Tomoharu Kuboyama

Tomoharu Kuboyama

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Tomoharu Kuboyama

Tomoharu Kuboyama

Publications by authors named "Tomoharu Kuboyama"

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33Publications

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[Development of New Therapies for Neurodegenerative Diseases via Axonal Growth].

Yakugaku Zasshi 2019 ;139(11):1385-1390

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama.

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http://dx.doi.org/10.1248/yakushi.19-00147DOI Listing
February 2020

Combined Treatment with Two Water Extracts of Leaf and Rhizome of Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults.

Nutrients 2020 Jan 23;12(2). Epub 2020 Jan 23.

Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.3390/nu12020303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070741PMC
January 2020

Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury.

Neural Regen Res 2019 Nov;14(11):1961-1967

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.4103/1673-5374.259625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676875PMC
November 2019

(Schenk) Wight Extract Enhances Hindlimb Performance and Attenuates Myosin Heavy Chain IId/IIx Expression in Cast-Immobilized Mice.

Evid Based Complement Alternat Med 2019 22;2019:9283171. Epub 2019 Oct 22.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1155/2019/9283171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925718PMC
October 2019

Memory Enhancement by Oral Administration of Extract of Leaves and Active Compounds Transferred in the Brain.

Nutrients 2019 May 22;11(5). Epub 2019 May 22.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.3390/nu11051142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567285PMC
May 2019

Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression.

Phytother Res 2019 Apr 15;33(4):1114-1121. Epub 2019 Feb 15.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1002/ptr.6305DOI Listing
April 2019

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons.

J Vis Exp 2018 10 30(140). Epub 2018 Oct 30.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama;

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http://dx.doi.org/10.3791/58229DOI Listing
October 2018

Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth and .

Front Pharmacol 2018 30;9:1228. Epub 2018 Oct 30.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2018.01228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232869PMC
October 2018

Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice.

Front Pharmacol 2018 7;9:446. Epub 2018 May 7.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2018.00446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949560PMC
May 2018

Author Correction: HDAC3 inhibition ameliorates spinal cord injury by immunomodulation.

Sci Rep 2018 Apr 27;8(1):6920. Epub 2018 Apr 27.

Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.

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http://dx.doi.org/10.1038/s41598-018-25249-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924372PMC
April 2018

Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer's Disease.

Front Pharmacol 2017 14;8:805. Epub 2017 Nov 14.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2017.00805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694549PMC
November 2017

HDAC3 inhibition ameliorates spinal cord injury by immunomodulation.

Sci Rep 2017 08 17;7(1):8641. Epub 2017 Aug 17.

Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.

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http://dx.doi.org/10.1038/s41598-017-08535-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561061PMC
August 2017

A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule.

Front Pharmacol 2017 19;8:340. Epub 2017 Jun 19.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of ToyamaToyama, Japan.

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http://dx.doi.org/10.3389/fphar.2017.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474478PMC
June 2017

A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.

J Biol Chem 2017 01 9;292(4):1240-1250. Epub 2016 Dec 9.

From the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan,

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http://dx.doi.org/10.1074/jbc.M116.748871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270470PMC
January 2017

The Extract of Roots of Sophora flavescens Enhances the Recovery of Motor Function by Axonal Growth in Mice with a Spinal Cord Injury.

Front Pharmacol 2015 14;6:326. Epub 2016 Jan 14.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2015.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712302PMC
February 2016

Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ(25-35)-Induced Axonal Atrophy.

J Nat Prod 2015 Sep 24;78(9):2297-300. Epub 2015 Aug 24.

Division of Neuromedical Science, Department of Bioscience, and ‡Division of Kampo Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.5b00290
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http://dx.doi.org/10.1021/acs.jnatprod.5b00290DOI Listing
September 2015

Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth.

Sci Rep 2015 Jul 14;5:12055. Epub 2015 Jul 14.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/srep12055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501001PMC
July 2015

Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage.

Neurobiol Aging 2015 May 13;36(5):1808-19. Epub 2015 Feb 13.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580150010
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http://dx.doi.org/10.1016/j.neurobiolaging.2015.02.005DOI Listing
May 2015

Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working towards the development of a global study.

Phytother Res 2015 Mar 23;29(3):351-6. Epub 2014 Oct 23.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan; Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1002/ptr.5250DOI Listing
March 2015

Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.

Biol Pharm Bull 2014 ;37(6):892-7

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama.

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http://dx.doi.org/10.1248/bpb.b14-00022DOI Listing
January 2015

New reliable scoring system, Toyama mouse score, to evaluate locomotor function following spinal cord injury in mice.

BMC Res Notes 2014 Jun 3;7:332. Epub 2014 Jun 3.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1186/1756-0500-7-332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057812PMC
June 2014

[New perspective in pharmacology brought by studying traditional medicine].

Nihon Yakurigaku Zasshi 2014 Feb;143(2):73-7

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http://dx.doi.org/10.1254/fpj.143.73DOI Listing
February 2014

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration.

Exp Neurol 2013 Oct 21;248:157-69. Epub 2013 Jun 21.

Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan; Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.expneurol.2013.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773816PMC
October 2013

Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice.

Sci Rep 2012 26;2:535. Epub 2012 Jul 26.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/srep00535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405293PMC
March 2013

Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD.

Int J Neurosci 2011 Dec 11;121(12):641-8. Epub 2011 Aug 11.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Japan.

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http://dx.doi.org/10.3109/00207454.2011.602809DOI Listing
December 2011

Current and future therapeutic strategies for functional repair of spinal cord injury.

Pharmacol Ther 2011 Oct 27;132(1):57-71. Epub 2011 May 27.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 930-0194 Toyama, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01637258110011
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http://dx.doi.org/10.1016/j.pharmthera.2011.05.006DOI Listing
October 2011

Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade.

Neuropsychopharmacology 2006 Jun;31(6):1158-64

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan.

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http://dx.doi.org/10.1038/sj.npp.1300943DOI Listing
June 2006

Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration.

Eur J Neurosci 2006 Mar;23(6):1417-26

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2006.04664.xDOI Listing
March 2006

Search for natural products related to regeneration of the neuronal network.

Neurosignals 2005 ;14(1-2):34-45

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.

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https://www.karger.com/Article/FullText/85384
Publisher Site
http://dx.doi.org/10.1159/000085384DOI Listing
August 2005

Neuritic regeneration and synaptic reconstruction induced by withanolide A.

Br J Pharmacol 2005 Apr;144(7):961-71

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/sj.bjp.0706122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576076PMC
April 2005

Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha.

Neuroreport 2002 Oct;13(14):1715-20

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.

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http://dx.doi.org/10.1097/00001756-200210070-00005DOI Listing
October 2002

Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities.

Chem Pharm Bull (Tokyo) 2002 Jun;50(6):760-5

Department of Metabolic Engineering, Toyama Medical and Pharmaceutical University, Sugitani, Japan.

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http://dx.doi.org/10.1248/cpb.50.760DOI Listing
June 2002