Tooru Shimosegawa

Tooru Shimosegawa

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Tooru Shimosegawa

Tooru Shimosegawa

Publications by authors named "Tooru Shimosegawa"

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100Publications

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A new manometry device for evaluating the sphincter of Oddi using a fiber-optic pressure sensor.

Minim Invasive Ther Allied Technol 2018 Aug 12;27(4):226-232. Epub 2017 Dec 12.

b Graduate School of Biomedical Engineering , Tohoku University , Sendai , Japan.

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August 2018

Cellular Membrane Trafficking Machineries Used by the Hepatitis Viruses.

Hepatology 2018 Aug;68(2):751-762

Department of Biochemistry and Molecular Biology and Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, MN.

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August 2018

Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells.

Dig Dis Sci 2018 07 4;63(7):1868-1877. Epub 2018 Apr 4.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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July 2018

Inhibitory effect of silibinin on hepatitis B virus entry.

Biochem Biophys Rep 2018 Jul 31;14:20-25. Epub 2018 Mar 31.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, Japan.

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July 2018

[Early chronic pancreatitis:current issues and perspective].

Nihon Shokakibyo Gakkai Zasshi 2017;114(12):2089-2096

Division of Gastroenterology, Tohoku University Graduate School of Medicine.

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June 2018

Acute-onset Autoimmune Hepatitis in a Young Woman with Type 1 Diabetes Mellitus.

Intern Med 2018 Jun 11;57(11):1591-1596. Epub 2018 Jan 11.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.

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June 2018

Clinical Practice Guidelines for Pancreatic Cancer 2016 From the Japan Pancreas Society: A Synopsis.

Pancreas 2017 May/Jun;46(5):595-604

From the *Clinic of Fukuoka Government Building, Hamanomachi Hospital, Fukuoka; †Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital; ‡Department of Gastroenterology, Tokyo Women's Medical University; §Department of Medical Oncology, Faculty of Medicine, Kyorin University; ∥Department of Radiation Oncology, National Cancer Center Hospital, Tokyo; ¶Department of Gastroenterology, JA Onomichi General Hospital, Onomichi; #Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai; and **Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.

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March 2018

Residual Lesions on Capsule Endoscopy Is Associated with Postoperative Clinical Recurrence in Patients with Crohn's Disease.

Dig Dis Sci 2018 Mar 29;63(3):768-774. Epub 2018 Jan 29.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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March 2018

Evidence-based clinical practice guidelines for inflammatory bowel disease.

J Gastroenterol 2018 Mar 10;53(3):305-353. Epub 2018 Feb 10.

Guidelines Committee for Creating and Evaluating the ''Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease in Japan'', The Japanese Society of Gastroenterology (JSGE), 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, Japan.

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March 2018

Effective and less invasive diagnostic strategy for gastrointestinal GVHD.

Endosc Int Open 2018 Mar 1;6(3):E281-E291. Epub 2018 Mar 1.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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March 2018

Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping.

J Gastroenterol 2018 Feb 30;53(2):172-180. Epub 2017 Nov 30.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.

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February 2018

Estrogen-Dependent Nrf2 Expression Protects Against Reflux-Induced Esophagitis.

Dig Dis Sci 2018 02 27;63(2):345-355. Epub 2017 Dec 27.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

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February 2018

Differences in Gut Microbiota Profiles between Autoimmune Pancreatitis and Chronic Pancreatitis.

Tohoku J Exp Med 2018 02;244(2):113-117

Division of Gastroenterology, Tohoku University Graduate School of Medicine.

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February 2018

Nationwide survey of hereditary pancreatitis in Japan.

J Gastroenterol 2018 01 31;53(1):152-160. Epub 2017 Aug 31.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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January 2018

Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.

Am J Physiol Gastrointest Liver Physiol 2018 01 28;314(1):G65-G74. Epub 2017 Sep 28.

Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai , Japan.

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January 2018

Exosomes derived from pancreatic cancer cells induce activation and profibrogenic activities in pancreatic stellate cells.

Biochem Biophys Res Commun 2018 01 28;495(1):71-77. Epub 2017 Oct 28.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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January 2018

Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn's disease is a risk factor for disease relapse in Japanese patients.

J Gastroenterol 2017 Dec 22;52(12):1230-1239. Epub 2017 Feb 22.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.

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December 2017

Severity assessment of acute pancreatitis using four prognostic factors - a nationwide multicenter study of 3682 cases in Japan.

United European Gastroenterol J 2017 Dec 3;5(8):1136-1137. Epub 2017 Aug 3.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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December 2017

Gastroesophageal Variceal Bleeding Successfully Controlled by Partial Splenic Embolization.

Intern Med 2017 1;56(11):1339-1343. Epub 2017 Jun 1.

Division of Gastroenterology1, Tohoku University Hospital, Japan.

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October 2017

The slow progressive nature of duodenal neuroendocrine tumor: a case report of long-term observation over 14 years.

Clin J Gastroenterol 2017 Oct 29;10(5):469-473. Epub 2017 Jun 29.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.

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October 2017

Endoscopic removal of migrated colonic self-expandable metallic stent using a sliding tube.

Endoscopy 2017 10 18;49(10):E240-E241. Epub 2017 Jul 18.

Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

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October 2017

Risk factors associated with postoperative recurrence and repeat surgery in Japanese patients with Crohn's disease.

Int J Colorectal Dis 2017 Oct 22;32(10):1407-1413. Epub 2017 Jul 22.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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October 2017

Management of aorto-esophageal fistula secondary after thoracic endovascular aortic repair: a review of literature.

Clin J Gastroenterol 2017 Oct 1;10(5):393-402. Epub 2017 Aug 1.

Division of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 981-8574, Japan.

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October 2017

Chronic pancreatitis.

Nat Rev Dis Primers 2017 Sep 7;3:17060. Epub 2017 Sep 7.

Department of General Surgery, University of Heidelberg, Heidelberg, Germany.

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September 2017

International consensus for the treatment of autoimmune pancreatitis.

Pancreatology 2017 Jan - Feb;17(1):1-6. Epub 2016 Dec 12.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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August 2017

Factors Associated With Metachronous Gastric Cancer Development After Endoscopic Submucosal Dissection for Early Gastric Cancer.

J Clin Gastroenterol 2017 Jul;51(6):494-499

*Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai †Department of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.

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July 2017

Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis.

Carcinogenesis 2017 06;38(6):661-670

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

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June 2017

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones.

Gastroenterology 2017 05 11;152(6):1521-1535.e8. Epub 2017 Jan 11.

Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan; Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (CREST), Tokyo, Japan.

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May 2017

Kindlin-2 in pancreatic stellate cells promotes the progression of pancreatic cancer.

Cancer Lett 2017 04 16;390:103-114. Epub 2017 Jan 16.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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April 2017

American Pancreatic Association and Japan Pancreas Society: Sisterhood Memorandum of Understanding.

Pancreas 2017 04;46(4):453-454

From the *UCLA Agi Hirshberg Center for Pancreatic Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA; †Japan Pancreas Society, Tohoku University Graduate School of Medicine, Sendai, Japan; ‡American Pancreatic Association, University of Miami, Miami, FL; §Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; and ∥Pancreas Research Foundation of Japan, Tokyo, Japan.

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April 2017

Transition of early-phase treatment for acute pancreatitis: An analysis of nationwide epidemiological survey.

World J Gastroenterol 2017 Apr;23(16):2826-2831

Shin Hamada, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

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April 2017

Variants in the UBR1 gene are not associated with chronic pancreatitis in Japan.

Pancreatology 2016 Sep-Oct;16(5):814-8. Epub 2016 Jul 2.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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March 2017

Evidence-based clinical practice guidelines for cholelithiasis 2016.

J Gastroenterol 2017 Mar 10;52(3):276-300. Epub 2016 Dec 10.

, Guidelines Committee for the Japanese Society of Gastroenterology ''Evidence-based clinical practice guidelines for cholelithiasis'', Hiroshima, Japan.

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March 2017

Plasma Kallikrein-Dependent Transforming Growth Factor-β Activation in Patients With Chronic Pancreatitis and Pancreatic Cancer.

Pancreas 2017 03;46(3):e20-e22

Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Japan; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Japan; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Japan

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March 2017

Exosomes Derived From Pancreatic Stellate Cells: MicroRNA Signature and Effects on Pancreatic Cancer Cells.

Pancreas 2017 01;46(1):19-27

From the Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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January 2017

Chronic pancreatitis: An international draft consensus proposal for a new mechanistic definition.

Pancreatology 2016 Mar-Apr;16(2):218-24. Epub 2016 Feb 16.

Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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December 2016

DNA Damage in CD133-Positive Cells in Barrett's Esophagus and Esophageal Adenocarcinoma.

Mediators Inflamm 2016 10;2016:7937814. Epub 2016 Mar 10.

Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan.

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December 2016

PD-L1MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment.

Sci Rep 2016 12 14;6:39296. Epub 2016 Dec 14.

Division of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo, Aoba, Sendai City, 980-8574, Miyagi, Japan.

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December 2016

Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society.

Pancreas 2016 11;45(10):1411-1417

From the *Japan Pancreas Society, Sendai; †Department of Surgery, Graduate School of Medicine, Osaka University, Osaka; ‡Second Department of Surgery, Wakayama Medical University, Wakayama; §Department of Surgery and ∥Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai; ¶Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; #Department of Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki; **Department of Surgery, Kansai Medical University, Osaka; ††Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya; ‡‡Department of Surgery, Shiga University of Medical Science, Otsu; §§Department of Gastroenterology, IMS Sapporo Digestive Center General Hospital, Sapporo; ∥∥Department of Endoscopy, Nagoya University Hospital; and ¶¶Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya; ##Kyushu University Hospital Cancer Center, Fukuoka; ***Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo; †††Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto; and ‡‡‡Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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November 2016

Usefulness of Endoscopic Imaging to Visualize Regional Alterations in Acid Secretion of Noncancerous Gastric Mucosa after Eradication.

J Gastric Cancer 2016 Sep 30;16(3):152-160. Epub 2016 Sep 30.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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September 2016

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015.

J Gastroenterol 2016 Aug 21;51(8):751-67. Epub 2016 Jun 21.

Guidelines Committee for Creating and Evaluating the "Evidence-based Clinical Practice Guidelines for Gastroesophageal Reflux Disease", the Japanese Society of Gastroenterology (JSGE), K-18 Building 8F, 8-9-13, Ginza, Chuo, Tokyo, 104-0061, Japan.

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August 2016

Notch1 directly induced CD133 expression in human diffuse type gastric cancers.

Oncotarget 2016 Aug;7(35):56598-56607

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi 980-8574, Japan.

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August 2016

Current status of ERCP pancreatitis and matters in future.

Nihon Shokakibyo Gakkai Zasshi 2016 08;113(8):1365-70

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University, School of Medicine.

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August 2016

Evidence-based clinical practice guidelines for liver cirrhosis 2015.

J Gastroenterol 2016 Jul 31;51(7):629-50. Epub 2016 May 31.

Guidelines Committee for creating and evaluating the ''Evidence-based clinical practice guidelines for liver cirrhosis'', Japanese Society of Gastroenterology (JSGE), K-18 Building 8F, 8-9-13, Ginza, Chuo, Tokyo, 104-0061, Japan.

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July 2016

MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6.

World J Gastrointest Oncol 2016 Jul;8(7):532-42

Toshihiro Tadano, Yoichi Kakuta, Shin Hamada, Yosuke Shimodaira, Masatake Kuroha, Yoko Kawakami, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

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July 2016

Management of acute pancreatitis in Japan: Analysis of nationwide epidemiological survey.

World J Gastroenterol 2016 Jul;22(28):6335-44

Shin Hamada, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

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July 2016

No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.

Gastroenterology 2016 06 3;150(7):1558-1560.e5. Epub 2016 Mar 3.

Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address:

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June 2016

Reactivation of resolved hepatitis B virus infection with immune escape mutations after long-term corticosteroid therapy.

Clin J Gastroenterol 2016 Apr 26;9(2):93-8. Epub 2016 Feb 26.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai, 980-8574, Japan.

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April 2016

A case of a ruptured submucosal aneurysm of the small intestine identified using double-balloon enteroscopy.

Clin J Gastroenterol 2016 Apr 18;9(2):49-54. Epub 2016 Mar 18.

Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai, 980-8574, Japan.

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April 2016

Clinical Impact of Elevated Serum Triglycerides in Acute Pancreatitis: Validation from the Nationwide Epidemiological Survey in Japan.

Am J Gastroenterol 2016 04;111(4):575-6

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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April 2016

Evidence-based clinical practice guidelines for peptic ulcer disease 2015.

J Gastroenterol 2016 Mar 15;51(3):177-94. Epub 2016 Feb 15.

Guidelines Committee for creating and evaluating the "Evidence-based clinical practice guidelines for peptic ulcer", the Japanese Society of Gastroenterology (JSGE), K-18 Building 8F, 8-9-13, Ginza, Chuo, Tokyo, 104-0061, Japan.

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March 2016

Gastric cancer development after the successful eradication of Helicobacter pylori.

World J Gastrointest Oncol 2016 Mar;8(3):271-81

Kaname Uno, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Hospital, Miyagi 981-8574, Japan.

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March 2016

Gender difference in gastro-esophageal reflux diseases.

World J Gastroenterol 2016 Feb;22(5):1800-10

Kiyotaka Asanuma, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi Prefecture 980-8574, Japan.

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February 2016

A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis.

Gastroenterol Res Pract 2016 20;2016:3162595. Epub 2016 Jan 20.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, Japan.

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February 2016

Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis.

World J Gastrointest Pathophysiol 2016 Feb;7(1):131-7

Gen Kusaka, Kaname Uno, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Hospital, Sendai, Miyagi 981-8574, Japan.

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February 2016