Tony R Merriman

Tony R Merriman

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Tony R Merriman

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Population-specific factors associated with fractional excretion of uric acid.

Arthritis Res Ther 2019 Nov 12;21(1):234. Epub 2019 Nov 12.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand.

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http://dx.doi.org/10.1186/s13075-019-2016-6DOI Listing
November 2019

Differential DNA methylation of networked signaling, transcriptional, innate and adaptive immunity, and osteoclastogenesis genes and pathways in gout.

Arthritis Rheumatol 2019 Nov 18. Epub 2019 Nov 18.

Division of Rheumatology, Allergy and Immunology, Department of Medicine (and San Diego VA for RLB and RT), La Jolla, CA, 92093.

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http://dx.doi.org/10.1002/art.41173DOI Listing
November 2019

Associations of autozygosity with a broad range of human phenotypes.

Authors:
David W Clark Yukinori Okada Kristjan H S Moore Dan Mason Nicola Pirastu Ilaria Gandin Hannele Mattsson Catriona L K Barnes Kuang Lin Jing Hua Zhao Patrick Deelen Rebecca Rohde Claudia Schurmann Xiuqing Guo Franco Giulianini Weihua Zhang Carolina Medina-Gomez Robert Karlsson Yanchun Bao Traci M Bartz Clemens Baumbach Ginevra Biino Matthew J Bixley Marco Brumat Jin-Fang Chai Tanguy Corre Diana L Cousminer Annelot M Dekker David A Eccles Kristel R van Eijk Christian Fuchsberger He Gao Marine Germain Scott D Gordon Hugoline G de Haan Sarah E Harris Edith Hofer Alicia Huerta-Chagoya Catherine Igartua Iris E Jansen Yucheng Jia Tim Kacprowski Torgny Karlsson Marcus E Kleber Shengchao Alfred Li Ruifang Li-Gao Anubha Mahajan Koichi Matsuda Karina Meidtner Weihua Meng May E Montasser Peter J van der Most Matthias Munz Teresa Nutile Teemu Palviainen Gauri Prasad Rashmi B Prasad Tallapragada Divya Sri Priyanka Federica Rizzi Erika Salvi Bishwa R Sapkota Daniel Shriner Line Skotte Melissa C Smart Albert Vernon Smith Ashley van der Spek Cassandra N Spracklen Rona J Strawbridge Salman M Tajuddin Stella Trompet Constance Turman Niek Verweij Clara Viberti Lihua Wang Helen R Warren Robyn E Wootton Lisa R Yanek Jie Yao Noha A Yousri Wei Zhao Adebowale A Adeyemo Saima Afaq Carlos Alberto Aguilar-Salinas Masato Akiyama Matthew L Albert Matthew A Allison Maris Alver Tin Aung Fereidoun Azizi Amy R Bentley Heiner Boeing Eric Boerwinkle Judith B Borja Gert J de Borst Erwin P Bottinger Linda Broer Harry Campbell Stephen Chanock Miao-Li Chee Guanjie Chen Yii-Der I Chen Zhengming Chen Yen-Feng Chiu Massimiliano Cocca Francis S Collins Maria Pina Concas Janie Corley Giovanni Cugliari Rob M van Dam Anna Damulina Maryam S Daneshpour Felix R Day Graciela E Delgado Klodian Dhana Alexander S F Doney Marcus Dörr Ayo P Doumatey Nduna Dzimiri S Sunna Ebenesersdóttir Joshua Elliott Paul Elliott Ralf Ewert Janine F Felix Krista Fischer Barry I Freedman Giorgia Girotto Anuj Goel Martin Gögele Mark O Goodarzi Mariaelisa Graff Einat Granot-Hershkovitz Francine Grodstein Simonetta Guarrera Daniel F Gudbjartsson Kamran Guity Bjarni Gunnarsson Yu Guo Saskia P Hagenaars Christopher A Haiman Avner Halevy Tamara B Harris Mehdi Hedayati David A van Heel Makoto Hirata Imo Höfer Chao Agnes Hsiung Jinyan Huang Yi-Jen Hung M Arfan Ikram Anuradha Jagadeesan Pekka Jousilahti Yoichiro Kamatani Masahiro Kanai Nicola D Kerrison Thorsten Kessler Kay-Tee Khaw Chiea Chuen Khor Dominique P V de Kleijn Woon-Puay Koh Ivana Kolcic Peter Kraft Bernhard K Krämer Zoltán Kutalik Johanna Kuusisto Claudia Langenberg Lenore J Launer Deborah A Lawlor I-Te Lee Wen-Jane Lee Markus M Lerch Liming Li Jianjun Liu Marie Loh Stephanie J London Stephanie Loomis Yingchang Lu Jian'an Luan Reedik Mägi Ani W Manichaikul Paolo Manunta Gísli Másson Nana Matoba Xue W Mei Christa Meisinger Thomas Meitinger Massimo Mezzavilla Lili Milani Iona Y Millwood Yukihide Momozawa Amy Moore Pierre-Emmanuel Morange Hortensia Moreno-Macías Trevor A Mori Alanna C Morrison Taulant Muka Yoshinori Murakami Alison D Murray Renée de Mutsert Josyf C Mychaleckyj Mike A Nalls Matthias Nauck Matt J Neville Ilja M Nolte Ken K Ong Lorena Orozco Sandosh Padmanabhan Gunnar Pálsson James S Pankow Cristian Pattaro Alison Pattie Ozren Polasek Neil Poulter Peter P Pramstaller Lluis Quintana-Murci Katri Räikkönen Sarju Ralhan Dabeeru C Rao Wouter van Rheenen Stephen S Rich Paul M Ridker Cornelius A Rietveld Antonietta Robino Frank J A van Rooij Daniela Ruggiero Yasaman Saba Charumathi Sabanayagam Maria Sabater-Lleal Cinzia Felicita Sala Veikko Salomaa Kevin Sandow Helena Schmidt Laura J Scott William R Scott Bahareh Sedaghati-Khayat Bengt Sennblad Jessica van Setten Peter J Sever Wayne H-H Sheu Yuan Shi Smeeta Shrestha Sharvari Rahul Shukla Jon K Sigurdsson Timo Tonis Sikka Jai Rup Singh Blair H Smith Alena Stančáková Alice Stanton John M Starr Lilja Stefansdottir Leon Straker Patrick Sulem Gardar Sveinbjornsson Morris A Swertz Adele M Taylor Kent D Taylor Natalie Terzikhan Yih-Chung Tham Gudmar Thorleifsson Unnur Thorsteinsdottir Annika Tillander Russell P Tracy Teresa Tusié-Luna Ioanna Tzoulaki Simona Vaccargiu Jagadish Vangipurapu Jan H Veldink Veronique Vitart Uwe Völker Eero Vuoksimaa Salma M Wakil Melanie Waldenberger Gurpreet S Wander Ya Xing Wang Nicholas J Wareham Sarah Wild Chittaranjan S Yajnik Jian-Min Yuan Lingyao Zeng Liang Zhang Jie Zhou Najaf Amin Folkert W Asselbergs Stephan J L Bakker Diane M Becker Benjamin Lehne David A Bennett Leonard H van den Berg Sonja I Berndt Dwaipayan Bharadwaj Lawrence F Bielak Murielle Bochud Mike Boehnke Claude Bouchard Jonathan P Bradfield Jennifer A Brody Archie Campbell Shai Carmi Mark J Caulfield David Cesarini John C Chambers Giriraj Ratan Chandak Ching-Yu Cheng Marina Ciullo Marilyn Cornelis Daniele Cusi George Davey Smith Ian J Deary Rajkumar Dorajoo Cornelia M van Duijn David Ellinghaus Jeanette Erdmann Johan G Eriksson Evangelos Evangelou Michele K Evans Jessica D Faul Bjarke Feenstra Mary Feitosa Sylvain Foisy Andre Franke Yechiel Friedlander Paolo Gasparini Christian Gieger Clicerio Gonzalez Philippe Goyette Struan F A Grant Lyn R Griffiths Leif Groop Vilmundur Gudnason Ulf Gyllensten Hakon Hakonarson Anders Hamsten Pim van der Harst Chew-Kiat Heng Andrew A Hicks Hagit Hochner Heikki Huikuri Steven C Hunt Vincent W V Jaddoe Philip L De Jager Magnus Johannesson Åsa Johansson Jost B Jonas J Wouter Jukema Juhani Junttila Jaakko Kaprio Sharon L R Kardia Fredrik Karpe Meena Kumari Markku Laakso Sander W van der Laan Jari Lahti Matthias Laudes Rodney A Lea Wolfgang Lieb Thomas Lumley Nicholas G Martin Winfried März Giuseppe Matullo Mark I McCarthy Sarah E Medland Tony R Merriman Andres Metspalu Brian F Meyer Karen L Mohlke Grant W Montgomery Dennis Mook-Kanamori Patricia B Munroe Kari E North Dale R Nyholt Jeffery R O'connell Carole Ober Albertine J Oldehinkel Walter Palmas Colin Palmer Gerard G Pasterkamp Etienne Patin Craig E Pennell Louis Perusse Patricia A Peyser Mario Pirastu Tinca J C Polderman David J Porteous Danielle Posthuma Bruce M Psaty John D Rioux Fernando Rivadeneira Charles Rotimi Jerome I Rotter Igor Rudan Hester M Den Ruijter Dharambir K Sanghera Naveed Sattar Reinhold Schmidt Matthias B Schulze Heribert Schunkert Robert A Scott Alan R Shuldiner Xueling Sim Neil Small Jennifer A Smith Nona Sotoodehnia E-Shyong Tai Alexander Teumer Nicholas J Timpson Daniela Toniolo David-Alexandre Tregouet Tiinamaija Tuomi Peter Vollenweider Carol A Wang David R Weir John B Whitfield Cisca Wijmenga Tien-Yin Wong John Wright Jingyun Yang Lei Yu Babette S Zemel Alan B Zonderman Markus Perola Patrik K E Magnusson André G Uitterlinden Jaspal S Kooner Daniel I Chasman Ruth J F Loos Nora Franceschini Lude Franke Chris S Haley Caroline Hayward Robin G Walters John R B Perry Tōnu Esko Agnar Helgason Kari Stefansson Peter K Joshi Michiaki Kubo James F Wilson

Nat Commun 2019 Oct 31;10(1):4957. Epub 2019 Oct 31.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/s41467-019-12283-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823371PMC
October 2019

The Māori and Pacific specific CREBRF variant and adult height.

Int J Obes (Lond) 2019 Sep 22. Epub 2019 Sep 22.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1038/s41366-019-0437-6DOI Listing
September 2019

Mouse models for human hyperuricaemia: a critical review.

Nat Rev Rheumatol 2019 Jul;15(7):413-426

Department of Women's and Children's Health, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1038/s41584-019-0222-xDOI Listing
July 2019

Are Liquid Sugars Different from Solid Sugar in Their Ability to Cause Metabolic Syndrome?

Obesity (Silver Spring) 2019 Jun 4;27(6):879-887. Epub 2019 May 4.

Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1002/oby.22472DOI Listing
June 2019

Response to: 'The reference levels of serum urate for clinically evident incident gout' by Chen and Ding.

Ann Rheum Dis 2019 May 21;78(5):e42. Epub 2018 Mar 21.

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1136/annrheumdis-2018-213372DOI Listing
May 2019

Genetic advances in gout: potential applications in clinical practice.

Curr Opin Rheumatol 2019 Mar;31(2):144-151

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland.

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http://dx.doi.org/10.1097/BOR.0000000000000571DOI Listing
March 2019

Interactions between serum urate-associated genetic variants and sex on gout risk: analysis of the UK Biobank.

Arthritis Res Ther 2019 01 9;21(1):13. Epub 2019 Jan 9.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand.

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1787-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327586PMC
January 2019

No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study.

PLoS Med 2019 01 15;16(1):e1002725. Epub 2019 Jan 15.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://dx.plos.org/10.1371/journal.pmed.1002725
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http://dx.doi.org/10.1371/journal.pmed.1002725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333326PMC
January 2019

ABCG2 rs2231142 (Q141K) and oxypurinol concentrations in people with gout receiving allopurinol.

Drug Metab Pharmacokinet 2018 12 18;33(6):241-242. Epub 2018 Sep 18.

Department of Medicine, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.

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https://linkinghub.elsevier.com/retrieve/pii/S13474367183010
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http://dx.doi.org/10.1016/j.dmpk.2018.09.002DOI Listing
December 2018

A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression.

Hum Mol Genet 2018 11;27(22):3964-3973

Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1093/hmg/ddy295DOI Listing
November 2018

Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts.

BMJ 2018 Oct 10;363:k3951. Epub 2018 Oct 10.

Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174725PMC
http://dx.doi.org/10.1136/bmj.k3951DOI Listing
October 2018

Expert opinion on emerging urate-lowering therapies.

Expert Opin Emerg Drugs 2018 09;23(3):201-209

c Medicine Service , VA Medical Center , Birmingham , AL , USA.

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http://dx.doi.org/10.1080/14728214.2018.1527899DOI Listing
September 2018

Testicular Cancer in New Zealand (TCNZ) study: protocol for a national case-control study.

BMJ Open 2018 08 5;8(8):e025212. Epub 2018 Aug 5.

Cancer and Chronic Conditions (C3) Research Group, Department of Public Health, University of Otago, Wellington, New Zealand.

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http://dx.doi.org/10.1136/bmjopen-2018-025212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078234PMC
August 2018

Mediation analysis to understand genetic relationships between habitual coffee intake and gout.

Arthritis Res Ther 2018 07 5;20(1):135. Epub 2018 Jul 5.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand.

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http://dx.doi.org/10.1186/s13075-018-1629-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034252PMC
July 2018

An association of smoking with serum urate and gout: A health paradox.

Semin Arthritis Rheum 2018 06 22;47(6):825-842. Epub 2017 Nov 22.

Department of Medicine, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand.

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http://dx.doi.org/10.1016/j.semarthrit.2017.11.004DOI Listing
June 2018

An update on the genetics of hyperuricaemia and gout.

Nat Rev Rheumatol 2018 06;14(6):341-353

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1038/s41584-018-0004-xDOI Listing
June 2018

Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities.

Arthritis Res Ther 2018 05 3;20(1):90. Epub 2018 May 3.

Department of Epidemiology and Biostatistics, Michigan State University, 220 Trowbridge Rd, East Lansing, MI 48824, USA.

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http://dx.doi.org/10.1186/s13075-018-1558-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932762PMC
May 2018

Application of Genetic Epidemiology to CETP (Cholesteryl Ester Transfer Protein) Concentration and Risk of Cardiovascular Disease.

Authors:
Tony R Merriman

Circ Genom Precis Med 2018 05;11(5):e002138

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1161/CIRCGEN.118.002138DOI Listing
May 2018

Cardio-metabolic disease genetic risk factors among Māori and Pacific Island people in Aotearoa New Zealand: current state of knowledge and future directions.

Ann Hum Biol 2018 May;45(3):202-214

b Department of Mathematics and Statistics , University of Otago , Dunedin , Aotearoa , New Zealand.

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http://dx.doi.org/10.1080/03014460.2018.1461929DOI Listing
May 2018

Mitochondrial genetic variation and gout in Māori and Pacific people living in Aotearoa New Zealand.

Ann Rheum Dis 2018 04 15;77(4):571-578. Epub 2017 Dec 15.

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1136/annrheumdis-2017-212416DOI Listing
April 2018

Association between ABCG2 rs2231142 and poor response to allopurinol: replication and meta-analysis.

Rheumatology (Oxford) 2018 04;57(4):656-660

Department of Medicine, University of Otago, Christchurch, New Zealand.

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http://dx.doi.org/10.1093/rheumatology/kex467DOI Listing
April 2018

Multiplexed Nanopore Sequencing of HLA-B Locus in Māori and Pacific Island Samples.

Front Genet 2018 30;9:152. Epub 2018 Apr 30.

Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.

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http://dx.doi.org/10.3389/fgene.2018.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936980PMC
April 2018

Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans.

Am J Hypertens 2017 Nov;30(12):1196-1202

Division of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado, USA.

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http://dx.doi.org/10.1093/ajh/hpx123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248421PMC
November 2017

Performance of gout definitions for genetic epidemiological studies: analysis of UK Biobank.

Arthritis Res Ther 2017 08 9;19(1):181. Epub 2017 Aug 9.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand.

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http://dx.doi.org/10.1186/s13075-017-1390-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551011PMC
August 2017

Geo-epidemiology of temporal artery biopsy-positive giant cell arteritis in Australia and New Zealand: is there a seasonal influence?

RMD Open 2017 29;3(2):e000531. Epub 2017 Aug 29.

Department of Ophthalmology, Centre for Eye Research Australia, The University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1136/rmdopen-2017-000531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706482PMC
August 2017

Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.

Arthritis Res Ther 2017 07 5;19(1):161. Epub 2017 Jul 5.

Biochemistry Department, University of Otago, 710 Cumberland Street, Box 56, Dunedin, 9054, New Zealand.

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http://dx.doi.org/10.1186/s13075-017-1369-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499049PMC
July 2017

Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.

Sci Rep 2017 07 13;7(1):5261. Epub 2017 Jul 13.

Arthritis Research UK Centre for Genetics and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1038/s41598-017-05447-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509675PMC
July 2017

The genetics of gout: towards personalised medicine?

BMC Med 2017 05 31;15(1):108. Epub 2017 May 31.

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1186/s12916-017-0878-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452604PMC
May 2017

ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches.

Pharmgenomics Pers Med 2017 20;10:129-142. Epub 2017 Apr 20.

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.2147/PGPM.S105854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404803PMC
April 2017

Population-specific association between ABCG2 variants and tophaceous disease in people with gout.

Arthritis Res Ther 2017 03 7;19(1):43. Epub 2017 Mar 7.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand.

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http://dx.doi.org/10.1186/s13075-017-1254-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341474PMC
March 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253231PMC
January 2017

Gout.

Lancet 2016 Oct 21;388(10055):2039-2052. Epub 2016 Apr 21.

Department of Medicine, University of Otago, Christchurch, New Zealand.

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http://dx.doi.org/10.1016/S0140-6736(16)00346-9DOI Listing
October 2016

SRBreak: A Read-Depth and Split-Read Framework to Identify Breakpoints of Different Events Inside Simple Copy-Number Variable Regions.

Front Genet 2016 15;7:160. Epub 2016 Sep 15.

Department of Biochemistry, University of OtagoDunedin, New Zealand; Virtual Institute of Statistical GeneticsDunedin, New Zealand.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023681PMC
http://dx.doi.org/10.3389/fgene.2016.00160DOI Listing
September 2016

Insight into rheumatological cause and effect through the use of Mendelian randomization.

Nat Rev Rheumatol 2016 08 14;12(8):486-96. Epub 2016 Jul 14.

Department of Biochemistry, 710 Cumberland Street, University of Otago, Dunedin 9054, New Zealand.

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http://dx.doi.org/10.1038/nrrheum.2016.102DOI Listing
August 2016

Hyperuricaemia: contributions of urate transporter ABCG2 and the fractional renal clearance of urate.

Ann Rheum Dis 2016 07 1;75(7):1363-6. Epub 2015 Dec 1.

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1136/annrheumdis-2015-208111DOI Listing
July 2016

Clinical and genetic features of diuretic-associated gout: a case-control study.

Rheumatology (Oxford) 2016 07 17;55(7):1172-6. Epub 2016 Mar 17.

Department of Medicine, University of Auckland, Auckland,

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http://dx.doi.org/10.1093/rheumatology/kew018DOI Listing
July 2016

PTPN22 R620W minor allele is a genetic risk factor for giant cell arteritis.

RMD Open 2016 7;2(1):e000246. Epub 2016 Apr 7.

Department of Rheumatology, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia; The Health Observatory, University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1136/rmdopen-2016-000246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838769PMC
April 2016

Modulation of genetic associations with serum urate levels by body-mass-index in humans.

Authors:
Jennifer E Huffman Eva Albrecht Alexander Teumer Massimo Mangino Karen Kapur Toby Johnson Zoltán Kutalik Nicola Pirastu Giorgio Pistis Lorna M Lopez Toomas Haller Perttu Salo Anuj Goel Man Li Toshiko Tanaka Abbas Dehghan Daniela Ruggiero Giovanni Malerba Albert V Smith Ilja M Nolte Laura Portas Amanda Phipps-Green Lora Boteva Pau Navarro Asa Johansson Andrew A Hicks Ozren Polasek Tõnu Esko John F Peden Sarah E Harris Federico Murgia Sarah H Wild Albert Tenesa Adrienne Tin Evelin Mihailov Anne Grotevendt Gauti K Gislason Josef Coresh Pio D'Adamo Sheila Ulivi Peter Vollenweider Gerard Waeber Susan Campbell Ivana Kolcic Krista Fisher Margus Viigimaa Jeffrey E Metter Corrado Masciullo Elisabetta Trabetti Cristina Bombieri Rossella Sorice Angela Döring Eva Reischl Konstantin Strauch Albert Hofman Andre G Uitterlinden Melanie Waldenberger H-Erich Wichmann Gail Davies Alan J Gow Nicola Dalbeth Lisa Stamp Johannes H Smit Mirna Kirin Ramaiah Nagaraja Matthias Nauck Claudia Schurmann Kathrin Budde Susan M Farrington Evropi Theodoratou Antti Jula Veikko Salomaa Cinzia Sala Christian Hengstenberg Michel Burnier Reedik Mägi Norman Klopp Stefan Kloiber Sabine Schipf Samuli Ripatti Stefano Cabras Nicole Soranzo Georg Homuth Teresa Nutile Patricia B Munroe Nicholas Hastie Harry Campbell Igor Rudan Claudia Cabrera Chris Haley Oscar H Franco Tony R Merriman Vilmundur Gudnason Mario Pirastu Brenda W Penninx Harold Snieder Andres Metspalu Marina Ciullo Peter P Pramstaller Cornelia M van Duijn Luigi Ferrucci Giovanni Gambaro Ian J Deary Malcolm G Dunlop James F Wilson Paolo Gasparini Ulf Gyllensten Tim D Spector Alan F Wright Caroline Hayward Hugh Watkins Markus Perola Murielle Bochud W H Linda Kao Mark Caulfield Daniela Toniolo Henry Völzke Christian Gieger Anna Köttgen Veronique Vitart

PLoS One 2015 26;10(3):e0119752. Epub 2015 Mar 26.

Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374966PMC
March 2016

Predicting allopurinol response in patients with gout.

Br J Clin Pharmacol 2016 Feb 29;81(2):277-89. Epub 2015 Dec 29.

Department of Medicine, University of Otago, Christchurch.

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http://dx.doi.org/10.1111/bcp.12799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833152PMC
February 2016

Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.

Ann Hum Genet 2015 Nov 29;79(6):470-80. Epub 2015 Sep 29.

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1111/ahg.12132DOI Listing
November 2015

Body mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout.

Arthritis Res Ther 2015 Sep 22;17:263. Epub 2015 Sep 22.

Department of Biochemistry, Division of Health Sciences, University of Otago, 710 Cumberland Street, Dunedin, 9016, New Zealand.

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http://dx.doi.org/10.1186/s13075-015-0781-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578754PMC
September 2015

A human leukocyte antigen locus haplotype confers risk for allopurinol-related adverse effects in Caucasian patients with gout.

Pharmacogenet Genomics 2015 Aug;25(8):412-5

Departments of aSurgical Sciences bBiochemistry, Dunedin School of Medicine, University of Otago, Dunedin cWellington Regional Rheumatology Unit, Hutt Hospital, Lower Hutt dDepartment of Medicine, University of Auckland, Auckland eDepartment of Medicine, University of Otago, Wellington fDepartment of Medicine, University of Otago, Christchurch, New Zealand.

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http://dx.doi.org/10.1097/FPC.0000000000000147DOI Listing
August 2015

Does midlife obesity really lower dementia risk?

Lancet Diabetes Endocrinol 2015 Jul;3(7):501

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1016/S2213-8587(15)00218-1DOI Listing
July 2015

Mendelian randomization analysis to examine for a causal effect of urate on bone mineral density.

J Bone Miner Res 2015 Jun;30(6):985-91

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1002/jbmr.2434DOI Listing
June 2015

An update on the genetic architecture of hyperuricemia and gout.

Authors:
Tony R Merriman

Arthritis Res Ther 2015 Apr 10;17:98. Epub 2015 Apr 10.

Department of Biochemistry, University of Otago, Box 56, Dunedin, 9054, New Zealand.

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http://dx.doi.org/10.1186/s13075-015-0609-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392805PMC
April 2015

Smoking behaviour modifies IL23r-associated disease risk in patients with Crohn's disease.

J Gastroenterol Hepatol 2015 Feb;30(2):299-307

CSIRO Computational Informatics/Australian E-Health Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Victoria, Australia; Preventative Health Flagship, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/jgh.12674DOI Listing
February 2015

Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels.

Circ Cardiovasc Genet 2014 Dec 23;7(6):830-7. Epub 2014 Sep 23.

From the Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan (H.R.); and Department of Biochemistry, University of Otago, Dunedin, New Zealand (K.H., T.J.F., T.R.M.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270849PMC
December 2014

Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid.

Hum Mol Genet 2014 Oct 12;23(19):5061-8. Epub 2014 May 12.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/hmg/ddu227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159153PMC
October 2014

A bioinformatics workflow for detecting signatures of selection in genomic data.

Front Genet 2014 26;5:293. Epub 2014 Aug 26.

Department of Biochemistry, University of Otago Dunedin, New Zealand ; Virtual Institute of Statistical Genetics Rotorua, New Zealand.

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http://dx.doi.org/10.3389/fgene.2014.00293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144660PMC
September 2014

The global burden of gout: estimates from the Global Burden of Disease 2010 study.

Ann Rheum Dis 2014 Aug 3;73(8):1470-6. Epub 2014 Mar 3.

Department of Rheumatology, Royal North Shore Hospital, Northern Clinical School, Institute of Bone and Joint Research, University of Sydney, St Leonards, New South Wales, Australia.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20464
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August 2014

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Authors:
Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso Mohammed K Ali Raghib Ali Nelson Alvis Guzman Walid Ammar Palwasha Anwari Amitava Banerjee Simon Barquera Sanjay Basu Derrick A Bennett Zulfiqar Bhutta Jed Blore Norberto Cabral Ismael Campos Nonato Jung-Chen Chang Rajiv Chowdhury Karen J Courville Michael H Criqui David K Cundiff Kaustubh C Dabhadkar Lalit Dandona Adrian Davis Anand Dayama Samath D Dharmaratne Eric L Ding Adnan M Durrani Alireza Esteghamati Farshad Farzadfar Derek F J Fay Valery L Feigin Abraham Flaxman Mohammad H Forouzanfar Atsushi Goto Mark A Green Rajeev Gupta Nima Hafezi-Nejad Graeme J Hankey Heather C Harewood Rasmus Havmoeller Simon Hay Lucia Hernandez Abdullatif Husseini Bulat T Idrisov Nayu Ikeda Farhad Islami Eiman Jahangir Simerjot K Jassal Sun Ha Jee Mona Jeffreys Jost B Jonas Edmond K Kabagambe Shams Eldin Ali Hassan Khalifa Andre Pascal Kengne Yousef Saleh Khader Young-Ho Khang Daniel Kim Ruth W Kimokoti Jonas M Kinge Yoshihiro Kokubo Soewarta Kosen Gene Kwan Taavi Lai Mall Leinsalu Yichong Li Xiaofeng Liang Shiwei Liu Giancarlo Logroscino Paulo A Lotufo Yuan Lu Jixiang Ma Nana Kwaku Mainoo George A Mensah Tony R Merriman Ali H Mokdad Joanna Moschandreas Mohsen Naghavi Aliya Naheed Devina Nand K M Venkat Narayan Erica Leigh Nelson Marian L Neuhouser Muhammad Imran Nisar Takayoshi Ohkubo Samuel O Oti Andrea Pedroza Dorairaj Prabhakaran Nobhojit Roy Uchechukwu Sampson Hyeyoung Seo Sadaf G Sepanlou Kenji Shibuya Rahman Shiri Ivy Shiue Gitanjali M Singh Jasvinder A Singh Vegard Skirbekk Nicolas J C Stapelberg Lela Sturua Bryan L Sykes Martin Tobias Bach X Tran Leonardo Trasande Hideaki Toyoshima Steven van de Vijver Tommi J Vasankari J Lennert Veerman Gustavo Velasquez-Melendez Vasiliy Victorovich Vlassov Stein Emil Vollset Theo Vos Claire Wang XiaoRong Wang Elisabete Weiderpass Andrea Werdecker Jonathan L Wright Y Claire Yang Hiroshi Yatsuya Jihyun Yoon Seok-Jun Yoon Yong Zhao Maigeng Zhou Shankuan Zhu Alan D Lopez Christopher J L Murray Emmanuela Gakidou

Lancet 2014 Aug 29;384(9945):766-81. Epub 2014 May 29.

Institute for Health Metrics and Evaluation, Seattle, WA, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624264PMC
August 2014

Mutations in the zinc finger protein gene, ZNF469, contribute to the pathogenesis of keratoconus.

Invest Ophthalmol Vis Sci 2014 Aug 5;55(9):5629-35. Epub 2014 Aug 5.

Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand Eye Department, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand.

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http://dx.doi.org/10.1167/iovs.14-14532DOI Listing
August 2014

The CNVrd2 package: measurement of copy number at complex loci using high-throughput sequencing data.

Front Genet 2014 1;5:248. Epub 2014 Aug 1.

Department of Biochemistry, University of Otago Dunedin, New Zealand ; Department of Biochemistry, Virtual Institute of Statistical Genetics, University of Otago Dunedin, New Zealand.

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http://dx.doi.org/10.3389/fgene.2014.00248DOI Listing
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August 2014

Hyperuricaemia in the Pacific: why the elevated serum urate levels?

Rheumatol Int 2014 Jun 31;34(6):743-57. Epub 2013 Dec 31.

Department of Anatomy, Allan Wilson Centre for Molecular Ecology and Evolution, University of Otago, PO Box 913, Dunedin, New Zealand,

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http://dx.doi.org/10.1007/s00296-013-2922-xDOI Listing
June 2014

The genetic basis of gout.

Rheum Dis Clin North Am 2014 May 19;40(2):279-90. Epub 2014 Feb 19.

Department of Medicine, University of Auckland, Auckland 1023, New Zealand.

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May 2014