Tomo Šarić

Tomo Šarić

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Tomo Šarić

Publications by authors named "Tomo Šarić"

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Ketamine Increases Proliferation of Human iPSC-Derived Neuronal Progenitor Cells via Insulin-Like Growth Factor 2 and Independent of the NMDA Receptor.

Cells 2019 Sep 24;8(10). Epub 2019 Sep 24.

Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, 51373 Leverkusen, Germany.

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http://dx.doi.org/10.3390/cells8101139DOI Listing
September 2019

Acid-Sensitive Ion Channels Are Expressed in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Stem Cells Dev 2019 Jul 25;28(14):920-932. Epub 2019 Jun 25.

1Cardiac Signaling Center of University of South Carolina, Medical University of South Carolina, Clemson University, Charleston, South Carolina.

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https://www.liebertpub.com/doi/10.1089/scd.2018.0234
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http://dx.doi.org/10.1089/scd.2018.0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648204PMC
July 2019

Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs.

Cell Stem Cell 2019 May 11;24(5):736-752.e12. Epub 2019 Apr 11.

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), University of Cantabria, Cantabria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.03.004DOI Listing
May 2019

In Vitro Grown Micro-Tissues for Cardiac Cell Replacement Therapy in Vivo.

Cell Physiol Biochem 2019 ;52(6):1309-1324

Center for Physiology and Pathophysiology, Institute of Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.33594/000000092DOI Listing
May 2019

Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation.

Stem Cell Reports 2018 08;11(2):552-564

iBET, Instituto de Biologia Experimental e Biológica, Oeiras, Portugal; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094163PMC
August 2018

Effects of hawthorn ( Crataegus pentagyna) leaf extract on electrophysiologic properties of cardiomyocytes derived from human cardiac arrhythmia-specific induced pluripotent stem cells.

FASEB J 2018 03 3;32(3):1440-1451. Epub 2018 Jan 3.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture, and Research, Tehran, Iran.

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http://www.fasebj.org/doi/10.1096/fj.201700494RR
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http://dx.doi.org/10.1096/fj.201700494RRDOI Listing
March 2018

Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling.

Circ Res 2017 Jun 12;121(1):56-70. Epub 2017 Apr 12.

From the Cardiology, Heart Center (M.M., K.F., M.L., J.G., L.R., C.K., J.S., T.R., M.M., M.H., G.P., D.M., M.A., K.M., T.K.R., S.B., A.K., V.R.), Center for Molecular Medicine Cologne (M.M., K.F., M.L., J.G., L.R., C.K., J.S., T.R., M.M., M.H., G.P., D.M., M.A., K.M., T.K.R., S.B., A.K., V.R.), and Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty (T.S.), University of Cologne, Germany; University Heart Center Hamburg, Germany (J.K., D.L.); General and Interventional Cardiology (F.G.D.) and Experimental Pharmacology and Toxicology (B.G., T.E.), University Heart Center Hamburg, University Hospital Hamburg-Eppendorf (UKE), Germany; Institute of Biophysics, Czech Academy of Sciences, Brno (L.K.); International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic (L.K., A.K.); Mathematics, Cleveland State University, OH (Y.W.); and Cellular and Molecular Medicine and Cardiovascular Medicine, Cleveland Clinic, OH (W.H.W.T., S.L.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482785PMC
June 2017

From Early Embryonic to Adult Stage: Comparative Study of Action Potentials of Native and Pluripotent Stem Cell-Derived Cardiomyocytes.

Stem Cells Dev 2016 10 30;25(19):1397-406. Epub 2016 Aug 30.

1 Department of Internal Medicine III, University of Cologne , Cologne, Germany .

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http://dx.doi.org/10.1089/scd.2016.0073DOI Listing
October 2016

Murine transgenic iPS cell line for monitoring and selection of cardiomyocytes.

Stem Cell Res 2016 09 21;17(2):266-272. Epub 2016 Jul 21.

Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.07.007DOI Listing
September 2016

Calcium Imaging in Pluripotent Stem Cell-Derived Cardiac Myocytes.

Methods Mol Biol 2016 ;1353:131-46

Center for Physiology and Pathophysiology, Institute for Vegetative Physiology, Medical Faculty, University of Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany.

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http://dx.doi.org/10.1007/7651_2015_267DOI Listing
August 2016

Effective Hypothermic Storage of Human Pluripotent Stem Cell-Derived Cardiomyocytes Compatible With Global Distribution of Cells for Clinical Applications and Toxicology Testing.

Stem Cells Transl Med 2016 May 29;5(5):658-69. Epub 2016 Mar 29.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal.

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http://dx.doi.org/10.5966/sctm.2015-0238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835249PMC
May 2016

Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor.

Stem Cell Reports 2016 Apr 24;6(4):539-551. Epub 2016 Mar 24.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 1665659911, Iran; Department of Developmental Biology, University of Science and Culture, ACECR, Tehran 1461968151, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834053PMC
April 2016

Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.

Stem Cell Res 2016 Mar 6;16(2):304-7. Epub 2016 Jan 6.

Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.12.039DOI Listing
March 2016

Chromosome tracking in fused cells by single nucleotide polymorphisms.

Methods Mol Biol 2015 ;1313:95-106

Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Robert Koch Str. 39, Cologne, 50931, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2703-6_6DOI Listing
February 2016

Regionally diverse mitochondrial calcium signaling regulates spontaneous pacing in developing cardiomyocytes.

Cell Calcium 2015 May 18;57(5-6):321-36. Epub 2015 Feb 18.

Cardiac Signaling Center of USC, MUSC, & Clemson University, Charleston, SC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2015.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725313PMC
May 2015

Human cardiac extracellular matrix supports myocardial lineage commitment of pluripotent stem cells.

Eur J Cardiothorac Surg 2015 Mar 28;47(3):416-25; discussion 425. Epub 2014 Apr 28.

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité Campus Virchow-Klinikum, Berlin, Germany Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany

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https://academic.oup.com/ejcts/article-lookup/doi/10.1093/ej
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http://dx.doi.org/10.1093/ejcts/ezu163DOI Listing
March 2015

Optimized Generation of Functional Neutrophils and Macrophages from Patient-Specific Induced Pluripotent Stem Cells: Ex Vivo Models of X(0)-Linked, AR22(0)- and AR47(0)- Chronic Granulomatous Diseases.

Biores Open Access 2014 Dec;3(6):311-26

Techniques de l' Ingénierie Médicale et de la Complexité-Informatique, Mathématiques et Applications, Grenoble (TIMC-IMAG), Université Grenoble Alpes , Grenoble, France . ; Centre Diagnostic et Recherche sur la CGD (CDiReC), Pôle Biologie, Centre Hospitalier Universitaire de Grenoble , Grenoble, France .

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http://dx.doi.org/10.1089/biores.2014.0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245876PMC
December 2014

Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells.

Stem Cell Reports 2014 Sep 14;3(3):414-22. Epub 2014 Aug 14.

Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical School, 52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266008PMC
September 2014

Baicalin maintains late-stage functional cardiomyocytes in embryoid bodies derived from murine embryonic stem cells.

Cell Physiol Biochem 2013 5;32(1):86-99. Epub 2013 Jul 5.

Department of Physiology and Chinese-German Stem Cell Center, Tongji Medical College, Huazhong University of Science and Technology, The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei, China.

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http://dx.doi.org/10.1159/000350127DOI Listing
March 2014

Induced pluripotent stem cells as cardiac arrhythmic in vitro models and the impact for drug discovery.

Expert Opin Drug Discov 2014 Jan 3;9(1):55-76. Epub 2013 Dec 3.

University of Cologne, Institute for Neurophysiology, Center for Physiology and Pathophysiology, Medical Center , Robert Koch Str. 39, 50931 Cologne , Germany +49 221 478 86686 ; +49 221 478-3834 ;

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http://dx.doi.org/10.1517/17460441.2014.863275DOI Listing
January 2014

Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis.

Proc Natl Acad Sci U S A 2014 Jan 2;111(3):E354-63. Epub 2014 Jan 2.

Ministry of Education Key Laboratory of Protein Sciences, Center for Structural Biology, School of Life Sciences, and Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, People's Republic of China.

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http://dx.doi.org/10.1073/pnas.1317535111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903230PMC
January 2014

Expansion and differentiation of germline-derived pluripotent stem cells on biomaterials.

Tissue Eng Part A 2013 May 26;19(9-10):1067-80. Epub 2013 Feb 26.

Interdisciplinary Centre for Clinical Research Aachen IZKF Aachen, RWTH Aachen University, Aachen 52074, Germany.

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http://dx.doi.org/10.1089/ten.TEA.2012.0185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609644PMC
May 2013

In vitro model for assessing arrhythmogenic properties of drugs based on high-resolution impedance measurements.

Cell Physiol Biochem 2012 11;29(5-6):819-32. Epub 2012 May 11.

Institute of Neurophysiology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000188069DOI Listing
November 2012

Dual color photoactivation localization microscopy of cardiomyopathy-associated desmin mutants.

J Biol Chem 2012 May 8;287(19):16047-57. Epub 2012 Mar 8.

E. & H. Klessmann Institute for Cardiovascular Research & Development, Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany.

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http://dx.doi.org/10.1074/jbc.M111.313841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346104PMC
May 2012

Cardiac cell therapies: the next generation.

Cardiovasc Ther 2011 Feb 14;29(1):2-16. Epub 2010 Oct 14.

Department of Cardiothoracic Surgery, Heart Center and Center of Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/j.1755-5922.2010.00191.xDOI Listing
February 2011

Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro.

FASEB J 2009 Dec 24;23(12):4168-80. Epub 2009 Aug 24.

Institute for Neurophysiology, Medical Center, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1096/fj.08-128546DOI Listing
December 2009

Biological pacemakers: characterization in an in vitro coculture model.

J Electrocardiol 2008 Nov-Dec;41(6):562-6. Epub 2008 Sep 13.

Pediatric Cardiology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1016/j.jelectrocard.2008.06.017DOI Listing
January 2009

Immunological barriers to embryonic stem cell-derived therapies.

Cells Tissues Organs 2008 27;188(1-2):78-90. Epub 2008 Feb 27.

Center for Physiology, Medical Faculty of the University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000118784DOI Listing
September 2008

Scalable selection of hepatocyte- and hepatocyte precursor-like cells from culture of differentiating transgenically modified murine embryonic stem cells.

Stem Cells 2008 Sep 12;26(9):2245-56. Epub 2008 Jun 12.

Institute for Neurophysiology, Center of Physiology and Pathophysiology, University of Cologne, Robert-Koch Str. 39, D-50931 Cologne, Germany.

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http://dx.doi.org/10.1634/stemcells.2008-0387DOI Listing
September 2008

Stem cells and nuclear reprogramming.

Minim Invasive Ther Allied Technol 2008 ;17(2):64-78

Medical Center, Institute for Neurophysiology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1080/13645700801969303DOI Listing
June 2008

Concise review: role and function of the ubiquitin-proteasome system in mammalian stem and progenitor cells.

Stem Cells 2007 Oct 19;25(10):2408-18. Epub 2007 Jul 19.

Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1634/stemcells.2007-0255DOI Listing
October 2007

Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL.

J Immunol 2007 Mar;178(6):3390-9

Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany.

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http://dx.doi.org/10.4049/jimmunol.178.6.3390DOI Listing
March 2007

CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.

Blood 2006 Jul 7;108(1):228-37. Epub 2006 Mar 7.

Molecular Tumor Biology and Tumor Immunology, the Clinic I for Internal Medicine, Hematology and Oncology, the Institute of Neurophysiology, and the Institute for Pathology, University Hospital at the University of Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2005-08-3507DOI Listing
July 2006

Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases.

J Biol Chem 2004 Nov 24;279(45):46723-32. Epub 2004 Aug 24.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406537200
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http://dx.doi.org/10.1074/jbc.M406537200DOI Listing
November 2004

Non-covalent interaction of ubiquitin with insulin-degrading enzyme.

Mol Cell Endocrinol 2003 Jun;204(1-2):11-20

Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, P.O. Box 180, 10002 Zagreb, Croatia.

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http://dx.doi.org/10.1016/s0303-7207(03)00154-0DOI Listing
June 2003

An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.

Nat Immunol 2002 Dec 18;3(12):1169-76. Epub 2002 Nov 18.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ni859DOI Listing
December 2002

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.

Nat Immunol 2002 Dec 18;3(12):1177-84. Epub 2002 Nov 18.

Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1038/ni860DOI Listing
December 2002

Protein degradation and the generation of MHC class I-presented peptides.

Adv Immunol 2002 ;80:1-70

Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

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November 2002

The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.

Mol Immunol 2002 Oct;39(3-4):147-64

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0161-5890(02)00098-6DOI Listing
October 2002