Tony Tiganis

Tony Tiganis

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Tony Tiganis

Tony Tiganis

Publications by authors named "Tony Tiganis"

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Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.

Cell Rep 2019 Sep;28(11):2905-2922.e5

Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Monash Metabolic Phenotyping Facility, Monash University, VIC, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.019DOI Listing
September 2019

T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.

Diabetes 2019 06 1;68(6):1251-1266. Epub 2019 Apr 1.

Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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http://dx.doi.org/10.2337/db18-1362DOI Listing
June 2019

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice.

Neuroendocrinology 2019 16;109(4):374-390. Epub 2019 Apr 16.

Department of Physiology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1159/000500201DOI Listing
April 2019

Isolation and Characterization of Mouse Intrahepatic Lymphocytes by Flow Cytometry.

Methods Mol Biol 2018 ;1725:301-311

Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7568-6_23DOI Listing
January 2019

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.

Cell Rep 2019 01;26(2):346-355.e3

Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.061DOI Listing
January 2019

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.

Cell 2018 11 25;175(5):1289-1306.e20. Epub 2018 Oct 25.

Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183130
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http://dx.doi.org/10.1016/j.cell.2018.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242467PMC
November 2018

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development.

Oncotarget 2018 Oct 23;9(83):35378-35393. Epub 2018 Oct 23.

Infection and Immunity Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Melbourne, Victoria 3800, Australia.

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http://dx.doi.org/10.18632/oncotarget.26237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226044PMC
October 2018

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.

Diabetes 2018 07 30;67(7):1246-1257. Epub 2018 Apr 30.

Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria, Australia

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http://dx.doi.org/10.2337/db17-1485DOI Listing
July 2018

Age-Related Decline in Primary CD8 T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 T Cells.

Cell Rep 2018 06;23(12):3512-3524

Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.057DOI Listing
June 2018

PTPN2: a tumor suppressor you want deleted?

Immunol Cell Biol 2017 11 10;95(10):859-861. Epub 2017 Oct 10.

Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2017.70DOI Listing
November 2017

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

J Exp Med 2017 Sep 10;214(9):2733-2758. Epub 2017 Aug 10.

Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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http://dx.doi.org/10.1084/jem.20161903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584121PMC
September 2017

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.

Cell Metab 2017 Aug;26(2):375-393.e7

Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.07.013DOI Listing
August 2017

Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.

FEBS J 2017 07 30;284(14):2231-2250. Epub 2017 Jun 30.

Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/febs.14118DOI Listing
July 2017

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity.

J Autoimmun 2017 01 19;76:85-100. Epub 2016 Sep 19.

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.09.004DOI Listing
January 2017

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Diabetologia 2016 12 15;59(12):2632-2644. Epub 2016 Sep 15.

Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.

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http://dx.doi.org/10.1007/s00125-016-4084-3DOI Listing
December 2016

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.

Endocrinology 2016 Dec 12;157(12):4732-4743. Epub 2016 Oct 12.

The Development and Stem Cells Program of the Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology (J.C.Y.L., A.E.O., M.K.O.), The Obesity and Metabolism Program of the Biomedicine Discovery Institute (J.C.Y.L., Z.B.A., T.T., M.J.W.), Departments of Physiology (J.C.Y.L., Z.B.A., M.J.W.) and Biochemistry and Molecular Biology (T.T.), and Monash Micro Imaging (C.L.), Monash University, Victoria 3800, Australia.

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http://dx.doi.org/10.1210/en.2016-1487DOI Listing
December 2016

Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Diabetologia 2016 12;59(12):2729

Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.

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http://dx.doi.org/10.1007/s00125-016-4124-zDOI Listing
December 2016

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Immunity 2016 10 4;45(4):749-760. Epub 2016 Oct 4.

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.09.007DOI Listing
October 2016

PTPN2 attenuates T-cell lymphopenia-induced proliferation.

Nat Commun 2014 ;5:3073

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1038/ncomms4073DOI Listing
November 2015

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.

Nat Immunol 2015 Nov 5;16(11):1153-61. Epub 2015 Oct 5.

Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1038/ni.3271DOI Listing
November 2015

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.

Trends Pharmacol Sci 2015 Oct;36(10):661-674

Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia. Electronic address:

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http://www.cell.com/trends/pharmacological-sciences/pdf/S016
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http://linkinghub.elsevier.com/retrieve/pii/S016561471500142
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http://dx.doi.org/10.1016/j.tips.2015.07.003DOI Listing
October 2015

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets.

Diabetes 2015 Jul 2;64(7):2489-96. Epub 2015 Mar 2.

St Vincent's Institute of Medical Research, Melbourne, Victoria, Australia Department of Medicine, St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-1575DOI Listing
July 2015

Pioneer of Eph biology and therapeutics: Martin Lackmann (1956-2014).

Growth Factors 2014 Dec 17;32(6):171-3. Epub 2014 Nov 17.

Ludwig Institute for Cancer Research , Melbourne, VIC , Australia .

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http://dx.doi.org/10.3109/08977194.2014.983226DOI Listing
December 2014

PTPN2 restrains CD8⁺ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice.

J Autoimmun 2014 Sep 2;53:105-14. Epub 2014 Jul 2.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2014.05.008DOI Listing
September 2014

Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis.

Cell Commun Signal 2014 Mar 10;12:13. Epub 2014 Mar 10.

Department of Nutrition, University of California Davis, One Shields Ave, 3135 Meyer Hall, Davis, CA 95616, USA.

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http://dx.doi.org/10.1186/1478-811X-12-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016516PMC
March 2014

Characterization of PTPN2 and its use as a biomarker.

Methods 2014 Jan 30;65(2):239-46. Epub 2013 Aug 30.

Goodman Cancer Research Center, McGill University, Montreal, QC, Canada; Department of Biochemistry, McGill University, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2013.08.020DOI Listing
January 2014

Special issue--signalling. Introduction: Frontiers in cell signalling.

FEBS J 2013 Nov 23;280(21):5163. Epub 2013 Sep 23.

Department of Biochemistry and Molecular Biology, Monash University, Australia.

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http://dx.doi.org/10.1111/febs.12508DOI Listing
November 2013

PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis.

Authors:
Tony Tiganis

FEBS J 2013 Jan 18;280(2):445-58. Epub 2012 Apr 18.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08563.xDOI Listing
January 2013

Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase.

Endocrinology 2012 Sep 25;153(9):4278-89. Epub 2012 Jun 25.

Department of Physiology, Monash University, Clayton, 3800 Victoria, Australia.

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http://dx.doi.org/10.1210/en.2012-1127DOI Listing
September 2012

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

J Clin Invest 2011 Dec 14;121(12):4758-74. Epub 2011 Nov 14.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1172/JCI59492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226006PMC
December 2011

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.

Biochem J 2011 Oct;439(1):151-9

Institute of Biological Chemistry, Academia Sinica, Taipei, 115 Taiwan.

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http://dx.doi.org/10.1042/BJ20110799DOI Listing
October 2011

Reactive oxygen species and insulin resistance: the good, the bad and the ugly.

Authors:
Tony Tiganis

Trends Pharmacol Sci 2011 Feb 14;32(2):82-9. Epub 2010 Dec 14.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1016/j.tips.2010.11.006DOI Listing
February 2011

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.

Nature 2010 Oct;467(7317):844-8

The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1038/nature09448DOI Listing
October 2010

Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1.

Endocrinology 2010 Jan 4;151(1):185-94. Epub 2009 Dec 4.

Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1210/en.2009-0590DOI Listing
January 2010

Replication checkpoint control by a PTK/STAT3/cyclin D1 axis.

Cell Cycle 2009 Jan;8(2):223-30

Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.

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http://dx.doi.org/10.4161/cc.8.2.7382DOI Listing
January 2009

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.

Blood 2008 Nov 20;112(10):4098-108. Epub 2008 Aug 20.

Sylvester Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Medicine, Monash University, Victoria, Australia.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-03-14
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http://dx.doi.org/10.1182/blood-2008-03-148726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582009PMC
November 2008

Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signalling by the protein tyrosine phosphatase TCPTP.

Cell Cycle 2008 Nov 8;7(21):3405-16. Epub 2008 Nov 8.

Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.

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http://dx.doi.org/10.4161/cc.7.21.6950DOI Listing
November 2008

DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression.

Cancer Cell 2008 Aug;14(2):166-79

Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.

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http://dx.doi.org/10.1016/j.ccr.2008.06.003DOI Listing
August 2008

Protein tyrosine phosphatase function: the substrate perspective.

Biochem J 2007 Feb;402(1):1-15

Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.

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http://dx.doi.org/10.1042/BJ20061548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783993PMC
February 2007

Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization.

Biochem J 2005 Jul;389(Pt 2):343-54

Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.

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http://dx.doi.org/10.1042/BJ20041932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175111PMC
July 2005

Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.

Nat Immunol 2005 Mar 6;6(3):253-60. Epub 2005 Feb 6.

Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.

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http://dx.doi.org/10.1038/ni1169DOI Listing
March 2005

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

Mol Cell Biol 2005 Jan;25(2):819-29

Department of Biochemistry and Molecular Biology, P.O. Box 13D, Monash University, Victoria 3800, Australia.

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http://dx.doi.org/10.1128/MCB.25.2.819-829.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC543412PMC
January 2005

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

J Biol Chem 2004 Sep 10;279(36):37716-25. Epub 2004 Jun 10.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1074/jbc.M404606200DOI Listing
September 2004

Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.

Int J Cancer 2003 Jun;105(3):331-9

Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.

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http://dx.doi.org/10.1002/ijc.11085DOI Listing
June 2003

Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor.

Authors:
Tony Tiganis

IUBMB Life 2002 Jan;53(1):3-14

Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.

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http://dx.doi.org/10.1080/15216540210811DOI Listing
January 2002