Torsten Klengel

Torsten Klengel

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Torsten Klengel

Torsten Klengel

Publications by authors named "Torsten Klengel"

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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Authors:
Caroline M Nievergelt Adam X Maihofer Torsten Klengel Elizabeth G Atkinson Chia-Yen Chen Karmel W Choi Jonathan R I Coleman Shareefa Dalvie Laramie E Duncan Joel Gelernter Daniel F Levey Mark W Logue Renato Polimanti Allison C Provost Andrew Ratanatharathorn Murray B Stein Katy Torres Allison E Aiello Lynn M Almli Ananda B Amstadter Søren B Andersen Ole A Andreassen Paul A Arbisi Allison E Ashley-Koch S Bryn Austin Esmina Avdibegovic Dragan Babić Marie Bækvad-Hansen Dewleen G Baker Jean C Beckham Laura J Bierut Jonathan I Bisson Marco P Boks Elizabeth A Bolger Anders D Børglum Bekh Bradley Megan Brashear Gerome Breen Richard A Bryant Angela C Bustamante Jonas Bybjerg-Grauholm Joseph R Calabrese José M Caldas-de-Almeida Anders M Dale Mark J Daly Nikolaos P Daskalakis Jürgen Deckert Douglas L Delahanty Michelle F Dennis Seth G Disner Katharina Domschke Alma Dzubur-Kulenovic Christopher R Erbes Alexandra Evans Lindsay A Farrer Norah C Feeny Janine D Flory David Forbes Carol E Franz Sandro Galea Melanie E Garrett Bizu Gelaye Elbert Geuze Charles Gillespie Aferdita Goci Uka Scott D Gordon Guia Guffanti Rasha Hammamieh Supriya Harnal Michael A Hauser Andrew C Heath Sian M J Hemmings David Michael Hougaard Miro Jakovljevic Marti Jett Eric Otto Johnson Ian Jones Tanja Jovanovic Xue-Jun Qin Angela G Junglen Karen-Inge Karstoft Milissa L Kaufman Ronald C Kessler Alaptagin Khan Nathan A Kimbrel Anthony P King Nastassja Koen Henry R Kranzler William S Kremen Bruce R Lawford Lauren A M Lebois Catrin E Lewis Sarah D Linnstaedt Adriana Lori Bozo Lugonja Jurjen J Luykx Michael J Lyons Jessica Maples-Keller Charles Marmar Alicia R Martin Nicholas G Martin Douglas Maurer Matig R Mavissakalian Alexander McFarlane Regina E McGlinchey Katie A McLaughlin Samuel A McLean Sarah McLeay Divya Mehta William P Milberg Mark W Miller Rajendra A Morey Charles Phillip Morris Ole Mors Preben B Mortensen Benjamin M Neale Elliot C Nelson Merete Nordentoft Sonya B Norman Meaghan O'Donnell Holly K Orcutt Matthew S Panizzon Edward S Peters Alan L Peterson Matthew Peverill Robert H Pietrzak Melissa A Polusny John P Rice Stephan Ripke Victoria B Risbrough Andrea L Roberts Alex O Rothbaum Barbara O Rothbaum Peter Roy-Byrne Ken Ruggiero Ariane Rung Bart P F Rutten Nancy L Saccone Sixto E Sanchez Dick Schijven Soraya Seedat Antonia V Seligowski Julia S Seng Christina M Sheerin Derrick Silove Alicia K Smith Jordan W Smoller Scott R Sponheim Dan J Stein Jennifer S Stevens Jennifer A Sumner Martin H Teicher Wesley K Thompson Edward Trapido Monica Uddin Robert J Ursano Leigh Luella van den Heuvel Miranda Van Hooff Eric Vermetten Christiaan H Vinkers Joanne Voisey Yunpeng Wang Zhewu Wang Thomas Werge Michelle A Williams Douglas E Williamson Sherry Winternitz Christiane Wolf Erika J Wolf Jonathan D Wolff Rachel Yehuda Ross McD Young Keith A Young Hongyu Zhao Lori A Zoellner Israel Liberzon Kerry J Ressler Magali Haas Karestan C Koenen

Nat Commun 2019 Oct 8;10(1):4558. Epub 2019 Oct 8.

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-12576-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783435PMC
October 2019

A Potential Role for the Noncoding Transcriptome in Psychiatric Disorders.

Authors:
Torsten Klengel

Harv Rev Psychiatry 2018 Nov/Dec;26(6):364-373

From Harvard Medical School and Division of Depression and Anxiety, McLean Hospital, Belmont, MA.

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http://dx.doi.org/10.1097/HRP.0000000000000206DOI Listing
June 2019

Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study.

Biol Psychiatry 2019 May 21;85(10):838-849. Epub 2019 Jan 21.

Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Institute of Genetic Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2018.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552666PMC
May 2019

Does sleep disruption mediate the effects of childhood maltreatment on brain structure?

Eur J Psychotraumatol 2017 28;8(Suppl 7):1450594. Epub 2018 Mar 28.

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1080/20008198.2018.1450594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965034PMC
March 2018

Exposure to Violence Accelerates Epigenetic Aging in Children.

Sci Rep 2017 08 21;7(1):8962. Epub 2017 Aug 21.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle NE (Clifton RD NE), Atlanta, GA, 30322, USA.

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http://www.nature.com/articles/s41598-017-09235-9
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http://dx.doi.org/10.1038/s41598-017-09235-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566406PMC
August 2017

Epigenetic Signatures of Cigarette Smoking.

Circ Cardiovasc Genet 2016 Oct 20;9(5):436-447. Epub 2016 Sep 20.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267325PMC
October 2016

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.

Biol Psychiatry 2016 09 12;80(5):372-80. Epub 2015 Aug 12.

Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1016/j.biopsych.2015.08.005DOI Listing
September 2016

LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family.

Am J Med Genet B Neuropsychiatr Genet 2016 06 16;171(4):534-45. Epub 2016 Mar 16.

Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California.

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http://dx.doi.org/10.1002/ajmg.b.32437DOI Listing
June 2016

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

PLoS One 2014 5;9(9):e107241. Epub 2014 Sep 5.

Department of Molecular Medicine, Byrd Alzheimer's Research Institute, University of South Florida, Tampa, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107241PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156438PMC
February 2016

Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala.

Neuropsychopharmacology 2016 Feb 15;41(3):832-46. Epub 2015 Jul 15.

Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.

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http://dx.doi.org/10.1038/npp.2015.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707829PMC
February 2016

Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice.

Neuropsychopharmacology 2016 Jan 18;41(1):219-31. Epub 2015 Aug 18.

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1038/npp.2015.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677139PMC
January 2016

The transcriptional landscape of age in human peripheral blood.

Authors:
Marjolein J Peters Roby Joehanes Luke C Pilling Claudia Schurmann Karen N Conneely Joseph Powell Eva Reinmaa George L Sutphin Alexandra Zhernakova Katharina Schramm Yana A Wilson Sayuko Kobes Taru Tukiainen Yolande F Ramos Harald H H Göring Myriam Fornage Yongmei Liu Sina A Gharib Barbara E Stranger Philip L De Jager Abraham Aviv Daniel Levy Joanne M Murabito Peter J Munson Tianxiao Huan Albert Hofman André G Uitterlinden Fernando Rivadeneira Jeroen van Rooij Lisette Stolk Linda Broer Michael M P J Verbiest Mila Jhamai Pascal Arp Andres Metspalu Liina Tserel Lili Milani Nilesh J Samani Pärt Peterson Silva Kasela Veryan Codd Annette Peters Cavin K Ward-Caviness Christian Herder Melanie Waldenberger Michael Roden Paula Singmann Sonja Zeilinger Thomas Illig Georg Homuth Hans-Jörgen Grabe Henry Völzke Leif Steil Thomas Kocher Anna Murray David Melzer Hanieh Yaghootkar Stefania Bandinelli Eric K Moses Jack W Kent Joanne E Curran Matthew P Johnson Sarah Williams-Blangero Harm-Jan Westra Allan F McRae Jennifer A Smith Sharon L R Kardia Iiris Hovatta Markus Perola Samuli Ripatti Veikko Salomaa Anjali K Henders Nicholas G Martin Alicia K Smith Divya Mehta Elisabeth B Binder K Maria Nylocks Elizabeth M Kennedy Torsten Klengel Jingzhong Ding Astrid M Suchy-Dicey Daniel A Enquobahrie Jennifer Brody Jerome I Rotter Yii-Der I Chen Jeanine Houwing-Duistermaat Margreet Kloppenburg P Eline Slagboom Quinta Helmer Wouter den Hollander Shannon Bean Towfique Raj Noman Bakhshi Qiao Ping Wang Lisa J Oyston Bruce M Psaty Russell P Tracy Grant W Montgomery Stephen T Turner John Blangero Ingrid Meulenbelt Kerry J Ressler Jian Yang Lude Franke Johannes Kettunen Peter M Visscher G Gregory Neely Ron Korstanje Robert L Hanson Holger Prokisch Luigi Ferrucci Tonu Esko Alexander Teumer Joyce B J van Meurs Andrew D Johnson

Nat Commun 2015 Oct 22;6:8570. Epub 2015 Oct 22.

The National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1038/ncomms9570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639797PMC
October 2015

Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions.

Neuron 2015 Jun;86(6):1343-57

Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.05.036DOI Listing
June 2015

Epigenetic mechanisms underlying learning and the inheritance of learned behaviors.

Trends Neurosci 2015 Feb 24;38(2):96-107. Epub 2014 Dec 24.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1016/j.tins.2014.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323865PMC
February 2015

DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain.

Am J Med Genet B Neuropsychiatr Genet 2015 Jan 29;168B(1):36-44. Epub 2014 Oct 29.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia; Genetics and Molecular Biology Program, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1002/ajmg.b.32278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610814PMC
January 2015

FKBP5 allele-specific epigenetic modification in gene by environment interaction.

Neuropsychopharmacology 2015 Jan;40(1):244-6

1] Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany [2] Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1038/npp.2014.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262902PMC
January 2015

Hypothalamic-pituitary-adrenocortical axis activity as a potential predictor for withdrawal symptoms in addiction to flupirtine, a nonopiate analgesic.

J Clin Psychopharmacol 2014 Dec;34(6):e6-8

Max Planck Institute of Psychiatry Munich, Germany; Max Planck Institute of Psychiatry Munich, Germany.

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http://dx.doi.org/10.1097/JCP.0000000000000096DOI Listing
December 2014

The role of DNA methylation in stress-related psychiatric disorders.

Neuropharmacology 2014 May 19;80:115-32. Epub 2014 Jan 19.

Department of Translational Research, Max Planck Institute of Psychiatry, Munich 80804, Germany; Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.01.013DOI Listing
May 2014

Accounting for population stratification in DNA methylation studies.

Genet Epidemiol 2014 Apr 29;38(3):231-41. Epub 2014 Jan 29.

Department of Biostatistics, Harvard University, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.21789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090102PMC
April 2014

Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans.

Hum Genet 2013 Sep 9;132(9):1027-37. Epub 2013 May 9.

Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE #3049, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/s00439-013-1311-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744600PMC
September 2013

Epigenetics, depression and antidepressant treatment.

Curr Pharm Des 2012 ;18(36):5879-89

Max Planck Institute of Psychiatry, Munich, Germany.

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http://dx.doi.org/10.2174/138161212803523590DOI Listing
May 2013

Gene × environment interactions in the prediction of response to antidepressant treatment.

Int J Neuropsychopharmacol 2013 Apr 14;16(3):701-11. Epub 2012 Dec 14.

Max Planck Institute of Psychiatry, Munich, Germany.

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https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S14
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http://dx.doi.org/10.1017/S1461145712001459DOI Listing
April 2013

Gene-environment interactions in major depressive disorder.

Can J Psychiatry 2013 Feb;58(2):76-83

Max Planck Institute of Psychiatry, Munich, Germany.

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http://dx.doi.org/10.1177/070674371305800203DOI Listing
February 2013

Peripheral blood gene expression: it all boils down to the RNA collection tubes.

BMC Res Notes 2012 Jan 4;5. Epub 2012 Jan 4.

Max Planck Institute of Psychiatry, Kraepelinstr, 10, D-80804 Munich, Germany.

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http://dx.doi.org/10.1186/1756-0500-5-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280191PMC
January 2012

Peripheral blood gene expression: it all boils down to the RNA collection tubes.

BMC Res Notes 2012 Jan 4;5. Epub 2012 Jan 4.

Max Planck Institute of Psychiatry, Kraepelinstr, 10, D-80804 Munich, Germany.

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http://dx.doi.org/10.1186/1756-0500-5-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280191PMC
January 2012

Using gene-environment interactions to target personalized treatment in mood disorder.

Per Med 2011 Jan;8(1):23-34

Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.2217/pme.10.73DOI Listing
January 2011