Toru Maruyama

Toru Maruyama

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Toru Maruyama

Publications by authors named "Toru Maruyama"

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α-Acid Glycoprotein Has the Potential to Serve as a Biomimetic Drug Delivery Carrier for Anticancer Agents.

J Pharm Sci 2019 Nov 6;108(11):3592-3598. Epub 2019 Jul 6.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2019.07.002DOI Listing
November 2019

Prognostic significance of red cell distribution width in hospitalized older patients with heart failure or infection.

Geriatr Gerontol Int 2019 Oct 8;19(10):988-992. Epub 2019 Aug 8.

Department of Medicine, Karatsu Higashimatsuura Medical Center, Karatsu, Japan.

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http://dx.doi.org/10.1111/ggi.13755DOI Listing
October 2019

Unique Hydrolysis of an Ester-Type Prodrug of Levodopa in Human Plasma: Relay-Type Role Sharing between Alpha-1 Acid Glycoprotein and Human Serum Albumin.

Mol Pharm 2019 Oct 28;16(10):4131-4138. Epub 2019 Aug 28.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00435DOI Listing
October 2019

Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape.

J Control Release 2019 Jun 10;304:156-163. Epub 2019 May 10.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.05.015DOI Listing
June 2019

Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities.

Molecules 2019 Apr 30;24(9). Epub 2019 Apr 30.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.

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http://dx.doi.org/10.3390/molecules24091689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539915PMC
April 2019

Enrichment of bacteria and alginate lyase genes potentially involved in brown alga degradation in the gut of marine gastropods.

Sci Rep 2019 Feb 14;9(1):2129. Epub 2019 Feb 14.

Research Organization for Nano & Life Innovation, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku, Tokyo, 162-0041, Japan.

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http://dx.doi.org/10.1038/s41598-018-38356-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375959PMC
February 2019

Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases.

J Arrhythm 2019 Feb 12;35(1):43-51. Epub 2018 Oct 12.

Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan.

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http://dx.doi.org/10.1002/joa3.12125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373829PMC
February 2019

Sarcopenia in Chronic Kidney Disease: Factors, Mechanisms, and Therapeutic Interventions.

Biol Pharm Bull 2019 ;42(9):1437-1445

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.

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http://dx.doi.org/10.1248/bpb.b19-00513DOI Listing
January 2019

Does intrawound vancomycin powder reduce surgical site infection after posterior instrumented spinal surgery? A propensity score-matched analysis.

Spine J 2018 12 26;18(12):2205-2212. Epub 2018 Apr 26.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo Hospital, 113-8655, 7-3-1, Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1016/j.spinee.2018.04.015DOI Listing
December 2018

Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies.

Carbohydr Polym 2018 Nov 7;199:141-149. Epub 2018 Jul 7.

Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.

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http://dx.doi.org/10.1016/j.carbpol.2018.07.016DOI Listing
November 2018

Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications.

Curr Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto. Japan.

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http://www.eurekaselect.com/167311/article
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http://dx.doi.org/10.2174/0929867325666181113122340DOI Listing
November 2018

Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites.

Biochem Biophys Rep 2018 Jul 11;14:155-160. Epub 2018 May 11.

Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.

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http://dx.doi.org/10.1016/j.bbrep.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986994PMC
July 2018

Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique.

Genes Environ 2018 4;40:12. Epub 2018 Jun 4.

1Laboratory of Environmental Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8654 Japan.

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http://dx.doi.org/10.1186/s41021-018-0099-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985587PMC
June 2018

Role of Parathyroid Hormone in Regulating Transporter and Metabolizing Enzyme Function.

Ther Apher Dial 2018 Jun;22(3):251-254

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1111/1744-9987.12686DOI Listing
June 2018

Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.

Alzheimers Dement 2018 05 20;14(5):623-633. Epub 2017 Dec 20.

Department of Medicine (Biomedical Genetics), Boston University, Boston, MA, USA; Neurogenetics and Integrated Genomics, Andover Innovative Medicines (AiM) Institute, Eisai Inc, Andover, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938137PMC
May 2018

Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery.

J Control Release 2018 05 10;277:23-34. Epub 2018 Mar 10.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183011
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http://dx.doi.org/10.1016/j.jconrel.2018.02.037DOI Listing
May 2018

A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis.

Redox Biol 2018 04 11;14:354-360. Epub 2017 Oct 11.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975211PMC
April 2018

Dual Therapeutic Effects of an Albumin-Based Nitric Oxide Donor on 2 Experimental Models of Chronic Kidney Disease.

J Pharm Sci 2018 03 24;107(3):848-855. Epub 2017 Oct 24.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.10.023DOI Listing
March 2018

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity.

Int J Pharm 2018 Jan 6;535(1-2):140-147. Epub 2017 Nov 6.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.11.012DOI Listing
January 2018

Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.

Biochem Pharmacol 2017 12 24;145:192-201. Epub 2017 Aug 24.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, Kumamoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.08.016DOI Listing
December 2017

Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome.

J Arrhythm 2017 Oct 6;33(5):424-429. Epub 2017 Feb 6.

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Maidashi 3-1-1, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.joa.2016.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634679PMC
October 2017

Clinical Implications Associated With the Posttranslational Modification-Induced Functional Impairment of Albumin in Oxidative Stress-Related Diseases.

J Pharm Sci 2017 09 14;106(9):2195-2203. Epub 2017 Mar 14.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.03.002DOI Listing
September 2017

Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition.

Nitric Oxide 2017 Sep 13;69:28-34. Epub 2017 Apr 13.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2017.04.005DOI Listing
September 2017

The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders.

J Pharm Sci 2017 09 13;106(9):2392-2400. Epub 2017 Apr 13.

Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.04.006DOI Listing
September 2017

Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin.

J Pharm Sci 2017 09 26;106(9):2860-2867. Epub 2017 Apr 26.

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, Kumamoto 860-0082, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.04.025DOI Listing
September 2017

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer.

Biomaterials 2017 Sep 22;140:162-169. Epub 2017 Jun 22.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.06.021DOI Listing
September 2017

Successful management of wound dehiscence after implantation of a subcutaneous implantable cardioverter-defibrillator without device removal.

HeartRhythm Case Rep 2017 Sep 14;3(9):415-417. Epub 2017 Jul 14.

Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.hrcr.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601323PMC
September 2017

Oral branched-chain amino acid granules improve structure and function of human serum albumin in cirrhotic patients.

J Gastroenterol 2017 Jun 21;52(6):754-765. Epub 2016 Nov 21.

Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuou-ku, Kumamoto City, Kumamoto, 860-8556, Japan.

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http://link.springer.com/10.1007/s00535-016-1281-2
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http://dx.doi.org/10.1007/s00535-016-1281-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437197PMC
June 2017

Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B.

Bioorg Med Chem 2017 06 29;25(12):3046-3052. Epub 2017 Mar 29.

Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1016/j.bmc.2017.03.059DOI Listing
June 2017

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.

Anal Chim Acta 2017 May 22;969:18-25. Epub 2017 Mar 22.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

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http://dx.doi.org/10.1016/j.aca.2017.03.027DOI Listing
May 2017

An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats.

Carbohydr Polym 2017 Apr 23;161:21-25. Epub 2016 Dec 23.

Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2016.12.057DOI Listing
April 2017

Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism.

Kidney Int 2017 03 15;91(3):658-670. Epub 2016 Dec 15.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, Kumamoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.09.041DOI Listing
March 2017

SAG-QC: quality control of single amplified genome information by subtracting non-target sequences based on sequence compositions.

BMC Bioinformatics 2017 Mar 4;18(1):152. Epub 2017 Mar 4.

Department of Life Science & Medical Bioscience, Graduate School of Advanced Science & Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12859-017-1572-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336615PMC
March 2017

Methylated site display (MSD)-AFLP, a sensitive and affordable method for analysis of CpG methylation profiles.

BMC Mol Biol 2017 03 9;18(1). Epub 2017 Mar 9.

Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1186/s12867-017-0083-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345256PMC
March 2017

Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers.

J Funct Biomater 2017 Mar 18;8(1). Epub 2017 Mar 18.

Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 862-0082, Japan.

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http://dx.doi.org/10.3390/jfb8010011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371884PMC
March 2017

Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties.

Int J Nanomedicine 2016;11:5611-5620. Epub 2016 Oct 27.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.2147/IJN.S118185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089833PMC
February 2017

Anticoagulation Stability Depends on CHADS Score and Hepatorenal Function in Warfarin-treated Patients, Including Those with Atrial Fibrillation.

J Atheroscler Thromb 2017 Jan 16;24(1):68-76. Epub 2016 Jun 16.

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences.

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http://dx.doi.org/10.5551/jat.35121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225134PMC
January 2017

Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists.

ACS Med Chem Lett 2017 Jan 13;8(1):107-112. Epub 2016 Dec 13.

Medicinal Chemistry Research Laboratories, Department of Biology & Pharmacology, and Discovery Research Alliance, Ono Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238478PMC
January 2017

[Human Serum Albumin as Carrier in Drug Delivery Systems].

Yakugaku Zasshi 2016 ;136(1):39-47

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.

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http://dx.doi.org/10.1248/yakushi.15-00227-1DOI Listing
December 2016

Braces for Idiopathic Scoliosis in Adolescents.

Spine (Phila Pa 1976) 2016 Dec;41(23):1813-1825

*Physical and Rehabilitation Medicine, University of Brescia, IRCCS Fondazione Don Gnocchi Milan, Brescia, Italy †Department of Epidemiology, Lazio Regional Health Service, Rome, Italy ‡School of Health and Social Care, University of Teesside, Middlesbrough, United Kingdom §Faculty of Health, Staffordshire University, Stoke-on-Trent, United Kingdom ¶Department of Trauma and Orthopedics, Tzanio General Hospital of Piraeus, Piraeus, Greece ||Department of Pediatric Orthopedics and Traumatology, University of Medical Sciences, Poznan, Poland **Department of Orthopedic Surgery, Saitama Medical University, Kawagoe, Japan ††ISICO, Italian Scientific Spine Institute, Milan, Italy.

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http://dx.doi.org/10.1097/BRS.0000000000001887DOI Listing
December 2016

Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease.

Biochem Biophys Res Commun 2016 Oct 23;479(3):578-583. Epub 2016 Sep 23.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2016.09.113DOI Listing
October 2016

Increased coupling interval variability -- mechanistic, diagnostic and prognostic implication of premature ventricular contractions and underlying heart diseases.

Circ J 2015 17;79(11):2317-9. Epub 2015 Sep 17.

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences.

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http://dx.doi.org/10.1253/circj.CJ-15-0963DOI Listing
August 2016

Influence of Molecular Structure on O2-Binding Properties and Blood Circulation of Hemoglobin‒Albumin Clusters.

PLoS One 2016 19;11(2):e0149526. Epub 2016 Feb 19.

Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27, Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149526PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760709PMC
July 2016

Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis.

J Control Release 2016 07 9;234:49-58. Epub 2016 May 9.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan,. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.05.016DOI Listing
July 2016

Tyrosine411 and Arginine410 of Human Serum Albumin Play an Important Role in the Binding of Sodium 4-Phenylbutyrate to Site II.

J Pharm Sci 2016 06 22;105(6):1987-1994. Epub 2016 Apr 22.

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, Kumamoto 860-0082, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.03.012DOI Listing
June 2016

Antioxidant and renoprotective activity of 2-hydroxypropyl-β-cyclodextrin in nephrectomized rats.

J Pharm Pharmacol 2016 May 9;68(5):608-14. Epub 2015 Jun 9.

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.

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http://dx.doi.org/10.1111/jphp.12446DOI Listing
May 2016

Monodisperse Picoliter Droplets for Low-Bias and Contamination-Free Reactions in Single-Cell Whole Genome Amplification.

PLoS One 2015 21;10(9):e0138733. Epub 2015 Sep 21.

Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan; Research Organization for Nano & Life Innovation, Waseda University, 513, Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan; Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST), 5, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138733PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577099PMC
May 2016

Structural optimization and structure-functional selectivity relationship studies of G protein-biased EP2 receptor agonists.

Bioorg Med Chem Lett 2016 05 31;26(10):2446-2449. Epub 2016 Mar 31.

Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X163034
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http://dx.doi.org/10.1016/j.bmcl.2016.03.110DOI Listing
May 2016

Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury.

PLoS One 2015 18;10(6):e0130248. Epub 2015 Jun 18.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto, 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto, 862-0973, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130248PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473075PMC
April 2016

Editorial: Trapped pacemaker lead extraction: Necessity, challenge, and beyond.

J Cardiol Cases 2016 Mar 29;13(3):85-86. Epub 2015 Dec 29.

Heart Center, Kyushu University Hospital, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.jccase.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280685PMC
March 2016

Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations.

J Pharm Sci 2016 Mar;105(3):1043-9

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2015.12.015DOI Listing
March 2016

Discovery of G Protein-Biased EP2 Receptor Agonists.

ACS Med Chem Lett 2016 Mar 4;7(3):306-11. Epub 2016 Jan 4.

Medicinal Chemistry Research Laboratories, Department of Biology & Pharmacology, and Discovery Research Alliance, Ono Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789666PMC
March 2016

The clinical significance of plasma neopterin in heart failure with preserved left ventricular ejection fraction.

ESC Heart Fail 2016 Mar 9;3(1):53-59. Epub 2015 Nov 9.

Faculty of Life Sciences, Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.

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http://dx.doi.org/10.1002/ehf2.12070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063166PMC
March 2016

The pivotal role of eNOS uncoupling in vascular endothelial dysfunction in patients with heart failure with preserved ejection fraction.

Int J Cardiol 2015 21;190:335-7. Epub 2015 Apr 21.

Faculty of Life Sciences, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.ijcard.2015.04.162DOI Listing
February 2016

Using zebrafish in systems toxicology for developmental toxicity testing.

Congenit Anom (Kyoto) 2016 Jan;56(1):18-27

Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie.

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http://dx.doi.org/10.1111/cga.12142DOI Listing
January 2016

Memantine Exacerbates Corrected QT Interval Prolongation in Alzheimer's Disease: A Case Report from an Unintentional Rechallenge.

J Am Geriatr Soc 2016 Jan;64(1):232-3

Counseling and Health Center, Faculty of Arts and Science, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/jgs.13897DOI Listing
January 2016

Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury.

Clin Exp Nephrol 2015 Dec 23;19(6):1007-14. Epub 2015 Apr 23.

Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.

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http://dx.doi.org/10.1007/s10157-015-1111-5DOI Listing
December 2015

Direct radical scavenging activity of benzbromarone provides beneficial antioxidant properties for hyperuricemia treatment.

Biol Pharm Bull 2015 15;38(3):487-92. Epub 2015 Jan 15.

Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University; Center for Clinical Pharmaceutical Sciences, 5-1 Oe-honmachi, Chuo-ku 862-0973, Japan.

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http://dx.doi.org/10.1248/bpb.b14-00514DOI Listing
November 2015

Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia.

J Pharm Sci 2015 Nov 6;104(11):3968-3976. Epub 2015 Aug 6.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Chuo-ku, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1002/jps.24607DOI Listing
November 2015

S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes.

J Control Release 2015 Nov 22;217:1-9. Epub 2015 Aug 22.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Science, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.08.036DOI Listing
November 2015

Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock.

Biochem Pharmacol 2015 Oct 29;97(3):310-9. Epub 2015 Jul 29.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, 862-0973 Kumamoto, Japan,; Center for Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, 862-0973 Kumamoto, Japan,. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.07.035DOI Listing
October 2015

Nitration of indoxyl sulfate facilitates its cytotoxicity in human renal proximal tubular cells via expression of heme oxygenase-1.

Biochem Biophys Res Commun 2015 Sep 13;465(3):481-7. Epub 2015 Aug 13.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.08.043DOI Listing
September 2015

Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients.

Sci Rep 2015 Sep 23;5:14381. Epub 2015 Sep 23.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

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http://dx.doi.org/10.1038/srep14381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585768PMC
September 2015

Analysis of bacterial xylose isomerase gene diversity using gene-targeted metagenomics.

J Biosci Bioeng 2015 Aug 3;120(2):174-80. Epub 2015 Feb 3.

Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan; Institute for Nanoscience and Nanotechnology, Waseda University, 513 Waseda-tsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan; Core Research for Evolutionary Science and Technology Project (CREST), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2014.12.022DOI Listing
August 2015

Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants.

Life Sci 2015 Aug 30;134:36-41. Epub 2015 May 30.

Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00243205150028
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http://dx.doi.org/10.1016/j.lfs.2015.05.010DOI Listing
August 2015

Research quality in scoliosis conservative treatment: state of the art.

Scoliosis 2015 11;10:21. Epub 2015 Jul 11.

Deparment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy ; IRCCS Fondazione Don Gnocchi, Milan, Italy.

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http://dx.doi.org/10.1186/s13013-015-0046-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537531PMC
August 2015

Safety Evaluation of Hemoglobin-Albumin Cluster "HemoAct" as a Red Blood Cell Substitute.

Sci Rep 2015 Jul 29;5:12778. Epub 2015 Jul 29.

Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.

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http://dx.doi.org/10.1038/srep12778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518235PMC
July 2015

Braces for idiopathic scoliosis in adolescents.

Cochrane Database Syst Rev 2015 Jun 18(6):CD006850. Epub 2015 Jun 18.

Physical and Rehabilitation Medicine, University of Brescia - IRCCS Fondazione Don Gnocchi Milan, Viale Europa, Brescia, Italy, 25121.

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http://dx.doi.org/10.1002/14651858.CD006850.pub3DOI Listing
June 2015

Effectiveness of brace treatment for adolescent idiopathic scoliosis.

Scoliosis 2015 11;10(Suppl 2):S12. Epub 2015 Feb 11.

Department of Orthopaedic Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550 Japan.

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http://dx.doi.org/10.1186/1748-7161-10-S2-S12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331729PMC
May 2015

Mortality benefit of participation in BOOCS program: a follow-up study for 15 years in a Japanese working population.

J Occup Environ Med 2015 Mar;57(3):246-50

From the Ushibuka City Hospital (Dr Hoshuyama), Amakusa, Kumamoto; Department of Medicine and Biosystemic Science (Drs Odashiro and Fukata), Kyushu University Graduate School of Medical Sciences; Faculty of Arts and Science (Dr Maruyama), Kyushu University; and BOOCS Clinic (Dr Saito, Ms Wakana, Ms Fukumitsu, Dr Fujino), Fukuoka, Japan.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/JOM.0000000000000399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351997PMC
March 2015

Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide.

Cancer Sci 2015 Feb 28;106(2):194-200. Epub 2015 Jan 28.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Center for Clinical Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1111/cas.12577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399024PMC
February 2015

p-Cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress.

Pharmacol Res Perspect 2015 Feb 7;3(1):e00092. Epub 2014 Nov 7.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University Kumamoto, Japan ; Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University Kumamoto, Japan.

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http://doi.wiley.com/10.1002/prp2.92
Publisher Site
http://dx.doi.org/10.1002/prp2.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317224PMC
February 2015

Therapeutic impact of human serum albumin-thioredoxin fusion protein on influenza virus-induced lung injury mice.

Front Immunol 2014 5;5:561. Epub 2014 Nov 5.

Faculty of Pharmaceutical Sciences, Sojo University , Kumamoto , Japan ; DDS Research Institute, Sojo University , Kumamoto , Japan.

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http://dx.doi.org/10.3389/fimmu.2014.00561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220708PMC
November 2014