Toshiya Hirayama

Toshiya Hirayama

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Toshiya Hirayama

Toshiya Hirayama

Publications by authors named "Toshiya Hirayama"

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Response to ' infection of AZ-521 cells reveals a type IV secretion defect and VacA-independent CagA phosphorylation'.

Dis Model Mech 2017 12 19;10(12):1541-1543. Epub 2017 Dec 19.

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.

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http://dx.doi.org/10.1242/dmm.032821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769615PMC
December 2017

Study of the Stn protein in Salmonella; a regulator of membrane composition and integrity.

Methods Mol Biol 2015 ;1225:127-38

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, 1-12-4, Sakamoto, Nagasaki, 852-8523, Japan,

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http://dx.doi.org/10.1007/978-1-4939-1625-2_9DOI Listing
May 2016

New Insights into VacA Intoxication Mediated through Its Cell Surface Receptors.

Toxins (Basel) 2016 05 13;8(5). Epub 2016 May 13.

Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan.

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http://dx.doi.org/10.3390/toxins8050152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885067PMC
May 2016

VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets.

Thromb J 2013 Nov 12;11(1):23. Epub 2013 Nov 12.

Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898 Chuo, Yamanashi, Japan.

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http://dx.doi.org/10.1186/1477-9560-11-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842841PMC
November 2013

Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells.

Cell Host Microbe 2012 Dec;12(6):764-77

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.chom.2012.10.014DOI Listing
December 2012

Salmonella enterotoxin (Stn) regulates membrane composition and integrity.

Dis Model Mech 2012 Jul 2;5(4):515-21. Epub 2012 Feb 2.

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.009324
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http://dx.doi.org/10.1242/dmm.009324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380714PMC
July 2012

Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection.

J Clin Immunol 2012 Apr 13;32(2):290-9. Epub 2011 Dec 13.

Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

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http://dx.doi.org/10.1007/s10875-011-9626-3DOI Listing
April 2012

Enhanced expression of CXCL13 in human Helicobacter pylori-associated gastritis.

Dig Dis Sci 2011 Oct 7;56(10):2887-94. Epub 2011 Jun 7.

Second Department of Internal Medicine, Nagasaki University Hospital, Sakamoto 1-7-1, Nagasaki, 852-8102, Japan.

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http://link.springer.com/10.1007/s10620-011-1717-8
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http://dx.doi.org/10.1007/s10620-011-1717-8DOI Listing
October 2011

Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells.

Dig Dis Sci 2011 Apr 7;56(4):999-1006. Epub 2010 Oct 7.

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, and Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

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http://dx.doi.org/10.1007/s10620-010-1420-1DOI Listing
April 2011

MicroRNA signatures in Helicobacter pylori-infected gastric mucosa.

Int J Cancer 2011 Jan 23;128(2):361-70. Epub 2010 Mar 23.

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan.

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http://dx.doi.org/10.1002/ijc.25348DOI Listing
January 2011

Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells.

Dis Model Mech 2010 Sep-Oct;3(9-10):605-17. Epub 2010 Aug 3.

Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.004879
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http://dx.doi.org/10.1242/dmm.004879DOI Listing
December 2010

Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.

Tohoku J Exp Med 2010 Jan;220(1):3-14

Department of Endoscopy, Nagasaki University Hospital, Nagasaki, Japan.

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http://dx.doi.org/10.1620/tjem.220.3DOI Listing
January 2010

Helicobacter pylori VacA activates NF-kappaB in T cells via the classical but not alternative pathway.

Helicobacter 2009 Aug;14(4):271-9

Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.

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http://doi.wiley.com/10.1111/j.1523-5378.2009.00683.x
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http://dx.doi.org/10.1111/j.1523-5378.2009.00683.xDOI Listing
August 2009

Helicobacter pylori-induced interleukin-12 p40 expression.

Infect Immun 2009 Apr 29;77(4):1337-48. Epub 2009 Jan 29.

Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.

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http://dx.doi.org/10.1128/IAI.01456-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663134PMC
April 2009

[Pleiotropic effects of VacA: its role in the pathogenesis of Helicobacter pylori infection].

Tanpakushitsu Kakusan Koso 2009 Apr;54(5):607-13

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April 2009

Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis.

Clin Immunol 2009 Mar 8;130(3):290-7. Epub 2008 Nov 8.

Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki 852-8501, Japan.

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http://dx.doi.org/10.1016/j.clim.2008.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404125PMC
March 2009

Involvement of vesicle-associated membrane protein 7 in human gastric epithelial cell vacuolation induced by Helicobacter pylori-produced VacA.

Infect Immun 2008 Jun 24;76(6):2296-303. Epub 2008 Mar 24.

Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1128/IAI.01573-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423058PMC
June 2008

Unexpected expression of Hsp47, a replacement of one amino acid (Val 7 Leu) in the amino terminal region, in cultured human tumorigenic cell lines.

J Dermatol Sci 2008 Jan;49(1):33-8

Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Aomori 037-8561, Japan.

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January 2008

[Virulence mechanism of Helicobacter pylori VacA].

Authors:
Toshiya Hirayama

Nihon Saikingaku Zasshi 2007 Nov;62(4):387-96

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University.

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November 2007

[Structure and intoxication of VacA].

Nihon Rinsho 2005 Nov;63 Suppl 11:53-7

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University.

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November 2005

High concentrations of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infection.

World J Gastroenterol 2005 Aug;11(31):4782-7

Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398722PMC
http://dx.doi.org/10.3748/wjg.v11.i31.4782DOI Listing
August 2005

Vacuolating cytotoxin A is associated with increased thrombin generation in gastric mucosa.

Helicobacter 2005 Aug;10(4):323-31

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mie University School of Medicine, Edobashi 2-174, Tsu city, Mie 514-8507, Japan.

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http://dx.doi.org/10.1111/j.1523-5378.2005.00323.xDOI Listing
August 2005

Helicobacter pylori strain-specific modulation of gastric inflammation in Mongolian gerbils.

World J Gastroenterol 2005 Mar;11(10):1549-53

Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305702PMC
http://dx.doi.org/10.3748/wjg.v11.i10.1549DOI Listing
March 2005

Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.

Int J Med Microbiol 2005 Jan;294(7):427-35

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki 852-8523, Japan.

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http://dx.doi.org/10.1016/j.ijmm.2004.09.012DOI Listing
January 2005

Essential domain of receptor tyrosine phosphatase beta (RPTPbeta) for interaction with Helicobacter pylori vacuolating cytotoxin.

J Biol Chem 2004 Dec 20;279(49):51013-21. Epub 2004 Sep 20.

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan.

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http://dx.doi.org/10.1074/jbc.M406473200DOI Listing
December 2004

Helicobacter pylori vacuolating cytotoxin, VacA, is responsible for gastric ulceration.

J Biochem 2004 Dec;136(6):741-6

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan.

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https://academic.oup.com/jb/article-lookup/doi/10.1093/jb/mv
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http://dx.doi.org/10.1093/jb/mvh181DOI Listing
December 2004

Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells.

J Immunol 2004 Nov;173(9):5398-405

Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.4049/jimmunol.173.9.5398DOI Listing
November 2004

Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree.

Hepatology 2004 Oct;40(4):925-32

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

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http://dx.doi.org/10.1002/hep.20379DOI Listing
October 2004

Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cells.

J Biol Chem 2004 Feb 20;279(8):7024-8. Epub 2003 Nov 20.

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan.

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http://dx.doi.org/10.1074/jbc.M308898200DOI Listing
February 2004

Helicobacter pylori induces RANTES through activation of NF-kappa B.

Infect Immun 2003 Jul;71(7):3748-56

Department of Virology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162018PMC
http://dx.doi.org/10.1128/iai.71.7.3748-3756.2003DOI Listing
July 2003

Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor.

J Biol Chem 2003 May 6;278(21):19183-9. Epub 2003 Mar 6.

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M300117200
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http://dx.doi.org/10.1074/jbc.M300117200DOI Listing
May 2003

High molecular weight factor in FCS inhibits Helicobacter pylori VacA-binding to its receptor, RPTPbeta, on AZ-521.

Microbiol Immunol 2003 ;47(1):105-7

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Nagasaki 852-8523, Japan.

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http://dx.doi.org/10.1111/j.1348-0421.2003.tb02792.xDOI Listing
May 2003

Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor kappaB.

Gastroenterology 2003 Apr;124(4):983-92

Department of Virology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

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http://dx.doi.org/10.1053/gast.2003.50152DOI Listing
April 2003

Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.

Nat Genet 2003 Mar 24;33(3):375-81. Epub 2003 Feb 24.

Division of Molecular Neurobiology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji-cho, Okazaki 444-8585, Japan.

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http://dx.doi.org/10.1038/ng1112DOI Listing
March 2003

In vitro gene transfection using dendritic poly(L-lysine).

Bioconjug Chem 2002 May-Jun;13(3):510-7

Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, 852-8521, Japan.

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December 2002

Protein tyrosine phosphatase beta, a receptor for Helicobacter pylori vacA toxin.

Authors:
Toshiya Hirayama

Keio J Med 2002 Dec;51 Suppl 2:20-3

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.

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December 2002

Relationship between gastric ulcer and Helicobacter pylori VacA detected in gastric juice using bead-ELISA method.

Helicobacter 2002 Oct;7(5):281-6

Division of Diabetes, Digestive, and Kidney Disease, Department of Clinical Molecular Medicine, Kobe University School of Medicine, Kobe, Hyogo, Japan.

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October 2002

ADP ribosylation of human neutrophil peptide-1 regulates its biological properties.

Proc Natl Acad Sci U S A 2002 Jun;99(12):8231-5

Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bldg 10 Rm 6D03, Bethesda, MD 20892-1590, USA.

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http://dx.doi.org/10.1073/pnas.122238899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123050PMC
June 2002

Helicobacter pylori vacuolating cytotoxin, VacA.

Jpn J Infect Dis 2002 Feb;55(1):1-5

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.

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February 2002