Tomozumi Imamichi

Tomozumi Imamichi

UNVERIFIED PROFILE

Are you Tomozumi Imamichi?   Register this Author

Register author
Tomozumi Imamichi

Tomozumi Imamichi

Publications by authors named "Tomozumi Imamichi"

Are you Tomozumi Imamichi?   Register this Author

52Publications

975Reads

18Profile Views

Defective HIV-1 proviruses produce viral proteins.

Proc Natl Acad Sci U S A 2020 Feb 6;117(7):3704-3710. Epub 2020 Feb 6.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1917876117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035625PMC
February 2020

Profiles of Long Non-Coding RNAs and mRNA Expression in Human Macrophages Regulated by Interleukin-27.

Int J Mol Sci 2019 Dec 9;20(24). Epub 2019 Dec 9.

Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20246207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941108PMC
December 2019

siRNA containing a unique 5-nucleotide motif acts as a quencher of IFI16-mediated innate immune response.

Mol Immunol 2019 10 21;114:330-340. Epub 2019 Aug 21.

Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2019.08.007DOI Listing
October 2019

Complete Genome Sequence of Herpes Simplex Virus 1 Strain MacIntyre.

Microbiol Resour Announc 2019 Sep 12;8(37). Epub 2019 Sep 12.

Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MRA.00895-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742799PMC
September 2019

Complete Genome Sequence of Herpes Simplex Virus 1 Strain McKrae.

Microbiol Resour Announc 2019 Sep 26;8(39). Epub 2019 Sep 26.

Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MRA.00993-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763650PMC
September 2019

A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression.

Sci Rep 2018 01 17;8(1):900. Epub 2018 Jan 17.

Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-19259-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772045PMC
January 2018

STING is an essential mediator of the Ku70-mediated production of IFN-λ1 in response to exogenous DNA.

Sci Signal 2017 Jul 18;10(488). Epub 2017 Jul 18.

Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Research Directorate, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aah5054DOI Listing
July 2017

Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation.

PLoS One 2016 23;11(11):e0167091. Epub 2016 Nov 23.

Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167091PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120855PMC
June 2017

Genome-Wide Analyses of MicroRNA Profiling in Interleukin-27 Treated Monocyte-Derived Human Dendritic Cells Using Deep Sequencing: A Pilot Study.

Int J Mol Sci 2017 Apr 28;18(5). Epub 2017 Apr 28.

Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms18050925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454838PMC
April 2017

Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47.

Sci Rep 2017 02 27;7:43441. Epub 2017 Feb 27.

Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep43441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327488PMC
February 2017

Plasma interleukin-27 (IL-27) levels are not modulated in patients with chronic HIV-1 infection.

PLoS One 2014 4;9(6):e98989. Epub 2014 Jun 4.

Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098989PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045808PMC
October 2015

Activated platelet-T-cell conjugates in peripheral blood of patients with HIV infection: coupling coagulation/inflammation and T cells.

AIDS 2015 Jul;29(11):1297-308

aCMRS/Laboratory of Immunoregulation bResearch Technology Branch, NIAID, NIH, Bethesda cElectron Microscopy Laboratory, Cancer Research Technology Program dLaboratory of Human Retrovirology, Leidos Biomedical Research, Inc. Frederick eLaboratory of Pathology, NCI, NIH fBiostatistics Research Branch, DCR, NIAID, NIH, Bethesda gAIDS Monitoring Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000000701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502988PMC
July 2015

Construction of an isonucleoside on a 2,6-dioxobicyclo[3.2.0]-heptane skeleton.

Molecules 2015 Mar 12;20(3):4623-34. Epub 2015 Mar 12.

Laboratory of Human Retrovirology, Leidos Biochemical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules20034623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272333PMC
March 2015

Lifespan of effector memory CD4+ T cells determined by replication-incompetent integrated HIV-1 provirus.

AIDS 2014 May;28(8):1091-9

aClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda bClinical Services Program, Applied and Development Research Directorate, Leidos Biomedical Research Incorporated, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000000223DOI Listing
May 2014

siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway.

Nucleic Acids Res 2014 Jan 18;42(1):583-98. Epub 2013 Sep 18.

Laboratory of Human Retrovirology, Clinical Services Program, Applied and Developmental Directorate, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA, Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874163PMC
January 2014

Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection.

Cytokine Growth Factor Rev 2013 Dec 17;24(6):571-7. Epub 2013 Aug 17.

Applied and Developmental Research Directorate, Laboratory of Human Retrovirology, Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, 1050 Boyles Street, Frederick, MD 21702, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2013.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851681PMC
December 2013

Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway.

PLoS One 2013 20;8(3):e59194. Epub 2013 Mar 20.

Applied and Developmental Research Directorate (ADD), Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059194PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604098PMC
September 2013

HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.

AIDS 2013 Jul;27(12):1867-77

aCMRS/Laboratory of Immunoregulation, NIAID bExperimental Immunology Branch, NCI, NIH, Bethesda cLaboratory of Molecular Immunoregulation, NCI, NIH, Frederick dBiostatistics Research Branch, NIAID, NIH, Bethesda eCollaborative Clinical Research Branch, NIAID, NIH, Frederick, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0b013e3283618487DOI Listing
July 2013

Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties.

Biochem Biophys Res Commun 2013 May 25;434(2):228-34. Epub 2013 Mar 25.

Applied and Developmental Research Directorate, Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X130046
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2013.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700531PMC
May 2013

IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation.

J Exp Med 2013 Mar 4;210(3):517-34. Epub 2013 Mar 4.

Applied and Developmental Directorate, Science Applications International Corporation-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20120572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600911PMC
March 2013

Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells.

Antivir Ther 2012 21;17(5):883-92. Epub 2012 Mar 21.

University of Florida College of Medicine Biochemistry and Molecular Biology, Gainesville, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3851/IMP2090DOI Listing
January 2013

Interleukin-27 induces interferon-inducible genes: analysis of gene expression profiles using Affymetrix microarray and DAVID.

Methods Mol Biol 2012 ;820:25-53

Laboratory of Human Retrovirology, Clinical Services Programs (CSP), Applied Developmental Directorate (ADD), Science Applications International Corporation (SAIC)-Frederick, Inc., National Cancer Institute (NCI)-Frederick, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-439-1_3DOI Listing
March 2012

Synthesis of 5-thiodidehydropyranylcytosine derivatives as potential anti-HIV agents.

Bioorg Med Chem Lett 2011 Jun 9;21(11):3313-6. Epub 2011 Apr 9.

Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2011.04.006DOI Listing
June 2011

Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.

J Immunol 2011 Apr 11;186(8):4541-5. Epub 2011 Mar 11.

Applied and Developmental Research Directorate, Science Applications International Corporation-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1003389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720676PMC
April 2011

Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication.

Virus Res 2010 Nov 26;153(2):269-76. Epub 2010 Aug 26.

Laboratory of Human Retrovirology, Science Applications International Corporation-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virusres.2010.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956596PMC
November 2010

Interleukin-27, an anti-HIV-1 cytokine, inhibits replication of hepatitis C virus.

J Interferon Cytokine Res 2010 Jun;30(6):427-31

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jir.2009.0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964364PMC
June 2010

Design and synthesis of isonucleosides constructed on a 2-oxa-6-thiabicyclo[3.2.0]heptane scaffold.

J Org Chem 2010 Jun;75(12):4161-71

Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo100556uDOI Listing
June 2010

Extracting biological meaning from large gene lists with DAVID.

Curr Protoc Bioinformatics 2009 Sep;Chapter 13:Unit 13.11

National Cancer Institute at Frederick, Frederick, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471250953.bi1311s27DOI Listing
September 2009

A new entry to carbocyclic nucleosides: oxidative coupling reaction of cycloalkenylsilanes with a nucleobase mediated by hypervalent iodine reagent.

Org Lett 2008 Aug 10;10(16):3449-52. Epub 2008 Jul 10.

Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol8012155DOI Listing
August 2008

IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages.

AIDS 2008 Jan;22(1):39-45

Laboratory of Human Retrovirology, National Cancer Institute at Frederick, Frederick, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0b013e3282f3356cDOI Listing
January 2008

Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27.

Blood 2007 Mar 26;109(5):1841-9. Epub 2006 Oct 26.

Laboratory of Human Retrovirology, Clinical Services Program (CSP), Science Applications International Corporation (SAIC)-Frederick, National Cancer Institute (NCI), MD, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-02-00
Publisher Site
http://dx.doi.org/10.1182/blood-2006-02-001578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801045PMC
March 2007

Hydroxyurea and interleukin-6 synergistically reactivate HIV-1 replication in a latently infected promonocytic cell line via SP1/SP3 transcription factors.

J Biol Chem 2007 Feb 6;282(6):3594-604. Epub 2006 Dec 6.

Laboratory of Human Retrovirology, Clinical Services Program, Science Applications International Corporation-Frederick Inc., NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M608150200DOI Listing
February 2007

A transcription inhibitor, actinomycin D, enhances HIV-1 replication through an interleukin-6-dependent pathway.

J Acquir Immune Defic Syndr 2005 Dec;40(4):388-97

Laboratory of Human Retrovirology, Science Applications International Corporation (SAIC)-Frederick, Frederick, MD 21702-1201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.qai.0000179466.25700.2fDOI Listing
December 2005

Action of anti-HIV drugs and resistance: reverse transcriptase inhibitors and protease inhibitors.

Curr Pharm Des 2004 ;10(32):4039-53

Applied and Development Research Program, National Institute of Allergy and Infectious Diseases at Frederick, Science Applications International Corporation-Frederick, Inc., Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612043382440DOI Listing
January 2005

Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.

J Virol 2004 Sep;78(18):9987-97

HIV Drug Resistance Program, National Cancer Institute-FCRDC, P.O. Box B, Building 539, Room 130A, Frederick, MD 21702-1201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.78.18.9987-9997.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515022PMC
September 2004

Colinearity of reverse transcriptase inhibitor resistance mutations detected by population-based sequencing.

J Acquir Immune Defic Syndr 2003 Dec;34(4):398-402

Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573396PMC
http://dx.doi.org/10.1097/00126334-200312010-00006DOI Listing
December 2003