Publications by authors named "Tracy L Nero"

36Publications

Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments.

Pharmacol Ther 2020 07 12;211:107527. Epub 2020 Mar 12.

Cancer and Inflammation Program, Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, VIC, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2020.107527DOI Listing
July 2020

Repurposing of drugs as STAT3 inhibitors for cancer therapy.

Semin Cancer Biol 2019 Nov 8. Epub 2019 Nov 8.

Cancer and Inflammation Program, Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, Vic., Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcancer.2019.09.022DOI Listing
November 2019

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.

iScience 2019 Sep 19;19:110-118. Epub 2019 Jul 19.

ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2019.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669322PMC
September 2019

Protein structure and computational drug discovery.

Biochem Soc Trans 2018 10 20;46(5):1367-1379. Epub 2018 Sep 20.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20180202DOI Listing
October 2018

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

MAbs 2018 10 12;10(7):1018-1029. Epub 2018 Sep 12.

a St. Vincent's Institute of Medical Research , Australian Cancer Research Foundation Rational Drug Discovery Centre , Fitzroy , Victoria , Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19420862.2018.1494107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204844PMC
October 2018

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

Structure 2016 08 7;24(8):1271-1281. Epub 2016 Jul 7.

ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2016.05.017DOI Listing
August 2016

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9.

Bioorg Med Chem 2015 Oct 28;23(19):6280-96. Epub 2015 Aug 28.

ACRF Chemical Biology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, 1G Royal Parade, VIC 3052, Australia; School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Rd, VIC 3010, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2015.08.035DOI Listing
October 2015

The βc receptor family - Structural insights and their functional implications.

Cytokine 2015 Aug 14;74(2):247-58. Epub 2015 May 14.

Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10434666150006
Publisher Site
http://dx.doi.org/10.1016/j.cyto.2015.02.005DOI Listing
August 2015

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.

J Exp Med 2015 Feb 2;212(2):129-37. Epub 2015 Feb 2.

Baker IDI Heart and Diabetes Institute, St. Vincent's Institute of Medical Research, and Bio21 Institute, University of Melbourne, Melbourne, Victoria 3010, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20140391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322051PMC
February 2015

Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Mol Cell Oncol 2014 Oct-Dec;1(4):e969129. Epub 2014 Dec 31.

The Centre for Cancer Biology; SA Pathology and the University of South Australia ; Adelaide, South Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/23288604.2014.969129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905208PMC
June 2016

Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.

PLoS One 2014 23;9(9):e108235. Epub 2014 Sep 23.

MIMR-PHI Institute of Medical Research, Clayton, Victoria, Australia; Monash University, Clayton, Victoria, Australia.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108235PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172569PMC
December 2015

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

Sci Rep 2014 Apr 23;4:4765. Epub 2014 Apr 23.

1] ACRF Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3056, Australia [2] Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep04765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996483PMC
April 2014

Oncogenic protein interfaces: small molecules, big challenges.

Nat Rev Cancer 2014 Apr 13;14(4):248-62. Epub 2014 Mar 13.

1] Australian Cancer Research Foundation Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia. [2] Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc3690DOI Listing
April 2014

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

Acta Crystallogr F Struct Biol Commun 2014 Mar 19;70(Pt 3):358-61. Epub 2014 Feb 19.

Australian Cancer Research Foundation Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X14002593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944702PMC
March 2014

Small molecule proprotein convertase inhibitors for inhibition of embryo implantation.

PLoS One 2013 4;8(12):e81380. Epub 2013 Dec 4.

Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia ; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081380PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852413PMC
September 2014

Signalling by the βc family of cytokines.

Cytokine Growth Factor Rev 2013 Jun 25;24(3):189-201. Epub 2013 Mar 25.

The Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, South Australia 5000, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2013.03.002DOI Listing
June 2013

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.

J Biol Chem 2011 Jun 20;286(23):20952-62. Epub 2011 Apr 20.

Department of Microbiology and Immunology, the University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.237446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121471PMC
June 2011

Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta1-adrenergic receptor.

J Med Chem 2006 Jun;49(12):3467-77

Department of Medicine, Austin Health, Clinical Pharmacology and Therapeutics Unit, The University of Melbourne, Heidelberg, 3084, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm050624lDOI Listing
June 2006

Agonist binding and activation of the rat beta(1)-adrenergic receptor: role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43)).

Biochem Pharmacol 2004 Aug;68(4):675-88

Department of Medicine, Clinical Pharmacology and Therapeutics Unit, The University of Melbourne, Austin Health, Heidelberg 3084, Vic., Australia.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S000629520400313
Publisher Site
http://dx.doi.org/10.1016/j.bcp.2004.04.021DOI Listing
August 2004

Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding.

Eur J Med Chem 2004 Jul;39(7):625-31

Clinical Pharmacology and Therapeutics Unit, Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, 3084 Victoria, Australia.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S022352340400094
Publisher Site
http://dx.doi.org/10.1016/j.ejmech.2004.03.009DOI Listing
July 2004

Synthesis, beta-adrenoceptor pharmacology and toxicology of S-(-)-1-(4-(2-ethoxyethoxy)phenoxy)-2-hydroxy-3-(2-(3,4-dimethoxyphenyl)ethylamino)propane hydrochloride, a short acting beta(1)-specific antagonist.

Eur J Med Chem 2002 Sep;37(9):731-41

Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin and Repatriation Medical Centre, The University of Melbourne, Heidelberg, Vic 3084, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0223-5234(02)01399-5DOI Listing
September 2002

CoMFA analysis of the human beta(1)-adrenoceptor binding affinity of a series of phenoxypropanolamines.

Eur J Med Chem 2002 Feb;37(2):111-25

Department of Medicine, Clinical Pharmacology and Therapeutics Unit, The University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0223-5234(01)01315-0DOI Listing
February 2002