Toshihisa Ishikawa

Toshihisa Ishikawa

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Toshihisa Ishikawa

Publications by authors named "Toshihisa Ishikawa"

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Development of mediastinal adenitis six weeks after endobronchial ultrasound-guided transbronchial needle aspiration.

Respir Med Case Rep 2018 25;25:161-164. Epub 2018 Aug 25.

Department of Respiratory Internal Medicine, Yokosuka Kyosai Hospital, 1-16 Yonegahama dori, Yokosuka, Kanagawa, 238-8558, Japan.

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http://dx.doi.org/10.1016/j.rmcr.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115609PMC
August 2018

[FAMILIAL SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS INDUCED IN SUMMER AND WINTER AT THE WORK PLACE].

Arerugi 2017;66(10):1236-1239

Medical Center for Allergic and Immune Diseases, Yokohama City Minato Red Cross Hospital.

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http://dx.doi.org/10.15036/arerugi.66.1236DOI Listing
June 2018

Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?

Med Hypotheses 2018 May 24;114:19-22. Epub 2018 Feb 24.

Department of Otorhinolaryngology, Head & Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; HNO Praxis Prof. Sertel, Rottstraße 39, 67061 Ludwigshafen am Rhein, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03069877173105
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http://dx.doi.org/10.1016/j.mehy.2018.02.030DOI Listing
May 2018

Assessment of safety of 5-aminolevulinic acid-mediated photodynamic therapy in rat brain.

Photodiagnosis Photodyn Ther 2018 Mar 4;21:367-374. Epub 2018 Feb 4.

NGO Personalized Medicine & Healthcare, Saijo, Japan.

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http://dx.doi.org/10.1016/j.pdpdt.2018.02.002DOI Listing
March 2018

Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis.

Int J Mol Sci 2017 Feb 15;18(2). Epub 2017 Feb 15.

Department of Pharmacy, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.3390/ijms18020417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343951PMC
February 2017

Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence.

Biomed Res Int 2016 23;2016:7670483. Epub 2016 Feb 23.

RIKEN Center for Life Science Technology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan; NGO Personalized Medicine & Healthcare, Yokohama 226-0016, Japan.

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http://dx.doi.org/10.1155/2016/7670483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781944PMC
January 2017

ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population.

BMC Genet 2016 06 13;17(1):79. Epub 2016 Jun 13.

Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1186/s12863-016-0390-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906899PMC
June 2016

Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor.

Adv Cancer Res 2015 8;125:197-216. Epub 2015 Jan 8.

Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan.

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http://dx.doi.org/10.1016/bs.acr.2014.11.008DOI Listing
October 2015

ABC transporters and cancer. Preface.

Adv Cancer Res 2015 ;125:xv-xvii

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http://dx.doi.org/10.1016/S0065-230X(15)00010-XDOI Listing
October 2015

Genetic polymorphism in the NRF2 gene as a prognosis marker for cancer chemotherapy.

Front Genet 2014 4;5:383. Epub 2014 Nov 4.

Personalized Medicine Research Institute, NGO Personalized Medicine and Healthcare, Yokohama Japan ; RIKEN Center for Life Science Technologies, Yokohama Japan.

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http://dx.doi.org/10.3389/fgene.2014.00383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219421PMC
November 2014

Gefitinib enhances the antitumor activity of CPT-11 in vitro and in vivo by inhibiting ABCG2 but not ABCB1: a new clue to circumvent gastrointestinal toxicity risk.

Chemotherapy 2013 17;59(4):260-72. Epub 2014 Jan 17.

Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University, Tokyo, Japan.

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http://dx.doi.org/10.1159/000357772DOI Listing
October 2014

Clinical SNP detection by the SmartAmp method.

Methods Mol Biol 2013 ;1015:55-69

Center for Life Science Technologies, RIKEN, Yokohama, Japan.

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http://dx.doi.org/10.1007/978-1-62703-435-7_3DOI Listing
February 2014

Methods to examine the impact of nonsynonymous SNPs on protein degradation and function of human ABC transporter.

Methods Mol Biol 2013 ;1015:225-50

Center for Life Science Technologies, RIKEN, Yokohama, Japan.

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http://dx.doi.org/10.1007/978-1-62703-435-7_15DOI Listing
February 2014

Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1.

Phytomedicine 2014 Feb 14;21(3):323-32. Epub 2013 Oct 14.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113130032
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http://dx.doi.org/10.1016/j.phymed.2013.08.024DOI Listing
February 2014

Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout Risk.

Pharmaceuticals (Basel) 2013 Nov 4;6(11):1347-60. Epub 2013 Nov 4.

RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-1145, Japan.

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http://dx.doi.org/10.3390/ph6111347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854015PMC
November 2013

Human ABC transporter ABCG2 in cancer chemotherapy: drug molecular design to circumvent multidrug resistance.

Methods Mol Biol 2012 ;910:267-78

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

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http://dx.doi.org/10.1007/978-1-61779-965-5_11DOI Listing
September 2013

Role of Nrf2 in cancer photodynamic therapy: regulation of human ABC transporter ABCG2.

J Pharm Sci 2013 Sep 6;102(9):3058-69. Epub 2013 May 6.

RIKEN Center for Life Science Technologies, Tsurumi-ku, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1002/jps.23563DOI Listing
September 2013

ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression.

Pharmacogenomics 2013 Sep;14(12):1433-48

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.2217/pgs.13.139DOI Listing
September 2013

NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway.

Oncol Rep 2013 Apr 24;29(4):1492-500. Epub 2013 Jan 24.

Department of Pathology and Oncology, Juntendo University School of Medicine, Bunkyo, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.3892/or.2013.2249DOI Listing
April 2013

Gefitinib enhances the efficacy of photodynamic therapy using 5-aminolevulinic acid in malignant brain tumor cells.

Photodiagnosis Photodyn Ther 2013 Feb 20;10(1):42-50. Epub 2012 Jul 20.

Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan; Department of Neurosurgery, Pu Nan Hospital, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1016/j.pdpdt.2012.06.003DOI Listing
February 2013

Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion.

Front Genet 2012 2;3:306. Epub 2013 Jan 2.

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology Yokohama, Japan ; Omics Science Center, RIKEN Yokohama Institute Yokohama, Japan.

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http://dx.doi.org/10.3389/fgene.2012.00306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539816PMC
January 2013

The SmartAmp method: rapid detection of SNPs in thiopurine S-methyltransferase and ABC transporters ABCC4 and ABCG2.

Curr Drug Metab 2012 Sep;13(7):968-77

RIKEN Omics Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Japan.

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http://dx.doi.org/10.2174/138920012802138543DOI Listing
September 2012

Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro.

Photodiagnosis Photodyn Ther 2012 Sep 4;9(3):204-14. Epub 2012 Jan 4.

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1016/j.pdpdt.2011.12.004DOI Listing
September 2012

Identification of a novel locus associated with recurrence-free survival in Japanese breast cancer patients receiving adjuvant tamoxifen therapy.

Pharmacogenomics 2012 Jul;13(9):994-5

Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.2217/pgs.12.100DOI Listing
July 2012

Genetic variants in the human SLCO1B1 gene and individual variations in methotrexate clearance.

Pharmacogenomics 2012 Jul;13(9):993-4

Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.2217/pgs.12.74DOI Listing
July 2012

Ubiquitin-mediated proteasomal degradation of ABC transporters: a new aspect of genetic polymorphisms and clinical impacts.

J Pharm Sci 2011 Sep 12;100(9):3602-19. Epub 2011 May 12.

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1002/jps.22615DOI Listing
September 2011

Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.

Adv Pharmacol Sci 2010 8;2010:587306. Epub 2010 Jul 8.

Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1155/2010/587306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003952PMC
July 2011

Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method.

Clin Chim Acta 2011 Jun 21;412(13-14):1249-51. Epub 2011 Mar 21.

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.

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http://dx.doi.org/10.1016/j.cca.2011.03.017DOI Listing
June 2011

Pharmacogenomics of human ABC transporters: detection of clinically important SNPs by SmartAmp2 method.

Curr Pharm Biotechnol 2011 Apr;12(4):693-704

Omics Science Center, RIKEN Yokohama Institute, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.2174/138920111795164011DOI Listing
April 2011

Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.

Anticancer Res 2010 Dec;30(12):5189-94

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama City University Medical Center, Yokohama, Japan.

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December 2010

Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure.

Anticancer Agents Med Chem 2010 Oct;10(8):617-24

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319924PMC
http://dx.doi.org/10.2174/187152010794473975DOI Listing
October 2010

Emerging new technology: QSAR analysis and MO Calculation to characterize interactions of protein kinase inhibitors with the human ABC transporter, ABCG2 (BCRP).

Drug Metab Pharmacokinet 2010 ;25(1):72-83

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

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http://dx.doi.org/10.2133/dmpk.25.72DOI Listing
June 2010

Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.

Mol Pharm 2009 Nov-Dec;6(6):1678-88

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1021/mp9001156DOI Listing
February 2010

Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.

FEBS J 2009 Dec;276(24):7237-52

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07423.xDOI Listing
December 2009

Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics.

J Exp Ther Oncol 2009 ;8(1):5-24

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259-B-60, Yokohama 226-8501, Japan.

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October 2009

Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP).

AAPS J 2009 Sep 18;11(3):581-9. Epub 2009 Aug 18.

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Yokohama, Japan.

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http://dx.doi.org/10.1208/s12248-009-9137-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758130PMC
September 2009

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?

FASEB J 2009 Jun 21;23(6):2001-13. Epub 2009 Apr 21.

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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http://www.fasebj.org/content/23/6/2001.full.pdf
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http://dx.doi.org/10.1096/fj.09-129098DOI Listing
June 2009

Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.

Pharm Res 2009 Feb 9;26(2):449-58. Epub 2008 Oct 9.

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama, 226-8501, Japan.

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http://dx.doi.org/10.1007/s11095-008-9738-5DOI Listing
February 2009

Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.

Pharm Res 2009 Feb 29;26(2):469-79. Epub 2008 Oct 29.

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama, 226-8501, Japan.

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http://dx.doi.org/10.1007/s11095-008-9752-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628956PMC
February 2009

Emerging trends in human ABC transporters.

Pharm Res 2009 Feb 24;26(2):445-8. Epub 2008 Dec 24.

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http://dx.doi.org/10.1007/s11095-008-9808-8DOI Listing
February 2009

Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy.

J Exp Ther Oncol 2008 ;7(2):153-67

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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January 2009

Quality control of human ABCG2 protein in the endoplasmic reticulum: ubiquitination and proteasomal degradation.

Adv Drug Deliv Rev 2009 Jan 11;61(1):66-72. Epub 2008 Dec 11.

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1016/j.addr.2008.08.008DOI Listing
January 2009

The role of human ABC transporter ABCG2 (BCRP) in pharmacotherapy.

Adv Drug Deliv Rev 2009 Jan 31;61(1):1-2. Epub 2008 Dec 31.

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http://dx.doi.org/10.1016/j.addr.2008.12.001DOI Listing
January 2009

Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2.

Biochem J 2008 May;411(3):623-31

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

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http://biochemj.org/lookup/doi/10.1042/BJ20071229
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http://dx.doi.org/10.1042/BJ20071229DOI Listing
May 2008

Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems.

Expert Opin Drug Metab Toxicol 2008 Mar;4(3):255-72

Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1517/17425255.4.3.255DOI Listing
March 2008

Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4: site-specific expression of mouse Abcg4 in brain.

J Exp Ther Oncol 2007 ;6(4):321-33

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

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January 2008

Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress.

J Exp Ther Oncol 2007 ;6(4):335-48

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.

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January 2008

In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs.

Drug Metab Pharmacokinet 2007 Dec;22(6):428-40

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

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http://dx.doi.org/10.2133/dmpk.22.428DOI Listing
December 2007

[Role of ABC transporters in porphyrin biosynthesis and heme metabolism].

Nihon Yakurigaku Zasshi 2007 Oct;130(4):270-4

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http://dx.doi.org/10.1254/fpj.130.270DOI Listing
October 2007

Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein.

J Biol Chem 2007 Sep 8;282(38):27841-6. Epub 2007 Aug 8.

Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C700133200
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http://dx.doi.org/10.1074/jbc.C700133200DOI Listing
September 2007

The roles of copper transporters in cisplatin resistance.

Cancer Metastasis Rev 2007 Mar;26(1):71-83

Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10555-007-9045-3DOI Listing
March 2007

Genetic polymorphisms of human ABC transporter ABCG2: development of the standard method for functional validation of SNPs by using the Flp recombinase system.

J Exp Ther Oncol 2006 ;6(1):1-11

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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February 2007

Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.

Cancer Sci 2007 Feb;98(2):231-9

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan

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http://dx.doi.org/10.1111/j.1349-7006.2006.00371.xDOI Listing
February 2007

[Genetic polymorphisms of human ABC transporter ABCG2: Porphyria risk and ER quality control].

Seikagaku 2007 Feb;79(2):151-7

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo Institute of Technology B-60 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8501, Japan.

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February 2007

Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture.

Biochem Pharmacol 2007 Jan 12;73(1):34-43. Epub 2006 Sep 12.

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.

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http://dx.doi.org/10.1016/j.bcp.2006.09.002DOI Listing
January 2007

Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump.

Expert Opin Drug Saf 2007 Jan;6(1):71-86

Tokyo Institute of Technology, Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1517/14740338.6.1.71DOI Listing
January 2007

Human ABC transporter ABCG2 in xenobiotic protection and redox biology.

Drug Metab Rev 2006 ;38(3):371-91

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology, Yokohama, Japan.

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http://dx.doi.org/10.1080/03602530600727947DOI Listing
September 2006

High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis.

Mol Pharm 2006 May-Jun;3(3):252-65

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1021/mp060004wDOI Listing
August 2006

Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.

Mol Pharmacol 2006 Jul 11;70(1):287-96. Epub 2006 Apr 11.

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1124/mol.106.023556DOI Listing
July 2006

Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system.

J Exp Ther Oncol 2006 ;5(3):205-22

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8501, Japan.

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May 2006

Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer.

Cancer Lett 2006 Mar 23;234(1):81-9. Epub 2005 Nov 23.

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1016/j.canlet.2005.05.052DOI Listing
March 2006

High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.

Methods Enzymol 2005 ;400:485-510

Department of Biomolecular Engineering, Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Midoriku, Yokohama, Japan.

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http://dx.doi.org/10.1016/S0076-6879(05)00027-3DOI Listing
February 2006

Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells.

Curr Pharm Des 2006 ;12(3):313-25

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.2174/138161206775201992DOI Listing
February 2006

[Pharmacogenomics: current status and future prospectives].

Nihon Rinsho 2005 Dec;63 Suppl 12:50-6

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology.

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December 2005

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.

Expert Opin Pharmacother 2005 Nov;6(14):2455-73

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1517/14656566.6.14.2455DOI Listing
November 2005

Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.

Naturwissenschaften 2005 Oct;92(10):451-63

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama, 226-8501 Japan.

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http://dx.doi.org/10.1007/s00114-005-0019-4DOI Listing
October 2005

Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer.

Bioorg Med Chem Lett 2005 May;15(10):2601-5

Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0500344
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http://dx.doi.org/10.1016/j.bmcl.2005.03.038DOI Listing
May 2005

Does ABCG2 need a heterodimer partner? Expression and functional evaluation of ABCG2 (Arg 482)*.

Drug Metab Pharmacokinet 2002 ;17(2):130-5

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology.

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http://dx.doi.org/10.2133/dmpk.17.130DOI Listing
March 2005

Expression and functional characterization of human ABC transporter ABCG2 variants in insect cells.

Drug Metab Pharmacokinet 2003 ;18(3):194-202

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Kanagawa, Japan.

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http://dx.doi.org/10.2133/dmpk.18.194DOI Listing
March 2005

Human ATP-binding cassette transporter ABCC10: expression profile and p53-dependent upregulation.

J Exp Ther Oncol 2004 Oct;4(3):239-46

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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October 2004

The 24th International Symposium of Sapporo Cancer Seminar "Pharmacogenomics in Cancer Chemotherapy: Recent Advances in ABC Transporters and Genome Analyses". Hokkaido University Conference Hall, Sapporo, Japan, June 20-22, 2004.

J Exp Ther Oncol 2004 Oct;4(3):253-7

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

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October 2004

Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1).

Biol Pharm Bull 2004 Jul;27(7):939-48

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

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http://dx.doi.org/10.1248/bpb.27.939DOI Listing
July 2004

Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid.

J Exp Ther Oncol 2004 Apr;4(1):25-35

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

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April 2004

Functional evaluation of ABCB1 (P-glycoprotein) polymorphisms: high-speed screening and structure-activity relationship analyses.

Drug Metab Pharmacokinet 2004 Feb;19(1):1-14

Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

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http://dx.doi.org/10.2133/dmpk.19.1DOI Listing
February 2004