Tony L Yaksh

Tony L Yaksh

UNVERIFIED PROFILE

Are you Tony L Yaksh?   Register this Author

Register author
Tony L Yaksh

Tony L Yaksh

Publications by authors named "Tony L Yaksh"

Are you Tony L Yaksh?   Register this Author

100Publications

2802Reads

19Profile Views

Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling.

Anesthesiology 2019 07;131(1):132-147

From the Laboratory of Anesthesiology Research, Department of Anesthesiology (T.L.Y., K.A.E., S.K., R.R., Y.Z., Y.H., F.W., D.Q., S.A.M., J.J.S.) Department of Dermatology (Z.W., A.D.) Division of Trauma, Department of Surgery (B.P.E.), University of California, San Diego, California the Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina (K.L., W.K.K) Montreal Clinical Research Institute and the Department of Pharmacology and Physiology, University of Montreal, Quebec, Canada (P.W.S.) Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany (P.G.) Implantables Research and Technology, Medtronic, Inc., Restorative Therapies Group, Minneapolis, Minnesota (L.M.P., K.R.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0000000000002730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590697PMC
July 2019

Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway.

Mol Pain 2019 Jan-Dec;15:1744806919867842

1 Department of Anesthesiology, University of California San Diego, La Jolla CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1744806919867842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688145PMC
July 2019

Characterization of Effect of Repeated Bolus or Continuous Intrathecal Infusion of Morphine on Spinal Mass Formation in the Dog.

Neuromodulation 2019 May 23. Epub 2019 May 23.

Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ner.12963DOI Listing
May 2019

Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome.

Mol Pain 2018 Jan-Dec;14:1744806918815005. Epub 2018 Nov 5.

1 Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1744806918815005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287297PMC
April 2019

Letter to Editor re: "Unique Intradural Inflammatory Mass Containing Precipitated Morphine" by Kim et al.

Authors:
Tony L Yaksh

Pain Pract 2019 04 4;19(4):456. Epub 2019 Feb 4.

Departments of Anesthesiology, and Pharmacology, University of California, San Diego, La Jolla, California, U.S.A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/papr.12761DOI Listing
April 2019

Spinal Exparel®-an extended duration of preclinical study needed.

Br J Anaesth 2019 03 24;122(3):298-300. Epub 2018 Dec 24.

Departments of Anesthesiology, University of California, San Diego, CA, USA; Pharmacology, University of California, San Diego, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2018.11.021DOI Listing
March 2019

Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice.

Brain Behav Immun 2019 02 19;76:151-158. Epub 2018 Nov 19.

Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396982PMC
February 2019

Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery.

Scand J Pain 2019 01;19(1):193-206

Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Phone: +(619) 543-3597, Fax: +(619) 543-6070.

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/sjpain.ahead-of-print/sjpain
Publisher Site
http://dx.doi.org/10.1515/sjpain-2018-0120DOI Listing
January 2019

Botulinum toxin blocks mast cells and prevents rosacea like inflammation.

J Dermatol Sci 2019 Jan 28;93(1):58-64. Epub 2018 Dec 28.

Department of Dermatology, University of California, San Diego, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09231811183045
Publisher Site
http://dx.doi.org/10.1016/j.jdermsci.2018.12.004DOI Listing
January 2019

Development of New Analgesics: An Answer to Opioid Epidemic.

Trends Pharmacol Sci 2018 12;39(12):1000-1002

Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tips.2018.10.003DOI Listing
December 2018

Rapid continuous 3D printing of customizable peripheral nerve guidance conduits.

Mater Today (Kidlington) 2018 Nov 27;21(9):951-959. Epub 2018 Apr 27.

Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mattod.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538503PMC
November 2018

Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states.

Pain 2018 Oct;159(10):1908-1915

Department of Anesthesiology and Pain Medicine, University of California San Diego Health Sciences, La Jolla, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001306DOI Listing
October 2018

Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation.

Semin Immunopathol 2018 May 8;40(3):237-247. Epub 2018 Feb 8.

Department of Anesthesiology, University of California, San Diego, San Diego, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00281-017-0669-2DOI Listing
May 2018

Complexity of systems and actions underlying neurogenic inflammation.

Semin Immunopathol 2018 05;40(3):225-228

Department of Dermatology, University of California, San Diego, 9500 Gilman Drive #0869 , La Jolla, CA, 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00281-018-0683-zDOI Listing
May 2018

An overview of pathways encoding nociception.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):172. Epub 2018 Feb 6.

Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
April 2018

Target engagement and histopathology of neuraxial resiniferatoxin in dog.

Vet Anaesth Analg 2018 Mar 5;45(2):212-226. Epub 2017 Dec 5.

University of California, San Diego, Department of Anesthesiology, La Jolla, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaa.2017.10.005DOI Listing
March 2018

Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation.

Toxicol Appl Pharmacol 2018 01 27;338:54-64. Epub 2017 Oct 27.

Department of Anesthesiology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0041008X173042
Publisher Site
http://dx.doi.org/10.1016/j.taap.2017.10.017DOI Listing
January 2018

An overview of pathways encoding nociception.

Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):40-46. Epub 2017 Sep 29.

Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636838PMC
December 2017

Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.

Anesth Analg 2017 11;125(5):1714-1732

From the *Department of Anesthesiology, Advocate Illinois Masonic Medical Center Chicago, Illinois; Departments of †Anesthesiology and ‡Surgery, University of Illinois, Chicago, Illinois; §Department of Neurobiology, Harvard Medical School, and Boston Children's Hospital, Boston, Massachusetts; ‖Blue Therapeutics, Harvard Innovation Launch Lab, Allston, Massachusetts; and Departments of ¶Anesthesiology and #Pharmacology, University of California, San Diego, La Jolla, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000002442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679134PMC
November 2017

Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.

J Pain 2017 10 18;18(10):1184-1196. Epub 2017 Apr 18.

VistaGen Therapeutics, Inc, South San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpain.2017.03.014DOI Listing
October 2017

Modeling Spinal Intrathecal Drug Distribution: The Challenge of Defining and Predicting Cerebrospinal Fluid Dynamics.

Anesth Analg 2017 05;124(5):1403-1406

From the *Department of Radiology, University of Louisville Hospital, Louisville, Kentucky; †Department of Anesthesiology, Case Western Reserve University, Cleveland, Ohio; ‡Division of Pain Medicine, University Hospitals of Cleveland, Cleveland, Ohio; and §Departments of Anesthesiology and Pharmacology, University of California, San Diego, La Jolla, California.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00000539-201705000-0001
Publisher Site
http://dx.doi.org/10.1213/ANE.0000000000002071DOI Listing
May 2017

Current and Future Issues in the Development of Spinal Agents for the Management of Pain.

Curr Neuropharmacol 2017 ;15(2):232-259

University of California, San Diego, Anesthesia Research Lab 0818, 9500 Gilman Dr. LaJolla, CA 92093, United States.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412694PMC
March 2017

Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.

Brain Behav Immun 2017 Feb 7;60:282-292. Epub 2016 Nov 7.

Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, La Jolla, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214638PMC
February 2017

Ethical Concerns Regarding Human Study.

CNS Neurosci Ther 2016 10 31;22(10):866. Epub 2016 Aug 31.

Department of Anesthesiology, University of California, San Diego, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cns.12604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492918PMC
October 2016

Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia.

Brain Behav Immun 2016 Aug 9;56:378-89. Epub 2016 Mar 9.

Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, La Jolla, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917441PMC
August 2016

Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation.

Anesthesiology 2016 08;125(2):378-94

From the Departments of Anesthesiology (K.A.E., E.S.R., V.I.S., S.A.M., J.J.S., T.L.Y.) and Radiology (M.S.), University of California, San Diego, La Jolla, California; Departamento de Medicina Veterinária, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil (E.S.R.); Department of Anesthesiology, Veterans Affairs San Diego Healthcare System, La Jolla, California (V.I.S.); Department of Pathology, Oregon Health Sciences University, Portland, Oregon (M.R.G.); and Departments of Global Research and Neuromodulation, Medtronic, Inc., Minneapolis, Minnesota (K.R.H., L.M.P.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0000000000001166DOI Listing
August 2016

Role of myelin auto-antigens in pain: a female connection.

Neural Regen Res 2016 Jun;11(6):890-1

Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1673-5374.184452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962572PMC
June 2016

Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models.

Scand J Pain 2016 01 20;10:90-102. Epub 2015 Nov 20.

Department of Anesthesiology, University of California, San Diego, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sjpain.2015.10.006DOI Listing
January 2016

Current status and future directions of botulinum neurotoxins for targeting pain processing.

Toxins (Basel) 2015 Nov 4;7(11):4519-63. Epub 2015 Nov 4.

Department of Anesthesiology 0818, University of California, 214 Dickinson St., San Diego, CA 92103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins7114519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663519PMC
November 2015

Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents.

Neurobiol Dis 2015 Jul 6;79:111-22. Epub 2015 May 6.

Anesthesiology Research, Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2015.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458441PMC
July 2015

The effects of intraplantar and intrathecal botulinum toxin type B on tactile allodynia in mono and polyneuropathy in the mouse.

Anesth Analg 2015 Jul;121(1):229-38

From the *Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea; †Department of Anesthesiology, University of California, San Diego, La Jolla, California; and ‡Departamento de Medicina Veterinária, Universidade Federal de Mato Grosso do Sul Faculdade de Medicina Veterinária e Zootecnia, Vila Ipiranga - Campo Grande, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000000777DOI Listing
July 2015

The search for novel analgesics: targets and mechanisms.

F1000Prime Rep 2015 26;7:56. Epub 2015 May 26.

University of California, San Diego, Department of Anesthesiology 0818 9500 Gilman, Dr. (CTF C-312), La Jolla, CA 92093 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12703/P7-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447049PMC
June 2015

Alfentanil: correlations between absence of effect upon subcutaneous mast cells and absence of granuloma formation after intrathecal infusion in the dog.

Neuromodulation 2013 Sep-Oct;16(5):459-66; discussion 466. Epub 2012 Nov 21.

Anesthesiology Research, Department of Anesthesiology, University of California, San Diego, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1525-1403.2012.00534.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582801PMC
October 2014

Therapeutic use of botulinum toxin in migraine: mechanisms of action.

Br J Pharmacol 2014 Sep;171(18):4177-92

Anesthesiology Research, Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.12763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241086PMC
September 2014

TRPV1 expression regulation… A further step in defining its biology: commentary for K. Zavala et al. "The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons" [Neurosci. Lett. (2014) doi:10.1016/j.neulet.2014.01.021].

Authors:
Tony L Yaksh

Neurosci Lett 2014 Aug 25;578:209-10. Epub 2014 Apr 25.

Department of Anesthesiology, University of California, San Diego, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2014.04.022DOI Listing
August 2014

The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery.

Anesth Analg 2014 May;118(5):1097-112

From the *Department of Anesthesiology, Pain Clinic, University Medical Center Utrecht, Utrecht, The Netherlands; and †Department of Anesthesiology, University of California San Diego, San Diego, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000000161DOI Listing
May 2014

Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior.

Pain 2014 Apr 11;155(4):674-84. Epub 2013 Dec 11.

Anesthesiology Research, Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pain.2013.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960322PMC
April 2014

Preclinical toxicity screening of intrathecal oxytocin in rats and dogs.

Anesthesiology 2014 Apr;120(4):951-61

From the Department of Anesthesiology, University of California, San Diego, San Diego, California (T.L.Y.); Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, North Carolina (S.H., C.P., and J.C.E.); Diagnostic Laboratory, Animal Care Program, University of California, San Diego, San Diego, California (K.G.O.); Animal Care Program, Department of Pathology, University of California, San Diego, San Diego, California (P.J.R.); Anesthesiology Research Laboratory, University of California, San Diego, San Diego, California (S.S.R.); and Department of Pathology, Neuropathology Oregon Health Sciences University, Portland, Oregon (M.R.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0000000000000148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392224PMC
April 2014

Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice.

Cancer Chemother Pharmacol 2014 Jan 27;73(1):25-34. Epub 2013 Oct 27.

Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00280-013-2304-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917999PMC
January 2014

Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression.

Neuropharmacology 2013 Dec 26;75:1-8. Epub 2013 Jun 26.

Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, San Diego, La Jolla, CA 92093-0818, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2013.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865027PMC
December 2013

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice.

J Neuroinflammation 2013 Dec 9;10:148. Epub 2013 Dec 9.

Department of Pharmacology, University of California, 9500 Gilman Dr, MC 0636, La Jolla, San Diego, CA 92093-0636, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1742-2094-10-148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896749PMC
December 2013

Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.

J Pharmacol Exp Ther 2013 Nov 26;347(2):258-64. Epub 2013 Aug 26.

Department of Anesthesiology, University of California San Diego, La Jolla, California (M.K., T.L.Y., Q.X.); Department of Pharmacology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (M.K.); and Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Mibu, Tochigi Prefecture, Japan (T.Ta., T.Te.).

View Article

Download full-text PDF

Source
http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.113.20657
Publisher Site
http://dx.doi.org/10.1124/jpet.113.206573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807063PMC
November 2013

Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation.

Anesthesiology 2013 Nov;119(5):1163-77

* Research Fellow, † Staff Research Associate, # Postdoctoral Fellow, §§ Professor of Anesthesiology and Pharmacology, Department of Anesthesiology, University of California, San Diego, California. ‡ President, Tox Path Specialists, LLC, Frederick, Maryland. § Director, Campus Veterinary Medicine, ‖ Associate Director, Diagnostic Laboratory, Office of Animal Research, University of California. ** Vice President, †† President/CSO, ‡‡ Research Scientist, Advanced Targeting Systems, San Diego, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0b013e3182a95164DOI Listing
November 2013

Intrathecal neurosteroids and a neurosteroid antagonist: effects on inflammation-evoked thermal hyperalgesia and tactile allodynia.

Neurosci Lett 2013 Aug 23;548:27-32. Epub 2013 May 23.

Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2013.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761066PMC
August 2013

Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn.

Anesthesiology 2013 Aug;119(2):433-42

Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093-0818, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0b013e31829996b6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788114PMC
August 2013

Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog.

Neuromodulation 2012 Nov-Dec;15(6):508-19; discussion 519. Epub 2012 Jul 2.

Department of Anesthesiology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1525-1403.2012.00479.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514653PMC
May 2013

Spinal toll-like receptor signaling and nociceptive processing: regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ.

Pain 2013 May 30;154(5):733-42. Epub 2013 Jan 30.

Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pain.2013.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622773PMC
May 2013

Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation.

Anesthesiology 2013 Mar;118(3):664-78

Anesthesiology Research, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0818, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0b013e31828351aaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788115PMC
March 2013

Characteristics of distribution of morphine and metabolites in cerebrospinal fluid and plasma with chronic intrathecal morphine infusion in humans.

Anesth Analg 2012 Oct 19;115(4):797-804. Epub 2012 Jul 19.

Department of Anesthesiology, University of California-San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0b013e3182645dfdDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456964PMC
October 2012

Development and validation of an automated system for detection and assessment of scratching in the rodent.

J Neurosci Methods 2012 Oct 13;211(1):1-10. Epub 2012 Aug 13.

Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive-CTF C-312, La Jolla, CA 92093-0818, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2012.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473159PMC
October 2012

Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data.

Anesth Analg 2012 Sep 13;115(3):638-62. Epub 2012 Jul 13.

Portex Unit: Pain Research, UCL Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0b013e31826253f2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451199PMC
September 2012

Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity.

Anesth Analg 2012 Aug 30;115(2):450-60. Epub 2012 Mar 30.

Portex Unit: Pain Research, UCL Institute of Child Health and Great Ormond St. Hospital NHS Trust, 30 Guilford St., London WC1N 1EH, United Kingdom.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00000539-201208000-000
Publisher Site
http://dx.doi.org/10.1213/ANE.0b013e3182501a09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455964PMC
August 2012

K/BxN serum transfer arthritis as a model of inflammatory joint pain.

Methods Mol Biol 2012 ;851:249-60

Department of Anesthesiology, University of California San Diego, San Diego, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-561-9_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426904PMC
July 2012

Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice.

Proc Natl Acad Sci U S A 2012 Jul 16;109(31):12728-33. Epub 2012 Jul 16.

Unit of Rheumatology, Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, SE-171 77 Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1118748109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411968PMC
July 2012

Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse.

Neurocomputing 2012 May 31;84:47-52. Epub 2011 Dec 31.

School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California, 92037, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neucom.2011.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338856PMC
May 2012

The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats.

J Anesth 2011 Dec 9;25(6):884-91. Epub 2011 Oct 9.

Department of Anesthesiology and Pain Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-011-1240-2DOI Listing
December 2011

Care to wrestle with a Brazilian armed spider?

Authors:
Tony L Yaksh

Pain 2011 Oct 22;152(10):2193-5. Epub 2011 Jul 22.

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1016/j.pain.2011.07.001DOI Listing
October 2011

Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling.

Neurosci Lett 2011 Oct 21;504(3):215-8. Epub 2011 Sep 21.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0818, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043940110130
Publisher Site
http://dx.doi.org/10.1016/j.neulet.2011.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338641PMC
October 2011

A brief comparison of the pathophysiology of inflammatory versus neuropathic pain.

Curr Opin Anaesthesiol 2011 Aug;24(4):400-7

Department of Anesthesiology, University of California-San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACO.0b013e32834871dfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290396PMC
August 2011

Regulation of spinal substance p release by intrathecal calcium channel blockade.

Anesthesiology 2011 Jul;115(1):153-64

Department of Anesthesiology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan.

View Article

Download full-text PDF

Source
http://anesthesiology.pubs.asahq.org/Article.aspx?doi=10.109
Publisher Site
http://dx.doi.org/10.1097/ALN.0b013e31821950c2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360553PMC
July 2011

The effects of intrathecal and systemic gabapentin on spinal substance P release.

Anesth Analg 2011 Apr 8;112(4):971-6. Epub 2011 Mar 8.

Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi, Japan.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00000539-201104000-000
Publisher Site
http://dx.doi.org/10.1213/ANE.0b013e31820f2a16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347974PMC
April 2011

Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing.

PLoS One 2011 Apr 29;6(4):e19126. Epub 2011 Apr 29.

Department of Biological Sciences, University of California San Diego, La Jolla, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019126PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084763PMC
April 2011

Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis.

Pain 2010 Nov 23;151(2):394-403. Epub 2010 Aug 23.

Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pain.2010.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955775PMC
November 2010

Assessment of canine sensory function by using sine-wave electrical stimuli paradigm.

Physiol Behav 2010 Oct 4;101(3):327-30. Epub 2010 Jun 4.

Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2010.05.019DOI Listing
October 2010

Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord.

J Neurochem 2010 Aug 14;114(4):981-93. Epub 2010 May 14.

Department of Pharmacology, Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2010.06815.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994888PMC
August 2010

Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase.

Anesth Analg 2010 Aug 7;111(2):554-60. Epub 2010 Jul 7.

Department of Laboratory Sciences, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0b013e3181e3a2a2DOI Listing
August 2010

Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat.

Anesthesiology 2010 Jul;113(1):183-99

Department of Anesthesiology, University of California, San Diego, La Jolla, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0b013e3181dcd6ecDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902725PMC
July 2010

Correlation between myoclonus and the 3-glucuronide metabolites in patients treated with morphine or hydromorphone: a pilot study.

J Opioid Manag 2010 Mar-Apr;6(2):87-94

The Institute for Palliative Medicine, San Diego Hospice, California, USA.

View Article

Download full-text PDF

Source
June 2010

Role of spinal cyclooxygenase in human postoperative and chronic pain.

Anesthesiology 2010 May;112(5):1225-33

Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0b013e3181d94dc0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892621PMC
May 2010

Effects of intrathecal ketorolac on human experimental pain.

Anesthesiology 2010 May;112(5):1216-24

Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0b013e3181d94d8bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924167PMC
May 2010

Consent contraindicated?

Science 2010 Apr;328(5974):45; author reply 45

View Article

Download full-text PDF

Source
http://www.sciencemag.org/cgi/doi/10.1126/science.328.5974.4
Publisher Site
http://dx.doi.org/10.1126/science.328.5974.45-aDOI Listing
April 2010