Torben F Orntoft

Torben F Orntoft

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Torben F Orntoft

Publications by authors named "Torben F Orntoft"

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Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine.

Eur Urol Focus 2018 12 9;4(6):825-833. Epub 2017 Mar 9.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2017.02.018DOI Listing
December 2018

Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer.

Sci Rep 2017 09 15;7(1):11702. Epub 2017 Sep 15.

Department of Molecular Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.

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http://dx.doi.org/10.1038/s41598-017-11291-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600970PMC
September 2017

An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes.

Cell Syst 2017 06 7;4(6):587-599.e4. Epub 2017 Jun 7.

Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493283PMC
June 2017

Ectodermal dysplasia with immunodeficiency caused by a branch-point mutation in IKBKG/NEMO.

J Allergy Clin Immunol 2016 12 29;138(6):1706-1709.e4. Epub 2016 Jun 29.

Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark; International Center for Immunodeficiency Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Aarhus Research Center for Innate Immunity, Aarhus University, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.05.030DOI Listing
December 2016

Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma.

Mol Oncol 2016 11 17;10(9):1450-1460. Epub 2016 Aug 17.

Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423216PMC
November 2016

Genomic Alterations in Liquid Biopsies from Patients with Bladder Cancer.

Eur Urol 2016 07 20;70(1):75-82. Epub 2016 Jan 20.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.01.007DOI Listing
July 2016

BS-SNPer: SNP calling in bisulfite-seq data.

Bioinformatics 2015 Dec 28;31(24):4006-8. Epub 2015 Aug 28.

Department of Biomedicine, Aarhus University, Aarhus, Denmark, BGI Co. Ltd., Shenzhen 518083, China, BioInformatics Research Center (BIRC), Aarhus University, Aarhus 8000, Denmark.

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http://dx.doi.org/10.1093/bioinformatics/btv507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673977PMC
December 2015

Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case-control study.

BMC Cancer 2015 Oct 29;15:819. Epub 2015 Oct 29.

Department of Molecular Medicine, MOMA, Aarhus University Hospital, Skejby, DK-8200, Aarhus N, Denmark.

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http://dx.doi.org/10.1186/s12885-015-1832-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625973PMC
October 2015

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

J Exp Med 2015 Aug 27;212(9):1371-9. Epub 2015 Jul 27.

Department of Molecular Biology and Genetics, Aarhus Research Center for Innate Immunity, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark Department of Molecular Biology and Genetics, Aarhus Research Center for Innate Immunity, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark Department of Infectious Diseases, International Center for Immunodeficiency Diseases, Department of Molecular Medicine, Department of Clinical Immunology, Aarhus University Hospital Skejby, 8200 Aarhus, Denmark Department of Infectious Diseases, International Center for Immunodeficiency Diseases, Department of Molecular Medicine, Department of Clinical Immunology, Aarhus University Hospital Skejby, 8200 Aarhus, Denmark

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http://dx.doi.org/10.1084/jem.20142274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548062PMC
August 2015

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.

Cancer Epidemiol Biomarkers Prev 2015 Jul 2;24(7):1121-9. Epub 2015 Apr 2.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491026PMC
July 2015

Intratumour heterogeneity in urologic cancers: from molecular evidence to clinical implications.

Eur Urol 2015 Apr 2;67(4):729-37. Epub 2014 May 2.

CR-UK London Research Institute, London, UK; University College London Cancer Institute, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838140039
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http://dx.doi.org/10.1016/j.eururo.2014.04.014DOI Listing
April 2015

Prognostic DNA methylation markers for prostate cancer.

Int J Mol Sci 2014 Sep 18;15(9):16544-76. Epub 2014 Sep 18.

Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark.

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http://dx.doi.org/10.3390/ijms150916544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200823PMC
September 2014

Putative cis-regulatory drivers in colorectal cancer.

Nature 2014 Aug 23;512(7512):87-90. Epub 2014 Jul 23.

1] Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland [2] Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland [3] Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1038/nature13602DOI Listing
August 2014

High expression of GEM and EDNRA is associated with metastasis and poor outcome in patients with advanced bladder cancer.

BMC Cancer 2014 Aug 30;14:638. Epub 2014 Aug 30.

Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1186/1471-2407-14-638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164753PMC
August 2014

[In Process Citation].

Ugeskr Laeger 2014 Jun;176(11A)

Torben F. Ørntoft, Aarhus, Universitetshospital, Skejby, Brendstrupgardsvej 100, 8200 Aarhus N.

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June 2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Nat Commun 2014 Apr 3;5:3608. Epub 2014 Apr 3.

1] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Catalonia, Spain.

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http://dx.doi.org/10.1038/ncomms4608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988805PMC
April 2014

Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation.

Cell Rep 2014 Apr 13;7(2):501-513. Epub 2014 Apr 13.

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.041DOI Listing
April 2014

Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy.

Clin Cancer Res 2014 Apr;20(8):2169-81

Authors' Affiliations: Departments of Molecular Medicine and Urology and Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark; Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland; Department of Urology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland; Departments of Oncology and Pathology and Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2642DOI Listing
April 2014

Profiling of circulating microRNAs for prostate cancer biomarker discovery.

Drug Deliv Transl Res 2014 Feb;4(1):19-30

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1007/s13346-013-0169-4DOI Listing
February 2014

DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.

J Clin Oncol 2013 Sep 5;31(26):3250-8. Epub 2013 Aug 5.

Christa Haldrup, Kamilla Mundbjerg, Else Marie Vestergaard, Philippe Lamy, Michael Borre, Søren Høyer, Torben F. Ørntoft, and Karina D. Sørensen, Aarhus University Hospital, Aarhus, Denmark; Peter Wild, University Hospital Zurich, Zurich, Switzerland; Wolfgang A. Schulz and Christian Arsov, Heinrich Heine University, Düsseldorf, Germany; and Tapio Visakorpi, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://jco.ascopubs.org/content/early/2013/08/05/JCO.2012.47
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2012.47.1847
Publisher Site
http://dx.doi.org/10.1200/JCO.2012.47.1847DOI Listing
September 2013

The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers.

J Pathol 2013 Mar;229(4):630-9

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University - Hadassah Medical School, Jerusalem, Israel.

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http://doi.wiley.com/10.1002/path.4129
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http://dx.doi.org/10.1002/path.4129DOI Listing
March 2013

Evaluation of two commercial global miRNA expression profiling platforms for detection of less abundant miRNAs.

BMC Genomics 2011 Aug 26;12:435. Epub 2011 Aug 26.

Department of Molecular Medicine (MOMA), Aarhus University Hospital-Skejby, DK-8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1186/1471-2164-12-435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184117PMC
August 2011

Rseg--an R package to optimize segmentation of SNP array data.

Bioinformatics 2011 Feb 5;27(3):419-20. Epub 2010 Dec 5.

Department of Molecular Medicine, Aarhus University Hospital Skejby, Aarhus N, Denmark.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btq668DOI Listing
February 2011

Personalised treatment for bladder cancer.

Lancet Oncol 2011 Feb 20;12(2):111-2. Epub 2011 Jan 20.

Aarhus University Hospital, Department of Molecular Medicine, Brendstrupgaardsvej, Aarhus, Denmark.

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http://dx.doi.org/10.1016/S1470-2045(11)70001-8DOI Listing
February 2011

Identification of a core set of genes that signifies pathways underlying cardiac hypertrophy.

Comp Funct Genomics 2004 ;5(6-7):459-70

CHARC (Copenhagen Heart Arrhythmia Research Center), Department of Medicine B, H : S Rigshospitalet, University of Copenhagen Medical School, 20 Juliane Mariesvej, Copenhagen DK 2100, Denmark.

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http://dx.doi.org/10.1002/cfg.428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447423PMC
June 2010

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer.

Clin Cancer Res 2009 Dec;15(24):7642-7651

Authors' Affiliations: Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research; Anatomic Pathology Department, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom; Department of Medical Genetics, Biomedicum, University of Helsinki, Helsinki, Finland; Group of Molecular Oncology, Nanomedicine Research Program, Molecular Biology and Biochemistry Research Center (Centro de Investigación Bioquímica y Biología Molecular), Vall d'Hebron Hospital Research Institute, Barcelona, Spain; Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark; and GI Surgical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920750PMC
December 2009

Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.

Fam Cancer 2009 20;8(1):75-83. Epub 2008 Jun 20.

Clinical Research Centre and HNPCC-Register, Copenhagen University, Hvidovre University Hospital, Kettegård Allé 30, Hvidovre, 2650, Denmark.

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http://dx.doi.org/10.1007/s10689-008-9199-3DOI Listing
April 2009

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer.

J Mol Med (Berl) 2009 Jan 31;87(1):85-97. Epub 2008 Oct 31.

Molecular Diagnostic Laboratory, Center for Molecular Clinical Cancer Research, Arhus University Hospital/Skejby, 8200, Aarhus, Denmark.

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http://link.springer.com/10.1007/s00109-008-0409-0
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http://dx.doi.org/10.1007/s00109-008-0409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614561PMC
January 2009

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest.

Cancer Res 2008 Dec;68(24):10094-104

Department of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836584PMC
December 2008

Gene signatures for risk-adapted treatment of bladder cancer.

Scand J Urol Nephrol Suppl 2008 Sep(218):166-74

Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1080/03008880802283730DOI Listing
September 2008

Diagnostic and prognostic microRNAs in stage II colon cancer.

Cancer Res 2008 Aug;68(15):6416-24

Department of Clinical Biochemistry, Molecular Diagnostic Laboratory, Aarhus University Hospital, Aarhus N, Denmark.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6110DOI Listing
August 2008

Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.

Mol Cell Proteomics 2008 Jul 18;7(7):1214-24. Epub 2008 Mar 18.

Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1074/mcp.M700590-MCP200DOI Listing
July 2008

Increased cell motility and invasion upon knockdown of lipolysis stimulated lipoprotein receptor (LSR) in SW780 bladder cancer cells.

BMC Med Genomics 2008 Jul 22;1:31. Epub 2008 Jul 22.

Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1186/1755-8794-1-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492871PMC
July 2008

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling.

J Mol Signal 2007 Jul 16;2. Epub 2007 Jul 16.

Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1186/1750-2187-2-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976611PMC
July 2007

Transcriptional profile of Ki-Ras-induced transformation of thyroid cells.

Cancer Invest 2007 Jun;25(4):256-66

Dipartimento di Biologia e Patologia Cellulare e Molecolare, L. Califano, Universita' degli Studi di Napoli Federico II e/o Istituto di Endocrinologia e Oncologia Sperimentale G. Salvatore del CNR, Napoli, Italy.

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http://dx.doi.org/10.1080/07357900701206406DOI Listing
June 2007