Tony Kwan

Tony Kwan

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Tony Kwan

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Interleukin 17A promotes diabetic kidney injury.

Sci Rep 2019 Feb 19;9(1):2264. Epub 2019 Feb 19.

Kidney Node Laboratory, The Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1038/s41598-019-38811-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381173PMC
February 2019

Conserved expression of transposon-derived non-coding transcripts in primate stem cells.

BMC Genomics 2017 02 28;18(1):214. Epub 2017 Feb 28.

Department of Human Genetics, McGill University, Dr Penfield Avenue, Montreal, H3A 1B1, Canada.

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http://dx.doi.org/10.1186/s12864-017-3568-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331655PMC
February 2017

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

Cell 2016 11;167(5):1398-1414.e24

Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, University of Cambridge, Wort's Causeway, Cambridge CB1 8RN, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163144
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http://dx.doi.org/10.1016/j.cell.2016.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119954PMC
November 2016

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

Cell 2016 11;167(5):1415-1429.e19

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300907PMC
November 2016

The International Human Epigenome Consortium Data Portal.

Cell Syst 2016 11 15;3(5):496-499.e2. Epub 2016 Nov 15.

McGill University and Génome Québec Innovation Center, Montréal, QC H3A 0G1, Canada; Department of Human Genetics, McGill University, Montréal, QC H3A 0G1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.10.019DOI Listing
November 2016

Toll-Like Receptor 4 Deficiency Improves Short-term Renal Function but not Long-term Graft Survival in a Fully MHC-Mismatched Murine Model of Renal Allograft Transplantation.

Transplantation 2016 06;100(6):1219-27

1 Kidney Node Laboratory, The Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, Australia. 2 Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia.

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http://dx.doi.org/10.1097/TP.0000000000001168DOI Listing
June 2016

Exome and regulatory element sequencing of neuromyelitis optica patients.

J Neuroimmunol 2015 Dec 3;289:139-42. Epub 2015 Nov 3.

Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland; Molecular Neurology Programme, Research Program Unit, Biomedicum, University of Helsinki, Helsinki, Finland; University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jneuroim.2015.11.002DOI Listing
December 2015

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Authors:
Hou-Feng Zheng Vincenzo Forgetta Yi-Hsiang Hsu Karol Estrada Alberto Rosello-Diez Paul J Leo Chitra L Dahia Kyung Hyun Park-Min Jonathan H Tobias Charles Kooperberg Aaron Kleinman Unnur Styrkarsdottir Ching-Ti Liu Charlotta Uggla Daniel S Evans Carrie M Nielson Klaudia Walter Ulrika Pettersson-Kymmer Shane McCarthy Joel Eriksson Tony Kwan Mila Jhamai Katerina Trajanoska Yasin Memari Josine Min Jie Huang Petr Danecek Beth Wilmot Rui Li Wen-Chi Chou Lauren E Mokry Alireza Moayyeri Melina Claussnitzer Chia-Ho Cheng Warren Cheung Carolina Medina-Gómez Bing Ge Shu-Huang Chen Kwangbom Choi Ling Oei James Fraser Robert Kraaij Matthew A Hibbs Celia L Gregson Denis Paquette Albert Hofman Carl Wibom Gregory J Tranah Mhairi Marshall Brooke B Gardiner Katie Cremin Paul Auer Li Hsu Sue Ring Joyce Y Tung Gudmar Thorleifsson Anke W Enneman Natasja M van Schoor Lisette C P G M de Groot Nathalie van der Velde Beatrice Melin John P Kemp Claus Christiansen Adrian Sayers Yanhua Zhou Sophie Calderari Jeroen van Rooij Chris Carlson Ulrike Peters Soizik Berlivet Josée Dostie Andre G Uitterlinden Stephen R Williams Charles Farber Daniel Grinberg Andrea Z LaCroix Jeff Haessler Daniel I Chasman Franco Giulianini Lynda M Rose Paul M Ridker John A Eisman Tuan V Nguyen Jacqueline R Center Xavier Nogues Natalia Garcia-Giralt Lenore L Launer Vilmunder Gudnason Dan Mellström Liesbeth Vandenput Najaf Amin Cornelia M van Duijn Magnus K Karlsson Östen Ljunggren Olle Svensson Göran Hallmans François Rousseau Sylvie Giroux Johanne Bussière Pascal P Arp Fjorda Koromani Richard L Prince Joshua R Lewis Bente L Langdahl A Pernille Hermann Jens-Erik B Jensen Stephen Kaptoge Kay-Tee Khaw Jonathan Reeve Melissa M Formosa Angela Xuereb-Anastasi Kristina Åkesson Fiona E McGuigan Gaurav Garg Jose M Olmos Maria T Zarrabeitia Jose A Riancho Stuart H Ralston Nerea Alonso Xi Jiang David Goltzman Tomi Pastinen Elin Grundberg Dominique Gauguier Eric S Orwoll David Karasik George Davey-Smith Albert V Smith Kristin Siggeirsdottir Tamara B Harris M Carola Zillikens Joyce B J van Meurs Unnur Thorsteinsdottir Matthew T Maurano Nicholas J Timpson Nicole Soranzo Richard Durbin Scott G Wilson Evangelia E Ntzani Matthew A Brown Kari Stefansson David A Hinds Tim Spector L Adrienne Cupples Claes Ohlsson Celia M T Greenwood Rebecca D Jackson David W Rowe Cynthia A Loomis David M Evans Cheryl L Ackert-Bicknell Alexandra L Joyner Emma L Duncan Douglas P Kiel Fernando Rivadeneira J Brent Richards

Nature 2015 Oct 14;526(7571):112-7. Epub 2015 Sep 14.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.

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http://dx.doi.org/10.1038/nature14878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755714PMC
October 2015

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

Nat Commun 2015 May 29;6:7211. Epub 2015 May 29.

1] Department of Human Genetics, McGill University, 740 Docteur-Penfield Avenue, Montreal, Québec , Canada H3A 0G1 [2] McGill University and Genome Quebec Innovation Centre, 740 Docteur-Penfield Avenue, Montreal, Québec, Canada H3A 0G1.

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http://dx.doi.org/10.1038/ncomms8211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544751PMC
May 2015

Macrophages in renal transplantation: Roles and therapeutic implications.

Cell Immunol 2014 Sep-Oct;291(1-2):58-64. Epub 2014 Jun 14.

Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2014.05.009DOI Listing
February 2015

TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy.

PLoS One 2014 19;9(5):e97985. Epub 2014 May 19.

Renal Medicine and Transplant Research Group, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097985PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026484PMC
January 2015

Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping.

Epigenetics 2014 Sep 23;9(9):1238-51. Epub 2014 Jul 23.

Department of Human Genetics; McGill University; Montréal, QC Canada; McGill University and Genome Québec Innovation Centre; McGill University; Montréal, QC Canada.

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http://dx.doi.org/10.4161/epi.29920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169016PMC
September 2014

A rapid, sensitive method for quantitative analysis of underivatized amino acids by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Jan 18;944:166-74. Epub 2013 Nov 18.

Department of Pathology, Stanford University, Palo Alto, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2013.11.017DOI Listing
January 2014

A new LC-MS/MS method for the clinical determination of reduced and oxidized glutathione from whole blood.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Jun 12;929:51-5. Epub 2013 Apr 12.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, United States.

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http://dx.doi.org/10.1016/j.jchromb.2013.04.004DOI Listing
June 2013

Interleukin-18 binding protein therapy is protective in adriamycin nephropathy.

Am J Physiol Renal Physiol 2013 Jan 24;304(1):F68-76. Epub 2012 Oct 24.

Collaborative Transplant Research Group, Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1152/ajprenal.00669.2011DOI Listing
January 2013

Assessment of gene-by-sex interaction effect on bone mineral density.

J Bone Miner Res 2012 Oct;27(10):2051-64

Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue CT3, Boston,MA 02118, USA.

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http://dx.doi.org/10.1002/jbmr.1679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447125PMC
October 2012

Absence of MyD88 signaling induces donor-specific kidney allograft tolerance.

J Am Soc Nephrol 2012 Oct 9;23(10):1701-16. Epub 2012 Aug 9.

Transplant Research Group, University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1681/ASN.2012010052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458459PMC
October 2012

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Authors:
Karol Estrada Unnur Styrkarsdottir Evangelos Evangelou Yi-Hsiang Hsu Emma L Duncan Evangelia E Ntzani Ling Oei Omar M E Albagha Najaf Amin John P Kemp Daniel L Koller Guo Li Ching-Ti Liu Ryan L Minster Alireza Moayyeri Liesbeth Vandenput Dana Willner Su-Mei Xiao Laura M Yerges-Armstrong Hou-Feng Zheng Nerea Alonso Joel Eriksson Candace M Kammerer Stephen K Kaptoge Paul J Leo Gudmar Thorleifsson Scott G Wilson James F Wilson Ville Aalto Markku Alen Aaron K Aragaki Thor Aspelund Jacqueline R Center Zoe Dailiana David J Duggan Melissa Garcia Natàlia Garcia-Giralt Sylvie Giroux Göran Hallmans Lynne J Hocking Lise Bjerre Husted Karen A Jameson Rita Khusainova Ghi Su Kim Charles Kooperberg Theodora Koromila Marcin Kruk Marika Laaksonen Andrea Z Lacroix Seung Hun Lee Ping C Leung Joshua R Lewis Laura Masi Simona Mencej-Bedrac Tuan V Nguyen Xavier Nogues Millan S Patel Janez Prezelj Lynda M Rose Serena Scollen Kristin Siggeirsdottir Albert V Smith Olle Svensson Stella Trompet Olivia Trummer Natasja M van Schoor Jean Woo Kun Zhu Susana Balcells Maria Luisa Brandi Brendan M Buckley Sulin Cheng Claus Christiansen Cyrus Cooper George Dedoussis Ian Ford Morten Frost David Goltzman Jesús González-Macías Mika Kähönen Magnus Karlsson Elza Khusnutdinova Jung-Min Koh Panagoula Kollia Bente Lomholt Langdahl William D Leslie Paul Lips Östen Ljunggren Roman S Lorenc Janja Marc Dan Mellström Barbara Obermayer-Pietsch José M Olmos Ulrika Pettersson-Kymmer David M Reid José A Riancho Paul M Ridker François Rousseau P Eline Slagboom Nelson L S Tang Roser Urreizti Wim Van Hul Jorma Viikari María T Zarrabeitia Yurii S Aulchenko Martha Castano-Betancourt Elin Grundberg Lizbeth Herrera Thorvaldur Ingvarsson Hrefna Johannsdottir Tony Kwan Rui Li Robert Luben Carolina Medina-Gómez Stefan Th Palsson Sjur Reppe Jerome I Rotter Gunnar Sigurdsson Joyce B J van Meurs Dominique Verlaan Frances M K Williams Andrew R Wood Yanhua Zhou Kaare M Gautvik Tomi Pastinen Soumya Raychaudhuri Jane A Cauley Daniel I Chasman Graeme R Clark Steven R Cummings Patrick Danoy Elaine M Dennison Richard Eastell John A Eisman Vilmundur Gudnason Albert Hofman Rebecca D Jackson Graeme Jones J Wouter Jukema Kay-Tee Khaw Terho Lehtimäki Yongmei Liu Mattias Lorentzon Eugene McCloskey Braxton D Mitchell Kannabiran Nandakumar Geoffrey C Nicholson Ben A Oostra Munro Peacock Huibert A P Pols Richard L Prince Olli Raitakari Ian R Reid John Robbins Philip N Sambrook Pak Chung Sham Alan R Shuldiner Frances A Tylavsky Cornelia M van Duijn Nick J Wareham L Adrienne Cupples Michael J Econs David M Evans Tamara B Harris Annie Wai Chee Kung Bruce M Psaty Jonathan Reeve Timothy D Spector Elizabeth A Streeten M Carola Zillikens Unnur Thorsteinsdottir Claes Ohlsson David Karasik J Brent Richards Matthew A Brown Kari Stefansson André G Uitterlinden Stuart H Ralston John P A Ioannidis Douglas P Kiel Fernando Rivadeneira

Nat Genet 2012 Apr 15;44(5):491-501. Epub 2012 Apr 15.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://kooperberg.fhcrc.org/papers/2012estrada.pdf
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http://www.nature.com/doifinder/10.1038/ng.2249
Publisher Site
http://dx.doi.org/10.1038/ng.2249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338864PMC
April 2012

Cis-regulation of IRF5 expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines.

Arthritis Res Ther 2011 May 31;13(3):R80. Epub 2011 May 31.

Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Travesia Choupana sn, Santiago de Compostela E-15706, Spain.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218890PMC
May 2011

RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression.

Genome Res 2011 Apr 20;21(4):545-54. Epub 2010 Dec 20.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1101/gr.111211.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065702PMC
April 2011

Second pregnancy outcome in a patient with Gitelman syndrome without the use of parenteral electrolyte supplementation.

Aust N Z J Obstet Gynaecol 2011 Feb 6;51(1):94-5. Epub 2010 Dec 6.

Department of Nephrology, The Canberra Hospital, Canberra, ACT, Australia.

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http://doi.wiley.com/10.1111/j.1479-828X.2010.01248.x
Publisher Site
http://dx.doi.org/10.1111/j.1479-828X.2010.01248.xDOI Listing
February 2011

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Authors:
Hana Lango Allen Karol Estrada Guillaume Lettre Sonja I Berndt Michael N Weedon Fernando Rivadeneira Cristen J Willer Anne U Jackson Sailaja Vedantam Soumya Raychaudhuri Teresa Ferreira Andrew R Wood Robert J Weyant Ayellet V Segrè Elizabeth K Speliotes Eleanor Wheeler Nicole Soranzo Ju-Hyun Park Jian Yang Daniel Gudbjartsson Nancy L Heard-Costa Joshua C Randall Lu Qi Albert Vernon Smith Reedik Mägi Tomi Pastinen Liming Liang Iris M Heid Jian'an Luan Gudmar Thorleifsson Thomas W Winkler Michael E Goddard Ken Sin Lo Cameron Palmer Tsegaselassie Workalemahu Yurii S Aulchenko Asa Johansson M Carola Zillikens Mary F Feitosa Tõnu Esko Toby Johnson Shamika Ketkar Peter Kraft Massimo Mangino Inga Prokopenko Devin Absher Eva Albrecht Florian Ernst Nicole L Glazer Caroline Hayward Jouke-Jan Hottenga Kevin B Jacobs Joshua W Knowles Zoltán Kutalik Keri L Monda Ozren Polasek Michael Preuss Nigel W Rayner Neil R Robertson Valgerdur Steinthorsdottir Jonathan P Tyrer Benjamin F Voight Fredrik Wiklund Jianfeng Xu Jing Hua Zhao Dale R Nyholt Niina Pellikka Markus Perola John R B Perry Ida Surakka Mari-Liis Tammesoo Elizabeth L Altmaier Najaf Amin Thor Aspelund Tushar Bhangale Gabrielle Boucher Daniel I Chasman Constance Chen Lachlan Coin Matthew N Cooper Anna L Dixon Quince Gibson Elin Grundberg Ke Hao M Juhani Junttila Lee M Kaplan Johannes Kettunen Inke R König Tony Kwan Robert W Lawrence Douglas F Levinson Mattias Lorentzon Barbara McKnight Andrew P Morris Martina Müller Julius Suh Ngwa Shaun Purcell Suzanne Rafelt Rany M Salem Erika Salvi Serena Sanna Jianxin Shi Ulla Sovio John R Thompson Michael C Turchin Liesbeth Vandenput Dominique J Verlaan Veronique Vitart Charles C White Andreas Ziegler Peter Almgren Anthony J Balmforth Harry Campbell Lorena Citterio Alessandro De Grandi Anna Dominiczak Jubao Duan Paul Elliott Roberto Elosua Johan G Eriksson Nelson B Freimer Eco J C Geus Nicola Glorioso Shen Haiqing Anna-Liisa Hartikainen Aki S Havulinna Andrew A Hicks Jennie Hui Wilmar Igl Thomas Illig Antti Jula Eero Kajantie Tuomas O Kilpeläinen Markku Koiranen Ivana Kolcic Seppo Koskinen Peter Kovacs Jaana Laitinen Jianjun Liu Marja-Liisa Lokki Ana Marusic Andrea Maschio Thomas Meitinger Antonella Mulas Guillaume Paré Alex N Parker John F Peden Astrid Petersmann Irene Pichler Kirsi H Pietiläinen Anneli Pouta Martin Ridderstråle Jerome I Rotter Jennifer G Sambrook Alan R Sanders Carsten Oliver Schmidt Juha Sinisalo Jan H Smit Heather M Stringham G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Laura Zagato Lina Zgaga Paavo Zitting Helene Alavere Martin Farrall Wendy L McArdle Mari Nelis Marjolein J Peters Samuli Ripatti Joyce B J van Meurs Katja K Aben Kristin G Ardlie Jacques S Beckmann John P Beilby Richard N Bergman Sven Bergmann Francis S Collins Daniele Cusi Martin den Heijer Gudny Eiriksdottir Pablo V Gejman Alistair S Hall Anders Hamsten Heikki V Huikuri Carlos Iribarren Mika Kähönen Jaakko Kaprio Sekar Kathiresan Lambertus Kiemeney Thomas Kocher Lenore J Launer Terho Lehtimäki Olle Melander Tom H Mosley Arthur W Musk Markku S Nieminen Christopher J O'Donnell Claes Ohlsson Ben Oostra Lyle J Palmer Olli Raitakari Paul M Ridker John D Rioux Aila Rissanen Carlo Rivolta Heribert Schunkert Alan R Shuldiner David S Siscovick Michael Stumvoll Anke Tönjes Jaakko Tuomilehto Gert-Jan van Ommen Jorma Viikari Andrew C Heath Nicholas G Martin Grant W Montgomery Michael A Province Manfred Kayser Alice M Arnold Larry D Atwood Eric Boerwinkle Stephen J Chanock Panos Deloukas Christian Gieger Henrik Grönberg Per Hall Andrew T Hattersley Christian Hengstenberg Wolfgang Hoffman G Mark Lathrop Veikko Salomaa Stefan Schreiber Manuela Uda Dawn Waterworth Alan F Wright Themistocles L Assimes Inês Barroso Albert Hofman Karen L Mohlke Dorret I Boomsma Mark J Caulfield L Adrienne Cupples Jeanette Erdmann Caroline S Fox Vilmundur Gudnason Ulf Gyllensten Tamara B Harris Richard B Hayes Marjo-Riitta Jarvelin Vincent Mooser Patricia B Munroe Willem H Ouwehand Brenda W Penninx Peter P Pramstaller Thomas Quertermous Igor Rudan Nilesh J Samani Timothy D Spector Henry Völzke Hugh Watkins James F Wilson Leif C Groop Talin Haritunians Frank B Hu Robert C Kaplan Andres Metspalu Kari E North David Schlessinger Nicholas J Wareham David J Hunter Jeffrey R O'Connell David P Strachan H-Erich Wichmann Ingrid B Borecki Cornelia M van Duijn Eric E Schadt Unnur Thorsteinsdottir Leena Peltonen André G Uitterlinden Peter M Visscher Nilanjan Chatterjee Ruth J F Loos Michael Boehnke Mark I McCarthy Erik Ingelsson Cecilia M Lindgren Gonçalo R Abecasis Kari Stefansson Timothy M Frayling Joel N Hirschhorn

Nature 2010 Oct 29;467(7317):832-8. Epub 2010 Sep 29.

Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK.

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http://dx.doi.org/10.1038/nature09410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955183PMC
October 2010

Analysis of the impact of genetic variation on human gene expression.

Methods Mol Biol 2010 ;628:321-39

Department of Human Genetics, McGill University and Génome Québec Innovation Centre, McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-60327-367-1_18DOI Listing
May 2010

A probabilistic approach for SNP discovery in high-throughput human resequencing data.

Genome Res 2009 Sep 15;19(9):1542-52. Epub 2009 Jul 15.

McGill Centre for Bioinformatics, McGill University, Montréal H36 0B1, Canada;

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http://dx.doi.org/10.1101/gr.092072.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752119PMC
September 2009

Effect of polymorphisms within probe-target sequences on olignonucleotide microarray experiments.

Nucleic Acids Res 2008 Aug 2;36(13):4417-23. Epub 2008 Jul 2.

Department of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/nar/gkn409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490733PMC
August 2008

Genome-wide analysis of transcript isoform variation in humans.

Nat Genet 2008 Feb 13;40(2):225-31. Epub 2008 Jan 13.

Department of Human Genetics, McGill University, 740 Dr. Penfield, Room 7210, Montréal, Québec H3A 1A4, Canada.

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http://www.nature.com/articles/ng.2007.57
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http://dx.doi.org/10.1038/ng.2007.57DOI Listing
February 2008

Comparative genomic analysis of 18 Pseudomonas aeruginosa bacteriophages.

J Bacteriol 2006 Feb;188(3):1184-7

McIntyre Medical Sciences Building, Room 810, 3655 Promenade Sir William Osler, McGill University, Montreal, Quebec, Canada H3G 1Y6.

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http://dx.doi.org/10.1128/JB.188.3.1184-1187.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347338PMC
February 2006

The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages.

Proc Natl Acad Sci U S A 2005 Apr 23;102(14):5174-9. Epub 2005 Mar 23.

Targanta Therapeutics, 7170 Frederick Banting, Second Floor, Ville Saint Laurent, QC, Canada H4S 2A1.

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http://dx.doi.org/10.1073/pnas.0501140102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556006PMC
April 2005

Antimicrobial drug discovery through bacteriophage genomics.

Nat Biotechnol 2004 Feb 11;22(2):185-91. Epub 2004 Jan 11.

PhageTech Inc., 7170 Frederick Banting, 2nd Floor, Ville Saint Laurent, Quebec, Canada, H4S 2A1.

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http://dx.doi.org/10.1038/nbt932DOI Listing
February 2004

In vitro relaxation of vascular smooth muscle by atropine: involvement of K+ channels and endothelium.

Naunyn Schmiedebergs Arch Pharmacol 2003 Jul 11;368(1):1-9. Epub 2003 Jun 11.

Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1007/s00210-003-0759-7DOI Listing
July 2003

Pramanicin, an antifungal agent, raises cytosolic Ca2+ and causes cell death in vascular endothelial cells.

Vascul Pharmacol 2003 Jan;40(1):35-42

Department of Medicine, HSC-4N40, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.

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January 2003

Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction.

Life Sci 2002 Jun;71(5):497-507

Smooth Muscle Research Program, Department of Medicine, HSC 4N40, McMaster University, 1200 Main Street W., L8N 3Z5, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/s0024-3205(02)01708-3DOI Listing
June 2002

Calyculin A-induced endothelial cell shape changes are independent of [Ca(2+)](i) elevation and may involve actin polymerization.

Biochim Biophys Acta 2002 Apr;1589(2):93-103

Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/s0167-4889(02)00161-1DOI Listing
April 2002