Publications by authors named "Toshikazu Ushijima"

100Publications

Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level.

Clin Epigenetics 2020 Sep 21;12(1):142. Epub 2020 Sep 21.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1186/s13148-020-00937-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507826PMC
September 2020

Comparison of involved field radiotherapy and elective nodal irradiation in combination with concurrent chemotherapy for T1bN0M0 esophageal cancer.

Int J Clin Oncol 2020 Jun 18;25(6):1098-1104. Epub 2020 Mar 18.

Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10147-020-01652-7DOI Listing
June 2020

Clinicopathological and molecular correlations in traditional serrated adenoma.

J Gastroenterol 2020 Apr 12;55(4):418-427. Epub 2020 Feb 12.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00535-020-01673-zDOI Listing
April 2020

RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.

Nat Commun 2019 12 20;10(1):5805. Epub 2019 Dec 20.

Precision Medicine Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon, Gyeonggi-do, 16229, Republic of Korea.

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http://dx.doi.org/10.1038/s41467-019-13852-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925134PMC
December 2019

Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori.

Clin Epigenetics 2019 12 11;11(1):191. Epub 2019 Dec 11.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1186/s13148-019-0789-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907118PMC
December 2019

Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways.

Gastric Cancer 2020 01 25;23(1):105-115. Epub 2019 Sep 25.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10120-019-01010-1DOI Listing
January 2020

Novel prodrugs of decitabine with greater metabolic stability and less toxicity.

Clin Epigenetics 2019 08 1;11(1):111. Epub 2019 Aug 1.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1186/s13148-019-0709-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670186PMC
August 2019

LINC00162 confers sensitivity to 5-Aza-2'-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1.

Oncogene 2019 06 26;38(26):5281-5293. Epub 2019 Mar 26.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1038/s41388-019-0792-8DOI Listing
June 2019

DNA methylation genome-wide analysis in remnant and primary gastric cancers.

Gastric Cancer 2019 11 12;22(6):1109-1120. Epub 2019 Mar 12.

Department of Surgery, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 600N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.

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http://link.springer.com/10.1007/s10120-019-00949-5
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http://dx.doi.org/10.1007/s10120-019-00949-5DOI Listing
November 2019

Accumulation of genetic and epigenetic alterations in normal cells and cancer risk.

NPJ Precis Oncol 2019 6;3. Epub 2019 Mar 6.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045 Tokyo, Japan.

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http://dx.doi.org/10.1038/s41698-019-0079-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403339PMC
March 2019

The Origin of CIMP, At Last.

Cancer Cell 2019 02;35(2):165-167

Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, Sapporo 060-8556, Japan.

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http://dx.doi.org/10.1016/j.ccell.2019.01.015DOI Listing
February 2019

BRAF inhibitor: a novel therapy for ameloblastoma in mandible.

Chin J Cancer Res 2018 Dec;30(6):677-678

Department of Oral & Maxillofacial Surgery, University of Tokyo Hospital, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.21147/j.issn.1000-9604.2018.06.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328504PMC
December 2018

Invasive breast cancers in adolescent and young adult women show more aggressive immunohistochemical and clinical features than those in women aged 40-44 years.

Breast Cancer 2019 May 11;26(3):386-396. Epub 2018 Dec 11.

Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s12282-018-00937-0DOI Listing
May 2019

Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.

Acta Neuropathol Commun 2018 12 4;6(1):134. Epub 2018 Dec 4.

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-018-0630-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278135PMC
December 2018

DNA methylation marker to estimate the breast cancer cell fraction in DNA samples.

Med Oncol 2018 Sep 14;35(11):147. Epub 2018 Sep 14.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s12032-018-1207-3DOI Listing
September 2018

Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.

Brain Res 2018 10 15;1697:59-66. Epub 2018 Jun 15.

Department of Neurology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00068993183034
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http://dx.doi.org/10.1016/j.brainres.2018.06.017DOI Listing
October 2018

[Epigenetic Alterations in Gastrointestinal Cancers: Diagnostic and Therapeutic Applications].

Gan To Kagaku Ryoho 2018 Jan;45(1):1-7

Division of Epigenomics, National Cancer Center Research Institute.

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January 2018

MACON: a web tool for computing DNA methylation data obtained by the Illumina Infinium Human DNA methylation BeadArray.

Epigenomics 2018 03 18;10(3):249-258. Epub 2018 Jan 18.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.2217/epi-2017-0093DOI Listing
March 2018

Analysis of DNA Methylation in Tissues Exposed to Inflammation.

Methods Mol Biol 2018 ;1725:185-199

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1007/978-1-4939-7568-6_16DOI Listing
January 2019

PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma.

Cancer Res 2017 10 14;77(19):5259-5271. Epub 2017 Aug 14.

Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3144DOI Listing
October 2017

A novel method to quantify base substitution mutations at the 10 per bp level in DNA samples.

Cancer Lett 2017 09 19;403:152-158. Epub 2017 Jun 19.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.06.010DOI Listing
September 2017

WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps.

Am J Surg Pathol 2017 Sep;41(9):1188-1197

*Division of Pathology and Clinical Laboratories ∥Endoscopy Division, National Cancer Center Hospital †Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine ‡Division of Epigenomics §Division of Chemotherapy and Clinical Research #Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo ¶Division of Pathology, Research Center for Innovative Oncology, National Cancer Center, Chiba, Japan.

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http://dx.doi.org/10.1097/PAS.0000000000000877DOI Listing
September 2017

Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway.

Cancer Lett 2017 08 31;402:100-109. Epub 2017 May 31.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.05.017DOI Listing
August 2017

Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016.

Epigenomics 2017 07 22;9(7):937-941. Epub 2017 May 22.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.2217/epi-2017-0030DOI Listing
July 2017

How to stomach an epigenetic insult: the gastric cancer epigenome.

Nat Rev Gastroenterol Hepatol 2017 Aug 17;14(8):467-478. Epub 2017 May 17.

Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, 8 College Road, 169857 Singapore.

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http://dx.doi.org/10.1038/nrgastro.2017.53DOI Listing
August 2017

Autophagy impairment by Helicobacter pylori-induced methylation silencing of MAP1LC3Av1 promotes gastric carcinogenesis.

Int J Cancer 2017 May 14;140(10):2272-2283. Epub 2017 Mar 14.

Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1002/ijc.30657DOI Listing
May 2017

The Moment that KRAS Mutation Started to Evolve into Precision Medicine in Metastatic Colorectal Cancer.

Cancer Res 2016 11;76(22):6443-6444

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2867DOI Listing
November 2016

Degree of methylation burden is determined by the exposure period to carcinogenic factors.

Cancer Sci 2017 Mar;108(3):316-321

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.13136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378290PMC
March 2017

Establishment of a high-throughput detection system for DNA demethylating agents.

Epigenetics 2018 5;13(2):147-155. Epub 2018 Mar 5.

a Division of Epigenomics , National Cancer Center Research Institute , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan.

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http://dx.doi.org/10.1080/15592294.2016.1267887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873356PMC
December 2018

Molecular mechanisms of gastric carcinogenesis.

Nihon Shokakibyo Gakkai Zasshi 2016 ;113(11):1868-1877

Division of Epigenomics, National Cancer Center Research Institute.

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http://dx.doi.org/10.11405/nisshoshi.113.1868DOI Listing
March 2017

Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway.

Gastric Cancer 2017 Mar 7;20(Suppl 1):8-15. Epub 2016 Oct 7.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10120-016-0650-0DOI Listing
March 2017

High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes.

BMC Cancer 2016 06 3;16:350. Epub 2016 Jun 3.

Department of Oral & Maxillofacial Surgery, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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http://dx.doi.org/10.1186/s12885-016-2371-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891845PMC
June 2016

Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.

J Pathol 2016 06 9;239(2):133-8. Epub 2016 Apr 9.

Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1002/path.4709DOI Listing
June 2016

Epigenetic impact of infection on carcinogenesis: mechanisms and applications.

Genome Med 2016 Jan 28;8(1):10. Epub 2016 Jan 28.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1186/s13073-016-0267-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731931PMC
January 2016

Epigenetic inactivation of FAT4 contributes to gastric field cancerization.

Gastric Cancer 2017 Jan 20;20(1):136-145. Epub 2016 Jan 20.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10120-016-0593-5DOI Listing
January 2017

Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.

Mol Carcinog 2016 12 12;55(12):2077-2088. Epub 2016 Jan 12.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1002/mc.22452DOI Listing
December 2016

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.

Autophagy 2015 ;11(12):2309-22

a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); State Key Laboratory of Natural and Biomimetic Drugs; Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function; Department of Biochemistry and Molecular Biology; Peking University Health Science Center ; Beijing , China.

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http://dx.doi.org/10.1080/15548627.2015.1117734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835210PMC
October 2016

Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study.

Carcinogenesis 2015 Nov 8;36(11):1291-8. Epub 2015 Sep 8.

Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/carcin/bgv125DOI Listing
November 2015

Systemic Administration of Small Interfering RNA Targeting Human Nestin Inhibits Pancreatic Cancer Cell Proliferation and Metastasis.

Pancreas 2016 Jan;45(1):93-100

From the *Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku; †Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School, Bunkyo-ku; and ‡Division of Epigenomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1097/MPA.0000000000000427DOI Listing
January 2016

RHOA mutation may be associated with diffuse-type gastric cancer progression, but is it gain or loss?

Gastric Cancer 2016 Apr 22;19(2):326-328. Epub 2015 Aug 22.

Division of Epigenomics, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10120-015-0525-9DOI Listing
April 2016

Epigenetic mechanisms of chronic pain.

Trends Neurosci 2015 Apr 9;38(4):237-46. Epub 2015 Mar 9.

Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan; Life Science Tokyo Advanced Research Center (L-StaR), 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01662236150003
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http://dx.doi.org/10.1016/j.tins.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459752PMC
April 2015

Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.

Gastric Cancer 2016 Apr 13;19(2):361-369. Epub 2015 Feb 13.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10120-015-0475-2DOI Listing
April 2016

Comprehensive DNA Methylation and Extensive Mutation Analyses of HER2-Positive Breast Cancer.

Oncology 2015 14;88(6):377-84. Epub 2015 Jan 14.

Department of Medical Oncology, Musashino Red Cross Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1159/000369904DOI Listing
August 2015

Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy.

Carcinogenesis 2015 Feb 4;36(2):192-201. Epub 2014 Dec 4.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

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http://carcin.oxfordjournals.org/content/early/2014/12/23/ca
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgu238DOI Listing
February 2015

Frequent involvement of chromatin remodeler alterations in gastric field cancerization.

Cancer Lett 2015 Feb 22;357(1):328-338. Epub 2014 Nov 22.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.11.038DOI Listing
February 2015

Cancer epigenetics: now harvesting fruit and seeding for common diseases.

Biochem Biophys Res Commun 2014 Dec;455(1-2):1-2

Division of Epigenomics, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2014.11.008DOI Listing
December 2014

ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy.

J Cancer Res Clin Oncol 2015 Mar 2;141(3):453-63. Epub 2014 Oct 2.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s00432-014-1841-xDOI Listing
March 2015

Compendium of aberrant DNA methylation and histone modifications in cancer.

Biochem Biophys Res Commun 2014 Dec 4;455(1-2):3-9. Epub 2014 Sep 4.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.08.140DOI Listing
December 2014

Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis.

Clin Cancer Res 2014 Sep 9;20(17):4598-612. Epub 2014 Jul 9.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Etiology, Peking University Cancer Hospital and Institute, Fu-Cheng-Lu, Beijing, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309661PMC
September 2014

DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis.

Dig Dis Sci 2014 Oct 10;59(10):2444-51. Epub 2014 May 10.

Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan,

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http://link.springer.com/content/pdf/10.1007/s10620-014-3193
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http://link.springer.com/10.1007/s10620-014-3193-4
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http://dx.doi.org/10.1007/s10620-014-3193-4DOI Listing
October 2014

Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer.

Gastric Cancer 2015 Jan 9;18(1):65-76. Epub 2014 Feb 9.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10120-014-0348-0DOI Listing
January 2015

Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation.

PLoS One 2013 2;8(12):e82302. Epub 2013 Dec 2.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan ; Esophageal Surgery Division, National Cancer Center Hospital, Tokyo, Japan ; Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082302PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846724PMC
February 2015

[Epigenetics as a novel therapeutic target of cancer].

Gan To Kagaku Ryoho 2013 Nov;40(11):1429-35

Division of Epigenomics, National Cancer Center Research Institute.

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November 2013

Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors.

Cancer Sci 2013 Dec 8;104(12):1575-85. Epub 2013 Nov 8.

Center for Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Japan.

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http://dx.doi.org/10.1111/cas.12298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653529PMC
December 2013

Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis.

Int J Cancer 2014 Apr 8;134(7):1529-38. Epub 2013 Oct 8.

Radiobiology for Children's Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Japan; Radiation Effect Accumulation and Prevention Project, Fukushima Project Headquarters, National Institute of Radiological Sciences, Japan.

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http://dx.doi.org/10.1002/ijc.28480DOI Listing
April 2014

Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1.

Gastric Cancer 2014 Oct 15;17(4):750-6. Epub 2013 Sep 15.

Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10120-013-0298-yDOI Listing
October 2014

Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis.

Cancer Lett 2013 Oct 3;340(1):141-7. Epub 2013 Aug 3.

Division of Epigenomics, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1016/j.canlet.2013.07.034DOI Listing
October 2013

Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.

J Clin Invest 2013 Jul 17;123(7):2935-47. Epub 2013 Jun 17.

Division of Biochemistry and Innovative Cancer Therapeutics and Children's Cancer Research Center, Chiba Cancer Center Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1172/JCI65988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696554PMC
July 2013

Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells.

Nucleic Acids Res 2013 Aug 12;41(15):7231-9. Epub 2013 Jun 12.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan, Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark and Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1093/nar/gkt528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753646PMC
August 2013

Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas.

J Hum Genet 2013 Jul 6;58(7):428-33. Epub 2013 Jun 6.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2013.64DOI Listing
July 2013

EGFR L2 domain mutation is not correlated with resistance to cetuximab in metastatic colorectal cancer patients.

J Cancer Res Clin Oncol 2013 Aug 31;139(8):1391-6. Epub 2013 May 31.

Department of Clinical Oncology, Yamagata University, 2-2-2 Iidanishi, Yamagata, Yamagata, Japan.

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http://dx.doi.org/10.1007/s00432-013-1454-9DOI Listing
August 2013