Tong-Chuan He

Tong-Chuan He

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Tong-Chuan He

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Myelin sheath structure and regeneration in peripheral nerve injury repair.

Proc Natl Acad Sci U S A 2019 Oct 14. Epub 2019 Oct 14.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, University of Chicago Medical Center, Chicago, IL 60637.

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http://dx.doi.org/10.1073/pnas.1910292116DOI Listing
October 2019

"Imiquimod acts synergistically with BMP9 via the Notch pathway as an osteoinductive agent in vitro".

Plast Reconstr Surg 2019 Aug 1. Epub 2019 Aug 1.

Department of Surgery, Laboratory of Craniofacial Biology and Development, Section of Plastic Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue MC6035, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1097/PRS.0000000000006159DOI Listing
August 2019

A simplified 3D liver microsphere tissue culture model for hepatic cell signaling and drug-induced hepatotoxicity studies.

Int J Mol Med 2019 Aug 21. Epub 2019 Aug 21.

Ministry of Education Key Laboratory of Diagnostic Medicine, School of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.

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http://dx.doi.org/10.3892/ijmm.2019.4321DOI Listing
August 2019

Dentinogenesis and Tooth-Alveolar Bone Complex Defects in Knockout Mice.

Stem Cells Dev 2019 May 2;28(10):683-694. Epub 2019 Apr 2.

1 Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1089/scd.2018.0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534167PMC
May 2019

Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.

Chem Biol Interact 2018 Dec 18;296:1-8. Epub 2018 Aug 18.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.08.020DOI Listing
December 2018

A Simplified System to Express Circularized Inhibitors of miRNA for Stable and Potent Suppression of miRNA Functions.

Mol Ther Nucleic Acids 2018 Dec 4;13:556-567. Epub 2018 Oct 4.

Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S21622531183026
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http://dx.doi.org/10.1016/j.omtn.2018.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226557PMC
December 2018

Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.

Chem Biol Interact 2018 Dec 18;296:1-8. Epub 2018 Aug 18.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.08.020DOI Listing
December 2018

Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells.

Cell Physiol Biochem 2018 24;47(3):957-971. Epub 2018 May 24.

Departments of Nephrology, Orthopaedic Surgery, Cardiology, General Surgery, Plastic Surgery and Clinical Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1159/000490140DOI Listing
August 2018

A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model.

Sci Rep 2018 Jul 20;8(1):10988. Epub 2018 Jul 20.

Departments of Nephrology, Orthopaedic Surgery, Cardiology, General Surgery, and Clinical Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

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http://dx.doi.org/10.1038/s41598-018-29417-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054654PMC
July 2018

A thermoresponsive, citrate-based macromolecule for bone regenerative engineering.

J Biomed Mater Res A 2018 06 19;106(6):1743-1752. Epub 2018 Feb 19.

Biomedical Engineering Department and Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA.

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http://dx.doi.org/10.1002/jbm.a.36358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951299PMC
June 2018

Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.

Genes Dis 2018 Jun 12;5(2):77-106. Epub 2018 May 12.

Chongqing Key Laboratory of Molecular Oncology and Epigenetics, Departments of General Surgery, Clinical Laboratory Medicine, Orthopaedic Surgery, Plastic Surgery and Burn, and Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

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http://dx.doi.org/10.1016/j.gendis.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147049PMC
June 2018

Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs).

Genes Dis 2018 Jun 23;5(2):137-149. Epub 2018 Apr 23.

Departments of Nephrology, Orthopaedic Surgery, Cardiology, General Surgery, Plastic Surgery, and Clinical Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

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http://dx.doi.org/10.1016/j.gendis.2018.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147083PMC
June 2018

[Twist regulates proliferation, migration and invasion of osteosarcoma cells in vitro].

Nan Fang Yi Ke Da Xue Xue Bao 2018 May;38(5):554-560

Department of Pediatric Surgery, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.E-mail:

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May 2018

Whole-Proteome Analysis of Human Craniosynostotic Tissue Suggests a Link between Inflammatory Signaling and Osteoclast Activation in Human Cranial Suture Patency.

Plast Reconstr Surg 2018 02;141(2):250e-260e

Chicago, Ill.; and Los Angeles, Calif. From the University of Chicago Pritzker School of Medicine; the Computation Institute, Center for Research Informatics, University of Chicago; the Molecular Oncology Laboratory, Department of Orthopedic Surgery, Section of Neurosurgery, and the Laboratory of Craniofacial Development and Biology, Section of Plastic and Reconstructive Surgery, University of Chicago Medicine; and the Division of Plastic and Reconstructive Surgery, University of California, Los Angeles.

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http://dx.doi.org/10.1097/PRS.0000000000004025DOI Listing
February 2018

3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends.

Genes Dis 2017 Dec 22;4(4):185-195. Epub 2017 Nov 22.

Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003668PMC
December 2017

Epimedin C Promotes Vascularization during BMP2-Induced Osteogenesis and Tumor-Associated Angiogenesis.

Am J Chin Med 2017 28;45(5):1093-1111. Epub 2017 Jun 28.

* Academy of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P. R. China.

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http://www.worldscientific.com/doi/abs/10.1142/S0192415X1750
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http://dx.doi.org/10.1142/S0192415X17500598DOI Listing
September 2017

Repair of critical sized cranial defects with BMP9-transduced calvarial cells delivered in a thermoresponsive scaffold.

PLoS One 2017 1;12(3):e0172327. Epub 2017 Mar 1.

Department of Surgery, Section of Plastic Surgery, The University of Chicago Medical Center, Chicago, IL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332017PMC
August 2017

TRAIL-R1 as a novel surface marker for circulating giant cell tumor of bone.

Oncotarget 2017 Aug 11;8(31):50724-50730. Epub 2017 Apr 11.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago 60637, IL, USA.

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http://dx.doi.org/10.18632/oncotarget.17042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584197PMC
August 2017

In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma.

Medicine (Baltimore) 2017 Jul;96(27):e7245

aDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China bMolecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, IL.

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http://dx.doi.org/10.1097/MD.0000000000007245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502147PMC
July 2017

iPSC-based treatment of age-related macular degeneration (AMD): The path to success requires more than blind faith.

Genes Dis 2017 Jun 1;4(2):41-42. Epub 2017 Apr 1.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23523042173002
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http://dx.doi.org/10.1016/j.gendis.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136587PMC
June 2017

CRISPR/Cas9-Mediated Genome Editing Corrects Dystrophin Mutation in Skeletal Muscle Stem Cells in a Mouse Model of Muscle Dystrophy.

Mol Ther Nucleic Acids 2017 Jun 28;7:31-41. Epub 2017 Feb 28.

Division of Hematology/Oncology, Department of Medicine and Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363682PMC
June 2017

Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors.

Oncotarget 2017 Apr;8(16):27105-27119

Key Laboratory of Molecular Biology for Infectious Diseases of The Ministry of Education of China, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.18632/oncotarget.15637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432321PMC
April 2017

A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities.

Cell Physiol Biochem 2016 9;39(3):871-88. Epub 2016 Aug 9.

Departments of Obstetrics and Gynecology, and Physical Examination, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1159/000447797DOI Listing
February 2017

Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes.

Photochem Photobiol 2017 01 12;93(1):375-381. Epub 2016 Aug 12.

Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1111/php.12624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272907PMC
January 2017

A method for whole protein isolation from human cranial bone.

Anal Biochem 2016 Dec 25;515:33-39. Epub 2016 Sep 25.

The Laboratory of Craniofacial Development and Biology, Section of Plastic and Reconstructive Surgery, University of Chicago Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584578PMC
December 2016

An effective treatment of experimental osteomyelitis using the antimicrobial titanium/silver-containing nHP66 (nano-hydroxyapatite/polyamide-66) nanoscaffold biomaterials.

Sci Rep 2016 12 16;6:39174. Epub 2016 Dec 16.

Department of Orthopaedic Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.

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http://dx.doi.org/10.1038/srep39174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159876PMC
December 2016

Wnt and BMP Signaling Crosstalk in Regulating Dental Stem Cells: Implications in Dental Tissue Engineering.

Genes Dis 2016 Dec 5;3(4):263-276. Epub 2016 Oct 5.

Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, and the Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing 401147, China.

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http://dx.doi.org/10.1016/j.gendis.2016.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421560PMC
December 2016

The Prodomain-Containing BMP9 Produced from a Stable Line Effectively Regulates the Differentiation of Mesenchymal Stem Cells.

Int J Med Sci 2016 1;13(1):8-18. Epub 2016 Jan 1.

2. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, USA; 9. Department of General Surgery, the Research Center of Digestive Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.

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http://dx.doi.org/10.7150/ijms.13333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716815PMC
October 2016

An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor?

Genes Dis 2016 Sep 9;3(3):169-170. Epub 2016 Jul 9.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215798PMC
September 2016

A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells.

Biomed Mater 2016 Apr 21;11(2):025021. Epub 2016 Apr 21.

Department of Biomedical Engineering, School of Bioengineering, Chongqing University, Chongqing 400044, People's Republic of China. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1088/1748-6041/11/2/025021DOI Listing
April 2016

Transition to resistance: An unexpected role of the EMT in cancer chemoresistance.

Genes Dis 2016 Mar 28;3(1):3-6. Epub 2016 Jan 28.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421998PMC
March 2016

Medial approach to treat humeral mid-shaft fractures: a retrospective study.

J Orthop Surg Res 2016 Mar 17;11:32. Epub 2016 Mar 17.

Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China.

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http://dx.doi.org/10.1186/s13018-016-0366-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797333PMC
March 2016

Transiliac Osteotomy in Surgical Management of Pelvic Post-Traumatic Malunions: A Retrospective Study.

Medicine (Baltimore) 2016 Mar;95(13):e3144

From the Department of Orthopedics (SL, JW, BF, JD, YY, MX, GW, DZ), Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China; and Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, Illinois (T-CH).

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http://dx.doi.org/10.1097/MD.0000000000003144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998535PMC
March 2016

Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.

Genes Dis 2016 Mar 14;3(1):11-40. Epub 2016 Jan 14.

The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA; Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827448PMC
March 2016

The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.

Lab Invest 2016 Feb 30;96(2):116-36. Epub 2015 Nov 30.

Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University, Chongqing, China.

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http://www.boneandcancer.org/MOLab%20Publications%20in%20PDF
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http://www.nature.com/doifinder/10.1038/labinvest.2015.144
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http://dx.doi.org/10.1038/labinvest.2015.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731283PMC
February 2016

Red ginseng and cancer treatment.

Chin J Nat Med 2016 Jan;14(1):7-16

Tang Center for Herbal Medicine Research, and Department of Anesthesia & Critical Care, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA; Committee on Clinical Pharmacology and Pharmacogenomics, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.3724/SP.J.1009.2016.00007DOI Listing
January 2016

A simplified and versatile system for the simultaneous expression of multiple siRNAs in mammalian cells using Gibson DNA Assembly.

PLoS One 2014 14;9(11):e113064. Epub 2014 Nov 14.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, United States of America; Department of Orthopaedic Surgery, the Affiliated Xiang-Ya Hospital of Central South University, Changsha, 410008, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113064PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232585PMC
December 2015

For your eyes only: Harnessing human embryonic stem cell-derived retinal pigment epithelial cells to improve impaired vision.

Genes Dis 2015 Dec 30;2(4):293-294. Epub 2015 Jul 30.

The Editorial Office of Genes & Diseases, Chongqing, 400046, China.

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http://dx.doi.org/10.1016/j.gendis.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725060PMC
December 2015

Damage control: Harnessing prostaglandin E2 as a potential healing factor of tissue injuries.

Genes Dis 2015 Dec 30;2(4):295-298. Epub 2015 Sep 30.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725599PMC
December 2015

Authentication of experimental materials: A remedy for the reproducibility crisis?

Genes Dis 2015 Dec 7;2(4):283. Epub 2015 Jul 7.

Molecular Oncology Laboratory, The University of Chicago, Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2015.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758512PMC
December 2015

Noninvasive renal denervation for resistant hypertension using high-intensity focused ultrasound.

Hypertension 2015 Oct 3;66(4):e22-5. Epub 2015 Aug 3.

From the Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China (S.R., D.L., J.Q., Q. Zhu, Y.J., G.Y., C.D., D.Z., Q. Zhou, J.H.); the Clinical Center for HIFU Tumor Therapy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China (H.Z., K.Z.); the Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (H.L.); Molecular Oncology Laboratory, Department of Orthopedic Surgery, The University of Chicago Medical Center, IL (T.-C.H.); and National Engineering Research Center of Ultrasound Medicine, Chongqing, China (Z.W.).

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.115.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05754DOI Listing
October 2015

Biomimetic approaches to complex craniofacial defects.

Ann Maxillofac Surg 2015 Jan-Jun;5(1):4-13

Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Chicago Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.4103/2231-0746.161044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555947PMC
September 2015

Insider information: Testing cancer drug sensitivity for personalized therapy.

Genes Dis 2015 Sep 4;2(3):219-221. Epub 2015 Jun 4.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610196PMC
September 2015

Molecular pathogenesis and therapeutic strategies of human osteosarcoma.

J Biomed Res 2015 Aug 30;30. Epub 2015 Aug 30.

The University of Chicago Pritzker School of Medicine, and Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.7555/JBR.29.20150075DOI Listing
August 2015

Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo.

Am J Phys Med Rehabil 2015 Jul;94(7):530-8

From the Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois (YZ, AC, PS, RW, HSA); Veterans Affairs Medical Center, Philadelphia, Pennsylvania (YZ); Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia (YZ); Department of Orthopedic Surgery, University of Connecticut Health Center, Hartford (IM); Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois (E-YC); and Department of Orthopaedic Surgery and Rehabilitation Medicine, University of Chicago, Chicago, Illinois (T-CH).

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http://dx.doi.org/10.1097/PHM.0000000000000194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329109PMC
July 2015

American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice.

J Ginseng Res 2015 Jul 10;39(3):230-7. Epub 2015 Jan 10.

Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, USA ; Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA ; Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.jgr.2014.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506368PMC
July 2015

Functional characteristics of reversibly immortalized hepatic progenitor cells derived from mouse embryonic liver.

Cell Physiol Biochem 2014 2;34(4):1318-38. Epub 2014 Oct 2.

Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, the Children's Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1159/000366340DOI Listing
June 2015

Osteoprotegerin deficiency results in disruption of posterofrontal suture closure in mice: implications in nonsyndromic craniosynostosis.

Plast Reconstr Surg 2015 Jun;135(6):990e-999e

Chicago, Ill. From the Section of Plastic and Reconstructive Surgery, Department of Surgery, the Laboratory of Craniofacial Biology and Development, and the Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center.

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http://dx.doi.org/10.1097/PRS.0000000000001284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602410PMC
June 2015

Characterization of Reversibly Immortalized Calvarial Mesenchymal Progenitor Cells.

J Craniofac Surg 2015 Jun;26(4):1207-13

*The Laboratory of Craniofacial Development and Biology, Section of Plastic and Reconstructive Surgery, University of Chicago Medicine, Chicago, IL †University Plastic Surgery, Chicago Medical School, Rosalind Franklin University, North Chicago, IL ‡The Molecular Oncology Laboratory, Department of Orthopedic Surgery, University of Chicago Medicine, Chicago, IL.

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http://www.boneandcancer.org/MOLab%20Publications%20in%20PDF
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/SCS.0000000000001717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470299PMC
June 2015

Sustained high level transgene expression in mammalian cells mediated by the optimized transposon system.

Genes Dis 2015 Mar;2(1):96-105

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, USA ; Ministry of Education Key Laboratory of Diagnostic Medicine, and The Affiliated Hospitals of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1016/j.gendis.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372205PMC
March 2015

Adenovirus-mediated efficient gene transfer into cultured three-dimensional organoids.

PLoS One 2014 2;9(4):e93608. Epub 2014 Apr 2.

Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America; Ministry of Education Key Laboratory of Clinical Diagnostic Medicine, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093608PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973564PMC
February 2015

The piggyBac transposon-mediated expression of SV40 T antigen efficiently immortalizes mouse embryonic fibroblasts (MEFs).

PLoS One 2014 20;9(5):e97316. Epub 2014 May 20.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America; Ministry of Education Key Laboratory of Diagnostic Medicine, and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097316PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028212PMC
February 2015

American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice.

J Ginseng Res 2015 Jan 18;39(1):14-21. Epub 2014 Jul 18.

Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, USA ; Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA ; Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S12268453140008
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http://dx.doi.org/10.1016/j.jgr.2014.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268560PMC
January 2015

Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer.

Nutrients 2015 Jan 23;7(2):799-814. Epub 2015 Jan 23.

Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.3390/nu7020799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344561PMC
January 2015

TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol.

J Pharmacol Sci 2015 Jan 18;127(1):83-91. Epub 2014 Nov 18.

Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA; Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA; Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053100PMC
http://dx.doi.org/10.1016/j.jphs.2014.11.003DOI Listing
January 2015

Targeting BMP9-promoted human osteosarcoma growth by inactivation of notch signaling.

Curr Cancer Drug Targets 2014 ;14(3):274-85

Molecular Oncology Laboratory, The University of Chicago Medical Center, 5841 South Maryland Avenue, Room J-611, Chicago, IL 60637, USA.

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December 2014

Characterization of constitutive promoters for piggyBac transposon-mediated stable transgene expression in mesenchymal stem cells (MSCs).

PLoS One 2014 8;9(4):e94397. Epub 2014 Apr 8.

Stem Cell Biology and Therapy Laboratory of Ministry of Education Key Laboratory for Pediatrics, Chongqing Stem Cell Therapy and Engineering Center, and Department of Urology, The Children's Hospital of Chongqing Medical University, Chongqing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979777PMC
December 2014

Wnt Hippo: A balanced act or dynamic duo?

Genes Dis 2014 Dec;1(2):127-128

Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323082PMC
December 2014

Adenovirus-mediated gene transfer in mesenchymal stem cells can be significantly enhanced by the cationic polymer polybrene.

PLoS One 2014 21;9(3):e92908. Epub 2014 Mar 21.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America; Stem Cell Biology and Therapy Laboratory of the Ministry of Education Key Laboratory for Pediatrics, The Children's Hospital of Chongqing Medical University, Chongqing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092908PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962475PMC
November 2014

Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells.

Oncol Rep 2014 Sep 3;32(3):1013-20. Epub 2014 Jul 3.

Ministry of Education Key Laboratory of Clinical Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing 400016, P.R. China.

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http://dx.doi.org/10.3892/or.2014.3308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121423PMC
September 2014

CRISPR clear? Dimeric Cas9-Fok1 nucleases improve genome-editing specificity.

Genes Dis 2014 Sep;1(1):6-7

Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gendis.2014.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217641PMC
September 2014

Matrix metalloproteinase 9 (MMP-9) in osteosarcoma: review and meta-analysis.

Clin Chim Acta 2014 Jun 1;433:225-31. Epub 2014 Apr 1.

College of Laboratory Medicine, Key Laboratory of Laboratory Medical Diagnostics designated by Chinese Ministry of Education, Chongqing Medical University, 400016, China. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2014.03.023DOI Listing
June 2014

Regulation of cell proliferation and migration by p62 through stabilization of Twist1.

Proc Natl Acad Sci U S A 2014 Jun 9;111(25):9241-6. Epub 2014 Jun 9.

Departments of Medicine, Section of Dermatology,

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http://dx.doi.org/10.1073/pnas.1322913111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078859PMC
June 2014