Towfique Raj

Towfique Raj

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Towfique Raj

Publications by authors named "Towfique Raj"

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Early-onset pathologically proven multiple system atrophy with LRRK2 G2019S mutation.

Mov Disord 2019 Jul 11;34(7):1080-1082. Epub 2019 May 11.

Fresco Institute for Parkinson's and Movement Disorders, Department of Neurology, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1002/mds.27710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642007PMC
July 2019

Prioritizing Parkinson's disease genes using population-scale transcriptomic data.

Nat Commun 2019 03 1;10(1):994. Epub 2019 Mar 1.

Departments of Neuroscience, and Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.

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http://dx.doi.org/10.1038/s41467-019-08912-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397174PMC
March 2019

High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development.

PLoS One 2018 10;13(4):e0195771. Epub 2018 Apr 10.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195771PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892924PMC
July 2018

Untangling Genetic Risk for Alzheimer's Disease.

Biol Psychiatry 2018 02 22;83(4):300-310. Epub 2017 May 22.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699970PMC
February 2018

Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression.

Am J Hum Genet 2017 Nov 26;101(5):686-699. Epub 2017 Oct 26.

Department of Genetics, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.ajhg.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673624PMC
November 2017

Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation.

Am J Hum Genet 2017 Apr 9;100(4):581-591. Epub 2017 Mar 9.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384037PMC
April 2017

Genetic architecture of age-related cognitive decline in African Americans.

Neurol Genet 2017 Feb 21;3(1):e125. Epub 2016 Dec 21.

Program in Translational NeuroPsychiatric Genomics (T.R., L.B.C., J.M.R., P.L.D.J.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Center for Neurologic Disease (T.R., A.W., A.K., P.L.D.J.), Department of Neurology, and Division of Genetics (T.R., L.B.C., P.L.D.J.), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School (T.R., L.B.C., P.L.D.J.), Boston, MA; Program in Medical and Population genetics (T.R., L.B.C., C.M., J.M.R., P.L.D.J.), The Broad Institute, Cambridge, MA; Section of Genetic Medicine (B.S.), Department of Medicine, and Institute for Genomics and Systems Biology (B.S.), University of Chicago, IL; Indiana University Center for Aging Research (H.C.H.); Department of Psychiatry (F.W.U., H.C.H., K.S.H.), Department of Biostatistics (S.G.), Indiana University School of Medicine; Department of Medical and Molecular Genetics (J.M., T.F.), Indiana University, Indianapolis; Rush Institute for Healthy Aging (D.A.V.), Department of Internal Medicine, Department of Neurology (L.B., D.A.B.), and Rush Alzheimer's Disease Center (L.Y., L.B., D.A.B.), Rush University Medical Center, Chicago, IL. T.R. is currently affiliated with Ronald M. Loeb Center for Alzheimer's Disease, Departments of Neuroscience, and Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York.

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http://dx.doi.org/10.1212/NXG.0000000000000125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206965PMC
February 2017

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.

PLoS One 2015 16;10(10):e0140758. Epub 2015 Oct 16.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; BWH Pulmonary Genetics Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140758PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608673PMC
June 2016

Ethnically shared and heterogeneous impacts of molecular pathways suggested by the genome-wide meta-analysis of rheumatoid arthritis.

Rheumatology (Oxford) 2016 Jan 28;55(1):186-9. Epub 2015 Aug 28.

Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo and Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.

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http://dx.doi.org/10.1093/rheumatology/kev314DOI Listing
January 2016

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells.

Hum Mol Genet 2016 Jan 24;25(2):404-17. Epub 2015 Nov 24.

Ann Romney Center for Neurologic Diseases, Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Broad Institute at Harvard University and MIT, NRB-641, 77 Avenue Louis Pasteur, Boston, MA 02115, USA and

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http://dx.doi.org/10.1093/hmg/ddv474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881829PMC
January 2016

The transcriptional landscape of age in human peripheral blood.

Authors:
Marjolein J Peters Roby Joehanes Luke C Pilling Claudia Schurmann Karen N Conneely Joseph Powell Eva Reinmaa George L Sutphin Alexandra Zhernakova Katharina Schramm Yana A Wilson Sayuko Kobes Taru Tukiainen Yolande F Ramos Harald H H Göring Myriam Fornage Yongmei Liu Sina A Gharib Barbara E Stranger Philip L De Jager Abraham Aviv Daniel Levy Joanne M Murabito Peter J Munson Tianxiao Huan Albert Hofman André G Uitterlinden Fernando Rivadeneira Jeroen van Rooij Lisette Stolk Linda Broer Michael M P J Verbiest Mila Jhamai Pascal Arp Andres Metspalu Liina Tserel Lili Milani Nilesh J Samani Pärt Peterson Silva Kasela Veryan Codd Annette Peters Cavin K Ward-Caviness Christian Herder Melanie Waldenberger Michael Roden Paula Singmann Sonja Zeilinger Thomas Illig Georg Homuth Hans-Jörgen Grabe Henry Völzke Leif Steil Thomas Kocher Anna Murray David Melzer Hanieh Yaghootkar Stefania Bandinelli Eric K Moses Jack W Kent Joanne E Curran Matthew P Johnson Sarah Williams-Blangero Harm-Jan Westra Allan F McRae Jennifer A Smith Sharon L R Kardia Iiris Hovatta Markus Perola Samuli Ripatti Veikko Salomaa Anjali K Henders Nicholas G Martin Alicia K Smith Divya Mehta Elisabeth B Binder K Maria Nylocks Elizabeth M Kennedy Torsten Klengel Jingzhong Ding Astrid M Suchy-Dicey Daniel A Enquobahrie Jennifer Brody Jerome I Rotter Yii-Der I Chen Jeanine Houwing-Duistermaat Margreet Kloppenburg P Eline Slagboom Quinta Helmer Wouter den Hollander Shannon Bean Towfique Raj Noman Bakhshi Qiao Ping Wang Lisa J Oyston Bruce M Psaty Russell P Tracy Grant W Montgomery Stephen T Turner John Blangero Ingrid Meulenbelt Kerry J Ressler Jian Yang Lude Franke Johannes Kettunen Peter M Visscher G Gregory Neely Ron Korstanje Robert L Hanson Holger Prokisch Luigi Ferrucci Tonu Esko Alexander Teumer Joyce B J van Meurs Andrew D Johnson

Nat Commun 2015 Oct 22;6:8570. Epub 2015 Oct 22.

The National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1038/ncomms9570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639797PMC
October 2015

Allele-specific methylation occurs at genetic variants associated with complex disease.

PLoS One 2014 9;9(6):e98464. Epub 2014 Jun 9.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098464PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049588PMC
June 2015

Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):7219-24. Epub 2015 May 26.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1507977112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466754PMC
June 2015

Accurate and fast multiple-testing correction in eQTL studies.

Am J Hum Genet 2015 Jun 28;96(6):857-68. Epub 2015 May 28.

Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea; Department of Medicine, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457958PMC
June 2015

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.

Ann Neurol 2015 Mar;77(3):469-77

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, MA; Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA; Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ana.24337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461024PMC
March 2015

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

PLoS One 2014 10;9(2):e87645. Epub 2014 Feb 10.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919745PMC
October 2014

Intersection of population variation and autoimmunity genetics in human T cell activation.

Science 2014 Sep;345(6202):1254665

Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1254665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751028PMC
September 2014

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

PLoS Genet 2014 Jun 26;10(6):e1004404. Epub 2014 Jun 26.

Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America; Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072514PMC
June 2014

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility.

Hum Mol Genet 2014 May 30;23(10):2729-36. Epub 2013 Dec 30.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddt666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990171PMC
May 2014

Interindividual variation in human T regulatory cells.

Proc Natl Acad Sci U S A 2014 Mar 7;111(12):E1111-20. Epub 2014 Mar 7.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1401343111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970507PMC
March 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Genetics of human gene expression.

Curr Opin Genet Dev 2013 Dec 14;23(6):627-34. Epub 2013 Nov 14.

Section of Genetic Medicine, Department of Medicine, University of Chicago, IL, USA; Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2013.10.004DOI Listing
December 2013

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.

PLoS Genet 2013 Nov 21;9(11):e1003926. Epub 2013 Nov 21.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts, United States of America ; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Harvard Medical School, Boston, Massachusetts, United States of America ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836799PMC
November 2013

Common risk alleles for inflammatory diseases are targets of recent positive selection.

Am J Hum Genet 2013 Apr 21;92(4):517-29. Epub 2013 Mar 21.

Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham & Women's Hospital, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297130010
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http://dx.doi.org/10.1016/j.ajhg.2013.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617371PMC
April 2013

On the inclusion of self regulating branching processes in the working paradigm of evolutionary and population genetics.

Front Genet 2013 19;4:11. Epub 2013 Feb 19.

Department of Mathematics, Drexel University Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fgene.2013.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575575PMC
February 2013

Alzheimer disease susceptibility loci: evidence for a protein network under natural selection.

Am J Hum Genet 2012 Apr;90(4):720-6

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences Department of Neurology, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322230PMC
April 2012

Signatures of historical demography and pathogen richness on MHC class I genes.

Immunogenetics 2012 Mar 23;64(3):165-75. Epub 2011 Sep 23.

Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK.

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http://link.springer.com/10.1007/s00251-011-0576-y
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http://dx.doi.org/10.1007/s00251-011-0576-yDOI Listing
March 2012

Progress and promise of genome-wide association studies for human complex trait genetics.

Genetics 2011 Feb 29;187(2):367-83. Epub 2010 Nov 29.

Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://www.genetics.org/cgi/doi/10.1534/genetics.110.120907
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http://dx.doi.org/10.1534/genetics.110.120907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030483PMC
February 2011

me-PCR: a refined ultrafast algorithm for identifying sequence-defined genomic elements.

Bioinformatics 2004 Mar 22;20(4):588-90. Epub 2004 Jan 22.

Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia 19104-4318, USA.

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http://dx.doi.org/10.1093/bioinformatics/btg466DOI Listing
March 2004