Ton N Schumacher

Ton N Schumacher

UNVERIFIED PROFILE

Are you Ton N Schumacher?   Register this Author

Register author
Ton N Schumacher

Ton N Schumacher

Publications by authors named "Ton N Schumacher"

Are you Ton N Schumacher?   Register this Author

100Publications

4689Reads

39Profile Views

Tumor organoid-T-cell coculture systems.

Nat Protoc 2020 Jan 18;15(1):15-39. Epub 2019 Dec 18.

Department of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41596-019-0232-9DOI Listing
January 2020

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

PLoS One 2019 12;14(2):e0212053. Epub 2019 Feb 12.

Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212053PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372190PMC
November 2019

Defining 'T cell exhaustion'.

Nat Rev Immunol 2019 Nov 30;19(11):665-674. Epub 2019 Sep 30.

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0221-9DOI Listing
November 2019

Induction of neoantigen-reactive T cells from healthy donors.

Nat Protoc 2019 06 17;14(6):1926-1943. Epub 2019 May 17.

Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41596-019-0170-6DOI Listing
June 2019

Tissue patrol by resident memory CD8 T cells in human skin.

Nat Immunol 2019 06 20;20(6):756-764. Epub 2019 May 20.

Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0404-3DOI Listing
June 2019

Cancer Neoantigens.

Annu Rev Immunol 2019 04 14;37:173-200. Epub 2018 Dec 14.

Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; email: ,

View Article

Download full-text PDF

Source
https://www.annualreviews.org/doi/10.1146/annurev-immunol-04
Publisher Site
http://dx.doi.org/10.1146/annurev-immunol-042617-053402DOI Listing
April 2019

Radiotherapy and Cisplatin Increase Immunotherapy Efficacy by Enabling Local and Systemic Intratumoral T-cell Activity.

Cancer Immunol Res 2019 Apr 19;7(4):670-682. Epub 2019 Feb 19.

Division of Tumor Biology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-18-0654DOI Listing
April 2019

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells.

Cancer Immunol Res 2019 Apr 20;7(4):552-558. Epub 2019 Mar 20.

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-18-0647DOI Listing
April 2019

T Cell Dysfunction in Cancer.

Cancer Cell 2018 04;33(4):547-562

Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2018.03.012DOI Listing
April 2018

Regulation and Function of the PD-L1 Checkpoint.

Immunity 2018 03;48(3):434-452

Division of Molecular Oncology & Immunology, Oncode Institute, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747613183009
Publisher Site
http://dx.doi.org/10.1016/j.immuni.2018.03.014DOI Listing
March 2018

pMHC Multiplexing Strategy to Detect High Numbers of T Cell Responses in Parallel.

Methods Mol Biol 2017 ;1514:93-101

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, CX, 1066, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6548-9_7DOI Listing
January 2018

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.

Cell 2018 01 21;172(3):549-563.e16. Epub 2017 Dec 21.

Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.11.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786495PMC
January 2018

Genomics- and Transcriptomics-Based Patient Selection for Cancer Treatment With Immune Checkpoint Inhibitors: A Review.

JAMA Oncol 2016 Nov;2(11):1490-1495

Division of Molecular Oncology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaoncol.2016.2214DOI Listing
November 2016

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

N Engl J Med 2016 Sep 13;375(9):819-29. Epub 2016 Jul 13.

From the University of California, Los Angeles (UCLA) (J.M.Z., A.G.-D., D.S.S., H.E.-O., W.H., S.H.-L., D.Y.T., G.A.-R., S.S., L.B., J.S., B.H.M., B.C., K.R., I.P.S., P.J.S., C.P.-S., G.C., E.S., X.K., J.P., B.B.-M., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.), and Jonsson Comprehensive Cancer Center (B.C., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.) - both in Los Angeles; and the Division of Immunology, Netherlands Cancer Institute, Amsterdam (R.M., T.N.M.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1604958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007206PMC
September 2016

Editorial overview: Cancer immunology: genomics & biomarkers: Cancer immunity through the prism of genomics and proteomics.

Curr Opin Immunol 2016 08 6;41:ix-x. Epub 2016 Aug 6.

Broad Institute of Harvard and MIT, 149 13th St, Charlestown, MA 02129, USA; Cancer Center, Massachusetts General Hospital, Harvard Medical School, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2016.07.006DOI Listing
August 2016

Neoantigens encoded in the cancer genome.

Curr Opin Immunol 2016 08 9;41:98-103. Epub 2016 Aug 9.

Cancer Center and Center for Cancer Immunology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2016.07.005DOI Listing
August 2016

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

Science 2016 Jun 19;352(6291):1337-41. Epub 2016 May 19.

Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaf2288DOI Listing
June 2016

T Cell Fate at the Single-Cell Level.

Annu Rev Immunol 2016 05 11;34:65-92. Epub 2015 Dec 11.

Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), 81675 München, Germany; email: ,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-immunol-032414-112014DOI Listing
May 2016

CANCER IMMUNOLOGY. The "cancer immunogram".

Science 2016 May;352(6286):658-60

Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/cgi/doi/10.1126/science.aaf2834
Publisher Site
http://dx.doi.org/10.1126/science.aaf2834DOI Listing
May 2016

Reproducibility of Illumina platform deep sequencing errors allows accurate determination of DNA barcodes in cells.

BMC Bioinformatics 2016 Apr 2;17:151. Epub 2016 Apr 2.

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-016-0999-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818877PMC
April 2016

A liquid biopsy for cancer immunotherapy.

Nat Med 2016 Apr;22(4):340-1

Division of Immunology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.4074DOI Listing
April 2016

A Traceless Selection: Counter-selection System That Allows Efficient Generation of Transposon and CRISPR-modified T-cell Products.

Mol Ther Nucleic Acids 2016 Mar 22;5:e298. Epub 2016 Mar 22.

Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtna.2016.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014455PMC
March 2016

The Branching Point in Erythro-Myeloid Differentiation.

Cell 2015 Dec;163(7):1655-62

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2015.11.059DOI Listing
December 2015

Assessing T lymphocyte function and differentiation by genetically encoded reporter systems.

Trends Immunol 2015 Jul 10;36(7):392-400. Epub 2015 Jun 10.

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Freiburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2015.05.008DOI Listing
July 2015

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy.

Cancer Cell 2015 Jul;28(1):11-3

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2015.06.012DOI Listing
July 2015

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.

Science 2015 Apr 12;348(6230):124-8. Epub 2015 Mar 12.

Weill Cornell Medical College, New York, NY, 10065, USA. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaa1348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993154PMC
April 2015

Neoantigens in cancer immunotherapy.

Science 2015 Apr;348(6230):69-74

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://ggdpathway.wustl.edu/files/2014/08/Science-2015-Schum
Web Search
http://dx.doi.org/10.1126/science.aaa4971DOI Listing
April 2015

Adoptive cellular therapy: a race to the finish line.

Sci Transl Med 2015 Mar;7(280):280ps7

Division of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aaa3643DOI Listing
March 2015

Biomarkers in cancer immunotherapy.

Cancer Cell 2015 Jan;27(1):12-4

Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2014.12.004DOI Listing
January 2015

Intradermal vaccination by DNA tattooing.

Methods Mol Biol 2014 ;1143:131-40

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-0410-5_9DOI Listing
November 2014

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer.

Mol Ther 2014 Nov 22;22(11):1983-91. Epub 2014 Jul 22.

1] Max Delbrück Center for Molecular Medicine, Berlin, Germany [2] Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2014.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429734PMC
November 2014

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

Science 2014 Oct 28;346(6205):101-5. Epub 2014 Aug 28.

Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/cgi/doi/10.1126/science.1254803
Publisher Site
http://dx.doi.org/10.1126/science.1254803DOI Listing
October 2014

Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity.

Exp Hematol 2014 Sep 13;42(9):753-60. Epub 2014 Apr 13.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0301472X140014
Publisher Site
http://dx.doi.org/10.1016/j.exphem.2014.04.001DOI Listing
September 2014

Acquired and intrinsic resistance in cancer immunotherapy.

Mol Oncol 2014 Sep 24;8(6):1132-9. Epub 2014 Jul 24.

The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molonc.2014.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528612PMC
September 2014

Cellular barcoding: a technical appraisal.

Exp Hematol 2014 Aug 1;42(8):598-608. Epub 2014 Jul 1.

Division of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2014.05.003DOI Listing
August 2014

Towards error-free profiling of immune repertoires.

Nat Methods 2014 Jun 4;11(6):653-5. Epub 2014 May 4.

1] Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia. [2] Pirogov Russian National Research Medical University, Moscow, Russia. [3] Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.2960DOI Listing
June 2014

Single cell behavior in T cell differentiation.

Trends Immunol 2014 Apr 20;35(4):170-7. Epub 2014 Mar 20.

Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2014.02.006DOI Listing
April 2014

Determining lineage pathways from cellular barcoding experiments.

Cell Rep 2014 Feb 6;6(4):617-24. Epub 2014 Feb 6.

Hamilton Institute, National University of Ireland, Maynooth, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.01.016DOI Listing
February 2014

TCR repertoires of intratumoral T-cell subsets.

Immunol Rev 2014 Jan;257(1):72-82

Division of Immunology, The Netherlands Cancer Institute (NKI-AVL), Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imr.12140DOI Listing
January 2014

Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.

Proc Natl Acad Sci U S A 2014 Jan 16;111(1):403-8. Epub 2013 Dec 16.

Department of Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, N-0310 Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1306549111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890872PMC
January 2014

Pairing of T-cell receptor chains via emulsion PCR.

Eur J Immunol 2013 Sep 26;43(9):2507-15. Epub 2013 Jun 26.

Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201343453DOI Listing
September 2013

Blockade of TGF-β signaling greatly enhances the efficacy of TCR gene therapy of cancer.

J Immunol 2013 Sep 12;191(6):3232-9. Epub 2013 Aug 12.

Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1301270DOI Listing
September 2013

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Heterogeneous differentiation patterns of individual CD8+ T cells.

Science 2013 May 14;340(6132):635-9. Epub 2013 Mar 14.

Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1235487DOI Listing
May 2013

Diverse and heritable lineage imprinting of early haematopoietic progenitors.

Nature 2013 Apr 3;496(7444):229-32. Epub 2013 Apr 3.

Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12013DOI Listing
April 2013

Human cancer regression antigens.

Curr Opin Immunol 2013 Apr 6;25(2):284-90. Epub 2013 Apr 6.

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2013.03.005DOI Listing
April 2013

The cancer antigenome.

EMBO J 2013 Jan 21;32(2):194-203. Epub 2012 Dec 21.

Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2012.333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553384PMC
January 2013

Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses.

Hum Gene Ther 2012 Dec 31;23(12):1301-12. Epub 2012 Oct 31.

Division of Immunology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/hum.2012.101
Publisher Site
http://dx.doi.org/10.1089/hum.2012.101DOI Listing
December 2012

Behavior and function of tissue-resident memory T cells.

Adv Immunol 2012 ;114:203-16

Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/B97801239654860
Publisher Site
http://dx.doi.org/10.1016/B978-0-12-396548-6.00008-1DOI Listing
August 2012

Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers.

Nat Protoc 2012 Apr 12;7(5):891-902. Epub 2012 Apr 12.

Center for Cancer Immune Therapy, Department of Hematology, University Hospital Herlev, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2012.037DOI Listing
April 2012