Tomas Segura

Tomas Segura

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Tomas Segura

Tomas Segura

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Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA.

Neurology 2019 Aug 31;93(9):e851-e863. Epub 2019 Jul 31.

From the Neurovascular Research Laboratory (C.C., A.B.), Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona; Stroke Pharmacogenomics and Genetics (N.C., N.-T.A.) and Stroke Genomics and Genetics (E.M.), Fundació Docència i Recerca Mútua Terrassa; Department of Neuroscience (A.D.), Hospital Germans Trias i Pujol; Stroke Unit (E.L.-C.), Hospital Universitario Central de Asturias; Stroke Unit (M.R., C.A.M.), Hospital Universitari Vall d'Hebron; Stroke Unit, Hospital Universitari Vall d'Hebron; Department of Neurology (E.G.-S., C.S.-T., M.M.-C., J.J.-C., J.R.), Neurovascular Research Group, IMIM-Hospital del Mar; Neurobiology Laboratory (C.V.-B.), Institut d'Investigacio Sanitaria de Palma; Department of Neurology (R.D.N.), Hospital Universitari Son Espases; Department of Neurology (V.O.), Hospital Clínic i Provincial de Barcelona; Department of Neurology (J.F.A.), Hospital Clínico Universitario, University of Valladolid; Department of Neurology (T.S.) and Experimental Research Unit (G.S.-H.), Hospital Universitario de Albacete; Department of Neurology (J.M.-F.), Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau; Department of Neurology (M.F.), Hospital de Basurto; Department of Neurology (J.A.C.), Virgen del Rocío & Macarena Hospitals, IBIS, Spain; Department of Clinical Neuroscience/Neurology (T.T.), Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Sweden; Division of Emergency Medicine (L.H.), Department of Psychiatry (L.I., C.C.), and Department of Neurology (J.-M.L.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (D.S.), Helsinki University Hospital, Finland; Department of Neurology (J.M.), Virgen del Rocío & Macarena Hospitals, IBIS. Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona; and Stroke Pharmacogenomics and Genetics (I.F.-C.), Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Stroke Pharmacogenomics and Genetics, IIB-Sant Pau, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000007997DOI Listing
August 2019

PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome.

Circ Res 2019 01;124(1):114-120

From the Department of Neurology, Neurovascular Research Group, Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona/DCEXS-Universitat Pompeu Fabra (M.M.-C., C.S.-T., E.G.-S., A.R.-C., A.O., E.C.-G., R.M.V.-H., J.R., J.J.-C.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31353
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501820PMC
January 2019

Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 2;27(12):3425-3435. Epub 2018 Sep 2.

Neurology Department, Hospital Universitario de Albacete (Albacete), Albacete, Spain.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.08.001DOI Listing
December 2018

Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke.

N Engl J Med 2018 Jun 16;378(23):2182-2190. Epub 2018 May 16.

From Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Neurology and Stroke Center (P.A., P.C.L., L.M.T., J.L., P.-J.T.), and the Department of Cardiology (P.G.S.), Bichat Hospital, INSERM Laboratory for Vascular Translational Science-Unité 1148, Département Hospitalo-Universitaire Fibrose Inflammation Remodelage, Université Paris-Diderot, Sorbonne-Paris Cité, and AP-HP, Department of Biostatistics, Université Paris-Diderot, Sorbonne-Paris Cité, Fernand Widal Hospital (É.V.), Paris, and Université Lille, Centre Hospitalier Universitaire Lille, Équipe d'Accueil 2694-Santé Publique: Épidémiologie et Qualité des Soins, Lille (J.L.) - all in France; the Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA (G.W.A.); the Department of Neurology, Hôtel-Dieu de France, Saint Joseph University, Beirut, Lebanon (H. Abboud); the Stroke Unit, San Camillo Hospital, Rome (S.A.); Ärztliche Leitung der Klinik für Neurologie, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin (H. Audebert), Klinik für Neurologie, Allgemeines Krankenhaus Celle, Celle (W.H.), and the Department of Neurology, Universitäts Medizin Mannheim, Heidelberg University, Heidelberg (M.G.H.) - all in Germany; Shaare Zedek Medical Center, Jerusalem, Israel (N.M.B.); the Cerebrovascular Disease Service, Beth Israel Deaconess Medical Center, Harvard University, Boston (L.R.C.); Serviço de Neurologia, Hospital de Santo António-Centro Hospitalar do Porto, Porto (M.C.), and the Department of Neurosciences, Service of Neurology, Hospital Santa Maria, University of Lisbon, Lisbon (J.M.F.) - both in Portugal; the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia (G.A.D.); the Stroke Unit and Neurology Service, University Hospital José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico (F.G.-R.); the Neurovascular Research Unit and Health Research Board, Stroke Clinical Trials Network Ireland, University College Dublin, Dublin (P.J.K.); the Comprehensive Stroke Center, Palacký University and University Hospital Olomouc (M.K.), and the Department of Nursing, Faculty of Health Science, Palacký University (D.Š), Olomouc, Czech Republic; the Department of Neurology, Kaohsiung Medical University Chung-Ho Memorial Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan (H.-F.L.); the Stroke Unit, Department of Neurology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona (C.M.), the Stroke Unit, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Lleida (F.P.), and the Stroke Unit, Department of Neurology, Albacete University Hospital, Universidad de Castilla-La Mancha, Albacete (T.S.) - all in Spain; the Department of Neurology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea (J.M.P.); the Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford (P.M.R.), and the National Heart and Lung Institute Imperial College, Institute of Cardiovascular Medicine and Science Royal Brompton Hospital, London (P.G.S.) - both in the United Kingdom; the International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo (S.U.); the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing (Y.W.); and the Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong (L.K.S.W.).

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http://dx.doi.org/10.1056/NEJMoa1802712DOI Listing
June 2018

Combination of Thrombolysis and Statins in Acute Stroke Is Safe: Results of the STARS Randomized Trial (Stroke Treatment With Acute Reperfusion and Simvastatin).

Stroke 2016 11 6;47(11):2870-2873. Epub 2016 Oct 6.

From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).

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http://dx.doi.org/10.1161/STROKEAHA.116.014600DOI Listing
November 2016

PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients.

Stroke 2016 07 14;47(7):1926-9. Epub 2016 Jun 14.

From the Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca MutuaTerrassa, Hospital Mútua de Terrassa, Terrassa, Spain (C.G.-F., E.M., N.C., I.F.-C.); School of Medicine, University of Barcelona, Barcelona, Spain (C.G.-F.); Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona, Spain (C.C., J.M.); Division of Internal Medicine and Rehabilitation (J.-L.R.) and Division of Angiology and Haemostasis (P.F.), Geneva University Hospitals, Switzerland; Geneva Platelet Group, Faculty of Medicine, Geneva, Switzerland (J.-L.R., P.F.); Department of Neurology, Jagiellonian University Medical College, Krakow, Poland (A.S., J.P.); Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy (A.P.); Neurology Department, Albacete Hospital, Albacete, Spain (G.S.-H., T.S.); College of Applied Medical Sciences, Majmaah University, Saudi Arabia (A.-A.A.B.D.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (J.M.-F.); Neurology Service, Hospital Universitari Mútua Terrassa, Terrasa, Spain (J.K.); and School of Healthcare Science, Manchester Metropolitan University, Manchester, UK (J.K.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013340DOI Listing
July 2016

Carotid Intima-Media Thickness is Not Associated with Markers of Atherosclerosis in Stroke Patients.

J Stroke Cerebrovasc Dis 2016 May 4;25(5):1070-1075. Epub 2016 Feb 4.

Department of Neurology, Hospital Universitario de Albacete, Albacete, Spain.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.002DOI Listing
May 2016

TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke.

Stroke 2016 05 29;47(5):1180-6. Epub 2016 Mar 29.

From the Neuroscience Department, Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa (Barcelona), Spain (C.G.-F., J.M.-F., E.M., N.C., I.F.-C.); School of Medicine, University of Barcelona, Barcelona, Spain (C.G.-F.); Neurology Department, Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, Hospital Vall d'Hebron, Barcelona, Spain (C.C., J.M.); Division of Internal Medicine, and Rehabilitation, Trois-Chêne Hospital, University Hospitals of Geneva, Switzerland (J.-L.R.); Geneva Platelet Group, Faculty of Medicine, Geneva, Switzerland (J.-L.R., P.F.); Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland (P.F.); Department of Neurology, Jagiellonian University Medical College, Krakow, Poland (A.S., J.P.); Department of Clinical and Experimental Science, Neurological Clinic, Università degli Studi di Brescia, Brescia, Italy (A.P.); Neurology Department, Albacete Hospital, Albacete, Spain (G.S.-H., T.S.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (J.M.-F.); Neurology Service, Hospital Universitari Mútua Terrassa, Terrasa, (Barcelona), Spain (J.K.); and Neuroscience Department, School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom (J.K.).

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http://dx.doi.org/10.1161/STROKEAHA.115.012237DOI Listing
May 2016

[The value of ultrasounds in the detection of lingual fasciculations].

Rev Neurol 2015 Nov;61(9):431

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

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November 2015

[Guillain-Barré syndrome. Early ultrasound findings].

Rev Neurol 2015 Nov;61(10):471

Complejo Hospitalario Universitario de Albacete, Albacete, Espana.

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November 2015

[Carotidynia, back to an old controversial issue].

Rev Neurol 2015 May;60(10):473-4

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

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May 2015

The ARTICO study: identification of patients at high risk of vascular recurrence after a first non-cardioembolic stroke.

BMC Neurol 2015 Mar 11;15:28. Epub 2015 Mar 11.

Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1186/s12883-015-0278-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369369PMC
March 2015

[Effectiveness of transcranial ultrasound in deep brain stimulation].

Rev Neurol 2014 Aug;59(4):175

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

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August 2014

Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial.

Lancet Neurol 2014 May 2;13(5):453-60. Epub 2014 Apr 2.

August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Spanish Research Council, Barcelona, Spain.

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http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(
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http://linkinghub.elsevier.com/retrieve/pii/S147444221470054
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http://dx.doi.org/10.1016/S1474-4422(14)70054-7DOI Listing
May 2014

[Occipital neuralgia secondary to vasculitis of the occipital artery. Diagnosis using colour duplex].

Rev Neurol 2014 May;58(9):430-2

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

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May 2014

Cerebral hemodynamics and endothelial function in patients with Fabry disease.

BMC Neurol 2013 Nov 11;13:170. Epub 2013 Nov 11.

Department of Neurology, Hospital General Universitario de Albacete, C/Hermanos Falcó S/N, Albacete 02006, Spain.

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http://dx.doi.org/10.1186/1471-2377-13-170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828577PMC
November 2013

[The value of ultrasounds in the detection of muscle fasciculation].

Rev Neurol 2013 Jun;56(11):589

Servicio de Neurología, Complejo Hospitalario Universitario de Albacete, España.

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June 2013

[Optic nerve head drusen].

Rev Neurol 2013 Apr;56(8):447

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April 2013

A case of giant cell arteritis presenting as thunderclap headache.

Headache 2013 Mar 6;53(3):546-7. Epub 2012 Dec 6.

Department of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

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http://dx.doi.org/10.1111/j.1526-4610.2012.02294.xDOI Listing
March 2013

[Severe asymptomatic carotid stenosis: a neurological perspective].

Rev Neurol 2012 Sep;55(5):283-96

Servicio de Neurología, Hospital Universitario Virgen de la Victoria, Albacete, España.

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September 2012

Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins.

BMC Neurol 2012 Aug 3;12:65. Epub 2012 Aug 3.

Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Spain.

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http://dx.doi.org/10.1186/1471-2377-12-65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482606PMC
August 2012

[Usefulness of neurosonology in the diagnosis of acute hydrocephalus].

Rev Neurol 2012 Jun;54(11):699-700

Servicio de Neurología, Complejo Hospitalario Universitario de Albacete, Albacete, España.

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June 2012

Brainstem infarct due to traumatic basilar artery entrapment caused by longitudinal clival fracture.

Arch Neurol 2012 May;69(5):662-3

Department of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

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http://dx.doi.org/10.1001/archneurol.2011.1155DOI Listing
May 2012

[Transcranial duplex in moyamoya disease].

Rev Neurol 2012 Feb;54(4):249-50

Universitario de León, España.

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February 2012

Value of carotid intima-media thickness and significant carotid stenosis as markers of stroke recurrence.

Stroke 2011 Nov 18;42(11):3099-104. Epub 2011 Aug 18.

Neurology Department, Hospital Universitari del Mar, Passeig Marítim 25-29, 0003 Barcelona, Spain.

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http://dx.doi.org/10.1161/STROKEAHA.110.612010DOI Listing
November 2011

Vertebral artery halo sign in patients with stroke: a key clue for the prompt diagnosis of giant cell arteritis.

Stroke 2011 Nov 22;42(11):3287-90. Epub 2011 Sep 22.

Neurology Department, Complejo Hospitalario Universitario de Albacete, Hermanos Falcó 37, 02006 Albacete, Spain.

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http://dx.doi.org/10.1161/STROKEAHA.111.625152DOI Listing
November 2011

Periodic lateralized epileptiform discharges as manifestation of pneumococcal meningoencephalitis.

Int Arch Med 2011 Jun 25;4(1):23. Epub 2011 Jun 25.

Department of Neurology, Complejo Hospitalario Universitario de Albacete (Hermanos Falcó,37), Albacete (Postal code: 02/2006), Spain.

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http://dx.doi.org/10.1186/1755-7682-4-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141320PMC
June 2011

Usefulness of multimodal MR imaging in the differential diagnosis of HaNDL and acute ischemic stroke.

BMC Neurol 2010 Dec 2;10:120. Epub 2010 Dec 2.

Department of Neurology, Hospital Universitario de Albacete, C/ Hermanos Falcó, Albacete 02006, Spain.

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http://dx.doi.org/10.1186/1471-2377-10-120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017035PMC
December 2010

The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms.

Int J Stroke 2010 Aug;5(4):325-8

Comprehensive Stroke Center, Institute of Neurosciences, Hospital Clínic, Institute Investigacions Biomèdicas August Pi I Sunyer, University of Barcelona, Barcelona, Spain.

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http://journals.sagepub.com/doi/10.1111/j.1747-4949.2010.004
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http://dx.doi.org/10.1111/j.1747-4949.2010.00448.xDOI Listing
August 2010

Recommendations for the use of transcranial Doppler ultrasonography to determine the existence of cerebral circulatory arrest as diagnostic support for brain death.

Rev Neurosci 2009 ;20(3-4):251-9

Department ofNeurology, Hospital General Universitario de Albacete, Spain.

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March 2010

[Inflammation as a therapeutic agent in cerebral infarction: cellular inflammatory response and inflammatory mediators].

Rev Neurol 2010 Mar;50(6):349-59

Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, España.

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March 2010

Lateral medullary syndrome and ipsilateral hemiplegia (Opalski syndrome) due to left vertebral artery dissection.

Arch Neurol 2009 Dec;66(12):1574-5

Department of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

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http://dx.doi.org/10.1001/archneurol.2009.268DOI Listing
December 2009

Inflammation as therapeutic objective in stroke.

Curr Pharm Des 2008 ;14(33):3549-64

Grupo de Neurofarmacologia, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha. Centro Regional de Investigaciones Biomédicas, Avda Almansa, 14, 02006-Albacete, Spain.

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http://dx.doi.org/10.2174/138161208786848766DOI Listing
February 2009

Recurrent stroke and massive right-to-left shunt: results from the prospective Spanish multicenter (CODICIA) study.

Stroke 2008 Dec 25;39(12):3131-6. Epub 2008 Sep 25.

Department of Neurology, Hospital Universitario Dr Josep Trueta, Institut d'Investigació Biomèdica de Girona, Girona, Spain.

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http://dx.doi.org/10.1161/STROKEAHA.108.521427DOI Listing
December 2008

Recommendations and treatment strategies for the management of acute ischemic stroke.

Expert Opin Pharmacother 2008 May;9(7):1071-85

Hospital General Universitario de Albacete, Department of Neurology, Albacete-02006, Spain.

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http://dx.doi.org/10.1517/14656566.9.7.1071DOI Listing
May 2008

Cerebral hemodynamic reserve and early neurologic deterioration in acute ischemic stroke.

J Cereb Blood Flow Metab 2004 Nov;24(11):1267-71

Stroke Unit, Department of Neurology, Hospital Universitari Dr. Josep Trueta, 17007 Girona, Spain.

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http://dx.doi.org/10.1097/01.WCB.0000139370.93203.4ADOI Listing
November 2004

Stroke on awakening: looking for a more rational management.

Cerebrovasc Dis 2003 ;16(2):128-33

Department of Neurology, Hospital Universitari Doctor Josep Trueta, Girona, Spain.

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https://www.karger.com/Article/FullText/70592
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http://dx.doi.org/10.1159/000070592DOI Listing
August 2003

Public perception of stroke in Spain.

Cerebrovasc Dis 2003 ;16(1):21-6

Section of Neurology, Hospital General de Albacete, Barcelona, Spain.

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http://dx.doi.org/10.1159/000070110DOI Listing
July 2003