Toshifumi Inada

Toshifumi Inada

UNVERIFIED PROFILE

Are you Toshifumi Inada?   Register this Author

Register author
Toshifumi Inada

Toshifumi Inada

Publications by authors named "Toshifumi Inada"

Are you Toshifumi Inada?   Register this Author

58Publications

385Reads

18Profile Views

The proteasome's balancing act.

Authors:
Toshifumi Inada

Nat Plants 2019 Nov 18. Epub 2019 Nov 18.

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41477-019-0551-4DOI Listing
November 2019

Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Nature 2019 Jul;571(7764):E4

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1360-7DOI Listing
July 2019

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Nature 2019 Jun 12;570(7762):538-542. Epub 2019 Jun 12.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1307-zDOI Listing
June 2019

tRNA recycling on stalled ribosomes.

Authors:
Toshifumi Inada

Nat Struct Mol Biol 2019 05;26(5):340-342

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41594-019-0222-1DOI Listing
May 2019

Translation arrest as a protein quality control system for aberrant translation of the 3'-UTR in mammalian cells.

FEBS Lett 2019 Apr 23;593(8):777-787. Epub 2019 Mar 23.

Graduate School of Pharmaceutical Science, Tohoku University, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.13362DOI Listing
April 2019

Sequential Ubiquitination of Ribosomal Protein uS3 Triggers the Degradation of Non-functional 18S rRNA.

Cell Rep 2019 Mar;26(12):3400-3415.e7

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.02.067DOI Listing
March 2019

Recent Progress on the Molecular Mechanism of Quality Controls Induced by Ribosome Stalling.

Front Genet 2018 17;9:743. Epub 2019 Jan 17.

Gene Regulation Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2018.00743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344382PMC
January 2019

Crucial role of ATP-bound Sse1 in Upf1-dependent degradation of the truncated product.

Biochem Biophys Res Commun 2017 06 5;488(1):122-128. Epub 2017 May 5.

Graduate School of Pharmaceutical Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X173086
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2017.05.020DOI Listing
June 2017

The Ribosome as a Platform for mRNA and Nascent Polypeptide Quality Control.

Authors:
Toshifumi Inada

Trends Biochem Sci 2017 01 13;42(1):5-15. Epub 2016 Oct 13.

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2016.09.005DOI Listing
January 2017

RNA decay systems enhance reciprocal switching of sense and antisense transcripts in response to glucose starvation.

Genes Cells 2016 Dec 10;21(12):1276-1289. Epub 2016 Oct 10.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/gtc.12443DOI Listing
December 2016

Conserved functions of human Pelota in mRNA quality control of nonstop mRNA.

FEBS Lett 2016 09 7;590(18):3254-63. Epub 2016 Sep 7.

Graduate School of Pharmaceutical Science, Tohoku University, Aoba-ku, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.12366DOI Listing
September 2016

Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3' end of nonstop mRNA.

Sci Rep 2016 06 17;6:28234. Epub 2016 Jun 17.

Graduate School of Pharmaceutical Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep28234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911565PMC
June 2016

The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localized CBP1 mRNA.

J Biol Chem 2015 Jun 13;290(26):16021-30. Epub 2015 May 13.

From the Graduate School of Pharmaceutical Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan,

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M114.634592
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.634592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481206PMC
June 2015

Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast.

J Biol Chem 2015 Mar 5;290(13):8331-47. Epub 2015 Feb 5.

From the Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan,

View Article

Download full-text PDF

Source
http://www.jbc.org/content/290/13/8331.full.pdf
Web Search
http://www.jbc.org/lookup/doi/10.1074/jbc.M114.615088
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.615088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375487PMC
March 2015

Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation.

Front Genet 2014 20;5:135. Epub 2014 May 20.

Laboratory of Gene Regulation, Graduate School of Pharmaceutical Sciences, Tohoku University Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2014.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033010PMC
June 2014

Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray system.

Sci Rep 2014 May 28;4:5089. Epub 2014 May 28.

1] Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan [2] Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan [3] Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep05089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035584PMC
May 2014

Protein quality control systems associated with no-go and nonstop mRNA surveillance in yeast.

Genes Cells 2014 Jan 21;19(1):1-12. Epub 2013 Nov 21.

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/gtc.12106DOI Listing
January 2014

The Upf factor complex interacts with aberrant products derived from mRNAs containing a premature termination codon and facilitates their proteasomal degradation.

J Biol Chem 2013 Oct 8;288(40):28630-40. Epub 2013 Aug 8.

From the Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578 and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.460691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789962PMC
October 2013

[Ribosome as a hub for protein and mRNA quality control and gene regulation].

Authors:
Toshifumi Inada

Seikagaku 2013 Oct;85(10):932-7

Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-Ku, Sendai 980-8578, Miyagi prefecture, Japan.

View Article

Download full-text PDF

Source
October 2013

Quality control systems for aberrant mRNAs induced by aberrant translation elongation and termination.

Authors:
Toshifumi Inada

Biochim Biophys Acta 2013 Jun-Jul;1829(6-7):634-42. Epub 2013 Feb 14.

Tohoku University, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagrm.2013.02.004DOI Listing
August 2013

Stress-induced lncRNAs evade nuclear degradation and enter the translational machinery.

Genes Cells 2013 May 12;18(5):353-68. Epub 2013 Mar 12.

Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/gtc.12042DOI Listing
May 2013

Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx.

Cell Rep 2012 Sep 13;2(3):447-53. Epub 2012 Sep 13.

Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2012.08.010DOI Listing
September 2012

[A general role of Dom34: Hbs1 complex in RNA quality control systems].

Authors:
Toshifumi Inada

Seikagaku 2012 Sep;84(9):790-3

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.

View Article

Download full-text PDF

Source
September 2012

Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA.

Mol Cell 2012 May 11;46(4):518-29. Epub 2012 Apr 11.

Graduate School of Pharmaceutical Science, Tohoku University, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2012.03.013DOI Listing
May 2012

Dual functions of yeast tRNA ligase in the unfolded protein response: unconventional cytoplasmic splicing of HAC1 pre-mRNA is not sufficient to release translational attenuation.

Mol Biol Cell 2010 Nov 15;21(21):3722-34. Epub 2010 Sep 15.

Department of Chemistry and Division of Biological Science, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E10-08-0693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965688PMC
November 2010

Tethering of poly(A)-binding protein interferes with non-translated mRNA decay from the 5' end in yeast.

J Biol Chem 2010 Oct 23;285(44):33589-601. Epub 2010 Aug 23.

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.117150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962457PMC
October 2010

Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex.

Proc Natl Acad Sci U S A 2010 Oct 27;107(41):17575-9. Epub 2010 Sep 27.

Division of Structure Biology, Department of Basic Medical Sciences, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1009598107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955123PMC
October 2010

[Therapy for genetic disease by targeting posttranscriptional regulation].

Authors:
Toshifumi Inada

Nihon Rinsho 2010 Aug;68 Suppl 8:613-8

Division of Biological Science, Graduate School of Science, Nagoya University.

View Article

Download full-text PDF

Source
August 2010

[RNA program plays a central role in gene regulation].

Authors:
Toshifumi Inada

Tanpakushitsu Kakusan Koso 2009 Dec;54(16 Suppl):2025-31

View Article

Download full-text PDF

Source
December 2009

[Quality control as a master regulator of RNA program].

Authors:
Toshifumi Inada

Tanpakushitsu Kakusan Koso 2009 Dec;54(16 Suppl):2184-8

View Article

Download full-text PDF

Source
December 2009

Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome.

EMBO Rep 2009 Nov 2;10(11):1265-71. Epub 2009 Oct 2.

Department of Molecular Biology, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/embor.2009.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775173PMC
November 2009

Analysis of nonstop mRNA translation in the absence of tmRNA in Escherichia coli.

Genes Cells 2009 Jun 14;14(6):739-49. Epub 2009 May 14.

Department of Molecular Biology, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2443.2009.01304.xDOI Listing
June 2009

Nascent peptide-dependent translation arrest leads to Not4p-mediated protein degradation by the proteasome.

J Biol Chem 2009 Apr 9;284(16):10343-52. Epub 2009 Feb 9.

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M808840200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667721PMC
April 2009

Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.

J Cell Sci 2009 Mar 10;122(Pt 5):678-86. Epub 2009 Feb 10.

Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.044461DOI Listing
March 2009

Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans.

Genes Dev 2008 Apr;22(8):1025-36

Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1644008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335324PMC
April 2008

[Ribosome recognizes aberrant translation termination and induces mRNA surveillance system].

Authors:
Toshifumi Inada

Seikagaku 2007 Jan;79(1):50-4

Department of Molecular Biology, Graduate School of Science, Nagoya University, Japan.

View Article

Download full-text PDF

Source
January 2007

[Novel role of poly (A) tail in mRNA surveillance system].

Authors:
Toshifumi Inada

Tanpakushitsu Kakusan Koso 2006 Dec;51(16 Suppl):2549-55

View Article

Download full-text PDF

Source
December 2006

Translation of aberrant mRNAs lacking a termination codon or with a shortened 3'-UTR is repressed after initiation in yeast.

EMBO J 2005 Apr 31;24(8):1584-95. Epub 2005 Mar 31.

Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7600636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142571PMC
April 2005

Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli.

Mol Microbiol 2004 Nov;54(4):1063-75

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2958.2004.04329.xDOI Listing
November 2004

Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.

Mol Cell Biol 2004 May;24(9):3670-81

Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya University, and CREST, Japan Science and Technology Corporation, Chikusa-ku, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387745PMC
http://dx.doi.org/10.1128/mcb.24.9.3670-3681.2004DOI Listing
May 2004

[When trans-translation occurs?].

Tanpakushitsu Kakusan Koso 2004 May;49(7 Suppl):1067-8

View Article

Download full-text PDF

Source
May 2004

Ribosome stalling during translation elongation induces cleavage of mRNA being translated in Escherichia coli.

J Biol Chem 2004 Apr 26;279(15):15368-75. Epub 2004 Jan 26.

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M312805200
Publisher Site
http://dx.doi.org/10.1074/jbc.M312805200DOI Listing
April 2004

Nascent-peptide-mediated ribosome stalling at a stop codon induces mRNA cleavage resulting in nonstop mRNA that is recognized by tmRNA.

RNA 2004 Mar;10(3):378-86

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370933PMC
http://dx.doi.org/10.1261/rna.5169404DOI Listing
March 2004

Metabolic block at early stages of the glycolytic pathway activates the Rcs phosphorelay system via increased synthesis of dTDP-glucose in Escherichia coli.

Mol Microbiol 2004 Feb;51(4):1117-28

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2958.2003.03888.xDOI Listing
February 2004

The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast.

RNA 2003 Jun;9(6):654-62

Gene Expression Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370433PMC
http://dx.doi.org/10.1261/rna.5100903DOI Listing
June 2003

Accumulation of glucose 6-phosphate or fructose 6-phosphate is responsible for destabilization of glucose transporter mRNA in Escherichia coli.

J Biol Chem 2003 May 10;278(18):15608-14. Epub 2003 Feb 10.

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M300177200DOI Listing
May 2003

SsrA-mediated trans-translation plays a role in mRNA quality control by facilitating degradation of truncated mRNAs.

RNA 2003 Apr;9(4):408-18

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370408PMC
http://dx.doi.org/10.1261/rna.2174803DOI Listing
April 2003

The C-terminal amino acid sequence of nascent peptide is a major determinant of SsrA tagging at all three stop codons.

RNA 2002 Nov;8(11):1416-27

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370348PMC
http://dx.doi.org/10.1017/s1355838202020198DOI Listing
November 2002

One-step affinity purification of the yeast ribosome and its associated proteins and mRNAs.

RNA 2002 Jul;8(7):948-58

Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370311PMC
http://dx.doi.org/10.1017/s1355838202026018DOI Listing
July 2002