Tommy Andersson

Tommy Andersson

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Tommy Andersson

Tommy Andersson

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WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion.

Cancers (Basel) 2020 Feb 4;12(2). Epub 2020 Feb 4.

Cell and Experimental Pathology, Department of Translational Medicine, Clinical Research Centre, Skåne University Hospital, Lund University, SE-202 13 Malmö, Sweden.

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http://dx.doi.org/10.3390/cancers12020346DOI Listing
February 2020

ANCD thrombectomy device: in vitro evaluation.

J Neurointerv Surg 2020 Jan 13;12(1):77-81. Epub 2019 Jun 13.

Stroke Unit. Neurology, Hospital Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1136/neurintsurg-2019-014856DOI Listing
January 2020

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity.

Drug Metab Dispos 2020 Jan 4;48(1):8-17. Epub 2019 Nov 4.

Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway (V.K., I.R., A.Å., H.C.); Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway (V.K., A.Å.); Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca Gothenburg, Gothenburg, Sweden (A.P., C.W., S.A., T.B.A.); Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway (M.K.K.); Department of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway (M.K.K.); Department of Pharmacy, Uppsala University, Uppsala, Sweden (C.W., P.A.); The Morbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway (P.C.A., J.H.); Department of Surgery, Vestfold Hospital Trust, Tønsberg, Norway (P.C.A.); Department of Endocrinology, Morbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (J.H.); Late-Stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca Gothenburg, Gothenburg, Sweden (C.K.); Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (C.K.); and Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden (T.B.A.).

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http://dx.doi.org/10.1124/dmd.119.087940DOI Listing
January 2020

Intracranial Stenting after Failure of Thrombectomy with the emboTrap Device.

Clin Neuroradiol 2019 Dec 29;29(4):677-683. Epub 2018 May 29.

Department of Clinical Neuroscience, Karolinska Institutet and Department of Neuroradiology, Karolinska University Hospital, Solnavägen 1, 171 77, Stockholm, Solna, Sweden.

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http://dx.doi.org/10.1007/s00062-018-0697-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884426PMC
December 2019

Posterior Circulation Occlusions May Be Associated with Distal Emboli During Thrombectomy : Factors for Distal Embolization and a Review of the Literature.

Clin Neuroradiol 2019 Sep 22;29(3):425-433. Epub 2018 Mar 22.

Department of Clinical Neuroscience, Karolinska Institutet and Department of Neuroradiology, Karolinska University Hospital, Solnavägen 1, 171 77, Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00062-018-0679-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710331PMC
September 2019

Why Does Mechanical Thrombectomy in Large Vessel Occlusion Sometimes Fail? : A Review of the Literature.

Clin Neuroradiol 2019 Sep 20;29(3):401-414. Epub 2019 Mar 20.

Department of Clinical Neuroscience, Karolinska Institutet and Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00062-019-00777-1
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http://dx.doi.org/10.1007/s00062-019-00777-1DOI Listing
September 2019

Less dementia and stroke in low-risk patients with atrial fibrillation taking oral anticoagulation.

Eur Heart J 2019 Jul;40(28):2327-2335

Department of Clinical Sciences, Karolinska Institutet at Danderyd University Hospital, Storskogsvägen 5, Stockholm, Sweden.

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http://dx.doi.org/10.1093/eurheartj/ehz304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642728PMC
July 2019

Analysis of revascularisation in ischaemic stroke with EmboTrap (ARISE I study) and meta-analysis of thrombectomy.

Interv Neuroradiol 2019 Jun 18;25(3):261-270. Epub 2018 Dec 18.

7 Departments of Neuroradiology and Clinical Neuroscience, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.

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http://journals.sagepub.com/doi/10.1177/1591019918817406
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http://dx.doi.org/10.1177/1591019918817406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547199PMC
June 2019

[First donations and transplantations performed in Swedish kidney exchange program].

Lakartidningen 2019 Jun 11;116. Epub 2019 Jun 11.

Lund University - Department of Economics Lund, Sweden Lund University - Department of Economics Lund, Sweden.

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June 2019

The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer.

Anticancer Res 2019 Apr;39(4):1719-1728

Cell and Experimental Pathology, Department of Translational Medicine, Clinical Research Centre, Lund University, Malmö, Sweden

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13278DOI Listing
April 2019

Combination therapy targeting the elevated interleukin-6 level reduces invasive migration of BRAF inhibitor-resistant melanoma cells.

Mol Oncol 2019 02 10;13(2):480-494. Epub 2019 Jan 10.

Cell and Experimental Pathology, Department of Translational Medicine, Clinical Research Centre, Skåne University Hospital, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1002/1878-0261.12433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360505PMC
February 2019

The Aspirations of Direct Aspiration for Thrombectomy in Ischemic Stroke: A Critical Analysis.

J Stroke 2019 Jan 31;21(1):2-9. Epub 2019 Jan 31.

Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.5853/jos.2018.02026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372897PMC
January 2019

WNT5A as a therapeutic target in breast cancer.

Cancer Metastasis Rev 2018 12;37(4):767-778

Cell and Experimental Pathology, Department of Translational Medicine, Lund University, CRC, Malmö, Sweden.

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http://dx.doi.org/10.1007/s10555-018-9760-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510844PMC
December 2018

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.

Basic Clin Pharmacol Toxicol 2018 Sep 29;123 Suppl 5:42-50. Epub 2018 Apr 29.

Research Unit of Biomedicine, Pharmacology and Toxicology, Faculty of Medicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1111/bcpt.13004DOI Listing
September 2018

Mechanical Thrombectomy-A Brief Review of a Revolutionary new Treatment for Thromboembolic Stroke.

Clin Neuroradiol 2018 Sep 9;28(3):313-326. Epub 2018 May 9.

Departments of Neuroradiology and Clinical Neuroscience, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00062-018-0692-2DOI Listing
September 2018

Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines.

Biochem Pharmacol 2018 09 25;155:124-140. Epub 2018 Jun 25.

Drug Metabolism and Pharmacokinetics, Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bcp.2018.06.026DOI Listing
September 2018

Leverbytesprogram – framtid för Sverige?

Lakartidningen 2018 08 9;115. Epub 2018 Aug 9.

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August 2018

Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s.

Br J Pharmacol 2018 06 19;175(11):2116-2129. Epub 2018 Apr 19.

Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden.

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http://doi.wiley.com/10.1111/bph.14203
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http://dx.doi.org/10.1111/bph.14203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980217PMC
June 2018

Review of Post Ischemic Stroke Imaging and Its Clinical Relevance.

Eur J Radiol 2017 Nov 14;96:145-152. Epub 2017 Feb 14.

Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Medical Imaging, AZ Groeninge, Kortrijk, Belgium.

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http://dx.doi.org/10.1016/j.ejrad.2017.02.013DOI Listing
November 2017

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.

Basic Clin Pharmacol Toxicol 2017 Oct 3;121(4):234-238. Epub 2017 Jul 3.

Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden.

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http://dx.doi.org/10.1111/bcpt.12804DOI Listing
October 2017

Validation of Serial Alberta Stroke Program Early CT Score as an Outcome Predictor in Thrombolyzed Stroke Patients.

J Stroke Cerebrovasc Dis 2017 Oct 7;26(10):2264-2271. Epub 2017 Jun 7.

Division of Neurology, Department of Medicine, National University Health System, Singapore; Department of Clinical Neuroscience, Karolinska Institutet and Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.05.009DOI Listing
October 2017

Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.

PLoS One 2017 8;12(9):e0184418. Epub 2017 Sep 8.

Department of Translational Medicine, Division of Cell and Experimental Pathology, Lund University, Clinical Research Centre, Skåne University Hospital Malmö, Malmö, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590932PMC
October 2017

Thrombectomy in acute ischemic stroke: estimations of increasing demands.

J Neurointerv Surg 2017 Sep 26;9(9):830-833. Epub 2016 Aug 26.

Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/neurintsurg-2016-012575DOI Listing
September 2017

Reduced production and uptake of lactate are essential for the ability of WNT5A signaling to inhibit breast cancer cell migration and invasion.

Oncotarget 2017 Sep 20;8(42):71471-71488. Epub 2017 Apr 20.

Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, SE-20502 Malmö, Sweden.

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http://dx.doi.org/10.18632/oncotarget.17277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641063PMC
September 2017

Higher expression of WNT5A protein in oral squamous cell carcinoma compared with dysplasia and oral mucosa with a normal appearance.

Eur J Oral Sci 2017 08 12;125(4):237-246. Epub 2017 Jun 12.

Oral Pathology, Faculty of Odontology, Malmö University, Malmö, Sweden.

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http://dx.doi.org/10.1111/eos.12352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519933PMC
August 2017

Neutrophil extracellular traps in ischemic stroke thrombi.

Ann Neurol 2017 Aug 11;82(2):223-232. Epub 2017 Aug 11.

Laboratory for Thrombosis Research, KU Leuven, Campus Kulak Kortrijk, Kortrijk, Belgium.

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http://dx.doi.org/10.1002/ana.24993DOI Listing
August 2017

Synchronous cardiocerebral infarction in the era of endovascular therapy: which to treat first?

J Thromb Thrombolysis 2017 Jul;44(1):104-111

Division of Neurology, Department of Medicine, National University Health System, 1 E Kent Ridge Road, Singapore, 119228, Singapore.

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http://dx.doi.org/10.1007/s11239-017-1484-2DOI Listing
July 2017

Ruptured carotid-ophthalmic aneurysm treatment: a non-inferiority meta-analysis comparing endovascular coiling and surgical clipping.

Br J Neurosurg 2017 Jun 2;31(3):345-349. Epub 2017 Mar 2.

b Department of Clinical Neuroscience , Karolinska Institute , Stockholm , Sweden.

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http://dx.doi.org/10.1080/02688697.2017.1297371DOI Listing
June 2017

Optic perineuritis: a retrospective case series.

Int Med Case Rep J 2017 8;10:181-188. Epub 2017 Jun 8.

Department of Ophthalmology, Sahlgrenska University Hospital.

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http://dx.doi.org/10.2147/IMCRJ.S125972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476656PMC
June 2017

Nongated Cardiac Computed Tomographic Angiograms for Detection of Embolic Sources in Acute Ischemic Stroke.

Stroke 2017 05 6;48(5):1256-1261. Epub 2017 Apr 6.

From the Division of Neurology, Department of Medicine, National University Health System, Singapore (L.L.L.Y., B.Y.Q.T.); Department of Clinical Neuroscience (S.H., T.A., E.L.), Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology (S.H., T.A.) and Department of Neurology (E.L.), Karolinska University Hospital, Stockholm, Sweden; Department of Diagnostic Imaging (A.G., E.T., S.E.E.) and Emergency Medicine Department (E.L.L., B.S.H.L., W.S.K.), National University Hospital, National University Health System, Singapore; and Department of Cardiology, National University Heart Centre, Singapore (E.L.K.T.).

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http://dx.doi.org/10.1161/STROKEAHA.117.016903DOI Listing
May 2017

Thrombectomy in Acute Ischemic Stroke: Challenges to Procedural Success.

J Stroke 2017 May 31;19(2):121-130. Epub 2017 May 31.

Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.5853/jos.2017.00752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466290PMC
May 2017

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.

Drug Metab Dispos 2017 04 30;45(4):419-429. Epub 2017 Jan 30.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (C.C.B., V.M.L., S.U.V., T.B.A., M.I.-S.); Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden (H.P., T.B.A.); and CXR Biosciences Ltd., Dundee, United Kingdom (R.D.).

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http://dx.doi.org/10.1124/dmd.116.074369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363699PMC
April 2017

Clinical outcome after surgical clipping or endovascular coiling for cerebral aneurysms: a pragmatic meta-analysis of randomized and non-randomized trials with short- and long-term follow-up.

J Neurointerv Surg 2017 Mar 6;9(3):264-277. Epub 2016 Apr 6.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1136/neurintsurg-2016-012292DOI Listing
March 2017

Treatment of cerebral vasospasm with self-expandable retrievable stents: proof of concept.

J Neurointerv Surg 2017 Jan 14;9(1):52-59. Epub 2016 Jul 14.

The Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/neurintsurg-2016-012546DOI Listing
January 2017

Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach.

Drug Metab Dispos 2017 01 24;45(1):35-41. Epub 2016 Oct 24.

Oncology Innovative Medicines and Early Development Biotech Unit (B.C.J.) and Drug Safety and Metabolism (H.R.), AstraZeneca, Cambridge, United Kingdom; Quantitative Clinical Pharmacology (S.J.), and Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit (K.P.K., T.B.A.), AstraZeneca, Mölndal, Sweden; Quantitative Clinical Pharmacology, AstraZeneca, Hertfordshire, United Kingdom (C.L.); Quantitative Clinical Pharmacology, AstraZeneca, Waltham, Massachusetts (K.V.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (T.B.A.).

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http://dx.doi.org/10.1124/dmd.116.072025DOI Listing
January 2017

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.

Chem Res Toxicol 2016 12 23;29(12):1936-1955. Epub 2016 Sep 23.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet , SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00150DOI Listing
December 2016

Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells.

Mol Oncol 2016 11 1;10(9):1415-1429. Epub 2016 Aug 1.

Department of Translational Medicine, Division of Cell and Experimental Pathology, Skåne University Hospital Malmö, Lund University, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2016.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423213PMC
November 2016

Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition.

Arch Toxicol 2016 Oct 21;90(10):2497-511. Epub 2016 Jun 21.

Department of General-, Visceral- and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1007/s00204-016-1758-zDOI Listing
October 2016

Mechanical Thrombectomy in Acute Ischemic Stroke-Patients with Wake-Up Stroke and the Elderly May Benefit as Well.

J Stroke Cerebrovasc Dis 2016 Sep 6;25(9):2276-83. Epub 2016 Jun 6.

Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.05.019DOI Listing
September 2016

CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity.

Drug Metab Dispos 2016 09 11;44(9):1480-9. Epub 2016 Jul 11.

Cardiovascular and Metabolic Diseases, Drug Metabolism and Pharmacokinetics (M.A.H., X.-Q.L., T.B.A.) and Respiratory, Inflammation and Autoimmune Disease, Medicinal Chemistry (G.G.), Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (U.D.); Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (T.B.A.)

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http://dx.doi.org/10.1124/dmd.116.070805DOI Listing
September 2016

WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition.

J Exp Clin Cancer Res 2016 09 13;35(1):144. Epub 2016 Sep 13.

Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, SE-20502, Malmö, Sweden.

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http://dx.doi.org/10.1186/s13046-016-0421-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022188PMC
September 2016

Dual mechanisms of action of the RNA-binding protein human antigen R explains its regulatory effect on melanoma cell migration.

Transl Res 2016 06 23;172:45-60. Epub 2016 Feb 23.

Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2016.02.007DOI Listing
June 2016

Demonstration of a WNT5A-IL-6 positive feedback loop in melanoma cells: Dual interference of this loop more effectively impairs melanoma cell invasion.

Oncotarget 2016 Jun;7(25):37790-37802

Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, SE-20502 Malmö, Sweden.

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http://dx.doi.org/10.18632/oncotarget.9332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122349PMC
June 2016

The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer.

Eur Urol 2016 Mar 2;69(3):400-4. Epub 2015 Jul 2.

Department of Translational Medicine, Division of Urological Cancers, Skåne University Hospital Malmö, Lund University, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838150051
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http://dx.doi.org/10.1016/j.eururo.2015.06.016DOI Listing
March 2016

Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression.

J Oral Pathol Med 2015 Nov 2;44(10):776-84. Epub 2014 Dec 2.

Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1111/jop.12292DOI Listing
November 2015

Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?

Cancers (Basel) 2015 Sep 17;7(3):1900-24. Epub 2015 Sep 17.

Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, Malmö SE-20502, Sweden.

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http://dx.doi.org/10.3390/cancers7030868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586801PMC
September 2015

A Wnt5a signaling pathway in the pathogenesis of HIV-1 gp120-induced pain.

Pain 2015 Jul;156(7):1311-9

aDepartment of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA bDepartment of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX, USA cHainan Provincial Institute for Drug Control, Haikou, Hainan, China dDepartment of Laboratory Medicine, Lund University, Clinical Research Centre, Skane University Hospital, Malmo, Sweden.

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http://pdfs.journals.lww.com/pain/2015/07000/A_Wnt5a_signali
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/j.pain.0000000000000177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682897PMC
July 2015

Patients with subarachnoid haemorrhage from vertebrobasilar dissection: treatment with stent-in-stent technique.

Neuroradiology 2015 Jun 5;57(6):605-14. Epub 2015 Mar 5.

Department of Neuroradiology, The Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden,

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http://link.springer.com/10.1007/s00234-015-1505-9
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http://dx.doi.org/10.1007/s00234-015-1505-9DOI Listing
June 2015

Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.

Drug Metab Pharmacokinet 2014 11;29(4):352-5. Epub 2014 Feb 11.

Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge.

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http://dx.doi.org/10.2133/dmpk.dmpk-13-sh-138DOI Listing
May 2015

HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.

Drug Metab Dispos 2015 Jan 4;43(1):119-25. Epub 2014 Nov 4.

AstraZeneca R&D, Mölndal, Sweden; and Respiratory, Inflammation and Autoimmunity Innovative Medicines Drug Metabolism and Pharmacokinetics (K.R., K.G.), Cardiovascular and Metabolic Diseases Innovative Medicines (A.J., T.B.A.), Drug Safety and Metabolism Drug Metabolism and Pharmacokinetics (L.A.), Personalized Healthcare and Biomarkers (Z.B.), and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (T.B.A.).

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http://dx.doi.org/10.1124/dmd.114.059246DOI Listing
January 2015

Interleukin-6 drives melanoma cell motility through p38α-MAPK-dependent up-regulation of WNT5A expression.

Mol Oncol 2014 Dec 27;8(8):1365-78. Epub 2014 May 27.

Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, SE-20502 Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528610PMC
December 2014

Predictors of hospitalization for heart failure and of all-cause mortality after atrioventricular nodal ablation and right ventricular pacing for atrial fibrillation.

Europace 2014 Dec 16;16(12):1772-8. Epub 2014 Jul 16.

Department of Cardiology, Örebro University Hospital, Örebro, Sweden Department of Medicine, Örebro University, Örebro, Sweden.

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http://dx.doi.org/10.1093/europace/euu171DOI Listing
December 2014

Challenges of acute endovascular stroke trials.

Stroke 2014 Oct 28;45(10):3116-22. Epub 2014 Aug 28.

From the Department of Radiology and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada (M.G., M.A., B.M., M.H., A.D.); Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia (M.A.); Department of Neurosurgery, University of Florida, Gainesville (K.F.); Department of Neurology, John Hunter Hospital, University of Newcastle, Callaghan, Australia (M.P.); Department of Neurology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea (O.Y.B.); Department of Neurosurgery, Buffalo, NY (A.S.); Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden (T.A.); Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.A.); Department of Neuroradiology, University Hospital of Geneva, Geneva, Switzerland (V.M.); Department of Neurology, University Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain (A.D.); Department of Radiology, Medical University of South Carolina, Charleston (A.T.); Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN (J.M.); Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia (B.C.); Department of Neurology, Emory University, Atlanta, GA (R.N.); Wellstar Neurosurgery, Wellstar Neuroscience Institute, Wellstar Health System, Marietta, GA (R.G.); The Dublin Neurological Institute, Mater Misericordiae University Hospital, Dublin 7, Ireland (S.M.); Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, PA (T.J.); Departments of Neurology and Radiology, University of Cincinnati, OH (P.K., J.P.B.); Department of Interventional Neuroradiology, Capital University, Beijing, China (Z.M.); and Department of Neurology, University of California, Los Angeles (J.S.).

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http://stroke.ahajournals.org/content/45/10/3116.full.pdf
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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.114.
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http://dx.doi.org/10.1161/STROKEAHA.114.006288DOI Listing
October 2014

Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes.

Drug Metab Dispos 2014 Sep 30;42(9):1401-6. Epub 2014 Jun 30.

Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden (G.H., P.S., J.S.); Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden (G.H.); Department of Discovery Safety, Drug Safety and Metabolism, AstraZeneca R&D, Mölndal, Sweden (A.-K.S.); Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (I.B., T.B.A., M.I.-S.); Department of Bioscience, Cardiovascular and Metabolic Diseases, AstraZeneca R&D, Mölndal, Sweden (A.S.); NovaHep AB, Gothenburg, Sweden (P.B.); Department of Drug Metabolism and Pharmacokinetics, AstraZeneca R&D, Mölndal, Sweden (T.B.A.); and Cellectis AB, Gothenburg, Sweden (P.S., P.B., J.E.).

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http://dx.doi.org/10.1124/dmd.114.059154DOI Listing
September 2014

Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes.

Arch Toxicol 2014 Jul 10;88(7):1427-37. Epub 2014 Jun 10.

Cardiovascular and Metabolic Diseases Innovative Medicines, DMPK, AstraZeneca R&D, 431 83, Mölndal, Sweden,

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http://dx.doi.org/10.1007/s00204-014-1265-zDOI Listing
July 2014

Mechanical thrombectomy in acute ischemic stroke-experience from 6 years of practice.

Neuroradiology 2014 Jun 1;56(6):477-86. Epub 2014 Apr 1.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s00234-014-1353-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070491PMC
June 2014

The prognostic significance of Wnt-5a expression in primary breast cancer is extended to premenopausal women.

PLoS One 2013 22;8(8):e70890. Epub 2013 Aug 22.

Experimental Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden ; Surgery, Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070890PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750047PMC
April 2014

WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism.

Carcinogenesis 2014 Apr 30;35(4):784-94. Epub 2013 Nov 30.

Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, SE-20502 Malmö, Sweden.

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http://dx.doi.org/10.1093/carcin/bgt390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977146PMC
April 2014

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.

Mol Cancer 2014 Apr 26;13:88. Epub 2014 Apr 26.

Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö SE-20502, Sweden.

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http://dx.doi.org/10.1186/1476-4598-13-88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022450PMC
April 2014

Cytochrome p450 inhibitory properties of common efflux transporter inhibitors.

Drug Metab Dispos 2014 Mar 6;42(3):441-7. Epub 2014 Jan 6.

CNS and Pain Innovative Medicines DMPK, AstraZeneca R&D, Södertälje (G.E., P.L., C.S., J.J., J.H., L.A.); Cardiovascular and Metabolic Diseases Innovative Medicines DMPK, AstraZeneca R&D, Mölndal (P.L., T.B.A., D.P.); Department of Pharmacy, Uppsala University, Uppsala (P.L.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm (T.B.A.), Sweden.

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http://dx.doi.org/10.1124/dmd.113.054932DOI Listing
March 2014

Prediction of in vivo rat biliary drug clearance from an in vitro hepatocyte efflux model.

Drug Metab Dispos 2014 Mar 6;42(3):459-68. Epub 2014 Jan 6.

CNS and Pain Innovative Medicines DMPK, AstraZeneca R&D, Södertälje (P.L., J.L., U.F., I.S., J.J., S.B., J.H., L.A.); Cardiovascular and Metabolic Diseases Innovative Medicines DMPK, AstraZeneca R&D, Mölndal (P.L., T.B.A.); Department of Pharmacy, Uppsala University, Uppsala (P.L.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm (T.B.A.), Sweden.

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http://dx.doi.org/10.1124/dmd.113.054155DOI Listing
March 2014

Functional ATP-binding cassette drug efflux transporters in isolated human and rat hepatocytes significantly affect assessment of drug disposition.

Drug Metab Dispos 2014 Mar 6;42(3):448-58. Epub 2014 Jan 6.

CNS and Pain Innovative Medicines DMPK, AstraZeneca R&D, Södertälje, (P.L., G.E., C.S., J.L., J.J., J.H., L.A.); Cardiovascular and Gastrointestinal Innovative Medicines DMPK, AstraZeneca R&D, Mölndal, (P.L., T.B.A.); Department of Pharmacy, Uppsala University, Uppsala, (P.L.); and Section of Pharmacogenetics, Departments of Physiology and Pharmacology, Karolinska Institutet, Stockholm, (T.B.A.), Sweden.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.113.054528
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http://dx.doi.org/10.1124/dmd.113.054528DOI Listing
March 2014

The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions.

Drug Metab Dispos 2014 Mar 6;42(3):469-80. Epub 2014 Jan 6.

CNS and Pain Innovative Medicines DMPK, AstraZeneca R&D, Södertälje, (P.L., J.L., A.-K.S.-S., E.F., J.J., J.B., J.H., L.A.); Cardiovascular and Metabolic Diseases Innovative Medicines DMPK, AstraZeneca R&D, Mölndal, (P.L., T.B.A.); Department of Pharmacy, Uppsala University, Uppsala, (P.L.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, (T.B.A.), Sweden.

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http://dx.doi.org/10.1124/dmd.113.054676DOI Listing
March 2014

[More kidney transplantations with matching mechanism].

Lakartidningen 2013 Oct 16-22;110(42):1874

Nationalekonomiska institutionen, Ekonomihögskolan, Lunds universitet.

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January 2014

Image noise reduction algorithm for digital subtraction angiography: clinical results.

Radiology 2013 Nov 4;269(2):553-60. Epub 2013 Jun 4.

Department of Clinical Neuroscience, Karolinska Institutet and Department of Neuroradiology, Karolinska University Hospital, Stockholm 17176, Sweden; Department of Hospital Physics, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1148/radiol.13121262DOI Listing
November 2013

Radiation dose in neuroangiography using image noise reduction technology: a population study based on 614 patients.

Neuroradiology 2013 Nov 5;55(11):1365-72. Epub 2013 Sep 5.

Department of Clinical Neuroscience, Karolinska Institute and Department of Neuroradiology, Karolinska University Hospital - Solna, Stockholm, 17176, Sweden,

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http://dx.doi.org/10.1007/s00234-013-1276-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825538PMC
November 2013

WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells.

Mol Oncol 2013 Oct 28;7(5):870-83. Epub 2013 Apr 28.

Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Centre, Skåne University Hospital, SE-20502 Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528454PMC
October 2013

Endovascular treatment for acute ischemic stroke.

N Engl J Med 2013 06;368(25):2430

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http://dx.doi.org/10.1056/NEJMc1304759DOI Listing
June 2013