Publications


Intertumoral Heterogeneity within Medulloblastoma Subgroups.
Cancer Cell 2017 Jun;31(6):737-754.e6
The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:


A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis.
Neurooncol Pract 2016 Dec 7;3(4):272-280. Epub 2016 Jan 7.
Department of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).

Hypoxia-like tissue injury and glial response contribute to Balo concentric lesion development.
Neurology 2016 Nov 12;87(19):2000-2005. Epub 2016 Oct 12.
From the Departments of Neurology (Y.T., T.M., S.N., H.O., H.K., I.N., M.A., K.F.), Multiple Sclerosis Therapeutics (T.M., K.F.), Neurosurgery (R.S., M.K.), Diagnostic Radiology (S.M.), and Pathology (M.W.), Tohoku University Graduate School of Medicine, Sendai; Department of Neurology (T.M.), National Hospital Organization Hachinohe National Hospital; Department of Neurosurgery (Y.S.), Yamagata University School of Medicine; and Department of Neurosurgery (T.K.), Kitasato University School of Medicine, Kanagawa, Japan.


Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.
Lancet Oncol 2016 Apr 12;17(4):484-495. Epub 2016 Mar 12.
Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

Divergent clonal selection dominates medulloblastoma at recurrence.
Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.
Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.


Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.
Neuro Oncol 2015 Apr 10;17(4):555-65. Epub 2014 Oct 10.
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (M.K., Y.S., I.S., R.S., T.K., T.T.); Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H., S.M., M.D., H.K., K.T., H.M.); Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H.); Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (S.M., K.T., M.Y.); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (T.S.); Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan (M.W.); Department of Pathology and Laboratory Medicine, Sendai Medical Center, Sendai, Miyagi, Japan (H.S.); Department of Neurosurgery, Miyagi Cancer Center, Natori, Miyagi, Japan (Y.Y.).

Association between molecular alterations and tumor location and MRI characteristics in anaplastic gliomas.
Brain Tumor Pathol 2015 Apr 24;32(2):99-104. Epub 2014 Dec 24.
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan,


Malignant clinical features of anaplastic gliomas without IDH mutation.
Neuro Oncol 2015 Jan 23;17(1):136-44. Epub 2014 Jun 23.
Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan (I.S., Y.S., T.S., M.K., R.S., T.I., T.K., Y.Y., T.T.); Department of Public Health, Tohoku University School of Medicine, Sendai, Japan (T.W.); Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan (T.K.); Pathological Division, Tohoku University Hospital, Sendai, Japan (M.W.); Department of Pathology, Sendai Medical Center, Sendai, Japan (H.S.).


Cancer-specific health-related quality of life in children with brain tumors.
Qual Life Res 2014 May 17;23(4):1059-68. Epub 2013 Oct 17.
Department of Family Nursing, Faculty of Medicine, Graduate School of Health Sciences and Nursing, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Cytogenetic prognostication within medulloblastoma subgroups.
J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.
David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little




Clinical and histological characteristics of recurrent oligodendroglial tumors: comparison between primary and recurrent tumors in 18 cases.
Brain Tumor Pathol 2013 Jul 2;30(3):151-9. Epub 2012 Oct 2.
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Establishment of novel monoclonal antibodies KMab-1 and MMab-1 specific for IDH2 mutations.
Biochem Biophys Res Commun 2013 Mar 31;432(1):40-5. Epub 2013 Jan 31.
Regional Innovation Strategy Support Program, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

Factors influencing self- and parent-reporting health-related quality of life in children with brain tumors.
Qual Life Res 2013 Feb 3;22(1):185-201. Epub 2012 Mar 3.
Department of Family Nursing, Graduate School of Health Sciences and Nursing, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.


IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas.
Int J Clin Oncol 2012 Dec 6;17(6):551-61. Epub 2011 Oct 6.
Department of Neurosurgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Nature 2012 Aug;488(7409):49-56
Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.


Early detection of venous thromboembolism in patients with neuroepithelial tumor: efficacy of screening with serum D-dimer measurements and Doppler ultrasonography.
J Neurooncol 2011 Feb 29;101(3):495-504. Epub 2010 Jun 29.
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

O(6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma.
Int J Clin Oncol 2010 Aug 16;15(4):352-8. Epub 2010 Mar 16.
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.


Development of the Japanese version of the Pediatric Quality of Life Inventory Brain Tumor Module.
Health Qual Life Outcomes 2010 Apr 14;8:38. Epub 2010 Apr 14.
Department of Family Nursing, Graduate School of Health Sciences and Nursing, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.




Impact of late effects on health-related quality of life in survivors of pediatric brain tumors: motility disturbance of limb(s), seizure, ocular/visual impairment, endocrine abnormality, and higher brain dysfunction.
Cancer Nurs 2014 Nov-Dec;37(6):E1-E14
Author Affiliations: Department of Family Nursing, Graduate School of Health Sciences and Nursing, Faculty of Medicine, The University of Tokyo, Japan (Drs Sato and Kamibeppu and Mss Higuchi and Murayama); Children'sCancer Association of Japan, Tokyo, (Ms Higuchi); Department of Neuro-oncology/Neurosurgery, Division of Pediatric Neuro-oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Saitama, Japan (Dr Yanagisawa); Departments of Neurosurgery, Tohoku University Graduate School of Medicine, Japan (Dr Kumabe); Department of Clinical Oncology & Neuro-oncology Program, Cancer Treatment Center, Hiroshima University Hospital, Japan (Dr Sugiyama); Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, Japan (Drs Mukasa and Saito); Sawamura Neurosurgery Clinic, Sapporo, Japan (Dr Sawamura); Department of Neurosurgery, Kurume University School of Medicine, Fukuoka, Japan (Dr Terasaki); Neurosurgery and Neuro-oncology Division, National Cancer Center Hospital, Tokyo, Japan (Dr Shibui); Department of Neurosurgery, Tazuke Kofukai Medical Research Institute and Kitano Hospital, Osaka, Japan (Dr Takahashi); Department of Neuro-oncology/Neurosurgery, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Japan (Dr Nishikawa); and Center for Child Health, Prefectural Central Hospital, Ehime, Japan (Dr Ishida).



The whole-genome landscape of medulloblastoma subtypes.
Nature 2017 07;547(7663):311-317
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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