Publications by authors named "Toshio Kitamura"

100Publications

Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia.

Cell Rep 2020 Sep;32(13):108200

Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Yamagata 997-0052, Japan; Division of Hematological Malignancy, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108200DOI Listing
September 2020

Efficacy of tyrosine kinase inhibitors on a mouse chronic myeloid leukemia model and chronic myeloid leukemia stem cells.

Exp Hematol 2020 Sep 7. Epub 2020 Sep 7.

Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.exphem.2020.09.186DOI Listing
September 2020

Exp Hematol 2020 03 7;83. Epub 2020 Feb 7.

Terry Fox Laboratory, BC Cancer, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.exphem.2020.02.002DOI Listing
March 2020

ASXL1 mutation in clonal hematopoiesis.

Exp Hematol 2020 03 13;83:74-84. Epub 2020 Jan 13.

Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2020.01.002DOI Listing
March 2020

Epigenetic abnormalities and therapies for hematological malignancies.

Authors:
Toshio Kitamura

Int J Hematol 2019 Aug 6;110(2):147-149. Epub 2019 Jul 6.

Institute of Medical Science, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1007/s12185-019-02691-1DOI Listing
August 2019

Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms.

Sci Rep 2019 06 3;9(1):8171. Epub 2019 Jun 3.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-019-44496-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547685PMC
June 2019

The role of ASXL1 in hematopoiesis and myeloid malignancies.

Cell Mol Life Sci 2019 Jul 30;76(13):2511-2523. Epub 2019 Mar 30.

Division of Cellular Therapy, Advanced Clinical Research Center, and Division of Stem Cell Signaling, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 1088639, Japan.

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http://dx.doi.org/10.1007/s00018-019-03084-7DOI Listing
July 2019

Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasms.

Int J Hematol 2019 Aug 5;110(2):179-186. Epub 2018 Dec 5.

Division of Cellular Therapy, Advanced Clinical Research Center, Division of Stem Cell Signaling, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 1088639, Japan.

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http://dx.doi.org/10.1007/s12185-018-2563-7DOI Listing
August 2019

Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils.

Sci Rep 2018 11 27;8(1):17406. Epub 2018 Nov 27.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.

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http://dx.doi.org/10.1038/s41598-018-35699-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258681PMC
November 2018

ASXL1 as a critical regulator of epigenetic marks and therapeutic potential of mutated cells.

Oncotarget 2018 Oct 16;9(81):35203-35204. Epub 2018 Oct 16.

Daichi Inoue: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Zuckerman, New York, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.26230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219660PMC
October 2018

ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation.

Sci Rep 2018 10 26;8(1):15873. Epub 2018 Oct 26.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

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http://www.nature.com/articles/s41598-018-33881-2
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http://dx.doi.org/10.1038/s41598-018-33881-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203835PMC
October 2018

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance.

Nat Immunol 2018 11 15;19(11):1265-1276. Epub 2018 Oct 15.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

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http://www.nature.com/articles/s41590-018-0222-z
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http://dx.doi.org/10.1038/s41590-018-0222-zDOI Listing
November 2018

The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program.

Biochem Biophys Res Commun 2018 11 9;505(3):905-909. Epub 2018 Oct 9.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183214
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http://dx.doi.org/10.1016/j.bbrc.2018.10.006DOI Listing
November 2018

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.

Nat Commun 2018 07 16;9(1):2733. Epub 2018 Jul 16.

Division of Cellular Therapy, Advanced Clinical Research Center, and Division of Stem Cell Signaling, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, 1088639, Japan.

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http://dx.doi.org/10.1038/s41467-018-05085-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048047PMC
July 2018

Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice.

Sci Rep 2018 01 23;8(1):1408. Epub 2018 Jan 23.

Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.

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http://dx.doi.org/10.1038/s41598-018-19844-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780462PMC
January 2018

mutations gain a function.

Authors:
Toshio Kitamura

Blood 2018 01;131(3):274-275

University of Tokyo.

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http://dx.doi.org/10.1182/blood-2017-12-816595DOI Listing
January 2018

Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels.

Biochem Biophys Res Commun 2018 01 24;495(3):2310-2316. Epub 2017 Dec 24.

Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.12.135DOI Listing
January 2018

Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections.

J Invest Dermatol 2018 05 5;138(5):1221-1224. Epub 2017 Dec 5.

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.11.025DOI Listing
May 2018

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.

J Biol Chem 2017 07 23;292(30):12528-12541. Epub 2017 May 23.

From the Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 and

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http://dx.doi.org/10.1074/jbc.M117.785675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535027PMC
July 2017

Epigenetics in normal and malignant hematopoiesis: An overview and update 2017.

Cancer Sci 2017 Apr 20;108(4):553-562. Epub 2017 Apr 20.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1111/cas.13168
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http://dx.doi.org/10.1111/cas.13168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406607PMC
April 2017

Leaving IJH: joining to fly.

Int J Hematol 2017 Jan 5;105(1):1-2. Epub 2016 Dec 5.

Department of Hematology and Oncology, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1007/s12185-016-2136-6DOI Listing
January 2017

Neuropathic pain in patients with rotator cuff tears.

BMC Musculoskelet Disord 2016 11 2;17(1):451. Epub 2016 Nov 2.

Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Central Ward, Kumamoto City, 860-8556, Japan.

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http://dx.doi.org/10.1186/s12891-016-1311-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094022PMC
November 2016

Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia.

Exp Hematol 2016 08 9;44(8):745-754.e4. Epub 2016 May 9.

Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; Department of Molecular Laboratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Central Clinical Laboratory, Kumamoto University Hospital, Kumamoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.04.017DOI Listing
August 2016

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.

Exp Hematol 2016 Mar 15;44(3):172-6.e1. Epub 2015 Dec 15.

Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.11.011DOI Listing
March 2016

Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.

Gut 2016 May 11;65(5):777-87. Epub 2015 Feb 11.

Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1136/gutjnl-2014-308900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853571PMC
May 2016

A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.

Exp Hematol 2015 Apr 20;43(4):300-8.e1. Epub 2014 Dec 20.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.11.011DOI Listing
April 2015

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.

Nat Commun 2014 Jun 23;5:4177. Epub 2014 Jun 23.

1] Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan [2] JST, CREST, 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.

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http://dx.doi.org/10.1038/ncomms5177DOI Listing
June 2014

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.

Blood 2014 Jun 13;123(25):3932-42. Epub 2014 May 13.

Division of Cellular Therapy, Advanced Clinical Research Center, Division of Stem Cell Signaling, Center for Stem Cell Therapy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

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http://dx.doi.org/10.1182/blood-2013-01-476747DOI Listing
June 2014

A promoter-level mammalian expression atlas.

Authors:
Alistair R R Forrest Hideya Kawaji Michael Rehli J Kenneth Baillie Michiel J L de Hoon Vanja Haberle Timo Lassmann Ivan V Kulakovskiy Marina Lizio Masayoshi Itoh Robin Andersson Christopher J Mungall Terrence F Meehan Sebastian Schmeier Nicolas Bertin Mette Jørgensen Emmanuel Dimont Erik Arner Christian Schmidl Ulf Schaefer Yulia A Medvedeva Charles Plessy Morana Vitezic Jessica Severin Colin A Semple Yuri Ishizu Robert S Young Margherita Francescatto Intikhab Alam Davide Albanese Gabriel M Altschuler Takahiro Arakawa John A C Archer Peter Arner Magda Babina Sarah Rennie Piotr J Balwierz Anthony G Beckhouse Swati Pradhan-Bhatt Judith A Blake Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher A Maxwell Burroughs Andrea Califano Carlo V Cannistraci Daniel Carbajo Yun Chen Marco Chierici Yari Ciani Hans C Clevers Emiliano Dalla Carrie A Davis Michael Detmar Alexander D Diehl Taeko Dohi Finn Drabløs Albert S B Edge Matthias Edinger Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Michela Fagiolini Lynsey Fairbairn Hai Fang Mary C Farach-Carson Geoffrey J Faulkner Alexander V Favorov Malcolm E Fisher Martin C Frith Rie Fujita Shiro Fukuda Cesare Furlanello Masaaki Furino Jun-ichi Furusawa Teunis B Geijtenbeek Andrew P Gibson Thomas Gingeras Daniel Goldowitz Julian Gough Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Matthias Harbers Jayson Harshbarger Akira Hasegawa Yuki Hasegawa Takehiro Hashimoto Meenhard Herlyn Kelly J Hitchens Shannan J Ho Sui Oliver M Hofmann Ilka Hoof Furni Hori Lukasz Huminiecki Kei Iida Tomokatsu Ikawa Boris R Jankovic Hui Jia Anagha Joshi Giuseppe Jurman Bogumil Kaczkowski Chieko Kai Kaoru Kaida Ai Kaiho Kazuhiro Kajiyama Mutsumi Kanamori-Katayama Artem S Kasianov Takeya Kasukawa Shintaro Katayama Sachi Kato Shuji Kawaguchi Hiroshi Kawamoto Yuki I Kawamura Tsugumi Kawashima Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura S Peter Klinken Alan J Knox Miki Kojima Soichi Kojima Naoto Kondo Haruhiko Koseki Shigeo Koyasu Sarah Krampitz Atsutaka Kubosaki Andrew T Kwon Jeroen F J Laros Weonju Lee Andreas Lennartsson Kang Li Berit Lilje Leonard Lipovich Alan Mackay-Sim Ri-ichiroh Manabe Jessica C Mar Benoit Marchand Anthony Mathelier Niklas Mejhert Alison Meynert Yosuke Mizuno David A de Lima Morais Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Efthymios Motakis Hozumi Motohashi Christine L Mummery Mitsuyoshi Murata Sayaka Nagao-Sato Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Kenichi Nakazato Erik van Nimwegen Noriko Ninomiya Hiromi Nishiyori Shohei Noma Shohei Noma Tadasuke Noazaki Soichi Ogishima Naganari Ohkura Hiroko Ohimiya Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Arnab Pain Robert Passier Margaret Patrikakis Helena Persson Silvano Piazza James G D Prendergast Owen J L Rackham Jordan A Ramilowski Mamoon Rashid Timothy Ravasi Patrizia Rizzu Marco Roncador Sugata Roy Morten B Rye Eri Saijyo Antti Sajantila Akiko Saka Shimon Sakaguchi Mizuho Sakai Hiroki Sato Suzana Savvi Alka Saxena Claudio Schneider Erik A Schultes Gundula G Schulze-Tanzil Anita Schwegmann Thierry Sengstag Guojun Sheng Hisashi Shimoji Yishai Shimoni Jay W Shin Christophe Simon Daisuke Sugiyama Takaai Sugiyama Masanori Suzuki Naoko Suzuki Rolf K Swoboda Peter A C 't Hoen Michihira Tagami Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Zuotian Tatum Mark Thompson Hiroo Toyodo Tetsuro Toyoda Elvind Valen Marc van de Wetering Linda M van den Berg Roberto Verado Dipti Vijayan Ilya E Vorontsov Wyeth W Wasserman Shoko Watanabe Christine A Wells Louise N Winteringham Ernst Wolvetang Emily J Wood Yoko Yamaguchi Masayuki Yamamoto Misako Yoneda Yohei Yonekura Shigehiro Yoshida Susan E Zabierowski Peter G Zhang Xiaobei Zhao Silvia Zucchelli Kim M Summers Harukazu Suzuki Carsten O Daub Jun Kawai Peter Heutink Winston Hide Tom C Freeman Boris Lenhard Vladimir B Bajic Martin S Taylor Vsevolod J Makeev Albin Sandelin David A Hume Piero Carninci Yoshihide Hayashizaki

Nature 2014 Mar;507(7493):462-70

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http://dx.doi.org/10.1038/nature13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529748PMC
March 2014

Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3.

Int J Hematol 2014 Apr 22;99(4):393-406. Epub 2014 Feb 22.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.

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http://dx.doi.org/10.1007/s12185-014-1534-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412171PMC
April 2014

[An inhibitory receptor LMIR3/CD300f recognizes ceramide].

Seikagaku 2013 Dec;85(12):1071-5

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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December 2013

A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition.

Sci Rep 2014 Feb 6;4:4012. Epub 2014 Feb 6.

1] Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan [2] Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/srep04012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915272PMC
February 2014

Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis.

Exp Hematol 2014 May 31;42(5):369-379.e3. Epub 2014 Jan 31.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.01.009DOI Listing
May 2014

Age-related epigenetic drift in the pathogenesis of MDS and AML.

Genome Res 2014 Apr 10;24(4):580-91. Epub 2014 Jan 10.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA;

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http://dx.doi.org/10.1101/gr.157529.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975058PMC
April 2014

Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation.

J Allergy Clin Immunol 2014 Jan 12;133(1):270-3.e1-7. Epub 2013 Sep 12.

Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.08.008DOI Listing
January 2014

Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins.

Genes Cells 2013 Sep 25;18(9):810-22. Epub 2013 Jul 25.

Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8503, Japan.

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http://dx.doi.org/10.1111/gtc.12078DOI Listing
September 2013

Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells.

Blood 2013 Aug 9;122(7):1271-83. Epub 2013 Jul 9.

Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Edobashi, Tsu, Japan.

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http://dx.doi.org/10.1182/blood-2012-09-456665DOI Listing
August 2013

APC(CDH1) targets MgcRacGAP for destruction in the late M phase.

PLoS One 2013 16;8(5):e63001. Epub 2013 May 16.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656054PMC
December 2013

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.

Blood 2013 Apr 7;121(17):3434-46. Epub 2013 Mar 7.

Division of Radiation Information Registry, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-06-43
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http://dx.doi.org/10.1182/blood-2012-06-434423DOI Listing
April 2013

Guest editorial: Genetic and epigenetic alterations in hematopoietic malignancies.

Authors:
Toshio Kitamura

Int J Hematol 2013 Feb 9;97(2):163-4. Epub 2013 Feb 9.

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http://dx.doi.org/10.1007/s12185-013-1284-1DOI Listing
February 2013

The molecular profiles of neural stem cell niche in the adult subventricular zone.

PLoS One 2012 29;7(11):e50501. Epub 2012 Nov 29.

Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050501PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510163PMC
May 2013

[Molecules of signal transduction].

Nihon Rinsho 2012 Apr;70 Suppl 2:69-74

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo.

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April 2012

Passing a baton to the next generation.

Int J Hematol 2012 Nov;96(5):529-30

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http://dx.doi.org/10.1007/s12185-012-1203-xDOI Listing
November 2012

Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development.

J Biol Chem 2012 Dec 24;287(51):42455-68. Epub 2012 Oct 24.

Department of Biochemistry, Institute of Health Biosciences, Graduate School, Faculty of Medicine, University of Tokushima , Tokushima, Japan.

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http://dx.doi.org/10.1074/jbc.M112.383653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522248PMC
December 2012

Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice.

Int J Hematol 2012 Nov 25;96(5):638-48. Epub 2012 Oct 25.

Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1007/s12185-012-1207-6DOI Listing
November 2012

MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia.

Int J Hematol 2012 Sep 28;96(3):334-41. Epub 2012 Jul 28.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1007/s12185-012-1143-5DOI Listing
September 2012

PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.

Int Immunol 2012 Oct 25;24(10):613-23. Epub 2012 Jul 25.

Division of Infectious Genetics, Department of Microbiology and Immunology, University of Tokyo, Minatoku, Tokyo108-8639, Japan.

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http://dx.doi.org/10.1093/intimm/dxs068DOI Listing
October 2012

HDACI-induced thrombocytopenia is caused by its unexpected target.

Exp Hematol 2012 Sep 4;40(9):695-7. Epub 2012 Jul 4.

Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.exphem.2012.07.001DOI Listing
September 2012

Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models.

Int J Hematol 2012 Feb 22;95(2):167-75. Epub 2011 Dec 22.

Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

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http://dx.doi.org/10.1007/s12185-011-0994-5DOI Listing
February 2012

IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells.

Int J Oncol 2012 Jan 7;40(1):53-62. Epub 2011 Sep 7.

Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Mie 514-8507, Japan.

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http://www.spandidos-publications.com/10.3892/ijo.2011.1192
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http://dx.doi.org/10.3892/ijo.2011.1192DOI Listing
January 2012

Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning.

Int J Oncol 2012 Jan 19;40(1):93-8. Epub 2011 Aug 19.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.3892/ijo.2011.1173DOI Listing
January 2012

[STAT3 inhibitor].

Authors:
Toshio Kitamura

Gan To Kagaku Ryoho 2011 Jan;38(1):19-22

Division of Cellular Therapy and Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, Japan.

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January 2011

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

Blood 2011 Mar 2;117(13):3617-28. Epub 2011 Feb 2.

Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1182/blood-2009-12-261602DOI Listing
March 2011

Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5.

J Biol Chem 2010 Nov 3;285(46):35274-83. Epub 2010 Sep 3.

Division of Cellular Therapy, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1074/jbc.M110.137166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975151PMC
November 2010

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.

Blood 2010 Nov 26;116(22):4474-82. Epub 2010 Aug 26.

Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-01-26
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http://dx.doi.org/10.1182/blood-2010-01-266528DOI Listing
November 2010

Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.

Dev Biol 2010 Jan 13;337(2):405-14. Epub 2009 Nov 13.

Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo, Kobe 650-0047, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060901359
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http://dx.doi.org/10.1016/j.ydbio.2009.11.013DOI Listing
January 2010

[Cytogenetic abnormalities and gene mutations in myeloid leukemia].

Nihon Rinsho 2009 Oct;67(10):1875-9

Division of Cellullar Therapy, The Institute of Medical Science, The University of Tokyo.

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October 2009