Toshihiko Doi

Toshihiko Doi

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Toshihiko Doi

Publications by authors named "Toshihiko Doi"

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Phase I study of ipatasertib as a single agent and in combination with abiraterone plus prednisolone in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2019 Aug 21;84(2):393-404. Epub 2019 Jun 21.

Department of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00280-019-03882-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647215PMC
August 2019

Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer.

Gastric Cancer 2019 07 9;22(4):793-802. Epub 2019 Jan 9.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-018-00922-8DOI Listing
July 2019

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8 T cells in the tumor microenvironment.

J Immunother Cancer 2018 10 11;6(1):106. Epub 2018 Oct 11.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0403-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186121PMC
October 2018

Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer.

Clin Cancer Res 2018 04 16;24(8):1816-1823. Epub 2018 Mar 16.

University of Washington/Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance, Seattle, Washington.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-1922DOI Listing
April 2018

Safety and Antitumor Activity of the Anti-Programmed Death-1 Antibody Pembrolizumab in Patients With Advanced Esophageal Carcinoma.

J Clin Oncol 2018 01 8;36(1):61-67. Epub 2017 Nov 8.

Toshihiko Doi, National Cancer Center East, Chiba, Japan; Sarina A. Piha-Paul, The University of Texas MD Anderson Cancer Center, Houston, TX; Shadia I. Jalal, Indiana University School of Medicine, Indianapolis, IN; Sanatan Saraf, Jared Lunceford, and Minori Koshiji, Merck, Kenilworth, NJ; and Jaafar Bennouna, Institut de Cancérologie de l'Ouest, Nantes, France.

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http://dx.doi.org/10.1200/JCO.2017.74.9846DOI Listing
January 2018

A retrospective study of the safety and efficacy of paclitaxel plus ramucirumab in patients with advanced or recurrent gastric cancer with ascites.

BMC Cancer 2018 01 31;18(1):120. Epub 2018 Jan 31.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1186/s12885-018-4057-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793350PMC
January 2018

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

Gastric Cancer 2017 Nov 2;20(6):1004-1009. Epub 2017 May 2.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-017-0720-yDOI Listing
November 2017

Large-scale comprehensive immunohistochemical biomarker analyses in esophageal squamous cell carcinoma.

J Cancer Res Clin Oncol 2017 Nov 29;143(11):2351-2361. Epub 2017 Jul 29.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-017-2482-7DOI Listing
November 2017

Safety and efficacy of radium-223 dichloride in Japanese patients with castration-resistant prostate cancer and bone metastases.

Int J Clin Oncol 2017 Oct 6;22(5):954-963. Epub 2017 May 6.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1007/s10147-017-1130-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608784PMC
October 2017

A Phase 1 study evaluating AMG 337 in Asian patients with advanced solid tumors.

Jpn J Clin Oncol 2017 Aug;47(8):772-776

National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1093/jjco/hyx067DOI Listing
August 2017

Analysis of esophagogastric cancer patients enrolled in the National Cancer Institute Cancer Therapy Evaluation Program sponsored phase 1 trials.

Gastric Cancer 2017 May 10;20(3):481-488. Epub 2016 Aug 10.

Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s10120-016-0629-xDOI Listing
May 2017

Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients.

Gastric Cancer 2017 May 14;20(3):407-415. Epub 2016 Sep 14.

Division of Pathology, Research Cancer for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-016-0631-3DOI Listing
May 2017

Immunotherapy for Esophageal Squamous Cell Carcinoma.

Curr Oncol Rep 2017 May;19(5):33

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s11912-017-0590-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374168PMC
May 2017

NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis.

Cancer Chemother Pharmacol 2017 03 21;79(3):569-578. Epub 2017 Feb 21.

Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Chiba, Japan.

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http://dx.doi.org/10.1007/s00280-017-3254-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344954PMC
March 2017

A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors.

Cancer Chemother Pharmacol 2017 Jan 3;79(1):89-98. Epub 2016 Dec 3.

National Cancer Center Hospital East, 5-1, Kashiwanoha 6-chome, Kashiwa-shi, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00280-016-3198-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225172PMC
January 2017

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma.

BMC Cancer 2017 01 9;17(1):36. Epub 2017 Jan 9.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://bmccancer.biomedcentral.com/articles/10.1186/s12885-0
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http://dx.doi.org/10.1186/s12885-016-3041-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220610PMC
January 2017

Gastrointestinal Perforation and Fistula Formation in 5 Patients With Colorectal Cancer During Treatment With Regorafenib.

Clin Colorectal Cancer 2016 Dec 28. Epub 2016 Dec 28.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1016/j.clcc.2016.11.003DOI Listing
December 2016

Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials.

BMC Cancer 2016 11 14;16(1):889. Epub 2016 Nov 14.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East (NCCHE), 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1186/s12885-016-2939-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109764PMC
November 2016

A multicenter phase II study of TAS-102 monotherapy in patients with pre-treated advanced gastric cancer (EPOC1201).

Eur J Cancer 2016 07 19;62:46-53. Epub 2016 May 19.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1016/j.ejca.2016.04.009DOI Listing
July 2016

[The Recommended Chemotherapy Duration-From the Viewpoint of Drug Resistance].

Gan To Kagaku Ryoho 2016 Jul;43(7):803-8

Dept. of Gastric Surgery, National Cancer Center Hospital East.

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July 2016

Salvage photodynamic therapy for local failure after chemoradiotherapy for esophageal squamous cell carcinoma.

Gastrointest Endosc 2016 Jun 1;83(6):1130-1139.e3. Epub 2015 Dec 1.

Department of Gastroenterology, Gastrointestinal Oncology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1016/j.gie.2015.11.016DOI Listing
June 2016

A phase I study evaluating cixutumumab, a type 1 insulin-like growth factor receptor inhibitor, given every 2 or 3 weeks in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2016 06 30;77(6):1253-62. Epub 2016 Apr 30.

Department Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa-shi, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00280-016-3041-7DOI Listing
June 2016

Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors.

Cancer Sci 2016 May 28;107(5):659-65. Epub 2016 Mar 28.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1111/cas.12912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970833PMC
May 2016

Pazopanib for both GIST and soft-tissue sarcoma.

Lancet Oncol 2016 05 5;17(5):549-50. Epub 2016 Apr 5.

National Cancer Center Hospital East, Departments of Surgery and Medical Oncology, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1016/S1470-2045(16)00101-7DOI Listing
May 2016

Bevacizumab safety in Japanese patients with colorectal cancer.

Jpn J Clin Oncol 2016 Mar 15;46(3):234-40. Epub 2016 Jan 15.

Bevacizumab Appropriate Use Committee Department of Medical Oncology and Hematology, Faculty of Medicine, Oita University, Oita, Japan.

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http://dx.doi.org/10.1093/jjco/hyv182DOI Listing
March 2016

[Molecular Subtypes of Gastric Cancer].

Gan To Kagaku Ryoho 2016 Mar;43(3):281-5

Dept. of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East.

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March 2016

Prognostic significance of tumor regression grade for patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery.

J Surg Oncol 2016 Mar 12;113(4):390-6. Epub 2016 Jan 12.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1002/jso.24151DOI Listing
March 2016

Phase I study of LY2603618, a CHK1 inhibitor, in combination with gemcitabine in Japanese patients with solid tumors.

Anticancer Drugs 2015 Nov;26(10):1043-53

aDepartment of Gastrointestinal Oncology bDepartment of Breast and Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba cEli Lilly Japan K.K., Kobe, Japan dEli Lilly and Company, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1097/CAD.0000000000000278DOI Listing
November 2015

Phase I Study of Axitinib in Combination with Cisplatin and Capecitabine in Patients with Previously Untreated Advanced Gastric Cancer.

Cancer Res Treat 2015 10 12;47(4):687-96. Epub 2015 Feb 12.

Department of Internal Medicine, Seoul National University Hospital and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4143/crt.2014.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614203PMC
October 2015

Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer.

Invest New Drugs 2015 Oct 12;33(5):1068-77. Epub 2015 Jul 12.

Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10637-015-0271-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768213PMC
October 2015

Clinical outcomes in 66 patients with advanced gastric cancer treated in phase I trials: the NCCHE experience.

Invest New Drugs 2015 Jun 15;33(3):664-70. Epub 2015 Mar 15.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East (NCCHE), 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://link.springer.com/10.1007/s10637-015-0231-9
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http://dx.doi.org/10.1007/s10637-015-0231-9DOI Listing
June 2015

[Clinical research of targeting therapy for cancer stem cells].

Nihon Rinsho 2015 May;73(5):823-30

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May 2015

Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma.

Gastric Cancer 2015 Apr 14;18(2):227-38. Epub 2014 Mar 14.

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-city, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-014-0360-4DOI Listing
April 2015

[VEGFR inhibitor (multi-target kinase inhibitors)].

Nihon Rinsho 2015 Feb;73 Suppl 2:261-6

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February 2015

Serum HER2 levels and HER2 status in tumor cells in advanced gastric cancer patients.

Jpn J Clin Oncol 2015 Jan 6;45(1):43-8. Epub 2014 Nov 6.

Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa.

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http://dx.doi.org/10.1093/jjco/hyu174DOI Listing
January 2015

Improving prognosis after surgery for gastric cancer.

Lancet Oncol 2014 Nov 15;15(12):1290-2. Epub 2014 Oct 15.

National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1016/S1470-2045(14)71019-8DOI Listing
November 2014

Tyrosine kinase inhibitors in the treatment of unresectable or metastatic gastrointestinal stromal tumors.

Expert Opin Pharmacother 2014 Oct 3;15(14):1979-89. Epub 2014 Jul 3.

National Cancer Center Hospital East, Surgery , 6-5-1 Kashiwanoha, Kashiwa, 277-8577 , Japan.

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http://dx.doi.org/10.1517/14656566.2014.937707DOI Listing
October 2014

Endoscopic submucosal dissection using a new scissors-type electrosurgical knife: a first-in-human feasibility study.

Endoscopy 2014 Sep 25;46(9):754-7. Epub 2014 Apr 25.

Department of Gastroenterology, Gastrointestinal Oncology Division, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1055/s-0034-1365473DOI Listing
September 2014

Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2014 Sep 25;74(3):629-36. Epub 2014 Jul 25.

National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan,

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http://dx.doi.org/10.1007/s00280-014-2521-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143601PMC
September 2014

Phase I study of olaratumab in Japanese patients with advanced solid tumors.

Cancer Sci 2014 Jul 27;105(7):862-9. Epub 2014 Jun 27.

National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1111/cas.12444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317910PMC
July 2014

Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III study.

J Clin Oncol 2014 Jul 27;32(19):2039-49. Epub 2014 May 27.

Taroh Satoh, Kinki University School of Medicine, Osaka; Toshihiko Doi and Atsushi Ohtsu, National Cancer Center Hospital East, Chiba; Akihito Tsuji, Kochi Health Sciences Center, Kochi; Yasushi Omuro, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital; Akihira Mukaiyama and Mikiro Kobayashi, GlaxoSmithKline, Tokyo; Hiroto Miwa, Hyogo College of Medicine, Hyogo, Japan; Rui-Hua Xu, Sun Yat-Sen University Cancer Center, Guangzhou; Guo-Ping Sun, First Affiliated Hospital of Anhui Medical University, Hefei; Jian-Ming Xu, 307 Hospital of the People's Liberation Army; Jin-Wan Wang, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Beijing; Jin Li, Fudan University Cancer Hospital, Shanghai; Shu-Kui Qin, People's Liberation Army 81 Hospital; Ji-Feng Feng, Cancer Hospital of Jiangsu Province, Nanjing, People's Republic of China; Hyun Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine; Yung-Jue Bang, Seoul National University College of Medicine, Seoul; Ik-Joo Chung, Chonnam National University Hwasun Hospital, Jeollanamdo, South Korea; and Kun-Huei Yeh, National Taiwan University Hospital, Taipei, Taiwan.

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http://jco.ascopubs.org/content/early/2014/05/20/JCO.2013.53
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.53.6136
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http://dx.doi.org/10.1200/JCO.2013.53.6136DOI Listing
July 2014

Correlation between overall survival and other endpoints in clinical trials of second-line chemotherapy for patients with advanced gastric cancer.

Gastric Cancer 2014 Apr 5;17(2):362-70. Epub 2013 Jun 5.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan,

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http://dx.doi.org/10.1007/s10120-013-0274-6DOI Listing
April 2014

Rechallenge of drugs in the era of targeted therapy.

Lancet Oncol 2013 Nov 18;14(12):1143-5. Epub 2013 Oct 18.

National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(13)70494-7DOI Listing
November 2013

[Chemotherapy for GI and pancreatic NETs].

Authors:
Toshihiko Doi

Gan To Kagaku Ryoho 2013 Jul;40(7):838-42

Dept. of GI oncology and Experimental Therapeutics, National Cancer Center Hospital East, Chiba, Japan.

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July 2013