Publications

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
Biochem Biophys Res Commun 2017 Jun 5;488(1):159-164. Epub 2017 May 5.
Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:


H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
Biochem Biophys Res Commun 2015 Oct 18;465(4):725-31. Epub 2015 Aug 18.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.
J Atheroscler Thromb 2015 Aug 4;22(8):754-72. Epub 2015 Jun 4.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), University of Tokyo.

Low-Dose Pelvic Computed Tomography Using Adaptive Iterative Dose Reduction 3-Dimensional Algorithm: A Phantom Study.
J Comput Assist Tomogr 2015 Jul-Aug;39(4):629-34
From the *Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; †Faculty of Medical Sciences, University of Groningen, MWF-Complex, Groningen, the Netherlands, ‡Toshiba Medical Systems Corporation, Otawara-Shi, Tochigi, Japan; and §Division of Radiology, Department of Medical Technology, Osaka University Hospital, Suita, Osaka, Japan.

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.
1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
J Biol Chem 2015 Feb 22;290(7):4163-77. Epub 2014 Dec 22.
From the Division of Metabolic Medicine, the Translational Systems Biology and Medicine Initiative Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo 153-8904, Japan,






Novel repressor regulates insulin sensitivity through interaction with Foxo1.
EMBO J 2012 May 17;31(10):2275-95. Epub 2012 Apr 17.
Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.


Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis.
Pathol Int 2011 May 17;61(5):290-7. Epub 2011 Mar 17.
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Chuou-ku, Niigata, Japan.


Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
J Biol Chem 2009 Aug 24;284(33):22195-205. Epub 2009 Jun 24.
Graduate School of Pharmaceutical Sciences, Osaka University, Department of Molecular Pharmaceutical Science, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
Genes Cells 2009 Aug 15;14(8):991-1001. Epub 2009 Jul 15.
Metabolism and Endocrinology Division, Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan.



COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
Pathol Int 2009 Mar;59(3):152-60
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.




Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.
Gene Expr Patterns 2008 Jan 9;8(2):96-106. Epub 2007 Oct 9.
Department of Metabolic Medicine, Graduate School of Medicine, B5, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.

Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.
Nucleic Acids Symp Ser (Oxf) 2007 (51):441-2
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophages.
Cell Immunol 2007 Aug 28;248(2):86-94. Epub 2007 Nov 28.
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1-757, Chuou-ku, Niigata 951-8510, Japan.

Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.
J Histochem Cytochem 2007 Jun 6;55(6):641-9. Epub 2007 Mar 6.
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan.


SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.
J Biol Chem 2007 Jun 4;282(26):19052-61. Epub 2007 Apr 4.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan.


Analysis of PPAR alpha function in human kidney cell line using siRNA.
Nucleic Acids Symp Ser (Oxf) 2006 (50):257-8
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
FEBS Lett 2006 Sep 14;580(20):4929-33. Epub 2006 Aug 14.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.



Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
Biochem Biophys Res Commun 2005 Aug;333(3):778-86
Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan.

Expression of the LXRalpha protein in human atherosclerotic lesions.
Arterioscler Thromb Vasc Biol 2005 Mar 29;25(3):622-7. Epub 2004 Dec 29.
Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, the University of Tokyo, Japan.

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation.
Mol Cell 2004 Aug;15(4):499-509
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, 67404 Illkirch, France.

A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage.
J Atheroscler Thromb 2004 ;11(2):88-97
Department of Molecular Biology and Medicine, Research Center for Advanced Technology and Science, The University of Tokyo, 4-6-1 Komada, Meguro-ku, Tokyo 153-8904, Japan.

A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.
J Biol Chem 2004 Apr 10;279(17):16954-62. Epub 2004 Feb 10.
Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, the Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.



Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats.
Nucl Recept 2003 8;1. Epub 2003 Aug 8.
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.




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