Publications by authors named "Toshio Suda"

250 Publications

Low-dose ionizing radiations leave scars on human hematopoietic stem and progenitor cells: the role of reactive oxygen species.

Haematologica 2021 ;106(1):320-322

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan; Cancer Science Institute, National University of Singapore, Singapore.

View Article and Find Full Text PDF
January 2021

Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal.

Cell Syst 2020 Dec 8;11(6):640-652.e5. Epub 2020 Dec 8.

Centre for Human Development, Stem Cells and Regeneration, University of Southampton, Southampton SO17 1BJ, UK; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK; Mathematical Sciences, University of Southampton, Southampton SO17 1BJ, UK. Electronic address:

View Article and Find Full Text PDF
December 2020

Myeloma cells self-promote migration by regulating TAB1-driven TIMP-1 expression in mesenchymal stem cells.

Biochem Biophys Res Commun 2021 Jan 9;534:843-848. Epub 2020 Nov 9.

Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City, 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
January 2021

[Efficacy of thrombopoietin in bone marrow failure].

Rinsho Ketsueki 2020 ;61(10):1449-1458

Cancer Science Institute, National University of Singapore.

View Article and Find Full Text PDF
January 2021

Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails.

Trends Cell Biol 2020 11 10;30(11):835-836. Epub 2020 Sep 10.

Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
November 2020

Low-dose X-rays leave scars on human hematopoietic stem and progenitor cells: the role of reactive oxygen species.

Haematologica 2020 Aug;105(8):1986-1988

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

View Article and Find Full Text PDF
August 2020

Hematopoietic Stem Cell Metabolism during Development and Aging.

Dev Cell 2020 07;54(2):239-255

Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599 Singapore, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
July 2020

A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.

Cell Rep 2020 02;30(6):1823-1834.e5

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore; International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
February 2020

Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation.

Ann N Y Acad Sci 2020 04 10;1466(1):51-58. Epub 2019 Jul 10.

International Research Center for Medical Sciences, Kumamoto University, Kumamoto City, Japan.

View Article and Find Full Text PDF
April 2020

Beginning of a New Era: Mapping the Bone Marrow Niche.

Cell 2019 06;177(7):1679-1681

Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
June 2019

Dynamic Changes in the Niche with N-Cadherin Revisited: The HSC "Niche Herein".

Cell Stem Cell 2019 03;24(3):355-356

Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
March 2019

PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells.

Cell Rep 2019 02;26(9):2316-2328.e6

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. Electronic address:

View Article and Find Full Text PDF
February 2019

Sphingosine-1-phosphate signaling modulates terminal erythroid differentiation through the regulation of mitophagy.

Exp Hematol 2019 04 16;72:47-59.e1. Epub 2019 Jan 16.

Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Kumamoto University, International Research Center for Medical Sciences, Kumamoto, Japan. Electronic address:

View Article and Find Full Text PDF
April 2019

Modification of the bone marrow MSC population in a xenograft model of early multiple myeloma.

Biochem Biophys Res Commun 2019 01 13;508(4):1175-1181. Epub 2018 Dec 13.

Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, 14 Medical Drive, #12-01, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City, 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
January 2019

Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.

Cell Rep 2018 11;25(7):1772-1785.e6

Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599 Singapore, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. Electronic address:

View Article and Find Full Text PDF
November 2018

Ca-mitochondria axis drives cell division in hematopoietic stem cells.

J Exp Med 2018 08 26;215(8):2097-2113. Epub 2018 Jun 26.

International Research Center for Medical Sciences, Kumamoto University, Japan

View Article and Find Full Text PDF
August 2018

[Ageing of hematopoietic stem cells].

Rinsho Ketsueki 2018;59(1):3-12

Cancer Science Institute, National University of Singapore.

View Article and Find Full Text PDF
February 2019

Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency.

Sci Rep 2018 01 26;8(1):1634. Epub 2018 Jan 26.

Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

View Article and Find Full Text PDF
January 2018