Publications by authors named "Ton Schumacher"

100Publications

Labeling and tracking of immune cells in ex vivo human skin.

Nat Protoc 2020 Dec 21. Epub 2020 Dec 21.

Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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December 2020

Long-distance modulation of bystander tumor cells by CD8 T cell-secreted IFNγ.

Nat Cancer 2020 Mar 9;1(3):291-301. Epub 2020 Mar 9.

Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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March 2020

A mouse model that is immunologically tolerant to reporter and modifier proteins.

Commun Biol 2020 May 29;3(1):273. Epub 2020 May 29.

Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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May 2020

The CD47-SIRPα Immune Checkpoint.

Immunity 2020 05;52(5):742-752

Division of Molecular Oncology and Immunology, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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May 2020

CD29 identifies IFN-γ-producing human CD8 T cells with an increased cytotoxic potential.

Proc Natl Acad Sci U S A 2020 03 11;117(12):6686-6696. Epub 2020 Mar 11.

Department of Hematopoiesis, Sanquin Research, 1066 CX Amsterdam, The Netherlands;

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March 2020

CD8 T cell states in human cancer: insights from single-cell analysis.

Nat Rev Cancer 2020 04 5;20(4):218-232. Epub 2020 Feb 5.

Division of Molecular Oncology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands.

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April 2020

Tumor organoid-T-cell coculture systems.

Nat Protoc 2020 01 18;15(1):15-39. Epub 2019 Dec 18.

Department of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

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January 2020

Defining 'T cell exhaustion'.

Nat Rev Immunol 2019 11 30;19(11):665-674. Epub 2019 Sep 30.

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

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November 2019

Tissue patrol by resident memory CD8 T cells in human skin.

Nat Immunol 2019 06 20;20(6):756-764. Epub 2019 May 20.

Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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June 2019

Induction of neoantigen-reactive T cells from healthy donors.

Nat Protoc 2019 06 17;14(6):1926-1943. Epub 2019 May 17.

Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

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June 2019

Radiotherapy and Cisplatin Increase Immunotherapy Efficacy by Enabling Local and Systemic Intratumoral T-cell Activity.

Cancer Immunol Res 2019 04 19;7(4):670-682. Epub 2019 Feb 19.

Division of Tumor Biology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, 1066 CX Amsterdam, The Netherlands.

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April 2019

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

PLoS One 2019 12;14(2):e0212053. Epub 2019 Feb 12.

Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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November 2019

Cancer Neoantigens.

Annu Rev Immunol 2019 04 14;37:173-200. Epub 2018 Dec 14.

Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; email: ,

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April 2019

T Cell Dysfunction in Cancer.

Cancer Cell 2018 04;33(4):547-562

Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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April 2018

Regulation and Function of the PD-L1 Checkpoint.

Immunity 2018 03;48(3):434-452

Division of Molecular Oncology & Immunology, Oncode Institute, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

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March 2018

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.

Cell 2018 01 21;172(3):549-563.e16. Epub 2017 Dec 21.

Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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January 2018

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Mübeccel Akdis Immanuel Andrä Francesco Annunziato Petra Bacher Vincenzo Barnaba Luca Battistini Wolfgang M Bauer Sabine Baumgart Burkhard Becher Wolfgang Beisker Claudia Berek Alfonso Blanco Giovanna Borsellino Philip E Boulais Ryan R Brinkman Martin Büscher Dirk H Busch Timothy P Bushnell Xuetao Cao Andrea Cavani Pratip K Chattopadhyay Qingyu Cheng Sue Chow Mario Clerici Anne Cooke Antonio Cosma Lorenzo Cosmi Ana Cumano Van Duc Dang Derek Davies Sara De Biasi Genny Del Zotto Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing Andreas Diefenbach James Di Santo Francesco Dieli Andreas Dolf Vera S Donnenberg Thomas Dörner Götz R A Ehrhardt Elmar Endl Pablo Engel Britta Engelhardt Charlotte Esser Bart Everts Anita Dreher Christine S Falk Todd A Fehniger Andrew Filby Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Paul S Frenette David Galbraith Natalio Garbi Maria Dolores García-Godoy Jens Geginat Kamran Ghoreschi Lara Gibellini Christoph Goettlinger Carl S Goodyear Andrea Gori Jane Grogan Mor Gross Andreas Grützkau Daryl Grummitt Jonas Hahn Quirin Hammer Anja E Hauser David L Haviland David Hedley Guadalupe Herrera Martin Herrmann Falk Hiepe Tristan Holland Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Christopher A Hunter Anna Iannone Hans-Martin Jäck Beatriz Jávega Stipan Jonjic Kerstin Juelke Steffen Jung Toralf Kaiser Tomas Kalina Baerbel Keller Srijit Khan Deborah Kienhöfer Thomas Kroneis Désirée Kunkel Christian Kurts Pia Kvistborg Joanne Lannigan Olivier Lantz Anis Larbi Salome LeibundGut-Landmann Michael D Leipold Megan K Levings Virginia Litwin Yanling Liu Michael Lohoff Giovanna Lombardi Lilly Lopez Amy Lovett-Racke Erik Lubberts Burkhard Ludewig Enrico Lugli Holden T Maecker Glòria Martrus Giuseppe Matarese Christian Maueröder Mairi McGrath Iain McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Kingston Mills David Mirrer Jenny Mjösberg Jonni Moore Barry Moran Alessandro Moretta Lorenzo Moretta Tim R Mosmann Susann Müller Werner Müller Christian Münz Gabriele Multhoff Luis Enrique Munoz Kenneth M Murphy Toshinori Nakayama Milena Nasi Christine Neudörfl John Nolan Sussan Nourshargh José-Enrique O'Connor Wenjun Ouyang Annette Oxenius Raghav Palankar Isabel Panse Pärt Peterson Christian Peth Jordi Petriz Daisy Philips Winfried Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Carlo Pucillo Sally A Quataert Timothy R D J Radstake Bartek Rajwa Jonathan A Rebhahn Diether Recktenwald Ester B M Remmerswaal Katy Rezvani Laura G Rico J Paul Robinson Chiara Romagnani Anna Rubartelli Beate Ruckert Jürgen Ruland Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Birgit Sawitzki Alexander Scheffold Matthias Schiemann Frank Schildberg Esther Schimisky Stephan A Schmid Steffen Schmitt Kilian Schober Thomas Schüler Axel Ronald Schulz Ton Schumacher Cristiano Scotta T Vincent Shankey Anat Shemer Anna-Katharina Simon Josef Spidlen Alan M Stall Regina Stark Christina Stehle Merle Stein Tobit Steinmetz Hannes Stockinger Yousuke Takahama Attila Tarnok ZhiGang Tian Gergely Toldi Julia Tornack Elisabetta Traggiai Joe Trotter Henning Ulrich Marlous van der Braber René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Konrad von Volkmann Ari Waisman Rachael Walker Michael D Ward Klaus Warnatz Sarah Warth James V Watson Carsten Watzl Leonie Wegener Annika Wiedemann Jürgen Wienands Gerald Willimsky James Wing Peter Wurst Liping Yu Alice Yue Qianjun Zhang Yi Zhao Susanne Ziegler Jakob Zimmermann

Eur J Immunol 2017 10;47(10):1584-1797

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse, Bern.

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October 2017

pMHC Multiplexing Strategy to Detect High Numbers of T Cell Responses in Parallel.

Methods Mol Biol 2017 ;1514:93-101

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, CX, 1066, The Netherlands.

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January 2018

Neoantigens encoded in the cancer genome.

Curr Opin Immunol 2016 08 9;41:98-103. Epub 2016 Aug 9.

Cancer Center and Center for Cancer Immunology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Electronic address:

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August 2016

Editorial overview: Cancer immunology: genomics & biomarkers: Cancer immunity through the prism of genomics and proteomics.

Curr Opin Immunol 2016 08 6;41:ix-x. Epub 2016 Aug 6.

Broad Institute of Harvard and MIT, 149 13th St, Charlestown, MA 02129, USA; Cancer Center, Massachusetts General Hospital, Harvard Medical School, USA. Electronic address:

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August 2016

Genomics- and Transcriptomics-Based Patient Selection for Cancer Treatment With Immune Checkpoint Inhibitors: A Review.

JAMA Oncol 2016 Nov;2(11):1490-1495

Division of Molecular Oncology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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November 2016

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

N Engl J Med 2016 Sep 13;375(9):819-29. Epub 2016 Jul 13.

From the University of California, Los Angeles (UCLA) (J.M.Z., A.G.-D., D.S.S., H.E.-O., W.H., S.H.-L., D.Y.T., G.A.-R., S.S., L.B., J.S., B.H.M., B.C., K.R., I.P.S., P.J.S., C.P.-S., G.C., E.S., X.K., J.P., B.B.-M., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.), and Jonsson Comprehensive Cancer Center (B.C., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.) - both in Los Angeles; and the Division of Immunology, Netherlands Cancer Institute, Amsterdam (R.M., T.N.M.S.).

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September 2016

CANCER IMMUNOLOGY. The "cancer immunogram".

Science 2016 May;352(6286):658-60

Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

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May 2016

A liquid biopsy for cancer immunotherapy.

Nat Med 2016 Apr;22(4):340-1

Division of Immunology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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April 2016

Reproducibility of Illumina platform deep sequencing errors allows accurate determination of DNA barcodes in cells.

BMC Bioinformatics 2016 Apr 2;17:151. Epub 2016 Apr 2.

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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April 2016

A Traceless Selection: Counter-selection System That Allows Efficient Generation of Transposon and CRISPR-modified T-cell Products.

Mol Ther Nucleic Acids 2016 Mar 22;5:e298. Epub 2016 Mar 22.

Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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March 2016

The Branching Point in Erythro-Myeloid Differentiation.

Cell 2015 Dec;163(7):1655-62

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

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December 2015

T Cell Fate at the Single-Cell Level.

Annu Rev Immunol 2016 05 11;34:65-92. Epub 2015 Dec 11.

Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), 81675 München, Germany; email: ,

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May 2016

Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization.

J Immunol 2015 Dec 2;195(11):5285-95. Epub 2015 Nov 2.

Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands;

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December 2015

Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage.

J Immunol 2015 Nov 23;195(9):4075-84. Epub 2015 Sep 23.

Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands;

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November 2015

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy.

Cancer Cell 2015 Jul;28(1):11-3

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

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July 2015

Assessing T lymphocyte function and differentiation by genetically encoded reporter systems.

Trends Immunol 2015 Jul 10;36(7):392-400. Epub 2015 Jun 10.

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Freiburg, Germany. Electronic address:

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July 2015

Neoantigens in cancer immunotherapy.

Science 2015 Apr;348(6230):69-74

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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April 2015

Adoptive cellular therapy: a race to the finish line.

Sci Transl Med 2015 Mar;7(280):280ps7

Division of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

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March 2015

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.

Science 2015 Apr 12;348(6230):124-8. Epub 2015 Mar 12.

Weill Cornell Medical College, New York, NY, 10065, USA. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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April 2015

Biomarkers in cancer immunotherapy.

Cancer Cell 2015 Jan;27(1):12-4

Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

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January 2015

Acquired and intrinsic resistance in cancer immunotherapy.

Mol Oncol 2014 Sep 24;8(6):1132-9. Epub 2014 Jul 24.

The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. Electronic address:

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September 2014

High sensitivity of cancer exome-based CD8 T cell neo-antigen identification.

Oncoimmunology 2014;3:e28836. Epub 2014 May 14.

Department of Immunology; The Netherlands Cancer Institute; Amsterdam, The Netherlands.

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May 2014

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer.

Mol Ther 2014 Nov 22;22(11):1983-91. Epub 2014 Jul 22.

1] Max Delbrück Center for Molecular Medicine, Berlin, Germany [2] Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.

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November 2014

Cellular barcoding: a technical appraisal.

Exp Hematol 2014 Aug 1;42(8):598-608. Epub 2014 Jul 1.

Division of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. Electronic address:

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August 2014

Towards error-free profiling of immune repertoires.

Nat Methods 2014 Jun 4;11(6):653-5. Epub 2014 May 4.

1] Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia. [2] Pirogov Russian National Research Medical University, Moscow, Russia. [3] Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

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June 2014

Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity.

Exp Hematol 2014 Sep 13;42(9):753-60. Epub 2014 Apr 13.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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September 2014

Intradermal vaccination by DNA tattooing.

Methods Mol Biol 2014 ;1143:131-40

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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November 2014

Single cell behavior in T cell differentiation.

Trends Immunol 2014 Apr 20;35(4):170-7. Epub 2014 Mar 20.

Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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April 2014

Determining lineage pathways from cellular barcoding experiments.

Cell Rep 2014 Feb 6;6(4):617-24. Epub 2014 Feb 6.

Hamilton Institute, National University of Ireland, Maynooth, Ireland.

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February 2014

Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.

Proc Natl Acad Sci U S A 2014 Jan 16;111(1):403-8. Epub 2013 Dec 16.

Department of Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, N-0310 Oslo, Norway.

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January 2014