Tomoyuki Mizuno

Tomoyuki Mizuno

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Tomoyuki Mizuno

Publications by authors named "Tomoyuki Mizuno"

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Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates.

Clin Pharmacol Ther 2019 Sep 12. Epub 2019 Sep 12.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/cpt.1607DOI Listing
September 2019

Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease.

Inflamm Bowel Dis 2019 Jul 9. Epub 2019 Jul 9.

Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1093/ibd/izz143DOI Listing
July 2019

Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.

Clin Pharmacokinet 2019 Jun;58(6):793-803

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC6018, Cincinnati, OH, 45229-3039, USA.

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http://link.springer.com/10.1007/s40262-018-0729-3
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http://dx.doi.org/10.1007/s40262-018-0729-3DOI Listing
June 2019

Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib.

Pediatr Blood Cancer 2019 May 24;66(5):e27618. Epub 2019 Jan 24.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.27618DOI Listing
May 2019

Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study.

Clin Pharmacol Ther 2019 Mar 8;105(3):761-768. Epub 2018 Nov 8.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://doi.wiley.com/10.1002/cpt.1249
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http://dx.doi.org/10.1002/cpt.1249DOI Listing
March 2019

Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia.

Eur J Pharm Sci 2019 Feb 8;128:209-214. Epub 2018 Dec 8.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09280987183053
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http://dx.doi.org/10.1016/j.ejps.2018.12.004DOI Listing
February 2019

Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma.

Pediatr Blood Cancer 2019 01 30;66(1):e27425. Epub 2018 Aug 30.

Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.27425DOI Listing
January 2019

Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial.

Intensive Care Med 2018 Nov 25;44(11):2006-2008. Epub 2018 Sep 25.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://link.springer.com/10.1007/s00134-018-5374-7
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http://dx.doi.org/10.1007/s00134-018-5374-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235707PMC
November 2018

Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management.

Br J Clin Pharmacol 2018 07 17;84(7):1410-1412. Epub 2018 Apr 17.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://doi.wiley.com/10.1111/bcp.13585
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http://dx.doi.org/10.1111/bcp.13585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005594PMC
July 2018

Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies.

Eur J Pharm Sci 2017 Nov 17;109S:S124-S131. Epub 2017 May 17.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.037DOI Listing
November 2017

Opportunities for model-based precision dosing in the treatment of sickle cell anemia.

Blood Cells Mol Dis 2017 09 9;67:143-147. Epub 2017 Aug 9.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677562PMC
September 2017

Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies.

Pediatr Blood Cancer 2017 Aug 16;64(8). Epub 2017 Feb 16.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.26470DOI Listing
August 2017

Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients.

J Thromb Thrombolysis 2017 Jul;44(1):38-47

Adolescent and Adult Congenital Program, Children's Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.

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http://dx.doi.org/10.1007/s11239-017-1499-8DOI Listing
July 2017

Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy.

Clin Transplant 2017 06 2;31(6). Epub 2017 May 2.

Division of Nephrology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1111/ctr.12975DOI Listing
June 2017

Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group.

Br J Clin Pharmacol 2017 05 20;83(5):1097-1107. Epub 2016 Dec 20.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1111/bcp.13181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401981PMC
May 2017

OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children.

Pharmacogenomics 2017 May 4;18(7):621-629. Epub 2017 May 4.

Department of Anesthesia, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.2217/pgs-2017-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591462PMC
May 2017

Mania is an extension of depression from the perspective of neuronal plasticity - Evaluation of our hypothesis through the affective spectrum.

Med Hypotheses 2017 05 11;102:87-88. Epub 2017 Mar 11.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

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http://dx.doi.org/10.1016/j.mehy.2017.03.018DOI Listing
May 2017

Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia.

Br J Clin Pharmacol 2016 Apr 5;81(4):742-52. Epub 2016 Feb 5.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://doi.wiley.com/10.1111/bcp.12851
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http://dx.doi.org/10.1111/bcp.12851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799926PMC
April 2016

Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia.

Pharmacogenomics 2016 04 5;17(6):547-59. Epub 2016 Apr 5.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 452294, USA.

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http://dx.doi.org/10.2217/pgs-2015-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558518PMC
April 2016

Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations.

J Clin Pharmacol 2016 Mar 21;56(3):291-7. Epub 2015 Sep 21.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1002/jcph.601DOI Listing
March 2016

Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury.

Ther Drug Monit 2015 Dec;37(6):792-6

*The Heart Institute, Children's Hospital Colorado, Department of Pediatrics, University of Colorado, Aurora; ‡Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine; and †Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH.

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http://dx.doi.org/10.1097/FTD.0000000000000214DOI Listing
December 2015

An autopsy case of hemiconvulsion-hemiplegia-epilepsy syndrome manifesting as cerebral hemiatrophy in an elderly man.

Neuropathology 2015 Dec 14;35(6):592-8. Epub 2015 Jul 14.

Department of Neurology, Ban Buntane Hotokukai Hospital, School of Medicine, Fujita Health University, Aichi, Japan.

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http://dx.doi.org/10.1111/neup.12225DOI Listing
December 2015

Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study.

J Pediatr 2015 Dec 11;167(6):1214-20.e3. Epub 2015 Sep 11.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2015.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662899PMC
December 2015

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

Ther Drug Monit 2015 Jun;37(3):395-9

*Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center; †Department of Pediatrics, College of Medicine, University of Cincinnati, OH; ‡iC42 Integrated Solutions in Clinical Research and Development, University of Colorado, Aurora; §Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD; ¶Division of Oncology, The Children's Hospital of Philadelphia; ‖Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia; **Division of Oncology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center; and ††Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, OH.

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http://dx.doi.org/10.1097/FTD.0000000000000130DOI Listing
June 2015

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system.

Behav Brain Res 2015 May 11;284:125-30. Epub 2015 Feb 11.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

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http://dx.doi.org/10.1016/j.bbr.2015.02.005DOI Listing
May 2015

The Effects of Chronic Right Hemispheric Damage on the Allocation of Spatial Attention: Alterations of Accuracy and Reliability.

J Int Neuropsychol Soc 2015 May 15;21(5):373-7. Epub 2015 Jun 15.

1Department of Neurology and Center for Neuropsychological Studies,Department of Veteran Affairs Medical Center,University of Florida College of Medicine,and Neurology Service. Gainesville,Florida,USA.

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http://dx.doi.org/10.1017/S1355617715000338DOI Listing
May 2015

Neuronal plasticity in depressive or manic states--new assessment of our hypothesis: mania is an extension of depression from the perspective of neuronal plasticity.

Med Hypotheses 2014 Dec 13;83(6):845-6. Epub 2014 Oct 13.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

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http://dx.doi.org/10.1016/j.mehy.2014.10.004DOI Listing
December 2014

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.

Pharmacogenomics 2014 Jul;15(10):1297-309

Department of Anesthesia, Cincinnati Children's Hospital Medical Center; 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.2217/pgs.14.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190075PMC
July 2014

Sorafenib in a hepatocellular carcinoma patient with end-stage renal failure: A pharmacokinetic study.

Hepatol Res 2014 Jun 31;44(6):685-8. Epub 2013 May 31.

Department of Surgery, Graduate School of Medicine Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/hepr.12156DOI Listing
June 2014

The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma.

Ther Drug Monit 2014 Jun;36(3):310-6

*Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan; †Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center; ‡Department of Pediatrics, College of Medicine, University of Cincinnati, Ohio; and §Department of Urology, Graduate School of Medicine, Kyoto University, Japan. Dr Terada is now with the Department of Pharmacy, Shiga University of Medical Science Hospital, Japan; Dr Katsura is now with the College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan; and Dr Inui is now with the Kyoto Pharmaceutical University, Japan.

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http://pdfs.journals.lww.com/drug-monitoring/2014/06000/The_
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FTD.0000000000000025DOI Listing
June 2014

Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children.

Br J Clin Pharmacol 2014 May;77(5):910-2

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto University, Kyoto.

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http://dx.doi.org/10.1111/bcp.12211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004414PMC
May 2014

Exposure-toxicity relationship of sorafenib in Japanese patients with renal cell carcinoma and hepatocellular carcinoma.

Clin Pharmacokinet 2014 Feb;53(2):185-96

Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan,

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http://link.springer.com/10.1007/s40262-013-0108-z
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http://dx.doi.org/10.1007/s40262-013-0108-zDOI Listing
February 2014

Impact of genetic variation in breast cancer resistance protein (BCRP/ABCG2) on sunitinib pharmacokinetics.

Drug Metab Pharmacokinet 2012 5;27(6):631-9. Epub 2012 Jun 5.

Department of Pharmacy, Kyoto University Hospital, Kyoto, Japan.

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September 2013

Effect of P-glycoprotein and breast cancer resistance protein inhibition on the pharmacokinetics of sunitinib in rats.

Drug Metab Dispos 2013 Aug 7;41(8):1592-7. Epub 2013 Jun 7.

Department of Pharmacy, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1124/dmd.112.050286DOI Listing
August 2013

Mania: not the opposite of depression, but an extension? Neuronal plasticity and polarity.

Med Hypotheses 2013 Aug 10;81(2):175-9. Epub 2013 Jun 10.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

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http://dx.doi.org/10.1016/j.mehy.2013.05.012DOI Listing
August 2013

Effect of dietary zinc deficiency on ischemic vulnerability of the brain.

Neurosci Lett 2012 Nov 17;531(1):10-3. Epub 2012 Oct 17.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

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http://dx.doi.org/10.1016/j.neulet.2012.10.013DOI Listing
November 2012

Switching to aripiprazole in subjects with pervasive developmental disorders showing tolerability issues with risperidone.

Prog Neuropsychopharmacol Biol Psychiatry 2012 Apr 8;37(1):128-31. Epub 2012 Jan 8.

Department of Neuropsychiatry, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-Cho, Yoshida-Gun, Fukui 910-1193, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S027858461200002
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http://dx.doi.org/10.1016/j.pnpbp.2011.12.015DOI Listing
April 2012

Tolerable sorafenib therapy for a renal cell carcinoma patient with hemodialysis: a case study.

Int J Clin Oncol 2010 Oct 26;15(5):512-4. Epub 2010 Mar 26.

Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan.

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http://dx.doi.org/10.1007/s10147-010-0070-9DOI Listing
October 2010

Assessment of EEG dynamical complexity in Alzheimer's disease using multiscale entropy.

Clin Neurophysiol 2010 Sep 18;121(9):1438-1446. Epub 2010 Apr 18.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

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http://dx.doi.org/10.1016/j.clinph.2010.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914820PMC
September 2010

Antipsychotics reverse abnormal EEG complexity in drug-naive schizophrenia: a multiscale entropy analysis.

Neuroimage 2010 May 10;51(1):173-82. Epub 2010 Feb 10.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10538119100015
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http://dx.doi.org/10.1016/j.neuroimage.2010.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849166PMC
May 2010

[The symptomatology of frontal and temporal lobe damages].

Brain Nerve 2009 Nov;61(11):1209-18

Department of Neurology, International University of Health and Welfare Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo 108-8329, Japan.

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November 2009

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.

Mol Pharmacol 2009 Jun 30;75(6):1280-6. Epub 2009 Mar 30.

Department of Pharmacy, Kyoto University Hospital, Japan.

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http://dx.doi.org/10.1124/mol.109.056242DOI Listing
June 2009

Dual imaging of pulmonary delivery and gene expression of dry powder inhalant by fluorescence and bioluminescence.

J Control Release 2009 Mar 30;134(2):149-54. Epub 2008 Nov 30.

Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya, Japan.

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http://dx.doi.org/10.1016/j.jconrel.2008.11.018DOI Listing
March 2009

Age-related variation in EEG complexity to photic stimulation: a multiscale entropy analysis.

Clin Neurophysiol 2009 Mar 23;120(3):476-83. Epub 2009 Feb 23.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

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http://dx.doi.org/10.1016/j.clinph.2008.12.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880484PMC
March 2009

[Evaluation of stability of temozolomide in solutions after opening the capsule].

Yakugaku Zasshi 2009 Mar;129(3):353-7

Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1248/yakushi.129.353DOI Listing
March 2009

Rapid exacerbation in an elderly case of adult-onset X-linked adrenoleukodystrophy with cerebral corticospinal tract involvement.

Arch Neurol 2008 Mar;65(3):416-7

Department of Neurology, International University of Health and Welfare Mita Hospital, Tokyo 108-8329, Japan.

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http://dx.doi.org/10.1001/archneur.65.3.416DOI Listing
March 2008

Neural correlates underlying perception of tonality-related emotional contents.

Neuroreport 2007 Oct;18(16):1651-5

Department of Cognitive Neuroscience, Graduate School of Medicine, International University of Health and Welfare Mita Hospital, Mita, Tokyo, Japan.

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http://dx.doi.org/10.1097/WNR.0b013e3282f0b787DOI Listing
October 2007

Ipsilesional attentional-approach neglect or crossover effect.

Neurocase 2006 Aug;12(4):207-11

Department of Neurology and Center for Neuropsychological Studies, University of Florida College of Medicine, and Neurology Service, Department of Veteran Affairs Medical Center, Gainesville, Florida 32610-0236, USA.

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http://dx.doi.org/10.1080/13554790600598758DOI Listing
August 2006

Vocal amusia in a professional tango singer due to a right superior temporal cortex infarction.

Neuropsychologia 2006 27;44(3):479-88. Epub 2005 Jun 27.

Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1016/j.neuropsychologia.2005.05.013DOI Listing
May 2006