Publications by authors named "Tony Tiganis"

81 Publications

PtdIns(3,4,5)P-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis.

Proc Natl Acad Sci U S A 2020 11 23;117(45):28056-28067. Epub 2020 Oct 23.

Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia;

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November 2020

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.

Mol Cell 2020 10;80(2):279-295.e8

Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia. Electronic address:

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October 2020

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells.

Cell Rep 2020 07;32(4):107957

Division of Animal Physiology and Immunology, TUM School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany; Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

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July 2020

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.

Cell Rep 2019 Sep;28(11):2905-2922.e5

Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Monash Metabolic Phenotyping Facility, Monash University, VIC, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address:

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September 2019

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice.

Neuroendocrinology 2019 16;109(4):374-390. Epub 2019 Apr 16.

Department of Physiology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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May 2020

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.

Cell Rep 2019 01;26(2):346-355.e3

Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia. Electronic address:

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January 2019

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development.

Oncotarget 2018 Oct 23;9(83):35378-35393. Epub 2018 Oct 23.

Infection and Immunity Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Melbourne, Victoria 3800, Australia.

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October 2018

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.

Cell 2018 11 25;175(5):1289-1306.e20. Epub 2018 Oct 25.

Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address:

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November 2018

Age-Related Decline in Primary CD8 T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 T Cells.

Cell Rep 2018 06;23(12):3512-3524

Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia. Electronic address:

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June 2018

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.

Diabetes 2018 07 30;67(7):1246-1257. Epub 2018 Apr 30.

Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria, Australia

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July 2018

Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway in .

Genetics 2018 04 13;208(4):1523-1533. Epub 2018 Feb 13.

School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia

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April 2018

Isolation and Characterization of Mouse Intrahepatic Lymphocytes by Flow Cytometry.

Methods Mol Biol 2018 ;1725:301-311

Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.

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January 2019

PTPN2: a tumor suppressor you want deleted?

Immunol Cell Biol 2017 11 10;95(10):859-861. Epub 2017 Oct 10.

Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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November 2017

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

J Exp Med 2017 Sep 10;214(9):2733-2758. Epub 2017 Aug 10.

Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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September 2017

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.

Cell Metab 2017 Aug;26(2):375-393.e7

Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. Electronic address:

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August 2017

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Immunity 2016 10 4;45(4):749-760. Epub 2016 Oct 4.

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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October 2016

Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Diabetologia 2016 12;59(12):2729

Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.

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December 2016

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.

Endocrinology 2016 Dec 12;157(12):4732-4743. Epub 2016 Oct 12.

The Development and Stem Cells Program of the Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology (J.C.Y.L., A.E.O., M.K.O.), The Obesity and Metabolism Program of the Biomedicine Discovery Institute (J.C.Y.L., Z.B.A., T.T., M.J.W.), Departments of Physiology (J.C.Y.L., Z.B.A., M.J.W.) and Biochemistry and Molecular Biology (T.T.), and Monash Micro Imaging (C.L.), Monash University, Victoria 3800, Australia.

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December 2016

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity.

J Autoimmun 2017 01 19;76:85-100. Epub 2016 Sep 19.

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia. Electronic address:

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January 2017