., P.P., E.R.G.), and Department of Neurology, Center for Neuro-Oncology (T.T.B., E.R.G., J.D.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000001861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553035PMC
August 2015

Genomic profiling of brain metastases: current knowledge and new frontiers.

Chin Clin Oncol 2015 Jun;4(2):22

Division of Neuro-Oncology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA.

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http://dx.doi.org/10.3978/j.issn.2304-3865.2015.06.04DOI Listing
June 2015

A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma.

Neuro Oncol 2015 Oct 24;17(10):1386-92. Epub 2015 May 24.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts (E.R.G., D.G.D., R.K.J., T.T.B.); Johns Hopkins Medical Center, Baltimore, Maryland (X.Y., S.G.); Martinos Center for Biomedical Imaging, Charlestown, Massachusetts (E.R.G., M.A.L.); Henry Ford Hospital, Detroit, Michigan (T.M.); Memorial Sloan Kettering Cancer Center, New York, New York (T.J.K.); Emory University, Atlanta, Georgia (J.J.O.); University of Alabama, Birmingham, Alabama (B.L.N.); Case Comprehensive Cancer Center, Cleveland, Ohio (M.S.A.); Dana-Farber Cancer Institute, Boston, Massachusetts (P.Y.W.).

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http://dx.doi.org/10.1093/neuonc/nov085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578584PMC
October 2015