Toshio Miyata

Toshio Miyata

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Toshio Miyata

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PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.

Am J Respir Cell Mol Biol 2019 Sep 12. Epub 2019 Sep 12.

University of Alabama at Birmingham, Birmingham, Alabama, United States;

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http://dx.doi.org/10.1165/rcmb.2019-0071OCDOI Listing
September 2019

Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning.

Biochem Biophys Res Commun 2019 Aug 20;516(2):500-505. Epub 2019 Jun 20.

Research Center for Regenerative Medicine, Tokai University School of Medicine, Kanagawa, 259-1193, Japan; Department of Hematology and Oncology, Tokai University School of Medicine, Kanagawa, 259-1193, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2019.06.076DOI Listing
August 2019

PAI-1 contributes to homocysteine-induced cellular senescence.

Cell Signal 2019 Aug 28;64:109394. Epub 2019 Aug 28.

Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2019.109394DOI Listing
August 2019

A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer's Disease.

J Alzheimers Dis 2018 ;64(2):447-457

Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.3233/JAD-180241DOI Listing
July 2019

Points-to-consider documents: Scientific information on the evaluation of genetic polymorphisms during non-clinical studies and phase I clinical trials in the Japanese population.

Drug Metab Pharmacokinet 2018 Jun 15;33(3):141-149. Epub 2018 Mar 15.

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; National Institute of Health Sciences (NIHS), Tokyo, Japan.

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http://dx.doi.org/10.1016/j.dmpk.2018.01.005DOI Listing
June 2018

Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression.

Int J Mol Sci 2018 Apr 27;19(5). Epub 2018 Apr 27.

Department of Immunology and Biochemistry, Biomedical Research Institute, Hasselt University, Martelarenlaan 42 3500 Hasselt, Belgium.

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http://dx.doi.org/10.3390/ijms19051311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983766PMC
April 2018

Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress.

Psychiatry Clin Neurosci 2018 Jan 30;72(1):35-44. Epub 2017 Nov 30.

Division of Molecular Medicine and Therapy, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1111/pcn.12613DOI Listing
January 2018

A null mutation in protects against biological aging in humans.

Sci Adv 2017 11 15;3(11):eaao1617. Epub 2017 Nov 15.

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/sciadv.aao1617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687852PMC
November 2017

TM5441, a plasminogen activator inhibitor-1 inhibitor, protects against high fat diet-induced non-alcoholic fatty liver disease.

Oncotarget 2017 Oct 21;8(52):89746-89760. Epub 2017 Sep 21.

Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.

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http://dx.doi.org/10.18632/oncotarget.21120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685706PMC
October 2017

PAI-1 is a critical regulator of FGF23 homeostasis.

Sci Adv 2017 09 13;3(9):e1603259. Epub 2017 Sep 13.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/sciadv.1603259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597312PMC
September 2017

Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model.

PLoS One 2016 3;11(6):e0157012. Epub 2016 Jun 3.

Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157012PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892642PMC
August 2017

Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.

FASEB J 2017 06 7;31(6):2625-2637. Epub 2017 Mar 7.

Division of Stem Cell Dynamics, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

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http://dx.doi.org/10.1096/fj.201600871RRDOI Listing
June 2017

Insurance systems and reimbursement concerning research and development of regenerative medicine in Japan.

Regen Med 2017 03 16;12(2):179-186. Epub 2017 Feb 16.

Department of Medical Innovation, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka, Japan.

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http://dx.doi.org/10.2217/rme-2016-0124DOI Listing
March 2017

The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma.

Br J Ophthalmol 2017 02 9;101(2):233-238. Epub 2016 Dec 9.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1136/bjophthalmol-2016-309504DOI Listing
February 2017

Effect of Scavenging Circulating Reactive Carbonyls by Oral Pyridoxamine in Uremic Rats on Peritoneal Dialysis.

Ther Apher Dial 2016 Dec 13;20(6):645-654. Epub 2016 Sep 13.

Department of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.

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http://dx.doi.org/10.1111/1744-9987.12446DOI Listing
December 2016

A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence.

Oncotarget 2016 Nov;7(45):72443-72457

Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.18632/oncotarget.12494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341920PMC
November 2016

Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.

Skelet Muscle 2016 5;6. Epub 2016 Mar 5.

Department of Medicine & Science in Sport & Exercise, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575 Japan.

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http://dx.doi.org/10.1186/s13395-016-0079-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779261PMC
September 2016

A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice.

Br J Pharmacol 2016 09 28;173(17):2622-32. Epub 2016 Jul 28.

Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea.

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http://dx.doi.org/10.1111/bph.13541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978161PMC
September 2016

Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model.

Glycoconj J 2016 08 13;33(4):627-30. Epub 2016 Jun 13.

Department of Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202, AZ, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s10719-016-9681-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975762PMC
August 2016

Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.

PLoS One 2015 24;10(7):e0133786. Epub 2015 Jul 24.

Division of Hematology, Oncology and Blood and Bone Marrow Transplantation, Department of Pediatrics, University of Southern California, Los Angeles, California, United States of America; The Saban Research Institute of Children's Hospital, Los Angeles, California, 90027, United States of America; Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133786PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514594PMC
May 2016

Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice.

Diabetes 2016 04 30;65(4):956-66. Epub 2015 Dec 30.

CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-1390DOI Listing
April 2016

Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma.

Am J Physiol Lung Cell Mol Physiol 2016 Feb 23;310(4):L328-36. Epub 2015 Dec 23.

Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;

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http://dx.doi.org/10.1152/ajplung.00217.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754904PMC
February 2016

Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

PLoS One 2015 10;10(3):e0116504. Epub 2015 Mar 10.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America; Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116504PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355068PMC
January 2016

Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis.

PLoS One 2015 27;10(4):e0124510. Epub 2015 Apr 27.

Department of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124510PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411110PMC
January 2016

Hypoxia-sensitive reporter system for high-throughput screening.

Tohoku J Exp Med 2015 02;235(2):151-9

Department of Medical Biochemistry, Sendai, Miyagi, Japan; Department of Molecular Medicine and Therapy, Tohoku University Graduate School of Medicine,

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http://www.journal.med.tohoku.ac.jp/2352/235_151.pdf
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https://www.jstage.jst.go.jp/article/tjem/235/2/235_151/_art
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http://dx.doi.org/10.1620/tjem.235.151DOI Listing
February 2015

Skin autofluorescence predicts cardiovascular mortality in patients on chronic hemodialysis.

Ther Apher Dial 2014 Oct 24;18(5):461-7. Epub 2014 Jan 24.

Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.

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http://dx.doi.org/10.1111/1744-9987.12160DOI Listing
October 2014

Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/- mice with or without diabetes.

Cardiovasc Res 2014 Oct 18;104(1):160-70. Epub 2014 Aug 18.

Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands Department of Internal Medicine, Laboratory for Metabolism and Vascular Medicine, MUMC, Debeyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands

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http://dx.doi.org/10.1093/cvr/cvu189DOI Listing
October 2014

Clinical features of schizophrenia with enhanced carbonyl stress.

Schizophr Bull 2014 Sep 23;40(5):1040-6. Epub 2013 Sep 23.

Project for Schizophrenia and Affective Disorder Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan; Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan;

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http://dx.doi.org/10.1093/schbul/sbt129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133661PMC
September 2014

Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis.

J Clin Oncol 2014 Aug 30;32(22):2380-5. Epub 2014 Jun 30.

Hajime Uno, Deborah Schrag, and Susanna Jacobus, Dana-Farber Cancer Institute; Brian Claggett, Hicham Skali, and Scott Solomon, Harvard Medical School, Brigham and Women's Hospital; Michael Hughes and Lee-Jen Wei, Harvard School of Public Health, Boston, MA; Lu Tian, Stanford University School of Medicine, Palo Alto, CA; Eisuke Inoue and Masahiro Takeuchi, Kitasato University; Toshio Miyata, Health and Global Policy Institute; Yoshiaki Uyama, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan; Paul Gallo, Novartis Pharmaceuticals, East Hanover, NJ; Lihui Zhao, Northwestern University Feinberg School of Medicine, Chicago, IL; and Milton Packer, University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1200/JCO.2014.55.2208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105489PMC
August 2014

Drug discovery in renal disease--towards a more efficient framework.

Nat Rev Nephrol 2014 May 18;10(5):290-6. Epub 2014 Mar 18.

Research Center for Clinical Pharmacology, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

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http://dx.doi.org/10.1038/nrneph.2014.36DOI Listing
May 2014

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

Proc Natl Acad Sci U S A 2014 May 28;111(19):7090-5. Epub 2014 Apr 28.

Department of Medicine andFeinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; and

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http://www.pnas.org/cgi/doi/10.1073/pnas.1321942111
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http://dx.doi.org/10.1073/pnas.1321942111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024885PMC
May 2014

Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration.

Stem Cells 2014 Apr;32(4):946-58

Division of Hematopoiesis, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

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http://dx.doi.org/10.1002/stem.1577DOI Listing
April 2014

Keap1 inhibition attenuates glomerulosclerosis.

Nephrol Dial Transplant 2014 Apr 11;29(4):783-91. Epub 2014 Feb 11.

Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1093/ndt/gfu002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967835PMC
April 2014

Carbonyl stress in schizophrenia.

Biochem Soc Trans 2014 Apr;42(2):468-72

†United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan.

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http://dx.doi.org/10.1042/BST20140044DOI Listing
April 2014

Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study.

Diabetol Metab Syndr 2014 Mar 6;6(1):33. Epub 2014 Mar 6.

Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, 2-1 Seiryo-machi, Aoba-ku 980-8575 Sendai, Japan.

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http://dx.doi.org/10.1186/1758-5996-6-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016590PMC
March 2014

Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis.

Expert Opin Investig Drugs 2014 Feb 11;23(2):149-62. Epub 2013 Nov 11.

The University of Tokyo, Department of Cardiovascular Medicine , 7-3-1 Hongo, Bunkyo-ku, Tokyo , Japan.

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http://dx.doi.org/10.1517/13543784.2014.855196DOI Listing
February 2014

Lower serum endogenous secretory receptor for advanced glycation end product level as a risk factor of metabolic syndrome among Japanese adult men: a 2-year longitudinal study.

J Clin Endocrinol Metab 2014 Feb 25;99(2):587-93. Epub 2013 Nov 25.

Division of Biomedical Engineering for Health and Welfare (H.M., R.N.), Graduate School of Biomedical Engineering, and Department of Medicine and Science in Sports and Exercise (Y.K., C.H., M.C., A.O.), United Centers for Advanced Research and Translational Medicine (T.M.), Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan; Department of Epidemiology (K.N.), School of Public Health, Tianjin Medical University, Tianjin 300192, People's Republic of China; and School of Nursing (H.T.) Miyagi University, Sendai 989-3126, Japan.

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http://dx.doi.org/10.1210/jc.2013-2936DOI Listing
February 2014

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.

Diabetologia 2014 Jan 26;57(1):224-35. Epub 2013 Oct 26.

Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Universiteitssingel 50, P.O. Box 616 (box 14), 6200 MD, Maastricht, the Netherlands,

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http://dx.doi.org/10.1007/s00125-013-3088-5DOI Listing
January 2014

Replication of enhanced carbonyl stress in a subpopulation of schizophrenia.

Psychiatry Clin Neurosci 2014 Jan 28;68(1):83-4. Epub 2013 Oct 28.

Project for Schizophrenia and Affective Disorder, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan; Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.

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http://doi.wiley.com/10.1111/pcn.12081
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http://dx.doi.org/10.1111/pcn.12081DOI Listing
January 2014

A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia.

Neurochem Res 2013 Dec 17;38(12):2588-94. Epub 2013 Oct 17.

Department of Neurology, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan.

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http://dx.doi.org/10.1007/s11064-013-1175-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898357PMC
December 2013

Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence.

Circulation 2013 Nov 3;128(21):2318-24. Epub 2013 Oct 3.

Department of Medicine (A.E.B., M.E., S.B.M., C.E.K., D.E.V.) and Feinberg Cardiovascular Research Institute (A.E.B., S.B.M., C.E.K., D.E.V.), Northwestern University Feinberg School of Medicine, Chicago, IL; United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Miyagi, Japan (A.I., T.M.); and Conrad Prebys Center for Chemical Genomics (D.T., D.M., L.H.S.) and Cardiopathobiology Program, Diabetes and Obesity Research Center (D.M., L.H.S.), Sanford Burnham Medical Research Institute at Lake Nona, Orlando FL.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.003192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933362PMC
November 2013

Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?

Kidney Int 2013 Oct 13;84(4):693-702. Epub 2013 Mar 13.

United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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http://dx.doi.org/10.1038/ki.2013.74DOI Listing
October 2013

TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells.

Thromb Res 2013 Jul 20;132(1):100-5. Epub 2013 Apr 20.

Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1016/j.thromres.2013.04.003DOI Listing
July 2013

Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression.

Int J Mol Sci 2013 Jul 29;14(8):15724-39. Epub 2013 Jul 29.

Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.3390/ijms140815724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759882PMC
July 2013

A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.

Arterioscler Thromb Vasc Biol 2013 May 7;33(5):935-42. Epub 2013 Mar 7.

Division of Molecular Medicine and Therapy, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1161/ATVBAHA.113.301224DOI Listing
May 2013

Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats.

Hypertens Res 2013 Apr 31;36(4):361-7. Epub 2013 Jan 31.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1038/hr.2012.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619051PMC
April 2013

[New perspective for drug discovery and clinical development in kidney disease].

Nihon Jinzo Gakkai Shi 2012 ;54(5):610-4

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January 2013

Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.

J Biochem 2012 Dec 11;152(6):549-55. Epub 2012 Sep 11.

Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan.

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http://dx.doi.org/10.1093/jb/mvs100DOI Listing
December 2012

The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

Kidney Int 2012 Oct 23;82(7):759-70. Epub 2012 May 23.

Key Lab for Organ Failure Research, Ministry of Education, Division of Nephrology, Research Institute of Nephrology Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/ki.2012.184DOI Listing
October 2012

High plasma pentosidine level is accompanied with cardiovascular events in hemodialysis patients.

Clin Exp Nephrol 2012 Jun 9;16(3):421-6. Epub 2011 Dec 9.

Renal Division, Department of Internal Medicine, Iwata City Hospital, Iwata, Japan.

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http://dx.doi.org/10.1007/s10157-011-0573-3DOI Listing
June 2012

Successful repair for isolated cleft mitral valve diagnosed by three-dimensional transesophageal echocardiography.

J Heart Valve Dis 2012 May;21(3):412

Division of Cardiovascular Surgery, Sakurabashi Watanabe Hospital, Osaka, Japan.

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May 2012

Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics.

Amino Acids 2012 Apr 20;42(4):1193-204. Epub 2010 Oct 20.

Department of Internal Medicine, University Hospital Maastricht, P. Debyelaan 25, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.

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http://link.springer.com/10.1007/s00726-010-0779-9
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http://dx.doi.org/10.1007/s00726-010-0779-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296013PMC
April 2012

Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis.

Am J Respir Cell Mol Biol 2012 Jan;46(1):87-95

Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, 35294-0022, USA.

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http://dx.doi.org/10.1165/rcmb.2011-0139OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262658PMC
January 2012

Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors.

Chem Pharm Bull (Tokyo) 2011 ;59(2):215-24

CT Laboratory, Hamari Chemicals, Ltd., Osaka, Japan.

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http://dx.doi.org/10.1248/cpb.59.215DOI Listing
December 2011

Glyoxalase I retards renal senescence.

Am J Pathol 2011 Dec 12;179(6):2810-21. Epub 2011 Oct 12.

Division of Nephrology and Endocrinology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.ajpath.2011.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260855PMC
December 2011

[Drug discovery and development in academia].

Authors:
Toshio Miyata

Rinsho Shinkeigaku 2011 Nov;51(11):1084

United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine.

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http://dx.doi.org/10.5692/clinicalneurol.51.1084DOI Listing
November 2011

[Molecular pathophysiology of schizophrenia and preventive strategy in pubertal period].

Seishin Shinkeigaku Zasshi 2011 ;113(7):672-8

Project for Schizophrenia and Affective Disorders Research, Tokyo Metropolitan Institute of Medical Science.

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October 2011

Skin advanced glycation end product accumulation and muscle strength among adult men.

Eur J Appl Physiol 2011 Jul 25;111(7):1545-52. Epub 2010 Dec 25.

Department of Medicine and Science in Sports and Exercise, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1007/s00421-010-1779-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114099PMC
July 2011

New era for drug discovery and development in renal disease.

Nat Rev Nephrol 2011 Jul 5;7(8):469-77. Epub 2011 Jul 5.

United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1038/nrneph.2011.84DOI Listing
July 2011

Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease.

J Stroke Cerebrovasc Dis 2011 Mar-Apr;20(2):111-6. Epub 2010 Jun 26.

Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2009.11.008DOI Listing
June 2011

Advanced glycation end products, carotid atherosclerosis, and circulating endothelial progenitor cells in patients with end-stage renal disease.

Metabolism 2011 Apr 24;60(4):453-9. Epub 2010 May 24.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

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http://dx.doi.org/10.1016/j.metabol.2010.04.001DOI Listing
April 2011

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets.

Am J Physiol Cell Physiol 2011 Feb 27;300(2):C226-31. Epub 2010 Oct 27.

United Centers for Advanced Research and Translational Medicine, Tohoku University School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1152/ajpcell.00430.2010DOI Listing
February 2011

Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.

J Biol Chem 2011 Jan 5;286(2):1374-80. Epub 2010 Nov 5.

Department of Internal Medicine, Division of General Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M110.144097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020745PMC
January 2011

[Translational research of novel PAI-1 inhibitors].

Nihon Yakurigaku Zasshi 2010 Dec;136(6):340-3

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http://dx.doi.org/10.1254/fpj.136.340DOI Listing
December 2010

Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.

Hypertension 2010 Sep 19;56(3):471-6. Epub 2010 Jul 19.

Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.156786DOI Listing
September 2010

Relationship of skin autofluorescence to cardiovascular disease in Japanese hemodialysis patients.

Ther Apher Dial 2010 Jun;14(3):334-40

Division of Nephrology and Hypertension, Fukushima Medical University Hospital, Hikarigaoka, Fukushima, Japan.

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http://dx.doi.org/10.1111/j.1744-9987.2009.00782.xDOI Listing
June 2010

A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates.

J Cereb Blood Flow Metab 2010 May 20;30(5):904-12. Epub 2010 Jan 20.

Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Miyagi, Aoba-ku, Sendai, Japan.

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http://dx.doi.org/10.1038/jcbfm.2009.272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949193PMC
May 2010

Structure-activity relationships of new 2-acylamino-3-thiophenecarboxylic acid dimers as plasminogen activator inhibitor-1 inhibitors.

Chem Pharm Bull (Tokyo) 2010 May;58(5):615-9

CT Laboratory, Hamari Chemicals, Ltd., 1-4-29 Kunijima, Higashiyodogawa-ku, Osaka 533-0024, Japan.

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http://dx.doi.org/10.1248/cpb.58.615DOI Listing
May 2010

Advanced glycation end-products, anti-hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction.

Eur J Heart Fail 2010 Apr 12;12(4):397-403. Epub 2010 Feb 12.

Department of Cardiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, The Netherlands.

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http://doi.wiley.com/10.1093/eurjhf/hfq001
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http://dx.doi.org/10.1093/eurjhf/hfq001DOI Listing
April 2010

Diabetic nephropathy: a disorder of oxygen metabolism?

Nat Rev Nephrol 2010 Feb 15;6(2):83-95. Epub 2009 Dec 15.

Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

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http://dx.doi.org/10.1038/nrneph.2009.211DOI Listing
February 2010

Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression.

Arterioscler Thromb Vasc Biol 2009 Dec 17;29(12):2132-7. Epub 2009 Sep 17.

Departments of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

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http://dx.doi.org/10.1161/ATVBAHA.109.196071DOI Listing
December 2009

Angiotensin II type 1A receptor deficiency and longevity.

Nephrol Dial Transplant 2009 Nov 7;24(11):3280-1. Epub 2009 Aug 7.

Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.

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http://dx.doi.org/10.1093/ndt/gfp381DOI Listing
November 2009