Publications by authors named "Tony Velkov"

100Publications

Comparative metabolomics reveals key pathways associated with the synergistic activity of polymyxin B and rifampicin combination against multidrug-resistant Acinetobacter baumannii.

Biochem Pharmacol 2020 Dec 30;184:114400. Epub 2020 Dec 30.

Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne 3800, Australia. Electronic address:

View Article and Find Full Text PDF
December 2020

Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-Resistant in a Murine Bloodstream Infection Model.

Microorganisms 2020 Nov 16;8(11). Epub 2020 Nov 16.

Infection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.

View Article and Find Full Text PDF
November 2020

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens.

Comput Struct Biotechnol J 2020 21;18:2247-2258. Epub 2020 Aug 21.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.

View Article and Find Full Text PDF
August 2020

Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency.

J Biol Chem 2020 Nov 10;295(47):15902-15912. Epub 2020 Sep 10.

Biomedicine Discovery Institute, Infection & Immunity Program, Department of Microbiology, Monash University, Melbourne, Victoria, Australia

View Article and Find Full Text PDF
November 2020

Outer Membranes of Polymyxin-Resistant with Phosphoethanolamine-Modified Lipid A and Lipopolysaccharide Loss Display Different Atomic-Scale Interactions with Polymyxins.

ACS Infect Dis 2020 10 15;6(10):2698-2708. Epub 2020 Sep 15.

Biomedicine Discovery Institute, Infection & Immunity Program, Department of Microbiology, Monash University, Melbourne, VIC 3800, Australia.

View Article and Find Full Text PDF
October 2020

Sialylation of Asparagine 612 Inhibits Aconitase Activity during Mouse Sperm Capacitation; a Possible Mechanism for the Switch from Oxidative Phosphorylation to Glycolysis.

Mol Cell Proteomics 2020 11 24;19(11):1860-1875. Epub 2020 Aug 24.

Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia

View Article and Find Full Text PDF
November 2020

Lipid A profiling and metabolomics analysis of paired polymyxin-susceptible and -resistant MDR Klebsiella pneumoniae clinical isolates from the same patients before and after colistin treatment.

J Antimicrob Chemother 2020 Oct;75(10):2852-2863

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.

View Article and Find Full Text PDF
October 2020

Structure-Activity Relationships of Daptomycin Lipopeptides.

J Med Chem 2020 11 6;63(22):13266-13290. Epub 2020 Aug 6.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.

View Article and Find Full Text PDF
November 2020

The Antimicrobial Activity of Cannabinoids.

Antibiotics (Basel) 2020 Jul 13;9(7). Epub 2020 Jul 13.

Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne 3010, VIC, Australia.

View Article and Find Full Text PDF
July 2020

Polymyxin-Induced Cell Death of Human Macrophage-Like THP-1 and Neutrophil-Like HL-60 Cells Associated with the Activation of Apoptotic Pathways.

Antimicrob Agents Chemother 2020 08 20;64(9). Epub 2020 Aug 20.

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria, Australia

View Article and Find Full Text PDF
August 2020

Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells.

ACS Infect Dis 2020 08 17;6(8):2110-2119. Epub 2020 Jul 17.

Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton, Melbourne, Victoria 3800, Australia.

View Article and Find Full Text PDF
August 2020

Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.

Int J Antimicrob Agents 2020 Aug 20;56(2):106061. Epub 2020 Jun 20.

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia. Electronic address:

View Article and Find Full Text PDF
August 2020

Polymyxins-Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment.

Antioxidants (Basel) 2020 Jun 9;9(6). Epub 2020 Jun 9.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, China.

View Article and Find Full Text PDF
June 2020

Pan-transcriptomic analysis identified common differentially expressed genes of Acinetobacter baumannii in response to polymyxin treatments.

Mol Omics 2020 08 29;16(4):327-338. Epub 2020 May 29.

Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, 19 Innovation Walk, Melbourne 3800, Australia.

View Article and Find Full Text PDF
August 2020

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study.

mSystems 2020 May 26;5(3). Epub 2020 May 26.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia

View Article and Find Full Text PDF
May 2020

Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline.

ACS Infect Dis 2020 06 25;6(6):1436-1450. Epub 2020 May 25.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

View Article and Find Full Text PDF
June 2020

Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity.

ACS Infect Dis 2020 06 21;6(6):1451-1459. Epub 2020 May 21.

College of Veterinary Medicine, China Agricultural University, Beijing 100193, P. R. China.

View Article and Find Full Text PDF
June 2020

Polymyxin Triple Combinations against Polymyxin-Resistant, Multidrug-Resistant, KPC-Producing Klebsiella pneumoniae.

Antimicrob Agents Chemother 2020 07 22;64(8). Epub 2020 Jul 22.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

View Article and Find Full Text PDF
July 2020

Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB.

Future Microbiol 2020 04 6;15:445-459. Epub 2020 Apr 6.

Biomedicine Discovery Institute & Department of Microbiology, Monash University, Melbourne 3800, Australia.

View Article and Find Full Text PDF
April 2020

Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606.

Int J Med Microbiol 2020 Apr 5;310(3):151412. Epub 2020 Feb 5.

Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Melbourne, VIC, 3800, Australia. Electronic address:

View Article and Find Full Text PDF
April 2020

Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice.

ACS Infect Dis 2020 04 20;6(4):715-724. Epub 2020 Feb 20.

College of Veterinary Medicine, China Agricultural University, Beijing 100193, P. R. China.

View Article and Find Full Text PDF
April 2020

Structure of micelle bound cationic peptides by NMR spectroscopy using a lanthanide shift reagent.

Chem Commun (Camb) 2020 Mar 10;56(19):2897-2900. Epub 2020 Feb 10.

Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria 3010, Australia.

View Article and Find Full Text PDF
March 2020

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections.

Int J Pharm 2020 Feb 6;575:118915. Epub 2019 Dec 6.

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address:

View Article and Find Full Text PDF
February 2020

Synthesis and structure-activity relationships of teixobactin.

Ann N Y Acad Sci 2020 01 2;1459(1):86-105. Epub 2019 Dec 2.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, the University of Melbourne, Parkville, Victoria, Australia.

View Article and Find Full Text PDF
January 2020

DNA variants are an unlikely explanation for the changing quality of spermatozoa within the same individual.

Hum Fertil (Camb) 2019 Oct 23:1-13. Epub 2019 Oct 23.

Department of Environmental and Life Sciences, University of Newcastle , Callaghan , New South Wales , Australia.

View Article and Find Full Text PDF
October 2019

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant .

Front Pharmacol 2019 3;10:1146. Epub 2019 Oct 3.

Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, VIC, Australia.

View Article and Find Full Text PDF
October 2019

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2019 12 20;64(1). Epub 2019 Dec 20.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia

View Article and Find Full Text PDF
December 2019

An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform.

J Mater Chem B 2019 11 11;7(43):6796-6809. Epub 2019 Oct 11.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, 381 Royal Pde, Parkville, VIC 3052, Australia. and Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Pde, Parkville, VIC 3052, Australia.

View Article and Find Full Text PDF
November 2019

T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction.

Arch Toxicol 2019 11 30;93(11):3041-3056. Epub 2019 Sep 30.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.

View Article and Find Full Text PDF
November 2019

The impact of backbone N-methylation on the structure-activity relationship of Leu -teixobactin.

J Pept Sci 2019 Sep 6;25(9):e3206. Epub 2019 Aug 6.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia.

View Article and Find Full Text PDF
September 2019

Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment.

J Infect 2019 10 30;79(4):312-321. Epub 2019 Jul 30.

Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne 3800, Australia. Electronic address:

View Article and Find Full Text PDF
October 2019

Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1.

J Antimicrob Chemother 2019 11;74(11):3190-3198

Department of Microbiology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

View Article and Find Full Text PDF
November 2019

Discovery of Novel Polymyxin-Like Antibiotics.

Adv Exp Med Biol 2019 ;1145:343-362

Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia.

View Article and Find Full Text PDF
September 2019

Mechanisms of Polymyxin-Induced Nephrotoxicity.

Adv Exp Med Biol 2019 ;1145:305-319

Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Clayton Campus, Melbourne, VIC, Australia.

View Article and Find Full Text PDF
September 2019

Polymyxins: Mode of Action.

Adv Exp Med Biol 2019 ;1145:37-54

Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Australia.

View Article and Find Full Text PDF
September 2019

History, Chemistry and Antibacterial Spectrum.

Adv Exp Med Biol 2019 ;1145:15-36

Centre for Medicine Use and Safety, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

View Article and Find Full Text PDF
September 2019

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant .

Front Pharmacol 2019 4;10:754. Epub 2019 Jul 4.

Biomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, VIC, Australia.

View Article and Find Full Text PDF
July 2019

The rise and spread of plasmid-mediated polymyxin resistance.

Crit Rev Microbiol 2019 Mar 23;45(2):131-161. Epub 2019 May 23.

b Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences , The University of Melbourne , Parkville , Australia.

View Article and Find Full Text PDF
March 2019

Global Metabolic Analyses of Acinetobacter baumannii.

Methods Mol Biol 2019 ;1946:321-328

Laboratory of Antimicrobial Systems Pharmacology, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.

View Article and Find Full Text PDF
July 2019

Metabolic Responses to Polymyxin Treatment in ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling.

mSystems 2019 Jan-Feb;4(1). Epub 2019 Feb 5.

Infection & Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Australia.

View Article and Find Full Text PDF
February 2019

Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae.

Antimicrob Agents Chemother 2019 04 27;63(4). Epub 2019 Mar 27.

Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria, Australia

View Article and Find Full Text PDF
April 2019

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa.

mSystems 2019 Jan-Feb;4(1). Epub 2019 Jan 8.

Biomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia.

View Article and Find Full Text PDF
January 2019

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR .

Comput Struct Biotechnol J 2018 10;16:587-599. Epub 2018 Nov 10.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville 3010, VIC, Australia.

View Article and Find Full Text PDF
November 2018

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant .

Front Microbiol 2018 16;9:2776. Epub 2018 Nov 16.

Biomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, VIC, Australia.

View Article and Find Full Text PDF
November 2018

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms.

ACS Infect Dis 2019 01 20;5(1):35-48. Epub 2018 Dec 20.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences , The University of Melbourne , Parkville , Victoria 3010 , Australia.

View Article and Find Full Text PDF
January 2019

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.

Cell Death Dis 2018 11 26;9(12):1164. Epub 2018 Nov 26.

College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, P. R. China.

View Article and Find Full Text PDF
November 2018

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention.

ACS Chem Neurosci 2019 01 7;10(1):120-131. Epub 2018 Nov 7.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine , China Agricultural University , No. 2 Yuanmingyuan West Road , Beijing 100193 , P. R. China.

View Article and Find Full Text PDF
January 2019

Exploiting Macromolecular Design To Optimize the Antibacterial Activity of Alkylated Cationic Oligomers.

Biomacromolecules 2018 12 6;19(12):4629-4640. Epub 2018 Nov 6.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology , Monash University , 381 Royal Pde , Parkville , VIC 3052 , Australia.

View Article and Find Full Text PDF
December 2018

Intracellular localization of polymyxins in human alveolar epithelial cells.

J Antimicrob Chemother 2019 01;74(1):48-57

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia.

View Article and Find Full Text PDF
January 2019

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains.

ACS Infect Dis 2018 12 5;4(12):1692-1704. Epub 2018 Oct 5.

Department of Pharmacology and Therapeutics , University of Melbourne , Parkville , Victoria 3010 , Australia.

View Article and Find Full Text PDF
December 2018

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Clinical Isolates.

Int J Mol Sci 2018 Aug 10;19(8). Epub 2018 Aug 10.

Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia.

View Article and Find Full Text PDF
August 2018

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation.

Int J Pharm 2018 Sep 3;548(1):443-453. Epub 2018 Jul 3.

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address:

View Article and Find Full Text PDF
September 2018

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant : A Metabolomic Study.

Front Pharmacol 2018 16;9:359. Epub 2018 Apr 16.

Monash Biomedicine Discovery Institute, Department of Microbiology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.

View Article and Find Full Text PDF
April 2018

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens.

Front Microbiol 2018 12;9:721. Epub 2018 Apr 12.

Monash Biomedicine Discovery Institute, Department of Microbiology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.

View Article and Find Full Text PDF
April 2018

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa.

Gigascience 2018 04;7(4)

Monash Biomedicine Discovery Institute, Department of Microbiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne 3800, Australia.

View Article and Find Full Text PDF
April 2018

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2018 06 25;62(6). Epub 2018 May 25.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

View Article and Find Full Text PDF
June 2018

Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensively Drug-Resistant Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2018 06 25;62(6). Epub 2018 May 25.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

View Article and Find Full Text PDF
June 2018

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules.

ACS Infect Dis 2018 05 2;4(5):646-655. Epub 2018 Apr 2.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences , Monash University , Parkville , Victoria 3052 , Australia.

View Article and Find Full Text PDF
May 2018

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

ERJ Open Res 2018 Jan 13;4(1). Epub 2018 Mar 13.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.

View Article and Find Full Text PDF
January 2018

Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae.

J Antimicrob Chemother 2018 06;73(6):1604-1610

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia.

View Article and Find Full Text PDF
June 2018

A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens.

Antimicrob Agents Chemother 2018 05 26;62(5). Epub 2018 Apr 26.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

View Article and Find Full Text PDF
May 2018

T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.

Food Chem Toxicol 2018 Apr 9;114:88-97. Epub 2018 Feb 9.

College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China. Electronic address:

View Article and Find Full Text PDF
April 2018

Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across 10 clinically relevant Gram-negative bacteria.

Int J Antimicrob Agents 2018 Apr 27;51(4):586-593. Epub 2017 Dec 27.

Infection and Immunity Programme, Monash Biomedicine Discovery Institute, Monash University, Victoria, Australia; Department of Microbiology, Monash University, Victoria, Australia. Electronic address:

View Article and Find Full Text PDF
April 2018

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens.

Eur J Med Chem 2018 Mar 6;148:507-518. Epub 2017 Oct 6.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences Monash University, VIC, 3052, Australia; School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China. Electronic address:

View Article and Find Full Text PDF
March 2018

Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.

ACS Chem Neurosci 2018 04 5;9(4):824-837. Epub 2018 Jan 5.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine , China Agricultural University , No.2 Yuanmingyuan West Road , Beijing 100193 , P. R. China.

View Article and Find Full Text PDF
April 2018

A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?

Vaccines (Basel) 2017 Dec 13;5(4). Epub 2017 Dec 13.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.

View Article and Find Full Text PDF
December 2017

Proteomic analysis of good- and poor-quality human sperm demonstrates that several proteins are routinely aberrantly regulated.

Biol Reprod 2018 08;99(2):395-408

Department of Environmental and Life Science, University of Newcastle, Callaghan, New South Wales, Australia.

View Article and Find Full Text PDF
August 2018

Design and Evaluation of Novel Polymyxin Fluorescent Probes.

Sensors (Basel) 2017 Nov 11;17(11). Epub 2017 Nov 11.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.

View Article and Find Full Text PDF
November 2017

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress.

Antimicrob Agents Chemother 2018 01 21;62(1). Epub 2017 Dec 21.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Melbourne, Victoria, Australia

View Article and Find Full Text PDF
January 2018

Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency.

J Mater Chem B 2017 Jan 13;5(3):531-536. Epub 2016 Dec 13.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, 381 Royal Pde, Parkville, VIC, Australia, 3052.

View Article and Find Full Text PDF
January 2017

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia

View Article and Find Full Text PDF
December 2017

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

View Article and Find Full Text PDF
December 2017

Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response.

J Antimicrob Chemother 2017 09;72(9):2562-2569

Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China.

View Article and Find Full Text PDF
September 2017

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

Org Biomol Chem 2017 Aug;15(34):7173-7180

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Australia.

View Article and Find Full Text PDF
August 2017

Polymyxins for CNS infections: Pharmacology and neurotoxicity.

Pharmacol Ther 2018 01 25;181:85-90. Epub 2017 Jul 25.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.

View Article and Find Full Text PDF
January 2018

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.

ACS Infect Dis 2017 08 11;3(8):606-619. Epub 2017 Jul 11.

Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville 3052, Victoria Australia.

View Article and Find Full Text PDF
August 2017

Pulsed-voltage atom probe tomography of low conductivity and insulator materials by application of ultrathin metallic coating on nanoscale specimen geometry.

Ultramicroscopy 2017 10 13;181:150-159. Epub 2017 May 13.

Department of Mechanical and Aerospace Engineering, Monash University, Clayton, VIC 3800, Australia; ARC Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia. Electronic address:

View Article and Find Full Text PDF
October 2017

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.

J Nat Prod 2017 05 2;80(5):1264-1274. Epub 2017 May 2.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University , Clayton, Victoria 3800, Australia.

View Article and Find Full Text PDF
May 2017

Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs.

PLoS One 2017 20;12(4):e0176149. Epub 2017 Apr 20.

Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, P. R. China.

View Article and Find Full Text PDF
September 2017

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia

View Article and Find Full Text PDF
June 2017

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'.

Essays Biochem 2017 02 3;61(1):115-125. Epub 2017 Mar 3.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.

View Article and Find Full Text PDF
February 2017

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress.

J Antimicrob Chemother 2017 06;72(6):1635-1645

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

View Article and Find Full Text PDF
June 2017

Rediscovering the octapeptins.

Nat Prod Rep 2017 03;34(3):295-309

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, VIC, 3800, Australia.

View Article and Find Full Text PDF
March 2017

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria.

J Control Release 2017 08 5;259:83-91. Epub 2017 Feb 5.

Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:

View Article and Find Full Text PDF
August 2017

Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin.

ACS Infect Dis 2017 03 10;3(3):249-258. Epub 2017 Feb 10.

Drug Development and Innovation, Drug Delivery, Disposition and Dynamics. Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia.

View Article and Find Full Text PDF
March 2017