Tommaso Martino, MD - S.C. Neurologia Ospedaliera - Ospedali Riuniti di Foggia - Medical Doctor

Tommaso Martino

MD

S.C. Neurologia Ospedaliera - Ospedali Riuniti di Foggia

Medical Doctor

Foggia, Puglia | Italy

Main Specialties: Epidemiology, Neurology, Neuropathology, Neuroradiology, Sleep Medicine, Statistics

ORCID logohttps://orcid.org/0000-0001-8877-4104

Tommaso Martino, MD - S.C. Neurologia Ospedaliera - Ospedali Riuniti di Foggia - Medical Doctor

Tommaso Martino

MD

Introduction

Primary Affiliation: S.C. Neurologia Ospedaliera - Ospedali Riuniti di Foggia - Foggia, Puglia , Italy

Specialties:

Education

Jul 2018
Università degli Studi di Bari Facoltà di Medicina e Chirurgia
Neurology Specialization

Publications

15Publications

258Reads

10Profile Views

2PubMed Central Citations

25 Hydroxyvitamin D Levels are Negatively and Independently Associated with Fat Mass in a Cohort of Healthy Overweight and Obese Subjects.

Endocr Metab Immune Disord Drug Targets 2019 ;19(6):838-844

Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy.

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http://dx.doi.org/10.2174/1871530319666190122094039DOI Listing
February 2020
3 Reads

Treatment with metformin in twelve patients with Lafora disease.

Orphanet J Rare Dis 2019 06 21;14(1):149. Epub 2019 Jun 21.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Ospedale Bellaria, Bologna, Italy.

Background: Lafora disease (LD) is a rare, lethal, progressive myoclonus epilepsy for which no targeted therapy is currently available. Studies on a mouse model of LD showed a good response to metformin, a drug with a well known neuroprotective effect. For this reason, in 2016, the European Medicines Agency granted orphan designation to metformin for the treatment of LD. However, no clinical data is available thus far.

Methods: We retrospectively collected data on LD patients treated with metformin referred to three Italian epilepsy centres.

Results: Twelve patients with genetically confirmed LD (6 EPM2A, 6 NHLRC1) at middle/late stages of disease were treated with add-on metformin for a mean period of 18?months (range: 6-36). Metformin was titrated to a mean maintenance dose of 1167?mg/day (range: 500-2000?mg). In four patients dosing was limited by gastrointestinal side-effects. No serious adverse events occurred. Three patients had a clinical response, which was temporary in two, characterized by a reduction of seizure frequency and global clinical improvement.

Conclusions: Metformin was overall safe in our small cohort of LD patients. Even though the clinical outcome was poor, this may be related to the advanced stage of disease in our cases and we cannot exclude a role of metformin in slowing down LD progression. Therefore, on the grounds of the preclinical data, we believe that treatment with metformin may be attempted as early as possible in the course of LD.

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http://dx.doi.org/10.1186/s13023-019-1132-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588886PMC
June 2019
17 Reads
3.358 Impact Factor

Faciobrachial dystonic seizures expressed as epileptic spasms, followed by focal seizures in anti-LGI1 encephalitis: a video-polygraphic study.

Epileptic Disord 2018 Dec;20(6):525-529

Epilepsy Centre - Clinic of Nervous System Diseases, Riuniti Hospital, Foggia, Italy.

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http://dx.doi.org/10.1684/epd.2018.1010DOI Listing
December 2018
4 Reads
0.899 Impact Factor

New Insights Into Immune Cell-Derived Extracellular Vesicles in Multiple Sclerosis.

Front Neurol 2018 13;9:604. Epub 2018 Aug 13.

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

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https://www.frontiersin.org/article/10.3389/fneur.2018.00604
Publisher Site
http://dx.doi.org/10.3389/fneur.2018.00604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099084PMC
August 2018
30 Reads

Wernicke's encephalopathy following reduced food intake due to depressive disorders.

Nutr Neurosci 2018 Jun 14;21(5):373-376. Epub 2017 Apr 14.

a Struttura Complessa di Neurologia Universitaria , Azienda Ospedaliero-Universitaria Ospedali Riuniti , Foggia , Italy.

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http://dx.doi.org/10.1080/1028415X.2017.1293761DOI Listing
June 2018
12 Reads
2.114 Impact Factor

Chronic coffee consumption and striatal DAT-SPECT findings in Parkinson's disease.

Neurol Sci 2018 Mar 23;39(3):551-555. Epub 2018 Jan 23.

Nuclear Medicine Unit - D.I.M, "Aldo Moro" University of Bari, Bari, Italy.

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http://dx.doi.org/10.1007/s10072-018-3253-1DOI Listing
March 2018
4 Reads
1.500 Impact Factor

First-aid management of tonic-clonic seizures among healthcare personnel: A survey by the Apulian section of the Italian League Against Epilepsy.

Epilepsy Behav 2018 03 3;80:321-325. Epub 2018 Feb 3.

Epilepsy Centre - Clinic of Nervous System Diseases, Riuniti Hospital, Foggia, Italy.

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http://dx.doi.org/10.1016/j.yebeh.2017.11.017DOI Listing
March 2018
1 Read
2.260 Impact Factor

The epilepsy phenotype in adult patients with intellectual disability and pathogenic copy number variants.

Seizure 2017 Dec 14;53:86-93. Epub 2017 Nov 14.

Medical Genetics Units, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.

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http://dx.doi.org/10.1016/j.seizure.2017.11.009DOI Listing
December 2017
88 Reads
2.060 Impact Factor

Smoking and age-at-onset of both motor and non-motor symptoms in Parkinson's disease.

Parkinsonism Relat Disord 2017 Dec 29;45:94-96. Epub 2017 Sep 29.

Department of Basic Medical Sciences, Neuroscience and Sense Organs, Aldo Moro University of Bari, Piazza Giulio Cesare, 11, IT-70124, Bari, Italy.

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http://dx.doi.org/10.1016/j.parkreldis.2017.09.022DOI Listing
December 2017
5 Reads
3.972 Impact Factor

Weight loss and decubitus duodenal ulcer in Parkinson's disease treated with levodopa-carbidopa intestinal gel infusion.

J Neural Transm (Vienna) 2016 12 10;123(12):1395-1398. Epub 2016 Sep 10.

SC Neurologia Universitaria-AOU Ospedali Riuniti of Foggia, Foggia, Italy.

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http://dx.doi.org/10.1007/s00702-016-1618-2DOI Listing
December 2016
7 Reads
1 Citation
2.402 Impact Factor

Intravenous lacosamide in seizure emergencies: Observations from a hospitalized in-patient adult population.

Seizure 2016 Nov 22;42:20-28. Epub 2016 Sep 22.

Epilepsy Centre - Clinic of Nervous System Diseases, University of Foggia, Riuniti Hospital, Foggia, Italy.

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http://dx.doi.org/10.1016/j.seizure.2016.09.004DOI Listing
November 2016
16 Reads
1 Citation
2.060 Impact Factor

Lacosamide in absence status epilepticus: effective or ineffective?

Seizure 2015 Feb 5;25:32. Epub 2014 Dec 5.

Epilepsy Centre - Clinic of Nervous System Diseases, University of Foggia, Ospedali Riuniti, Foggia, Italy.

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http://dx.doi.org/10.1016/j.seizure.2014.11.012DOI Listing
February 2015
4 Reads
2.060 Impact Factor

Bilateral putaminal necrosis and bronopol toxicity.

BMJ Case Rep 2015 Feb 19;2015. Epub 2015 Feb 19.

Clinic of Nervous System Diseases, Ospedali Riuniti Foggia, University of Foggia, Foggia, Italy.

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http://dx.doi.org/10.1136/bcr-2014-206405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336879PMC
February 2015
2 Reads

Top co-authors

Elena Carapelle
Elena Carapelle

University of Foggia

5
Maria Grazia Pascarella
Maria Grazia Pascarella

University of Foggia

4
Alessandra Lalla
Alessandra Lalla

SC Neurologia Universitaria-AOU Ospedali Riuniti of Foggia

4
Marina Trivisano
Marina Trivisano

Bambino Gesù Children's Hospital

3
Luigi M Specchio
Luigi M Specchio

University of Foggia

3
Giovanni Defazio
Giovanni Defazio

University of Bari

2
Angelo Fabio Gigante
Angelo Fabio Gigante

Aldo Moro University of Bari

2