Tomohiko Ai

Tomohiko Ai

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Tomohiko Ai

Tomohiko Ai

Publications by authors named "Tomohiko Ai"

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43Publications

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A novel automated image analysis system using deep convolutional neural networks can assist to differentiate MDS and AA.

Sci Rep 2019 Sep 16;9(1):13385. Epub 2019 Sep 16.

Department of Next Generation Hematology Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-019-49942-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746738PMC
September 2019

Human Soluble Recombinant Thrombomodulin, ART-123, Resolved Early Phase Coagulopathies, but Did Not Significantly Alter the 28 Day Outcome in the Treatment of DIC Associated with Infectious Systemic Inflammatory Response Syndromes.

J Clin Med 2019 Sep 27;8(10). Epub 2019 Sep 27.

Trauma and Acute Critical Care Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

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http://dx.doi.org/10.3390/jcm8101553DOI Listing
September 2019

Atypical profile of aortic injury associated with blunt trauma in the metropolitan area of Japan.

Trauma Surg Acute Care Open 2019 12;4(1):e000342. Epub 2019 Aug 12.

Trauma and Acute Critical Care Center, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1136/tsaco-2019-000342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699723PMC
August 2019

Performance evaluation of the Sysmex DI-60 overview application for tumor cell detection in body fluid samples.

Int J Lab Hematol 2019 Apr 29. Epub 2019 Apr 29.

Department of Next Generation Hematology Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/ijlh.13039DOI Listing
April 2019

A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG.

PLoS One 2016 25;11(8):e0161872. Epub 2016 Aug 25.

Cardiovascular and Respiratory Medicine, Shiga Univ. School of Medicine, Otsu, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999187PMC
August 2017

Drug-induced fatal arrhythmias: Acquired long QT and Brugada syndromes.

Pharmacol Ther 2017 Aug 18;176:48-59. Epub 2017 May 18.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.05.001DOI Listing
August 2017

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

Heart Rhythm 2016 08 7;13(8):1716-23. Epub 2016 May 7.

Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University, Indianapolis, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2016.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958519PMC
August 2016

Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.

PLoS One 2014 5;9(5):e96691. Epub 2014 May 5.

Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010514PMC
January 2015

Amiodarone inhibits apamin-sensitive potassium currents.

PLoS One 2013 29;8(7):e70450. Epub 2013 Jul 29.

Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070450PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726612PMC
August 2014

Hypokalemia promotes late phase 3 early afterdepolarization and recurrent ventricular fibrillation during isoproterenol infusion in Langendorff perfused rabbit ventricles.

Heart Rhythm 2014 Apr 27;11(4):697-706. Epub 2013 Dec 27.

Krannert Institute of Cardiology and the Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2013.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996562PMC
April 2014

Bilateral cardiac sympathetic denervation: the last resort?

Heart Rhythm 2014 Mar 12;11(3):367-8. Epub 2013 Dec 12.

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo, Japan; Department of Emergency Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2013.12.023DOI Listing
March 2014

Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles.

Circ Arrhythm Electrophysiol 2013 Apr 18;6(2):410-8. Epub 2013 Feb 18.

Department of Medicine, Division of Cardiology, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1161/CIRCEP.111.000152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678988PMC
April 2013

Imaging arrhythmogenic calcium signaling in intact hearts.

Pediatr Cardiol 2012 Aug 17;33(6):968-74. Epub 2012 Feb 17.

Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, 1800 N. Capitol Ave, E475, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1007/s00246-012-0236-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586331PMC
August 2012

Gene therapy for AF: A dream too far?

Heart Rhythm 2011 Nov 6;8(11):1730-1. Epub 2011 Jul 6.

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http://dx.doi.org/10.1016/j.hrthm.2011.07.001DOI Listing
November 2011

Is c-Src tyrosine kinase a new target for antiarrhythmic drug therapy?

J Am Coll Cardiol 2011 Nov;58(22):2340-1

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http://dx.doi.org/10.1016/j.jacc.2011.09.005DOI Listing
November 2011

Vagal stimulation promotes atrial electrical remodeling induced by rapid atrial pacing in dogs: evidence of a noncholinergic effect.

Pacing Clin Electrophysiol 2011 Sep 27;34(9):1092-9. Epub 2011 Jul 27.

Texas Heart Institute/St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1540-8159.2011.03133.xDOI Listing
September 2011

A novel SCN5A mutation V1340I in Brugada syndrome augmenting arrhythmias during febrile illness.

Heart Rhythm 2009 Sep 18;6(9):1318-26. Epub 2009 May 18.

Electrophysiology Research Laboratory, Texas Heart Institute/St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.hrthm.2009.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753513PMC
September 2009

A nonsense SCN5A mutation associated with Brugada-type electrocardiogram and intraventricular conduction defects.

Pacing Clin Electrophysiol 2009 Sep;32(9):1231-6

Electrophysiology Research Laboratory, Texas Heart Institute/St. Luke's Episcopal Hospital, Houston, Texas.

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http://dx.doi.org/10.1111/j.1540-8159.2009.02470.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747666PMC
September 2009

A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.

J Cardiovasc Electrophysiol 2007 Apr 10;18(4):434-40. Epub 2007 Jan 10.

Electrophysiology Research Laboratory, Texas Heart Institute/St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1540-8167.2007.00777.xDOI Listing
April 2007

Slow pathway ablation decreases vulnerability to pacing-induced atrial fibrillation: Possible role of vagal denervation.

Pacing Clin Electrophysiol 2006 Nov;29(11):1234-9

Texas Heart Institute/St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1540-8159.2006.00528.xDOI Listing
November 2006

CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).

J Gen Physiol 2005 Apr 14;125(4):361-75. Epub 2005 Mar 14.

Department of Medical Pharmacology and Physiology, University of Missouri-Columbia 65211, USA.

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http://dx.doi.org/10.1085/jgp.200409227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382195PMC
April 2005

Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating.

Pflugers Arch 2004 Oct;449(1):88-95

Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri-Columbia, MO 65211, USA.

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http://dx.doi.org/10.1007/s00424-004-1317-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201469PMC
October 2004

Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.

Mol Pharmacol 2004 Jun;65(6):1415-26

Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, USA.

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http://dx.doi.org/10.1124/mol.65.6.1415DOI Listing
June 2004

Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome.

Circulation 2003 Feb;107(6):838-44

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1161/01.cir.0000048142.85076.a2DOI Listing
February 2003

Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation.

Circulation 2002 Sep;106(10):1269-74

Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1161/01.cir.0000027139.42087.b6DOI Listing
September 2002

Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia.

Circulation 2002 Jun;105(22):2592-4

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1161/01.cir.0000019906.35135.a3DOI Listing
June 2002

Successful radiofrequency current catheter ablation of accessory atrioventricular pathway in Ebstein's anomaly using electroanatomic mapping.

Pacing Clin Electrophysiol 2002 Mar;25(3):374-5

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Sakyo, Japan.

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http://dx.doi.org/10.1046/j.1460-9592.2002.00374.xDOI Listing
March 2002